Alpha-2 adrenergic challenge with guanfacine one month after mild traumatic brain injury: Altered working memory and BOLD response

International Journal of Psychophysiology

Volumn 82, Issue 1, 2011, Pages 107-114

  McAllister, Thomas W ^a   McDonald, Brenna C ^a,b   Flashman, Laura A ^a   Ferrell, Richard B ^a   Tosteson, Tor D ^a   Yanofsky, Norman N ^a   Grove, Margaret R ^a   Saykin, Andrew J ^a,b  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alpha 2 adrenergic agonist; Functional MRI; Guanfacine; Traumatic brain injury; Working memory

Indexed keywords

GUANFACINE; PLACEBO;

ADULT; ARTICLE; BOLD SIGNAL; CLINICAL ARTICLE; COGNITION; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MALE; NEUROPROTECTION; PREFRONTAL CORTEX; PROSPECTIVE STUDY; PROVOCATION TEST; RANDOMIZED CONTROLLED TRIAL; TASK PERFORMANCE; TRAUMATIC BRAIN INJURY; VERBAL MEMORY; WORKING MEMORY;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; ADULT; BRAIN; BRAIN INJURIES; BRAIN MAPPING; COGNITION DISORDERS; DOUBLE-BLIND METHOD; FEMALE; GUANFACINE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MEMORY DISORDERS; MEMORY, SHORT-TERM; NEUROPSYCHOLOGICAL TESTS; OXYGEN; PROSPECTIVE STUDIES; TRAUMA SEVERITY INDICES; YOUNG ADULT;

EID: 80455174694     PISSN: 01678760     EISSN: 18727697     Source Type: Journal    
DOI: 10.1016/j.ijpsycho.2011.06.022     Document Type: Article

References (58)

1. Anticevic A., Repovs G., Shulman G.L., Barch D.M. When less is more: TPJ and default network deactivation during encoding predicts working memory performance. NeuroImage 2010, 49(3):2638-2648.
2. Arnsten A.F.T. Catecholamine modulation of prefrontal cortical cognitive function. Trends in Cognitive Sciences 1998, 2(11):436-447.
3. Arnsten A.F., Goldman-Rakic P.S. Alpha 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science 1985, 230(4731):1273-1276.
4. Arnsten A., Li B.-M. Neurobiology of executive functions: catecholamine influences on prefrontal cortical functions. Biological Psychiatry 2005, 57(11):1377-1384.
5. Arnsten A.F., Cai J.X., Goldman-Rakic P.S. The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes. Journal of Neuroscience 1988, 8(11):4287-4298.
6. Arnsten A.F.T., Steere J.C., Hunt R.D. The contribution of alpha-2 noradrenergic mechanisms to prefrontal cortical cognitive function: potential significance to Attention Deficit Hyperactivity Disorder. Archives of General Psychiatry 1996, 53:448-455.
7. Arnsten A.F., Steere J.C., Jentsch D.J., Li B.M. Noradrenergic influences on prefrontal cortical cognitive function: opposing actions at postjunctional alpha 1 versus alpha 2-adrenergic receptors. Advances in Pharmacology (New York) 1998, 42:764-767.
8. Avery R.A., Franowicz J.S., Studholme C., van Dyck C.H., Arnsten A.F. The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task. Neuropsychopharmacology 2000, 23(3):240-249.
9. Barth A., Vizi E., Zelles T., Lendvai B. Alpha2-adrenergic receptors modify dendritic spike generation via HCN channels in the prefrontal cortex. Journal of Neurophysiology 2008, 99:394-401.
10. Bartus R.T., Fleming D., Johnson H.R. Aging in the rhesus monkey: debilitation effects on short-term memory. Journal of Gerontology 1978, 33:858-871.
11. Binder L.M., Rohling M.L., Larrabee J. A review of mild head trauma. Part I: meta-analytic review of neuropsychological studies. Journal of Clinical and Experimental Neuropsychology 1997, 19(3):421-431.
12. Birnbaum S., Gobeske K.T., Auerbach J., Taylor J.R., Arnsten A.F. A role for norepinephrine in stress-induced cognitive deficits: alpha-1-adrenoceptor mediation in the prefrontal cortex. Biological Psychiatry 1999, 46(9):1266-1274.
13. Brozoski T., Brown R.M., Rosvold H.E., Goldman P.S. Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science 1979, 205:929-931.
14. Cai J.X., Xu L., Hu X. Reserpine impairs spatial working-memory performance in monkeys: reversal by the alpha-2 adrenergic agonist clonidine. Brain Research 1993, 614:191-196.
15. Carlson S., Tanila H., Rama P., Mecke E., Pertovaara A. Effects of medetomidine, an alpha-2 adrenoceptor agonist, and atipamezole, an alpha-2 antagonist, on spatial memory performance in adult and aged rats. Behavioral and Neural Biology 1992, 58(2):113-119.
16. Chen K., Reiman E.M., Alexander G.E., Bandy D., Renaut R., Crum W.R., Fox N.C., Rossor M.N. An automated algorithm for the computation of brain volume change from sequential MRIs using an iterative principal component analysis and its evaluation for the assessment of whole-brain atrophy rates in patients with probable Alzheimer's disease. Neuroimage 2004, 22(1):134-143.
17. Cicerone K., Dahlberg C., Kalmar K., Langenbahn D.M., Malec J., Bergquist T.F., Felicetti T., Giacino J.T., Harley J.P., Harrington D.E., Herzog J., Kneipp S., Laatsch L., Morse P.A. Evidence-based cognitive rehabilitation: recommendations for clinical practice. Archives of Physical Medicine and Rehabilitation 2000, 81:1596-1615.
18. Clerkin S., Schulz K., Halperin J., Newcorn J., Ivanov I., Tang C., Fan J. Guanfacine potentiates the activation of prefrontal cortex evoked by warning signals. Biological Psychiatry 2009, 66:307-312.
19. Crossley N.A., Mechelli A., Fusar-Poli P., Broome M.R., Mathiasson P., Johns L.C., Bramon E., Valmaggia L., Williams S.C.R., McGuire P.K. Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis. Human Brain Mapping 2009, 30(12):4129-4137.
20. Delis D.C., Kramer J.H., Kaplan E., Ober B.A. California Verbal Learning Test: Adult version 1987, The Psychological Corporation, New York.
21. Delis D.C., Kramer J.H., Kaplan E., Ober B.A. California Verbal Learning Test-Second Edition: Adult Version Manual 2000, The Psychological Corporation, San Antonio, TX.
22. Delis D.C., Kaplan E., Kramer J.F. Delis-Kaplan Executive Function System 2001, The Psychological Corporation, San Antonio, TX.
23. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis I Disorders 1997, American Psychiatric Press, Washington, D.C.
24. Franowicz J.S., Arnsten A.F. The alpha-2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys. Psychopharmacology 1998, 136(1):8-14.
25. Friston K.J., Holmes A.P., Worsley K.J., Poline J.P., Frith C.D., Frackowiak R.S.J. Statistical parametric maps in functional imaging: a general linear approach. Human Brain Mapping 1995, 2:189-210.
26. Gordon M., McClure F.D., Aylward G.P. Gordon Diagnostic System: Instruction Manual and Interpretive Guide 1986, DeWitt, NY, Gordon Systems, Inc.
27. Gronwall D. Paced Auditory Serial Addition Task: a measure of recovery from concussion. Perceptual Motor Skills 1977, 44:367-373.
28. Holmes A., Friston K. Generalisability, random effects, and population inference. Neuroimage 1998, 7:S754.
29. Hunt R.D., Arnsten A.F.T., Asbell M.D. An open trial of guanfacine in the treatment of Attention Deficit Hyperactivity Disorder. Journal of the American Academy of Child and Adolescent Psychiatry 1995, 34:50-54.
30. Jakala P., Riekkinen M., Sirvio J., Koivisto E., Kejonen K., Vanhanen M., Riekkinen P. Guanfacine, but not clonidine, improves planning and working memory performance in humans. Neuropsychopharmacology 1999, 20(5):460-470.
31. Jakala P., Sirvio J., Riekkinen M., Koivisto E., Kejonen K., Vanhanen M., Riekkinen P. Guanfacine and clonidine, alpha 2-agonists, improve paired associates learning, but not delayed matching to sample, in humans. Neuropsychopharmacology 1999, 20(2):119-130.
32. Kay T., Harrington D.E., Adams R., Anderson T., Berrol S., Cicerone K., Dahlberg C., Gerber D., Goka R., Harley P., Hilt J., Horn L., Lehmkuhl D., Malec J. Definition of mild traumatic brain injury. Journal of Head Trauma Rehabilitation 1993, 8(3):86-87.
33. Kobori N., Dash P.K. Reversal of brain injury-induced prefrontal glutamic acid decarboxylase expression and working memory deficits by D1 receptor antagonism. Journal of Neuroscience 2006, 26(16):4236-4246.
34. Kobori N., Clifton G.L., Dash P.K. Enhanced catecholamine synthesis in the prefrontal cortex following traumatic brain injury: implications for prefrontal dysfunction. J. Neurotrauma 2006, 23(7):1094-1102.
35. Levin H.S. Cognitive function outcomes after traumatic brain injury. Current Opinion in Neurology 1998, 11:643-646.
36. Levin H.S., Mattis S., Ruff R.M., Eisenberg H.M., Marshall L.F., Tabaddor K., High W.M., Frankowski R.F. Neurobehavioral outcome following minor head injury: a three-center study. Journal of Neurosurgery 1987, 66(2):234-243.
37. Lezak M.D. Neuropsychological Assessment 1995, Oxford University Press, New York.
38. Luine V., Bowling D., Hearns M. Spatial memory deficits in aged rats: contributions of monoaminergic systems. Brain research 1990, 537:271-278.
39. McAllister T., Arnsten A. Pharmacologic approaches to cognitive rehabilitation. Cognitive Neurorehabilitation 2008, 298-320. Cambridge University Press, Boston. D. Stuss, G. Winocur, I. Robertson (Eds.).
40. McAllister T.W., Saykin A.J., Flashman L.A., Sparling M.B., Johnson S.C., Guerin S.J., Mamourian A., Weaver J., Yanofsky N. Brain activation during working memory 1month after mild traumatic brain injury: a functional MRI study. Neurology 1999, 53:1300-1308.
41. McAllister T.W., Sparling M.B., Flashman L.A., Guerin S.J., Mamourian A.C., Saykin A.J. Differential working memory load effects after mild traumatic brain injury. Neuroimage 2001, 14(5):1004-1012.
42. McAllister T.W., Flashman L.A., Sparling M.B., Saykin A.J. Working memory deficits after mild traumatic brain injury: catecholaminergic mechanisms and prospects for catecholaminergic treatment-a review. Brain Injury 2004, 18(4):331-350.
43. McAllister T.W., Flashman L.A., McDonald B.C., Saykin A.J., McAllister T.W., Flashman L.A., McDonald B.C., Saykin A.J. Mechanisms of working memory dysfunction after mild and moderate TBI: evidence from functional MRI and neurogenetics. Journal of Neurotrauma 2006, 23(10):1450-1467.
44. McMillan T.M. Minor head injury. Current Opinion in Neurology 1997, 10(6):479-483.
45. Nejad A.B., Ebdrup B.H., Siebner H.R., Rasmussen H., Aggernææs B., Glenthøøj B.Y., Baaréé W.F.C. Impaired temporoparietal deactivation with working memory load in antipsychotic-naïve patients with first-episode schizophrenia. World Journal of Biological Psychiatry 2011, 12(4):271-281.
46. Perlstein W.M., Cole M.A., Demery J.A., Seignourel P.J., Dixit N.K., Larson M.J., Briggs R.W. Parametric manipulation of working memory load in traumatic brain injury: behavioral and neural correlates. Journal of the International Neuropsychological Society 2004, 10:724-741.
47. Rama P., Linnankoski I., Tanila H., Pertovaara A., Carlson S. Medetomidine, atipamezole, and guanfacine in delayed response performance of aged monkeys. Pharmacology, Biochemistry & Behavior 1996, 55(3):415-422.
48. Ramos B., Stark D., Verduzco L., van Dyck C., Arnsten A. Alpha-2A-Adrenoceptor stimulation improves prefrontal cortical regulation of behavior through inhibition of cAMP signaling in aging animals. Learning and Memory 2006, 13(6):770-776.
49. Reitan R.M., Wolfson D. The Halstead-Reitan Neuropsychological Test Battery: Theory and Clinical Interpretation 1993, Neuropsychology Press, Tucson, AZ. 2nd ed.
50. Sirvio J., Riekkinen P., Vajanto I., Koivisto E., Riekkinen P.J. The effects of guanfacine, alpha-2 agonist, on the performance of young and aged rats in spatial navigation task. Behav Neural Biol 1991, 56(1):101-107.
51. Spreen O., Strauss E. Controlled oral word association. A Compendium of Neuropsychological Tests 1998, 447-467. Oxford UP, New York.
52. Steere J.C., Arnsten A.F. The alpha-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys. Behavioral Neuroscience 1997, 111(5):883-891.
53. Tanila H., Rama P., Carlson S. The effects of prefrontal intracortical microinjections of an alpha-2 agonist, alpha-2 antagonist and lidocaine on the delayed alternation performance of aged rats. Brain Res Bull 1996, 40(2):117-119.
54. The Psychological Corporation WAIS-III Wechsler Adult Intelligence Scale-Third Edition WMS-III Wechsler Memory Scale-Third Edition Technical Manual 1997, The Psychological Corporation, San Antonio, TX.
55. Tomasi D., Ernst T., Caparelli E.C., Chang L. Common deactivation patterns during working memory and visual attention tasks: an intra-subject fMRI study at 4 Tesla. Human Brain Mapping 2006, 27(8):694-705.
56. Wang M., Ramos B., Paspalas C., Shu Y., Simen A., Duque A., et al. Alpha2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell 2007, 129:397-410.
57. Whyte J., Schuster K., Polansky M., Adams J., Coslett H.B. Frequency and duration of inattentive behavior after traumatic brain injury: effects of distraction, task, and practice. Journal of the International Neuropsychological Society 2000, 6(1):1-11.
58. Wilkinson G.S. The Wide Range Achievement Test (WRAT3): Administration Manual 1993, Wide Range, Inc., Wilmington, DE.