Protein replacement therapy partially corrects the cholesterol-storage phenotype in a mouse model of niemann-pick type C2 disease

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Nielsen, Gitte Krogh ^a   Dagnaes Hansen, Frederik ^a   Holm, Ida Elisabeth ^a   Meaney, Steve ^b   Symula, Derek ^c   Andersen, Niels Trolle ^a   Heegaard, Christian Würtz ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

^c WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; NPC1 PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; FLUORESCENT DYE; GLYCOPROTEIN; NPC2 PROTEIN, HUMAN; PRIMER DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD; BRAIN CORTEX; CEREBELLUM; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; HIPPOCAMPUS; HISTOPATHOLOGY; HUMORAL IMMUNITY; IN VIVO STUDY; KIDNEY; LIPID STORAGE; LIVER; LUNG; MALE; MOTOR COORDINATION; MOUSE; NIEMANN PICK DISEASE; NONHUMAN; SPLEEN; WEIGHT GAIN; ANIMAL; CELL CULTURE; DISEASE MODEL; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PHENOTYPE; POLYMERASE CHAIN REACTION; VALIDATION STUDY;

ANIMALIA; BOVINAE; MURINAE; MUS;

ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA PRIMERS; FLUORESCENT DYES; GLYCOPROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MICE; MICE, KNOCKOUT; NIEMANN-PICK DISEASE, TYPE C; PHENOTYPE; POLYMERASE CHAIN REACTION;

EID: 80455132074     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027287     Document Type: Article

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