Synthesis of new camptothecin analogs with improved antitumor activities

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 7, 2009, Pages 2018-2021

  Niizuma, Satoshi ^a   Tsukazaki, Masao ^a   Suda, Hitomi ^a   Murata, Takeshi ^a   Ohwada, Jun ^a   Ozawa, Sawako ^a   Fukuda, Hiroshi ^a   Murasaki, Chikako ^a   Kohchi, Masami ^a   Morikami, Kenji ^a   Yoshinari, Kiyoshi ^a   Endo, Mika ^a   Ura, Masako ^a   Tanimura, Hiromi ^a   Miyazaki, Yoko ^a   Takasuka, Tsuyoshi ^a   Kawashima, Akira ^a   Nanba, Eitaro ^a   Nakano, Kounosuke ^a   Ogawa, Kotaro ^a   Kobayashi, Kazuko ^a   Okabe, Hisafumi ^a   Umeda, Isao ^a   Shimma, Nobuo ^a   more..

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Anticancer agent; BCRP; Camptothecin analog; Topoisomerase I inhibitor

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; AMIDINE; BREAST CANCER RESISTANCE PROTEIN; CAMPTOTHECIN DERIVATIVE; CH 793076; CHO 793076; IRINOTECAN; RUBITECAN; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER MODEL; CELL PROLIFERATION; DRUG CONFORMATION; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MAXIMUM TOLERATED DOSE; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE I, EUKARYOTIC; HUMANS; MICE; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

MUS;

EID: 61849162882     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.02.031     Document Type: Article

References (8)

1. Hecht J.R. Am. J. Health Syst. Pharm. 65 (2008) S15-S21
2. Wu D. Tetrahedron 59 (2003) 8649-8687
3. Liew S.T., and Yang L.-X. Curr. Pharm. Des. 14 (2008) 1078-1097
4. Mitsui I., Kumazawa E., and Hirota Y. Jpn. J. Cancer Res. 86 (1995) 776-782
5. Redinbo M.R., Stewart L., Kuhn P., Champoux J.J., and Hol W.G.J. Science 279 (1998) 1504-1513
6. Staker B.L., Hjerrild K., Feese M.D., Behnke C.A., Burgin Jr. A.B., and Stewart L. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 15387-15392
7. Cao Z., Harris N., Kozielski A., Cardeman D., Stehlin J.S., and Giovanella B. J. Med. Chem. 41 (1998) 31-37
8. Kawabata S., Oka M., Shiozawa K., Tsukamoto K., Nakatomi K., Soda H., Fukuda M., Ikegami Y., Sugahara K., Yamada Y., Kamihira S., Doyle L.A., Ross D.D., and Kohno S. Biochem. Biophys. Res. Commun. 280 (2001) 1216-1223