Quantification of nicotine, cotinine, trans-3'-hydroxycotinine and varenicline in human plasma by a sensitive and specific UPLC-tandem mass-spectrometry procedure for a clinical study on smoking cessation

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 30, 2011, Pages 3574-3582

  Dobrinas, Maria ^a   Choong, Eva ^a   Noetzli, Muriel ^a   Cornuz, Jacques ^b   Ansermot, Nicolas ^a   Eap, Chin B ^a,c  

^a Hopital de Cery   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

HILIC; Nicotine; Nicotine metabolites; UPLC MS MS; Varenicline

Indexed keywords

HILIC; NICOTINE; NICOTINE METABOLITES; UPLC-MS/MS; VARENICLINE;

ACETONITRILE; AMMONIUM COMPOUNDS; BIOMOLECULES; COLUMN CHROMATOGRAPHY; DRUG PRODUCTS; ELECTROSPRAY IONIZATION; EXTRACTION; HYDROPHILICITY; IONIC LIQUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; PLASMA (HUMAN); PLASMA STABILITY; PLASMAS;

PYRIDINE;

3' HYDROXYCOTININE; AMMONIA; COTININE; CP 533633; NICOTINE; NICOTINIC AGENT; UNCLASSIFIED DRUG; VARENICLINE;

ACCURACY; ARTICLE; CATION EXCHANGE; CONCENTRATION (PARAMETERS); ELECTROSPRAY; HUMAN; HYDROPHILICITY; IONIZATION; LIQUID CHROMATOGRAPHY; PH MEASUREMENT; PRACTICE GUIDELINE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SMOKING CESSATION; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

BENZAZEPINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COTININE; DRUG STABILITY; HUMANS; LINEAR MODELS; NICOTINE; QUINOXALINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SMOKING CESSATION; TANDEM MASS SPECTROMETRY;

EID: 80555122815     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.09.046     Document Type: Article

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