Receptor-independent metabolic effects of thiazolidinediones in astrocytes

Open Cancer Immunology Journal

Volumn 3, Issue , 2010, Pages 36-40

  Akar, Candan ^a   Kalinin, Sergey ^a   Gavrilyuk, Vitaliy ^a   Spagnolo, Alessandra ^a   Weinberg, Guy ^a   Feinstein, Douglas L ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Brain; Lactate; Mitochondria; MitoNEET; PPAR

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; CRE RECOMBINASE; GLIAL FIBRILLARY ACIDIC PROTEIN; LACTIC ACID; MITOCHONDRIAL PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; PROTEIN MITONEET; RECEPTOR; SMALL INTERFERING RNA; TROGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; DRUG PROTEIN BINDING; GLIA CELL; GLIOMA CELL; METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; TRANSGENIC MOUSE; WILD TYPE;

EID: 80555123897     PISSN: None     EISSN: 18764010     Source Type: Journal    
DOI: 10.2174/1876401001003010036     Document Type: Article

References (24)

1. Rangwala SM, Lazar MA. Peroxisome proliferator-activated receptor gamma in diabetes and metabolism. Trends Pharmacol Sci 2004; 25(6): 331-6.
2. Pakala R, Kuchulakanti P, Rha SW, Cheneau E, Baffour R, Waksman R. Peroxisome proliferator-activated receptor gamma: its role in metabolic syndrome. Cardiovasc Radiat Med 2004; 5(2): 97-103.
3. Day C. Thiazolidinediones: a new class of antidiabetic drugs. Mar Diabet Med 1999; 16(3):179-92.
4. Hauner H. The mode of action of thiazolidinediones. Diabetes Metab Res Rev 2002;18 (Suppl 2): S10-S15.
5. Dello R.C, Gavrilyuk V, Weinberg G, et al. Peroxisome proliferator-activated receptor gamma thiazolidinedione agonists increase glucose metabolism in astrocytes. J Biol Chem 2003; 278(8): 5828-36.
6. Preininger K, Stingl H, Englisch R, et al. Acute troglitazone action in isolated perfused rat liver. Br J Pharmacol 1999; 126(1): 372-8.
7. Perez-Ortiz JM, Tranque P, Vaquero CF, et al. Glitazones differentially regulate primary astrocyte and glioma cell survival. Involvement of reactive oxygen species and peroxisome proliferator-activated receptor-gamma. Mar J Biol Chem 2004; 279(10): 8976-85.
8. Spagnolo A, Grant EN, Glick R, Lichtor T, Feinstein DL. Differential effects of PPARgamma agonists on the metabolic properties of gliomas and astrocytes. Neurosci Lett 2007; 417(1): 72-7.
9. Colca JR, McDonald WG, Waldon DJ, et al. Identification of a novel mitochondrial protein (mitoNEET) cross-linked specifically by a thiazolidinedione photoprobe. Am J Physiol Endocrinol Metab 2004; 286(2): E252-E60.
10. Dello Russo C, Polak PE, Mercado PR, et al. The heat-shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin suppresses glial inflammatory responses and ameliorates experimental autoimmune encephalomyelitis. J Neurochem 2006; 99(5): 1351-62.
11. Phulwani NK, Feinstein DL, Gavrilyuk V, Akar C, Kielian T. 15-deoxy-Delta12,14-prostaglandin J2 (15d-PGJ2) and ciglitazone modulate Staphylococcus aureus-dependent astrocyte activation primarily through a PPAR-gamma-independent pathway. J Neurochem 2006; 99(5): 1389-402.
12. Ciaraldi TP, Gilmore A, Olefsky JM, Goldberg M, Heidenreich KA. In vitro studies on the action of CS-045, a new antidiabetic agent. Metabolism 1990; 39(10): 1056-62.
13. Ranganathan S, Kern PA. Thiazolidinediones inhibit lipoprotein lipase activity in adipocytes. J Biol Chem 1998; 273(40): 26117-122.
14. Fulgencio JP, Kohl C, Girard J, Pegorier JP. Troglitazone inhibits fatty acid oxidation and esterification and gluconeogenesis in isolated hepatocytes from starved rats. Diabetes 1996; 45(11): 1556-62.
15. Wang M, Wise SC, Leff T, Su TZ. Troglitazone: an antidiabetic agent, inhibits cholesterol biosynthesis through a mechanism independent of peroxisome proliferator-activated receptor-gamma. Diabetes 1999; 48(2): 254-60.
16. Furnsinn C, Neschen S, Noe C, et al. Acute non-insulin-like stimulation of rat muscle glucose metabolism by troglitazone in vitro. Br J Pharmacol 1997; 122(7): 1367-74.
17. Brunmair B, Gras F, Neschen S, et al. Direct thiazolidinedione action on isolated rat skeletal muscle fuel handling is independent of peroxisome proliferator-activated receptor-gamma-mediated changes in gene expression. Diabetes 2001; 50(10): 2309-15.
18. Brunmair B, Staniek K, Gras F, et al. Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions? Diabetes 2004; 53(4): 1052-9.
19. Scatena R, Bottoni P, Vincenzoni F, et al. Bezafibrate induces a mitochondrial derangement in human cell lines: a PPAR-independent mechanism for a peroxisome proliferator. Chem Res Toxicol 2003; 16(11): 1440-7.
20. Paddock ML, Wiley SE, Axelrod HL, et al. MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone. Proc Natl Acad Sci USA 2007; 104(36): 14342-7.
21. Hou X, Liu R, Ross S, Smart EJ, Zhu H, Gong W. Crystallographic studies of human MitoNEET. J Biol Chem 2007; 282(46): 33242-6
22. Lin J, Zhou T, Ye K, Wang J. Crystal structure of human mitoNEET reveals distinct groups of iron sulfur proteins. Proc Natl Acad Sci USA 2007; 104(37): 14640-5.
23. Wiley SE, Murphy AN, Ross SA, van der GP, Dixon JE. MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacity. Proc Natl Acad Sci USA 2007; 104(13): 5318-23.
24. Spagnolo A, Glick RP, Lin H, Cohen EP, Feinstein DL, Lichtor T. Prolonged survival of mice with established intracerebral glioma receiving combined treatment with peroxisome proliferator-activated receptor-gamma thiazolidinedione agonists and interleukin-2-secreting syngeneic/allogeneic fibroblasts. J Neurosurg 2007; 106(2): 299-305.