The alpha-2A-adrenoceptor agonist, guanfacine, increases regional cerebral blood flow in dorsolateral prefrontal cortex of monkeys performing a spatial working memory task

Neuropsychopharmacology

Volumn 23, Issue 3, 2000, Pages 240-249

  Avery, Robert A ^a   Franowicz, Jenna S ^a   Studholme, Colin ^a   Van Dyck, Christopher H ^a   Arnsten, Amy F T ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alpha 2 adrenergic receptors; Cognition; Guanfacine; Norepinephrine; SPECT imaging; Working memory

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; CYSTEINE ETHYL ESTER TC 99M; GUANFACINE; POSTSYNAPTIC RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; BRAIN REGION; COGNITION; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PREFRONTAL CORTEX; PRIORITY JOURNAL; RHESUS MONKEY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPATIAL MEMORY; TASK PERFORMANCE; TEMPORAL CORTEX; WORKING MEMORY;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; CEREBROVASCULAR CIRCULATION; COGNITION; FEMALE; GUANFACINE; IMAGE PROCESSING, COMPUTER-ASSISTED; MACACA MULATTA; MAGNETIC RESONANCE IMAGING; MEMORY; PREFRONTAL CORTEX; RECEPTORS, ADRENERGIC, ALPHA-2; SPACE PERCEPTION; STIMULATION, CHEMICAL; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 0034285038     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(00)00111-1     Document Type: Article

References (41)

1. Arnsten A.F.T. Catecholamine modulation of prefrontal cortical cognitive function. Trends Cogn Sci. 2:1998;436-447.
2. Arnsten A.F.T., Cai J.X., Goldman-Rakic P.S. The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects. J Neurosci. 8:1988;4287-4298.
3. Arnsten A.F.T., Goldman-Rakic P.S. Alpha-2 adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates. Science. 230:1985;1273-1276.
4. Arnsten A.F.T., Steere J.C., Hunt R.D. The contribution of a-2 noradrenergic mechanisms to prefrontal cortical cognitive function. Potential significance to Attention Deficit Hyperactivity Disorder Arch Gen Psychiatry. 53:1996;448-455.
5. Cai J.X., Ma Y., Xu L., Hu X. Reserpine impairs spatial working memory performance in monkeys. Reversal by the alpha-2 adrenergic agonist clonidine Brain Res. 614:1993;191-196.
6. Carlson S., Ranila H., Rama P., Mecke E., Pertovaara A. Effects of medetomidine, an alpha-2 adrenoceptor agonist, and atipamezole, an alpha-2 antagonist, on spatial memory performance in adult and aged rats. Behav Neural Biol. 58:1992;113-119.
7. Chappell P.B., Riddle M.A., Scahill L., Lynch K.A., Schultz R., Arnsten A., Leckman J.F., Cohen D.J. Guanfacine treatment of comorbid attention deficit hyperactivity disorder and Tourette's Syndrome. Preliminary clinical experience J Am Acad Child Adolesc Psychiatry. 34:1995;1140-1146.
8. Cohen D.J., Young J.G., Nathanson J.A., Shaywitz B.A. Clonidine in Tourette's Syndrome. Lancet. 2:1979;551-553.
9. Coull J.T., Frith C.D., Dolan R.J., Frackowiak R.S., Grasby P.M. The neural correlates of the noradrenergic modulation of human attention, arousal and learning. Eur J Neurosci. 9:1997;589-598.
10. Coull J.T., Middleton H.C., Robbins T.W., Sahakian B.J. Contrasting effects of clonidine and diazepam on tests of working memory and planning. Psychopharmacology. 120:1995;311-321.
11. Davachi L (1999): Functional Imaging of the Neuronal Networks Underlying Recognition and Working Memory Processes in the Primate Brain: A 2-Deoxyglucose Investigation. Yale University.
12. Fields R.B., Van Kammen D.P., Peters J.L., Rosen J., Van Kammen W.B., Nugent A., Stipetic M., Linnoila M. Clonidine improves memory function in schizophrenia independently from change in psychosis. Schizophr Res. 1:1988;417-423.
13. Fitzpatrick J.M., Hill D.L.G., Shyr Y., West J., Studholme C., Maurer C.R. Visual assessment of the accuracy of retrospective registration of MR and CT images of the brain. IEEE Tran Med Imag. 17:1998;571-585.
14. Franowicz J.C.S., Arnsten A.F.T. The alpha-2A noradrenergic agonist, guanfacine, improves delayed response performance in young adult rhesus monkeys. Psychopharmacology. 136:1998;8-14.
15. Franowicz J.S., Arnsten A.F.T. Treatment with the noradrenergic alpha-2 agonist clonidine, but not diazepam, improves spatial working memory in normal young rhesus monkeys. Neuropsychopharmacology. 21:1999;611-621.
16. Franowicz J.S., Kessler L., Morgan C., Arnsten A.F.T. The alpha-2 noradrenergic agonist, guanfacine, improves spatial working memory in wild type mice but not mice with point mutations of the gene for the alpha-2A receptor. Soc Neurosci Abstr. 24:1998;711.
17. Friedman H.R., Goldman-Rakic P.S. Coactivation of prefrontal cortex and inferior parietal cortex in working memory tasks revealed by 2DG functional mapping in the rhesus monkey. J Neurosci. 14:1994;2775-2788.
18. Funahashi S., Bruce C.J., Goldman-Rakic P.S. Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. J Neurophysiol. 61:1989;331-349.
19. Goldman P.S., Rosvold H.E. Localization of function within the dorsolateral prefrontal cortex of the rhesus monkey. Exp Neurol. 27:1970;291-304.
20. Goldman-Rakic P.S. Circuitry of the primate prefrontal cortex and the regulation of behavior by representational memory. Plum F. Handbook of Physiology, The Nervous System, Higher Functions of the Brain, Vol. V. 1987;373-417 American Physiological Society, Bethesda, MD.
21. Horrigan J.P., Barnhill L.J. Guanfacine for treatment of Attention-Deficit-Hyperactivity Disorder in boys. J Child Adolesc Psychopharmacol. 5:1995;215-223.
22. Hunt R.D., Arnsten A.F.T., Asbell M.D. An open trial of guanfacine in the treatment of attention deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 34:1995;50-54.
23. Hunt R.D., Mindera R.B., Cohen D.J. Clonidine benefits children with Attention Deficit Disorder and Hyperactivity. Reports of a double-blind placebo-crossover therapeutic trial J Am Acad Child Psychiatry. 24:1985;617-629.
24. Jakala P., Riekkinen M., Sirvio J., Koivisto E., Kejonen K., Vanhanen M., Riekkinen P.J. Guanfacine, but not clonidine, improves planning and working memory performance in humans. Neuropsychopharmacology. 20:1999;460-470.
25. Lewis D.A., Morrison J.H. Noradrenergic innervation of monkey prefrontal cortex. A dopamine-beta-hydroxylase immunohistochemical study J Comp Neurol. 282:1989;317-330.
26. Li B.-M., Mao Z.-M., Wang M., Mei Z.-T. Alpha-2 adrenergic modulation of prefrontal cortical neuronal activity related to spatial working memory in monkeys. Neuropsychopharmacology. 21:1999;601-610.
27. Li B.-M., Mei Z.-T. Delayed response deficit induced by local injection of the alpha-2 adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeys. Behav Neural Biol. 62:1994;134-139.
28. Mair R.G., McEntee W.J. Cognitive enhancement in Korsakoff's psychosis by clonidine. A comparison with 1-dopa and ephedrine Psychopharmacology. 88:1986;374-380.
29. Mao Z.-M., Arnsten A.F.T., Li B.-M. Local infusion of alpha-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys. Biol Psychiatry. 46:1999;1259-1265.
30. McEntee W.J., Mair R.G. The Korsakoff syndrome. A neurochemical perspective Trends Neurosci. 13:1990;340-344.
31. Moffoot A., O'Carroll R.E., Murray C., Dougall N., Ebmeier K., Goodwin G.M. Clonidine infusion increases uptake of Tc-exametazime in anterior cingulate cortex in Korsakoff's psychosis. Psychol Med. 24:1994;53-61.
32. Riekkinen P., Riekkinen M. THA improves word priming and clonidine enhances fluency and working memory in Alzheimer's Disease. Neuropsychopharmacology. 20:1999;357-364.
33. Sawaguchi T. Attenuation of delay-period activity of monkey prefrontal cortical neurons by an alpha-2 adrenergic antagonist during an oculomotor delayed-response task. J Neurophysiol. 80:1998;2200-2205.
34. Spanaki M.V., Spencer S.S., Corsi M., MacMullan J., Seibyl J., Zubal I.G. The sensitivity and specificity of quantitative difference SPECT analysis in seizure localization. J Nucl Med. 40:1999;730-736.
35. Studholme C., Hill D.L.G., Hawkes D.J. Automated three-dimensional registration of magnetic resonance and positron emission tomography brain images by multi-resolution optimisation of voxel similarity measures. Med Physics. 24:1997;25-35.
36. Studholme C., Hill D.L.G., Hawkes D.J. An overlap invariant entropy measure of 3D medical image alignment. Pattern Recogn. 32:1999;71-86.
37. Tanila H., Mustonen K., Sallinen J., Scheinin M., Riekkinen P. Role of alpha-2C-adrenoceptor subtype in spatial working memory as revealed by mice with targeted disruption of the alpha-2C-adrenoceptor gene. Eur J Neurosci. 11:1999;599-603.
38. Tanila H., Rama P., Carlson S. The effects of prefrontal intracortical microinjections of an alpha-2 agonist, alpha-2 antagonist and lidocaine on the delayed alternation performance of aged rats. Brain Res Bull. 40:1996;117-119.
39. Uhlen S., Wikberg J.E.S. Delineation of rat kidney alpha 2A and alpha 2B-adrenoceptors with [3H]RX821002 radioligand binding. Computer modeling revels that guanfacine is an alpha-2A-selective compound Eur J Pharmacol. 202:1991;235-243.
40. Walovitch R.C., Hill T.C., Garrity S.T., Cheesman E.H., Burgess B.A., O'Leary D.H., Watson A.D., Ganey M.V., Morgan R.A., Williams S.J. Characterization of Technetium-99m-L,L-ECD for brain perfusion imaging. Part 1. Pharmacology of Technetium-99m ECD in nonhuman primates J Nucl Med. 30:1989;1892-1901.
41. West J., Fitzpatrick J.M., Wang M.Y., Dawant B.M., Maurer C.R., Kessler R.M., Maciunas R.J., Barillot C., Lemoine D., Collignon A., Maes F., Suetens P., Vandermeulen D., van den Elsen P.A., Napel S., Sumanaweera T.S., Harkness B., Hemler P.F., Hill D.L.G., Hawkes D.J., Studholme C., Maintz J.B.A., Viergever M.A., Malandain G., Pennec X., Noz M.E., Maquire G.Q., Pollack M., Pelizzari C.A., Robb R.A., Hanson D., Woods R.P. Comparison and evaluation of retrospective intermodality image registration techniques. J Comput Assist Tomogr. 21:1997;554-566.