Acute non-insulin-like stimulation of rat muscle glucose metabolism by troglitazone in vitro

British Journal of Pharmacology

Volumn 122, Issue 7, 1997, Pages 1367-1374

  Furnsinn C ^a,c   Neschen, S ^a   Noe, C ^a   Bisschop, M ^a   Roden, M ^a   Vogl, C ^b   Schneider, B ^a   Waldhausl W ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Glucose transport; Glycogen synthesis; Glycolysis; Insulin sensitivity; Lactate; Skeletal muscle; Troglitazone

Indexed keywords

INSULIN; LACTIC ACID; ORAL ANTIDIABETIC AGENT; TROGLITAZONE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOGEN SYNTHESIS; GLYCOLYSIS; HYPOXIA; MALE; MUSCLE METABOLISM; NONHUMAN; PRIORITY JOURNAL; RAT; SOLEUS MUSCLE;

EID: 0030831845     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701527     Document Type: Article

References (40)

1. AZEVEDO, J.L., CAREY, J.O., PORIES, W.J., MORRIS, P.G. & DOHM, G.L. (1995). Hypoxia stimulates glucose transport in insulin-resistant human skeletal muscle. Diabetes, 44, 695-698.
2. BARON, A.D., BRECHTEL, G., WALLACE, P. & EDELMAN, S.V. (1988). Rates and tissue sites of non-insulin and insulin-mediated glucose uptake in humans. Am. J. Physiol., 255, E769-E774.
3. CARTEE, G.D., DOUEN, A.G., RAMLAL, T., KLIP, A. & HOLLOSZY, J.O. (1991). Stimulation of glucose transport in skeletal muscle by hypoxia. J. Appl. Physiol., 70, 1593-1600.
4. CIARALDI, T.P., GILMORE, A., OLEFSKY, J.M., GOLDBERG, M. & HEIDENREICH, K.A. (1990). In vitro studies on the action of CS-045, a new antidiabetic agent. Metabolism, 39, 1056-1062.
5. CIARALDI, T.P., HUBER-KNUDSEN, K., HICKMAN, M. & OLEFSKY, J.M. (1995). Regulation of glucose transport in cultured muscle cells by novel hypoglycemic agents. Metabolism, 44, 976-982.
6. CRETTAZ, M., PRENTKI, M., ZANIETTI, D. & JEANRENAUD, B. (1980). Insulin resistance in soleus muscle from obese Zucker rats. Involvement of several defective sites. Biochem. J., 186, 525-534.
7. DEFRONZO, R.A., FERRANNINI, E., SATO, Y. & FELIG P. (1981). Synergistic interaction between exercise and insulin on peripheral glucose uptake. J. Clin. Invest., 68, 1468-1474.
8. DEFRONZO, R.A. (1988). The triumvirate β-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes, 37, 667-687.
9. DEVLIN, J.T. (1992). Effects of exercise on insulin sensitivity in humans. Diabetes Care, 15, 1690-1693.
10. DE VOS, P., LEFEBVRE, A.M., MILLER, S.G., GUERRE-MILLO, M., WONG, K., SALADIN, R., HAMANN, L.G., STAELS, B., BRIGGS, M.R. & AUWERX, J. (1996). Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor γ. J. Clin. Invest., 98, 1004-1009.
11. DIMITRIADIS, G.D., LEIGHTON, B., VLACHONIKOLIS, I.G., PARRY-BILLINGS, M., CHALLISS, R.A.J., WEST, D. & NEWSHOLME, E.A. (1988). Effects of hyperthyroidism on the sensitivity of glycolysis and glycogen synthesis to insulin in the soleus muscle of the rat. Biochem. J., 253, 87-92.
12. DUNNETT, C.W. (1964). New tables for multiple comparisons with a control. Biometrics, 20, 482-491.
13. + in alkaline hydrazine buffers: improved conditions for the assay of L-glutamate, L-lactate and other metabolites. Anal. Biochem., 88, 475-484.
14. 2 is a ligand for the adipocyte determination factor PPARγ. Cell, 83, 803-812.
15. FUJIWARA, T., YOSHIOKA, S., YOSHIOKA, T., USHIYAMA, I. & HORIKOSHI, H. (1988). Characterization of a new oral antidiabetic agent CS-045.Studies in KK and ob/ob mice and Zucker fatty rats. Diabetes, 37, 1549-1558.
16. FUJIWARA, T., WADA, M., FUKUDA, K., FUKAMI, M., YOSHIOKA, S., YOSHIOKA, T. & HORIKOSHI, H. (1991). Characterization of CS-045, a new oral antidiabetic agent. II. Effects on glycemic control and pancreatic islet structure at a late state of the diabetic syndrome in C57BL/KsJ-db/db mice. Metabolism 40, 1213-1218.
17. FUJIWARA, T., OKUNO, A., YOSHIOKA, S. & HORIKOSHI, H. (1995). Suppression of hepatic gluconeogenesis in long-term troglitazone treated diabetic KK and C57BI/KsJ-db/db mice. Metabolism, 44, 486-490.
18. FÜRNSINN, C., EBNER, K. & WALDHÄUSL, W. (1995). Failure of GLP-1(7-36)amide to affect glycogenesis in rat skeletal muscle. Diabetologia, 38, 864-867.
19. FÜRNSINN, C., ENGLISCH, R., EBNER, K., NOWOTNY, P., VOGL, C. & WALDHÄUSL, W. (1996). Insulin-like vs non-insulin like stimulation of glucose metabolism by vanadium, tungsten, and selenium compounds in rat muscle. Life Sci., 59, 1989-2000.
20. IWAMOTO, Y., KUZUYA, T., MATSUDA, A., AWATA, T., KUMAKURA, S., INOOKA, G. & SHIRAISHI, I. (1991). Effect of new oral antidiabetic agent CS-045 on glucose tolerance and insulin secretion in patients with NIDDM. Diabetes Care, 14, 1083-1086.
21. INOUE, I., TAKAHASHI, K., KATAYAMA, S., HARADA, Y., NEGISHI, K., ITABASHI, A. & ISHII, J. (1995). Effect of troglitazone (CS-045) and bezafibrate on glucose tolerance, liver glycogen synthase activity, and β-oxidation in fructose-fed rats. Metabolism, 44, 1626-1630.
22. KHOURSHED, M., MILES, P.D.G., GAO, K.M., LEE, M.K., MOOSSA, A.R. & OLEFSKY, J.M. (1995). Metabolic effects of troglitazone on fat-induced insulin resistance in the rat. Metabolism, 44, 1489-1494.
23. KREUTTER, D.K., ANDREWS, K.M., GIBBS, E.M., HUTSON, N.J. & STEVENSON, R.W. (1990). Insulin-like activity of new antidiabetic agent CP 68722 in 3T3-L1 adipocytes. Diabetes, 39, 1414-1419.
24. LEE, M.K., MILES, P.D.G., KHOURSHED, M., GAO, K.M., MOOSSA, A.R. & OLEFSKY, J.M. (1994). Metabolic effects of troglitazone on fructose-induced insulin resistance in the rat. Diabetes, 43, 1435-1439.
25. LEE, M.K. & OLEFSKY, J.M. (1995). Acute effects of troglitazone on in vivo insulin action in normal rats. Metabolism, 44, 1166-1169.
26. LEHMANN, J.M., MOORE, L.B., SMITH-OLIVER, T.A., WILKINSON, W.O., WILLSON, T.M. & KLIEWER, S.A. (1995). An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem., 270, 12953-12956.
27. MAEGAWA, H., IDE, R., HASEGAWA, M., UGI, S., EGAWA, K., IWANISHI, M., KIKKAWA, R., SHIGETA, Y. & KASHIWAGI, A. (1995). Thiazolidine derivatives ameliorate high glucose-induced insulin resistance via the normalization of protein-tyrosine phosphatase activities. J. Biol. Chem., 270, 7724-7730.
28. NOLAN, J.J., LUDVIK, B., BEERDSEN, P., JOYCE, M. & OLEFSKY, J. (1994). Improvement in glucose tolerance and insulin resistance in obese subjects treated with troglitazone. N. Engl. J. Med., 331, 1188-1193.
29. NOLTE, L.A., GULVE, E.A. & HOLLOSZY, J.O. (1994). Epinephrine-induced in vivo muscle glycogen depletion enhances insulin sensitivity of glucose transport. J.Appl. Physiol., 76, 2054-2058.
30. OSHIDA, Y., KAKO, M., LI, L., HU, X.-C., NAKAI, N., SHIMOMURA, Y. & SATO, Y. (1997). Troglitazone improves insulin sensitivity trough increased muscle glycogen contents in Zucker obese rats. Diabetologia, 40, (Suppl. 1), A309 (Abstract).
31. OKUNO, A., IKEDA, K., SHIOTA, M., FUJIWARA, T., YOSHIOKA, S., SUGANO, T. & HORIKOSHI, H. (1997). Acute effect of troglitazone on glucose metabolism in the absence or presence of insulin in perfused rat hindlimb. Metabolism, 46, 716-721.
32. OLEFSKY, J.M., KOLTERMAN, O.G. & SCARLETT, J.A. (1982). Insulin action and resistance in obesity and noninsulin-dependent type II diabetes mellitus. Am. J. Physiol., 243, E15-E30.
33. RICHTER, E.A., GARETTO, L.P., GOODMAN, M.N. & RUDERMAN, N.B. (1982). Muscle glucose metabolism following exercise in the rat. Increased sensitivity to insulin. J. Clin. Invest., 69, 785-793.
34. SHIBUKAWA, A., SAWADA, T., NAKAO, C., IZUMI, T. & NAKAGAWA, T. (1995). High-performance frontal analysis for the study of protein binding of troglitazone (CS-045) in albumin solution and in human plasma. J. Chromatography A, 697, 337-343.
35. SLIEKER, L.J., SUNDELL, K.L., BUSH, K.A., SAGE, S.W., FITCH, L. & SCHMIEGEL, K. (1994). Thiazolidinediones stimulate 2-deoxyglucose uptake into G9 myocytes secondary to inhibition of oxidative phosphorylation. Diabetes, 43, (Suppl. 1), 126A (Abstract).
36. STEVENSON, R.W., HUTSON, N.J., KRUPP, M.N., VOLKMAN, R.A., HOLLAND, G.F., EGGLER, J.F., CLARK, D.A., MCPHERSON, R.K., HALL, C.L., DANBURY, B.H., GIBBS, E.M. & KREUTTER, D.K. (1990). Actions of novel antidiabetic agent englitazone in hyperglycemic hyperinsuleinemic ob/ob mice. Diabetes, 39, 1218-1227.
37. SUGIYAMA, Y., TAKETOMI, S., SHIMURA, Y., IKEDA, H. & FUJITA, T. (1990). Effects of pioglitazone on glucose and lipid metabolism in Wistar fatty rats. Arzneimittelforschung, 40, 263-267.
38. VERGAUWEN, L., HESPEL, P. & RICHTER, E.A. (1994). Adenosine receptors mediate synergistic stimulation of glucose uptake and transport by insulin and by contractions in rat skeletal muscle. J. Clin. Invest., 93, 974-981.
39. WHEELER, T.J., FELL, R.D. & HAUCK, M.A. (1994). Translocation of two glucose transporters in heart: effects of rotenone, uncouplers, workload, palmitate, insulin and anoxia. Biochim. Biophvs. Acta, 1196, 191-200.
40. ZHANG, B., SZALKOWSKI, D., DIAZ, E., HAYES, N., SMITH, R. & BERGER, J. (1994). Potentiation of insulin stimulation of phosphatidylinositol 3-kinase by thiazolidinedione-derived antidiabetic agents in chinese hamster ovary cells expressing human insulin receptors and L6 myotubes. J. Biol. Chem., 269, 25735-25741.