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Volumn 17, Issue 37, 2011, Pages 4166-4173

Optimizing 6-mercaptopurine and azathioprine therapy in the management of inflammatory bowel disease

Author keywords

6 Mercaptopurine; Azathioprine; Drug levels; Inflammatory bowel disease; Thiopurine

Indexed keywords

ALLOPURINOL; AZATHIOPRINE; DRUG METABOLITE; GASTROINTESTINAL AGENT; INFLIXIMAB; MERCAPTOPURINE; METHOTREXATE; METHYLMERCAPTOPURINE; TIOGUANINE; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG;

EID: 80555136799     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v17.i37.4166     Document Type: Review
Times cited : (73)

References (82)
  • 1
    • 4344602852 scopus 로고    scopus 로고
    • Guidelines for the management of inflammatory bowel disease in adults
    • Carter MJ, Lobo AJ, Travis SP. Guidelines for the management of inflammatory bowel disease in adults. Gut 2004; 53 Suppl 5: V1-V16
    • (2004) Gut , vol.53 , Issue.SUPPL. 5
    • Carter, M.J.1    Lobo, A.J.2    Travis, S.P.3
  • 3
    • 0020048415 scopus 로고
    • Controlled trial of azathioprine in chronic ulcerative colitis
    • Kirk AP, Lennard-Jones JE. Controlled trial of azathioprine in chronic ulcerative colitis. Br Med J (Clin Res Ed) 1982; 284: 1291-1292
    • (1982) Br Med J (Clin Res Ed) , vol.284 , pp. 1291-1292
    • Kirk, A.P.1    Lennard-Jones, J.E.2
  • 4
    • 0016293798 scopus 로고
    • Azathioprine in ulcerative colitis: Final report on controlled therapeutic trial
    • Jewell DP, Truelove SC. Azathioprine in ulcerative colitis: final report on controlled therapeutic trial. Br Med J 1974; 4: 627-630
    • (1974) Br Med J , vol.4 , pp. 627-630
    • Jewell, D.P.1    Truelove, S.C.2
  • 5
    • 0025330168 scopus 로고
    • The therapeutic efficacy of 6-mercaptopurine in refractory ulcerative colitis
    • Adler DJ, Korelitz BI. The therapeutic efficacy of 6-mercaptopurine in refractory ulcerative colitis. Am J Gastroenterol 1990; 85: 717-722
    • (1990) Am J Gastroenterol , vol.85 , pp. 717-722
    • Adler, D.J.1    Korelitz, B.I.2
  • 7
    • 0037717938 scopus 로고    scopus 로고
    • Azathioprine: State of the art in inflammatory bowel disease
    • Sandborn WJ. Azathioprine: state of the art in inflammatory bowel disease. Scand J Gastroenterol Suppl 1998; 225: 92-99
    • (1998) Scand J Gastroenterol Suppl , vol.225 , pp. 92-99
    • Sandborn, W.J.1
  • 8
    • 84873020600 scopus 로고    scopus 로고
    • Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis
    • Timmer A, McDonald JW, Macdonald JK. Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis. Cochrane Database Syst Rev 2007; (1): CD000478
    • (2007) Cochrane Database Syst Rev , Issue.1
    • Timmer, A.1    McDonald, J.W.2    McDonald, J.K.3
  • 9
    • 29244457275 scopus 로고    scopus 로고
    • Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis
    • Ardizzone S, Maconi G, Russo A, Imbesi V, Colombo E, Bianchi Porro G. Randomised controlled trial of azathioprine and 5-aminosalicylic acid for treatment of steroid dependent ulcerative colitis. Gut 2006; 55: 47-53
    • (2006) Gut , vol.55 , pp. 47-53
    • Ardizzone, S.1    Maconi, G.2    Russo, A.3    Imbesi, V.4    Colombo, E.5    Bianchi Porro, G.6
  • 13
    • 78650166432 scopus 로고    scopus 로고
    • Dosing 6-thioguanine in inflammatory bowel disease: Expert-based guidelines for daily practice
    • Seinen ML, van Asseldonk DP, Mulder CJ, de Boer NK. Dosing 6-thioguanine in inflammatory bowel disease: expert-based guidelines for daily practice. J Gastrointestin Liver Dis 2010; 19: 291-294
    • (2010) J Gastrointestin Liver Dis , vol.19 , pp. 291-294
    • Seinen, M.L.1    van Asseldonk, D.P.2    Mulder, C.J.3    de Boer, N.K.4
  • 17
    • 33646011261 scopus 로고    scopus 로고
    • Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: A meta-analysis
    • Osterman MT, Kundu R, Lichtenstein GR, Lewis JD. Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis. Gastroenterology 2006; 130: 1047-1053
    • (2006) Gastroenterology , vol.130 , pp. 1047-1053
    • Osterman, M.T.1    Kundu, R.2    Lichtenstein, G.R.3    Lewis, J.D.4
  • 18
    • 0033794050 scopus 로고    scopus 로고
    • Use of 6-mercaptopurine in patients with inflammatory bowel disease previously intolerant of azathioprine
    • Bowen DG, Selby WS. Use of 6-mercaptopurine in patients with inflammatory bowel disease previously intolerant of azathioprine. Dig Dis Sci 2000; 45: 1810-1813
    • (2000) Dig Dis Sci , vol.45 , pp. 1810-1813
    • Bowen, D.G.1    Selby, W.S.2
  • 21
    • 0031423967 scopus 로고    scopus 로고
    • Pharmacokinetics of mercaptopurine: Plasma drug and red cell metabolite concentrations after an oral dose
    • Welch J, Lennard L, Morton GC, Lilleyman JS. Pharmacokinetics of mercaptopurine: plasma drug and red cell metabolite concentrations after an oral dose. Ther Drug Monit 1997; 19: 382-385
    • (1997) Ther Drug Monit , vol.19 , pp. 382-385
    • Welch, J.1    Lennard, L.2    Morton, G.C.3    Lilleyman, J.S.4
  • 22
    • 0035037706 scopus 로고    scopus 로고
    • Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease
    • Cuffari C, Hunt S, Bayless T. Utilisation of erythrocyte 6-thioguanine metabolite levels to optimise azathioprine therapy in patients with inflammatory bowel disease. Gut 2001; 48: 642-646
    • (2001) Gut , vol.48 , pp. 642-646
    • Cuffari, C.1    Hunt, S.2    Bayless, T.3
  • 23
    • 77956253035 scopus 로고    scopus 로고
    • Optimizing therapy with 6-mercaptopurine and azathioprine: To measure or not to measure?
    • Deshpande AR, Abreu MT. Optimizing therapy with 6-mercaptopurine and azathioprine: to measure or not to measure? Therap Adv Gastroenterol 2010; 3: 275-279
    • (2010) Therap Adv Gastroenterol , vol.3 , pp. 275-279
    • Deshpande, A.R.1    Abreu, M.T.2
  • 24
    • 0028073102 scopus 로고
    • High-performance liquid chromatographic assay of human red blood cell thiopurine methyltransferase activity
    • Lennard L, Singleton HJ. High-performance liquid chromatographic assay of human red blood cell thiopurine methyltransferase activity. J Chromatogr B Biomed Appl 1994; 661: 25-33
    • (1994) J Chromatogr B Biomed Appl , vol.661 , pp. 25-33
    • Lennard, L.1    Singleton, H.J.2
  • 27
    • 0027239758 scopus 로고
    • The George Hitchings and Gertrude Elion Lecture. The pharmacology of azathioprine
    • Elion GB. The George Hitchings and Gertrude Elion Lecture. The pharmacology of azathioprine. Ann N Y Acad Sci 1993; 685: 400-407
    • (1993) Ann N Y Acad Sci , vol.685 , pp. 400-407
    • Elion, G.B.1
  • 28
    • 0029923360 scopus 로고    scopus 로고
    • A review of immune modifier therapy for inflammatory bowel disease: Azathioprine, 6-mercaptopurine, cyclosporine, and methotrexate
    • Sandborn WJ. A review of immune modifier therapy for inflammatory bowel disease: azathioprine, 6-mercaptopurine, cyclosporine, and methotrexate. Am J Gastroenterol 1996; 91: 423-433
    • (1996) Am J Gastroenterol , vol.91 , pp. 423-433
    • Sandborn, W.J.1
  • 29
    • 33644855102 scopus 로고    scopus 로고
    • American Gastroenterological Association Institute medical position statement on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease
    • Lichtenstein GR, Abreu MT, Cohen R, Tremaine W. American Gastroenterological Association Institute medical position statement on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease. Gastroenterology 2006; 130: 935-939
    • (2006) Gastroenterology , vol.130 , pp. 935-939
    • Lichtenstein, G.R.1    Abreu, M.T.2    Cohen, R.3    Tremaine, W.4
  • 32
    • 4444224484 scopus 로고    scopus 로고
    • Azathioprine, 6-mercaptopurine in inflammatory bowel disease: Pharmacology, efficacy, and safety
    • Dubinsky MC. Azathioprine, 6-mercaptopurine in inflammatory bowel disease: pharmacology, efficacy, and safety. Clin Gastroenterol Hepatol 2004; 2: 731-743
    • (2004) Clin Gastroenterol Hepatol , vol.2 , pp. 731-743
    • Dubinsky, M.C.1
  • 33
    • 27744574836 scopus 로고    scopus 로고
    • A cost-effectiveness analysis of alternative disease management strategies in patients with Crohn's disease treated with azathioprine or 6-mercaptopurine
    • Dubinsky MC, Reyes E, Ofman J, Chiou CF, Wade S, Sandborn WJ. A cost-effectiveness analysis of alternative disease management strategies in patients with Crohn's disease treated with azathioprine or 6-mercaptopurine. Am J Gastroenterol 2005; 100: 2239-2247
    • (2005) Am J Gastroenterol , vol.100 , pp. 2239-2247
    • Dubinsky, M.C.1    Reyes, E.2    Ofman, J.3    Chiou, C.F.4    Wade, S.5    Sandborn, W.J.6
  • 35
    • 3543150184 scopus 로고    scopus 로고
    • Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease
    • Achkar JP, Stevens T, Easley K, Brzezinski A, Seidner D, Lashner B. Indicators of clinical response to treatment with six-mercaptopurine or azathioprine in patients with inflammatory bowel disease. Inflamm Bowel Dis 2004; 10: 339-345
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 339-345
    • Achkar, J.P.1    Stevens, T.2    Easley, K.3    Brzezinski, A.4    Seidner, D.5    Lashner, B.6
  • 36
    • 34247624461 scopus 로고    scopus 로고
    • Relationship between 6-mercaptopurine dose and 6-thioguanine nucleotide levels in patients with inflammatory bowel disease
    • Morales A, Salguti S, Miao CL, Lewis JD. Relationship between 6-mercaptopurine dose and 6-thioguanine nucleotide levels in patients with inflammatory bowel disease. Inflamm Bowel Dis 2007; 13: 380-385
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 380-385
    • Morales, A.1    Salguti, S.2    Miao, C.L.3    Lewis, J.D.4
  • 37
    • 77954360099 scopus 로고    scopus 로고
    • Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease
    • Dong XW, Zheng Q, Zhu MM, Tong JL, Ran ZH. Thiopurine S-methyltransferase polymorphisms and thiopurine toxicity in treatment of inflammatory bowel disease. World J Gastroenterol 2010; 16: 3187-3195
    • (2010) World J Gastroenterol , vol.16 , pp. 3187-3195
    • Dong, X.W.1    Zheng, Q.2    Zhu, M.M.3    Tong, J.L.4    Ran, Z.H.5
  • 38
    • 0018822866 scopus 로고
    • Mercaptopurine pharmacogenetics: Monogenic inheritance of erythrocyte thiopurine methyltransferase activity
    • Weinshilboum RM, Sladek SL. Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980; 32: 651-662
    • (1980) Am J Hum Genet , vol.32 , pp. 651-662
    • Weinshilboum, R.M.1    Sladek, S.L.2
  • 40
    • 0028891465 scopus 로고
    • A pharmacogenetic basis for the safe and effective use of azathioprine and other thiopurine drugs in dermatologic patients
    • Snow JL, Gibson LE. A pharmacogenetic basis for the safe and effective use of azathioprine and other thiopurine drugs in dermatologic patients. J Am Acad Dermatol 1995; 32: 114-116
    • (1995) J Am Acad Dermatol , vol.32 , pp. 114-116
    • Snow, J.L.1    Gibson, L.E.2
  • 41
    • 4644241129 scopus 로고    scopus 로고
    • Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel disease
    • Winter J, Walker A, Shapiro D, Gaffney D, Spooner RJ, Mills PR. Cost-effectiveness of thiopurine methyltransferase genotype screening in patients about to commence azathioprine therapy for treatment of inflammatory bowel disease. Aliment Pharmacol Ther 2004; 20: 593-599
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 593-599
    • Winter, J.1    Walker, A.2    Shapiro, D.3    Gaffney, D.4    Spooner, R.J.5    Mills, P.R.6
  • 43
    • 0030853187 scopus 로고    scopus 로고
    • Optimizing therapy for inflammatory bowel disease
    • Robinson M. Optimizing therapy for inflammatory bowel disease. Am J Gastroenterol 1997; 92: 12S-17S
    • (1997) Am J Gastroenterol , vol.92
    • Robinson, M.1
  • 44
    • 34247159530 scopus 로고    scopus 로고
    • Assessment of thiopurine methyltransferase enzyme activity is superior to genotype in predicting myelosuppression following azathioprine therapy in patients with inflammatory bowel disease
    • Winter JW, Gaffney D, Shapiro D, Spooner RJ, Marinaki AM, Sanderson JD, Mills PR. Assessment of thiopurine methyltransferase enzyme activity is superior to genotype in predicting myelosuppression following azathioprine therapy in patients with inflammatory bowel disease. Aliment Pharmacol Ther 2007; 25: 1069-1077
    • (2007) Aliment Pharmacol Ther , vol.25 , pp. 1069-1077
    • Winter, J.W.1    Gaffney, D.2    Shapiro, D.3    Spooner, R.J.4    Marinaki, A.M.5    Sanderson, J.D.6    Mills, P.R.7
  • 45
    • 37549016742 scopus 로고    scopus 로고
    • Tolerability and safety of mercaptopurine in azathioprine-intolerant patients with inflammatory bowel disease
    • Lees CW, Maan AK, Hansoti B, Satsangi J, Arnott ID. Tolerability and safety of mercaptopurine in azathioprine-intolerant patients with inflammatory bowel disease. Aliment Pharmacol Ther 2008; 27: 220-227
    • (2008) Aliment Pharmacol Ther , vol.27 , pp. 220-227
    • Lees, C.W.1    Maan, A.K.2    Hansoti, B.3    Satsangi, J.4    Arnott, I.D.5
  • 46
    • 55949090947 scopus 로고    scopus 로고
    • Efficacy of 6-mercaptopurine treatment after azathioprine hypersensitivity in inflammatory bowel disease
    • Nagy F, Molnar T, Szepes Z, Farkas K, Nyari T, Lonovics J. Efficacy of 6-mercaptopurine treatment after azathioprine hypersensitivity in inflammatory bowel disease. World J Gastroenterol 2008; 14: 4342-4346
    • (2008) World J Gastroenterol , vol.14 , pp. 4342-4346
    • Nagy, F.1    Molnar, T.2    Szepes, Z.3    Farkas, K.4    Nyari, T.5    Lonovics, J.6
  • 48
    • 0034528822 scopus 로고    scopus 로고
    • The use of 6-mercaptopurine in patients with inflammatory bowel disease after failure of azathioprine therapy
    • Boulton-Jones JR, Pritchard K, Mahmoud AA. The use of 6-mercaptopurine in patients with inflammatory bowel disease after failure of azathioprine therapy. Aliment Pharmacol Ther 2000; 14: 1561-1565
    • (2000) Aliment Pharmacol Ther , vol.14 , pp. 1561-1565
    • Boulton-Jones, J.R.1    Pritchard, K.2    Mahmoud, A.A.3
  • 49
    • 0036180977 scopus 로고    scopus 로고
    • Azathioprine intolerance in patients with IBD may be imidazole-related and is independent of TPMT activity
    • McGovern DP, Travis SP, Duley J, Shobowale-Bakreel M, Dalton HR. Azathioprine intolerance in patients with IBD may be imidazole-related and is independent of TPMT activity. Gastroenterology 2002; 122: 838-839
    • (2002) Gastroenterology , vol.122 , pp. 838-839
    • McGovern, D.P.1    Travis, S.P.2    Duley, J.3    Shobowale-Bakreel, M.4    Dalton, H.R.5
  • 50
    • 0038805258 scopus 로고    scopus 로고
    • Thioguanine: A potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine
    • Dubinsky MC, Feldman EJ, Abreu MT, Targan SR, Vasiliauskas EA. Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprine. Am J Gastroenterol 2003; 98: 1058-1063
    • (2003) Am J Gastroenterol , vol.98 , pp. 1058-1063
    • Dubinsky, M.C.1    Feldman, E.J.2    Abreu, M.T.3    Targan, S.R.4    Vasiliauskas, E.A.5
  • 51
    • 0033060622 scopus 로고    scopus 로고
    • Allergic reactions to 6-mercaptopurine during treatment of inflammatory bowel disease
    • Korelitz BI, Zlatanic J, Goel F, Fuller S. Allergic reactions to 6-mercaptopurine during treatment of inflammatory bowel disease. J Clin Gastroenterol 1999; 28: 341-344
    • (1999) J Clin Gastroenterol , vol.28 , pp. 341-344
    • Korelitz, B.I.1    Zlatanic, J.2    Goel, F.3    Fuller, S.4
  • 52
    • 77951652155 scopus 로고    scopus 로고
    • Desensitization of patients with allergic reactions to immunosuppressives in the treatment of inflammatory bowel disease
    • Korelitz BI, Reddy B, Bratcher J. Desensitization of patients with allergic reactions to immunosuppressives in the treatment of inflammatory bowel disease. Expert Opin Drug Saf 2010; 9: 379-382
    • (2010) Expert Opin Drug Saf , vol.9 , pp. 379-382
    • Korelitz, B.I.1    Reddy, B.2    Bratcher, J.3
  • 53
    • 18844482689 scopus 로고    scopus 로고
    • Successful desensitization for azathioprine skin rash in a patient with severe Crohn's disease
    • Lavaud F, Abdelli N, Thiefin G. Successful desensitization for azathioprine skin rash in a patient with severe Crohn's disease. Dig Dis Sci 1997; 42: 823
    • (1997) Dig Dis Sci , vol.42 , pp. 823
    • Lavaud, F.1    Abdelli, N.2    Thiefin, G.3
  • 54
    • 0034061968 scopus 로고    scopus 로고
    • Successful desensitization to 6-mercaptopurine in a patient with Crohn's disease
    • Mutinga M, Castells M, Horan R, Farraye FA. Successful desensitization to 6-mercaptopurine in a patient with Crohn's disease. Am J Gastroenterol 2000; 95: 1383-1384
    • (2000) Am J Gastroenterol , vol.95 , pp. 1383-1384
    • Mutinga, M.1    Castells, M.2    Horan, R.3    Farraye, F.A.4
  • 55
    • 0027276221 scopus 로고
    • Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia?
    • Lennard L, Davies HA, Lilleyman JS. Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia? Br J Cancer 1993; 68: 186-190
    • (1993) Br J Cancer , vol.68 , pp. 186-190
    • Lennard, L.1    Davies, H.A.2    Lilleyman, J.S.3
  • 56
    • 0036076821 scopus 로고    scopus 로고
    • TPMT in the treatment of Crohn's disease with azathioprine
    • Lennard L. TPMT in the treatment of Crohn's disease with azathioprine. Gut 2002; 51: 143-146
    • (2002) Gut , vol.51 , pp. 143-146
    • Lennard, L.1
  • 57
    • 0031874260 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving 6-thioguanine versus 6-mercaptopurine
    • Erb N, Harms DO, Janka-Schaub G. Pharmacokinetics and metabolism of thiopurines in children with acute lymphoblastic leukemia receiving 6-thioguanine versus 6-mercaptopurine. Cancer Chemother Pharmacol 1998; 42: 266-272
    • (1998) Cancer Chemother Pharmacol , vol.42 , pp. 266-272
    • Erb, N.1    Harms, D.O.2    Janka-Schaub, G.3
  • 59
    • 0034891450 scopus 로고    scopus 로고
    • An open-label pilot study using thioguanine as a therapeutic alternative in Crohn's disease patients resistant to 6-mercaptopurine therapy
    • Dubinsky MC, Hassard PV, Seidman EG, Kam LY, Abreu MT, Targan SR, Vasiliauskas EA. An open-label pilot study using thioguanine as a therapeutic alternative in Crohn's disease patients resistant to 6-mercaptopurine therapy. Inflamm Bowel Dis 2001; 7: 181-189
    • (2001) Inflamm Bowel Dis , vol.7 , pp. 181-189
    • Dubinsky, M.C.1    Hassard, P.V.2    Seidman, E.G.3    Kam, L.Y.4    Abreu, M.T.5    Targan, S.R.6    Vasiliauskas, E.A.7
  • 64
    • 77950998036 scopus 로고    scopus 로고
    • Oral 6-mercaptopurine versus oral 6-thioguanine and veno-occlusive disease in children with standard-risk acute lymphoblastic leukemia: Report of the Children's Oncology Group CCG-1952 clinical trial
    • Stork LC, Matloub Y, Broxson E, La M, Yanofsky R, Sather H, Hutchinson R, Heerema NA, Sorrell AD, Masterson M, Bleyer A, Gaynon PS. Oral 6-mercaptopurine versus oral 6-thioguanine and veno-occlusive disease in children with standard-risk acute lymphoblastic leukemia: report of the Children's Oncology Group CCG-1952 clinical trial. Blood 2010; 115: 2740-2748
    • (2010) Blood , vol.115 , pp. 2740-2748
    • Stork, L.C.1    Matloub, Y.2    Broxson, E.3    La, M.4    Yanofsky, R.5    Sather, H.6    Hutchinson, R.7    Heerema, N.A.8    Sorrell, A.D.9    Masterson, M.10    Bleyer, A.11    Gaynon, P.S.12
  • 65
    • 13444270315 scopus 로고    scopus 로고
    • Portal hypertension develops in a subset of children with standard risk acute lymphoblastic leukemia treated with oral 6-thioguanine during maintenance therapy
    • Broxson EH, Dole M, Wong R, Laya BF, Stork L. Portal hypertension develops in a subset of children with standard risk acute lymphoblastic leukemia treated with oral 6-thioguanine during maintenance therapy. Pediatr Blood Cancer 2005; 44: 226-231
    • (2005) Pediatr Blood Cancer , vol.44 , pp. 226-231
    • Broxson, E.H.1    Dole, M.2    Wong, R.3    Laya, B.F.4    Stork, L.5
  • 67
    • 42449087386 scopus 로고    scopus 로고
    • Use of allopurinol with low-dose 6-mercaptopurine in inflammatory bowel disease to achieve optimal active metabolite levels: A review of four cases and the literature
    • Witte TN, Ginsberg AL. Use of allopurinol with low-dose 6-mercaptopurine in inflammatory bowel disease to achieve optimal active metabolite levels: a review of four cases and the literature. Can J Gastroenterol 2008; 22: 181-185
    • (2008) Can J Gastroenterol , vol.22 , pp. 181-185
    • Witte, T.N.1    Ginsberg, A.L.2
  • 68
    • 33846820178 scopus 로고    scopus 로고
    • Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine
    • Sparrow MP, Hande SA, Friedman S, Cao D, Hanauer SB. Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine. Clin Gastroenterol Hepatol 2007; 5: 209-214
    • (2007) Clin Gastroenterol Hepatol , vol.5 , pp. 209-214
    • Sparrow, M.P.1    Hande, S.A.2    Friedman, S.3    Cao, D.4    Hanauer, S.B.5
  • 69
    • 24344480999 scopus 로고    scopus 로고
    • Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine
    • Sparrow MP, Hande SA, Friedman S, Lim WC, Reddy SI, Cao D, Hanauer SB. Allopurinol safely and effectively optimizes tioguanine metabolites in inflammatory bowel disease patients not responding to azathioprine and mercaptopurine. Aliment Pharmacol Ther 2005; 22: 441-446
    • (2005) Aliment Pharmacol Ther , vol.22 , pp. 441-446
    • Sparrow, M.P.1    Hande, S.A.2    Friedman, S.3    Lim, W.C.4    Reddy, S.I.5    Cao, D.6    Hanauer, S.B.7
  • 70
    • 0028277317 scopus 로고
    • The inhibitory effects of allopurinol on the production and cytotoxicity of tumor necrosis factor
    • Oláh T, Régely K, Mándi Y. The inhibitory effects of allopurinol on the production and cytotoxicity of tumor necrosis factor. Naunyn Schmiedebergs Arch Pharmacol 1994; 350: 96-99
    • (1994) Naunyn Schmiedebergs Arch Pharmacol , vol.350 , pp. 96-99
    • Oláh, T.1    Régely, K.2    Mándi, Y.3
  • 71
    • 0023583031 scopus 로고
    • Effect of allopurinol on the intestinal absorption of 6-mercaptopurine in rats
    • Sasaki H, Tsuru K, Nakamura J, Konishi R, Shibasaki J. Effect of allopurinol on the intestinal absorption of 6-mercaptopurine in rats. J Pharmacobiodyn 1987; 10: 697-702
    • (1987) J Pharmacobiodyn , vol.10 , pp. 697-702
    • Sasaki, H.1    Tsuru, K.2    Nakamura, J.3    Konishi, R.4    Shibasaki, J.5
  • 74
    • 67949112671 scopus 로고    scopus 로고
    • Risk of lymphoma associated with combination anti-tumor necrosis factor and immunomodulator therapy for the treatment of Crohn's disease: A meta-analysis
    • Siegel CA, Marden SM, Persing SM, Larson RJ, Sands BE. Risk of lymphoma associated with combination anti-tumor necrosis factor and immunomodulator therapy for the treatment of Crohn's disease: a meta-analysis. Clin Gastroenterol Hepatol 2009; 7: 874-881
    • (2009) Clin Gastroenterol Hepatol , vol.7 , pp. 874-881
    • Siegel, C.A.1    Marden, S.M.2    Persing, S.M.3    Larson, R.J.4    Sands, B.E.5
  • 75
    • 80555138854 scopus 로고    scopus 로고
    • Split-dose administration of 6MP/Azathiopurine: A novel and effective strategy for IBD patients with preferential 6MMP metabolism
    • Shih DQ, Nguyen M, Ibanez P, Kwan LY, Targan SR, Vasiliauskas EA. Split-dose administration of 6MP/Azathiopurine: a novel and effective strategy for IBD patients with preferential 6MMP metabolism. Gastroenterology 2009; 136: A677-A678
    • (2009) Gastroenterology , vol.136
    • Shih, D.Q.1    Nguyen, M.2    Ibanez, P.3    Kwan, L.Y.4    Targan, S.R.5    Vasiliauskas, E.A.6
  • 76
    • 20344375494 scopus 로고    scopus 로고
    • Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7
    • Knipp S, Hildebrandt B, Richter J, Haas R, Germing U, Gattermann N. Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7. Haematologica 2005; 90: 691-693
    • (2005) Haematologica , vol.90 , pp. 691-693
    • Knipp, S.1    Hildebrandt, B.2    Richter, J.3    Haas, R.4    Germing, U.5    Gattermann, N.6
  • 77
    • 22644446331 scopus 로고    scopus 로고
    • Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine
    • Kandiel A, Fraser AG, Korelitz BI, Brensinger C, Lewis JD. Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine. Gut 2005; 54: 1121-1125
    • (2005) Gut , vol.54 , pp. 1121-1125
    • Kandiel, A.1    Fraser, A.G.2    Korelitz, B.I.3    Brensinger, C.4    Lewis, J.D.5
  • 80
    • 56549085510 scopus 로고    scopus 로고
    • Hepatosplenic T cell lymphoma in inflammatory bowel disease
    • Shale M, Kanfer E, Panaccione R, Ghosh S. Hepatosplenic T cell lymphoma in inflammatory bowel disease. Gut 2008; 57: 1639-1641
    • (2008) Gut , vol.57 , pp. 1639-1641
    • Shale, M.1    Kanfer, E.2    Panaccione, R.3    Ghosh, S.4
  • 82
    • 0034075584 scopus 로고    scopus 로고
    • Azathioprine for maintenance of remission in Crohn's disease: Benefits outweigh the risk of lymphoma
    • Lewis JD, Schwartz JS, Lichtenstein GR. Azathioprine for maintenance of remission in Crohn's disease: benefits outweigh the risk of lymphoma. Gastroenterology 2000; 118: 1018-1024
    • (2000) Gastroenterology , vol.118 , pp. 1018-1024
    • Lewis, J.D.1    Schwartz, J.S.2    Lichtenstein, G.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.