A novel validated procedure for the determination of nicotine, eight nicotine metabolites and two minor tobacco alkaloids in human plasma or urine by solid-phase extraction coupled with liquid chromatography-electrospray ionization-tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 9-10, 2010, Pages 725-737

  Miller, Eleanor I ^a   Norris, Hye Ryun K ^a   Rollins, Douglas E ^a   Tiffany, Stephen T ^b   Wilkins, Diana G ^a  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

7 mg transdermal nicotine patch; LC ESI MS MS; Nicotine and nicotine metabolites; Plasma urine

Indexed keywords

ANALYTES; AUTOSAMPLERS; CALIBRATION CURVES; CLINICAL STUDY; CONCENTRATION RANGES; CONCENTRATION-DEPENDENT; COTININE; ELECTROSPRAY IONIZATION TANDEM MASS SPECTROMETRY; EXTRACTION METHOD; EXTRACTION RECOVERY; FREEZE-THAW CYCLES; GLUCURONIDES; HUMAN PLASMAS; INTERNAL STANDARDS; LC-ESI-MS/MS; LC-MS/MS; LIMITS OF QUANTIFICATION; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOW DOSE; MATRIX EFFECTS; MULTIPLE REACTION MONITORING; PHARMACOKINETIC STUDIES; QUANTITATIVE DETERMINATIONS; ROOM TEMPERATURE; SAMPLE PREPARATION; SIMULTANEOUS DETERMINATIONS; SOLID-PHASE EXTRACTION; TARGET ANALYTES; TOBACCO ALKALOIDS; TRANSDERMAL;

BIOMOLECULES; BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DEUTERIUM; ELECTROSPRAY IONIZATION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZATION; LIQUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; MATRIX ALGEBRA; METABOLISM; METABOLITES; PARTICLE DETECTORS; PHARMACOKINETICS; PLASMA (HUMAN); PLASMAS; REFRIGERATORS; SOLVENT EXTRACTION; TOBACCO;

PYRIDINE;

3 HYDROXYCOTININE; ALKALOID; ANABASINE; ANATABINE; COTININE; COTININE N BETA DEXTRO GLUCURONIDE; COTININE N OXIDE; DRUG METABOLITE; NICOTINE; NICOTINE N BETA DEXTRO GLUCURONIDE; NICOTINE N' OXIDE; NORCOTININE; NORNICOTINE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; LOW DRUG DOSE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; ROOM TEMPERATURE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TOBACCO; URINALYSIS;

ALKALOIDS; CHROMATOGRAPHY, LIQUID; HUMANS; LIMIT OF DETECTION; NICOTINE; PLANT EXTRACTS; SOLID PHASE EXTRACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TOBACCO;

NICOTIANA TABACUM;

EID: 77649190286     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.12.018     Document Type: Article

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