The α-2a noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys

Psychopharmacology

Volumn 136, Issue 1, 1998, Pages 8-14

  Franowicz, J Steere ^a   Arnsten, Amy F T ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Guanfacine; Memory; Norepinephrine; Prefrontal cortex

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; GUANFACINE; IDAZOXAN;

AGE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; INTRAMUSCULAR DRUG ADMINISTRATION; MONKEY; NONHUMAN; PRIORITY JOURNAL; SEDATION; TASK PERFORMANCE; WORKING MEMORY;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GUANFACINE; HYPNOTICS AND SEDATIVES; IDAZOXAN; MACACA MULATTA; MEMORY; PSYCHOMOTOR PERFORMANCE; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 0031931947     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050533     Document Type: Article

References (34)

1. Aoki C, Go C-G, Venkatesan C, Kurose H (1994) Perikaryal and synaptic localization of α-2A-adrenergic receptor-like immunoreactivity. Brain Res 650: 181-204
2. Arnsten AFT, Cai JX (1993) Post-synaptic α-2 receptor stimulation improves memory in aged monkeys: indirect effects of yohimbine versus direct effects of clonidine. Neurobiol Aging 14: 597-603
3. Arnsten AFT, Goldman-Rakic PS (1985) Alpha-2 adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged human primates. Science 230: 1273-1276
4. Arnsten AFT, Goldman-Rakic PS (1990) Analysis of α-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys. Neurobiol Aging 11: 583-590
5. Arnsten AFT, Leslie FM (1991) Behavioral and receptor binding analysis of the α-2 adrenergic agonist, 5-bromo-6 [2-imidazoline-2-YL amino] quinoxaline (UK-14304): evidence for cognitive enhancement at an α-2-adrenoceptor subtype. Neuropharmacology 30: 1279-1289
6. Arnsten AFT, Cai JX, Goldman-Rakic PS (1988) The α-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for α-2 receptor subtypes. J Neurosci 8: 4287-4298
7. 2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys. J Neurosci 15: 3429-3439
8. Arnsten AFT, Steere JC, Hunt RD (1996) The contribution of α-2 noradrenergic mechanisms to prefrontal cognitive function. Arch Gen Psychiatry 53: 448-455
9. Bigham MH, Lidow MS (1995) Adrenergic and serotonergic receptors in aged monkey neocortex. Neurobiol Aging 16: 91-104
10. Brown CM, MacKinnon AC, McGrath JC, Spedding M, Kilpatrick AT (1990) Alpha-2 adrenoceptor subtypes and imidazoline-like binding sites in the rat brain. Br J Pharmacol 99: 803-809
11. Brozoski TJ, Brown RM, Rosvold HE, Goldman PS (1979) Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science 215: 929-932
12. Cai JX, Ma Y, Xu L, Hu X (1993) Reserpine impairs spatial working memory performance in monkeys: reversal by the α-2-adrenergic agonist clonidine. Brain Res 614: 191-196
13. Chappell PB, Riddle MA, Scahill L, Lynch K, Schultz R, Arnsten AFT, Leckman JF, Cohen DL (1995) Guanfacine treatment of comorbid attention deficit hyperactivity disorder and tourette's syndrome: preliminary clinical experience. J Am Acad Child Adolesc Psychiatry 34: 50-54
14. 3h]rx821002 binding and definition of additional selective drugs. Eur J Pharmacol 252: 43-49
15. Goldman PS, Rosvold HE (1970) Localization of function within the dorsolateral prefrontal cortex of the rhesus monkey. Exp Neurol 27: 291-304
16. Goldman-Rakic PS, Brown RM (1981) Regional changes of monoamines in cerebral cortex and subcortical structures of aging rhesus monkeys. Neuroscience 6: 177-187
17. Korrigan JP, Barnhill LJ (1995) Guanfacine for treatment of attention-deficit hyperactivity disorder in boys. J Child Adolesc Psychopharmaol 5: 215-223
18. Hunt RD, Arnsten, AFT, Asbell MD (1995) An open trial of guanfacine in the treatment of attention deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 34: 50-54
19. Jackson WJ, Buccafusco JJ (1991) Clonidine enhances delayed matching-to-sample performance by young and aged monkeys. Pharmacol Biochem Behav 39: 79-84
20. Li B-M, Mei Z-T (1994) Delayed response deficit induced by local injection of the α-2 adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeys. Behav Neural Biol 62: 134-139
21. Nicholas AP, Pieribone V, Hökfelt T (1993) Distributions of mRNAs for α-2 adrenergic receptor subtypes in rat brain: an in situ hybridization study. J Comp Neurol 328: 575-594
22. Rajkowski J, Ivanova S, Kubiak P, Aston-Jones G (1995) Improved vigilance performance in monkey associated with altered locus coeruleus (LC) activity after clonidine. Soc Neurosci Abstr 21: 2092
23. Rama P, Linnankoski I, Tanila H, Pertovaara A, Carlson S (1996) Medetomidine, atipamezole, and guanfacine in delayed response performance of aged monkeys. Pharmacol Biochem Behav 55: 415-422
24. Rupniak NMJ, Samson NA, Steventon MJ, Iversen SD (1991) Induction of cognitive impairment by scopolamine and noncholinergic agents in rhesus monkeys. Life Sci 48: 893-899
25. Scheinin M, Lomasney JW, Hayden-Hixson DM, Schambra UB, Caron MG, Lefkowitz RJ, Fremeau RT (1994) Distribution of α-2 adrenergic recept. subtype gene express. in rat brain. Mol Brain Res 21: 133-149
26. Steere JC, Arnsten AFT (1994) The alpha-2A noradrenergic agonist, guanfacine, improves delayed response performance and calms behavior in young monkeys: relevance to attention-deficit disorder. Soc Neurosci Abstr 20: 831
27. Steere JC, Arnsten AFT (1997) The alpha-2A noradrenergic receptor agonist, guanfacine, improves visual object discrimination reversal performance in aged rhesus monkeys. Behav Neurosci 111: 1-9
28. Steere JC, Li B-M, Jentsch JD, Mathews R, Taylor JR, Arnsten AFT (1996) Alpha-1 noradrenergic stimulation impairs, while a-2 stimulation improves, prefrontal cortex spatial working memory function. Soc Neurosci Abstr 22: 1126
29. Svensson TH, Bunney BS, Aghajanian GK (1975) Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine. Brain Res 92: 291
30. 3H]RX821002 radioligand binding: computer modeling reveals that guanfacine is an α-2A-selective compound. Eur J Pharmacol 202: 235-243
31. 3H]MK912 binding delineates 2 α-2-adrenoceptor subtypes in rat CNS one of which is identical with the cloned pA2d α-2-adrenoceptor. Br J Pharmacol 106: 986-995
32. 3h]mk912 is α-2c selective amoung human α-2A, α-2B, and α-2C adrenoceptors. J Pharmacol Exp Ther 271: 1558-1565
33. Vigne P, Lazdunski M, Frelin (1989) Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes. Eur J Pharmacol 160: 295-98
34. Wenk GL, Pierce DJ, Struble RG, Price DL, Cork LC (1989) Age-related changes in multiple neurotransmitter systems in the monkey brain. Neurobiol Aging 10: 11-19