Persistent stimulation with interleukin-17 desensitizes cells through SCF β-TrCP-mediated degradation of Act1

Science Signaling

Volumn 4, Issue 197, 2011, Pages

  Shi, Peiqing ^a   Zhu, Shu ^a   Lin, Yingying ^a   Liu, Yongfeng ^a   Liu, Yan ^a   Chen, Zhijian ^b   Shi, Yufang ^a   Qian, Youcun ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTININ 1; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; I KAPPA B; INTERLEUKIN 17 RECEPTOR; POLYUBIQUITIN; BTRC PROTEIN, HUMAN; FBXW11 PROTEIN, HUMAN; IL17RA PROTEIN, HUMAN; INTERLEUKIN 17; TRAF3IP2 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CELL STIMULATION; DESENSITIZATION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; UBIQUITINATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL STRAIN HEK293; CYTOLOGY; DRUG EFFECT; FIBROBLAST; GENETICS; METABOLISM; MOUSE; MOUSE MUTANT; PHOSPHORYLATION; PROTEIN BINDING; RNA INTERFERENCE; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; BETA-TRANSDUCIN REPEAT-CONTAINING PROTEINS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELLS, CULTURED; FIBROBLASTS; HEK293 CELLS; HELA CELLS; HUMANS; INTERLEUKIN-17; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN BINDING; PROTEOLYSIS; RECEPTORS, INTERLEUKIN-17; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 80455163028     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001653     Document Type: Article

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