A trial of methadone tapering schedules in pediatric intensive care unit patients exposed to prolonged sedative infusions

Pediatric Critical Care Medicine

Volumn 12, Issue 5, 2011, Pages 504-511

  Bowens, Cindy D ^a   Thompson, Jennifer A ^a   Thompson, Marita T ^a   Breitzka, Robin L ^c   Thompson, Debbie G ^c   Sheeran, Paul W ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c CHILDREN S MEDICAL CENTER   (United States)

Author keywords

Critically ill children; Opiate dependence; Sedation; Withdrawal

Indexed keywords

DIAZEPAM; FENTANYL; LORAZEPAM; METHADONE; MIDAZOLAM; MORPHINE;

ARTICLE; CHILD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG INFUSION; DRUG MEGADOSE; DRUG RESPONSE; FEMALE; HUMAN; INFANT; INTENSIVE CARE UNIT; LENGTH OF STAY; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SEDATION; WITHDRAWAL SYNDROME;

EID: 80455128280     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3181fe38f5     Document Type: Article

References (48)

1. Twite MD, Rashid A, Zuk J, et al: Sedation, analgesia, and neuromuscular blockade in the pediatric intensive care unit: Survey of fellowship training programs. Pediatr Crit Care Med 2004; 5:521-532
2. Playfor S, Jenkins I, Boyles C, et al: Consensus guidelines on sedation and analgesia in critically ill children. Intensive Care Med 2006; 32:1125-1136 (Pubitemid 44232406)
3. Zuppa AF, Adamson PC, Mondick JT, et al: Drug utilization in the pediatric intensive care unit: Monitoring prescribing trends and establishing prioritization of pharmacotherapeutic evaluation of critically ill children. J Clin Pharmacol 2005; 45:1305-1312 (Pubitemid 41513054)
4. Tobias JD, Schleien CL, Haun SE: Methadone as treatment for iatrogenic narcotic dependency in pediatric intensive care unit patients. Crit Care Med 1990; 18:1292-1293 (Pubitemid 20377787)
5. Tobias JD, Deshpande JK, Gregory DF: Outpatient therapy of iatrogenic drug dependency following prolonged sedation in the pediatric intensive care unit. Intensive Care Med 1994; 20:504-507 (Pubitemid 24287783)
6. Anand KJ, Arnold JH: Opioid tolerance and dependence in infants and children. Crit Care Med 1994; 22:334-342 (Pubitemid 24061659)
7. Tobias JD: Tolerance, withdrawal, and physical dependency after long-term sedation and analgesia of children in the pediatric intensive care unit. Crit Care Med 2000; 28:2122-2132 (Pubitemid 30428787)
8. Fonsmark L, Rasmussen YH, Carl P: Occurrence of withdrawal in critically ill sedated children. Crit Care Med 1999; 27:196-199 (Pubitemid 29052837)
9. Sury MR, Billingham I, Russell GN, et al: Acute benzodiazepine withdrawal syndrome after midazolam infusions in children. Crit Care Med 1989; 17:301-302 (Pubitemid 19076096)
10. Ista E, van Dijk M, Gamel C, et al: Withdrawal symptoms in critically ill children after long-term administration of sedatives and/or analgesics: A first evaluation. Crit Care Med 2008; 36:2427-2432
11. Birchley G: Opioid and benzodiazepine withdrawal syndromes in the paediatric intensive care unit: A review of recent literature. Nurs Crit Care 2009; 14:26-37
12. Franck LS, Naughton I, Winter I: Opioid and benzodiazepine withdrawal symptoms in paediatric intensive care patients. Intensive Crit Care Nurs 2004; 20:344-351 (Pubitemid 39618480)
13. Jenkins IA, Playfor SD, Bevan C, et al: Current United Kingdom sedation practice in pediatric intensive care. Paediatr Anaesth 2007; 17:675-683 (Pubitemid 46911067)
14. Arnold JH, Truog RD, Orav EJ, et al: Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation. Anesthesiology 1990; 73:1136-1140
15. Katz R, Kelly HW, Hsi A: Prospective study on the occurrence of withdrawal in critically ill children who receive fentanyl by continuous infusion. Crit Care Med 1994; 22:763-767 (Pubitemid 24151067)
16. Suresh S, Anand KJ: Opioid tolerance in neonates: A state-of-the-art review. Paediatr Anaesth 2001; 11:511-521 (Pubitemid 34209026)
17. Meyer MM, Berens RJ: Efficacy of an enteral 10-day methadone wean to prevent opioid withdrawal in fentanyl-tolerant pediatric intensive care unit patients. Pediatr Crit Care Med 2001; 2:329-333
18. Lugo RA, MacLaren R, Cash J, et al: Enteral methadone to expedite fentanyl discontinuation and prevent opioid abstinence syndrome in the PICU. Pharmacotherapy 2001; 21: 1566-1573 (Pubitemid 33117258)
19. Shaheen PE, Walsh D, Lasheen W, et al: Opioid equianalgesic tables: Are they all equally dangerous? J Pain Symptom Manage 2009; 38: 409-417
20. Patanwala AE, Duby J, Waters D, et al: Opioid conversions in acute care. Ann Pharmacother 2007; 41:255-266
21. Gammaitoni AR, Fine P, Alvarez N, et al: Clinical application of opioid equianalgesic data. Clin J Pain 2003; 19:286-297 (Pubitemid 37080576)
22. Ripamonti C, Groff L, Brunelli C, et al: Switching from morphine to oral methadone in treating cancer pain: What is the equianalgesic dose ratio? J Clin Oncol 1998; 16:3216-3221 (Pubitemid 28481614)
23. Lawlor PG, Turner KS, Hanson J, et al: Dose ratio between morphine and methadone in patients with cancer pain: A retrospective study. Cancer 1998; 82:1167-1173 (Pubitemid 28136533)
24. Finnegan LP, Connaughton JF Jr, Kron RE, et al: Neonatal abstinence syndrome: Assessment and management. Addict Dis 1975; 2:141-158
25. Franck LS, Harris SK, Soetenga DJ, et al: The Withdrawal Assessment Tool-1 (WAT-1): An assessment instrument for monitoring opioid and benzodiazepine withdrawal symptoms in pediatric patients. Pediatr Crit Care Med 2008; 9:573-580
26. Devlin JW, Boleski G, Mlynarek M, et al: Motor Activity Assessment Scale: A valid and reliable sedation scale for use with mechanically ventilated patients in an adult surgical intensive care unit. Crit Care Med 1999; 27:1271-1275 (Pubitemid 29379363)
27. Clemmer TP, Wallace JC, Spuhler VJ, et al: Origins of the Motor Activity Assessment Scale score: A multi-institutional process. Crit Care Med 2000; 28:3124
28. Curley MA, Hibberd PL, Fineman LD, et al: Effect of prone positioning on clinical outcomes in children with acute lung injury: A randomized controlled trial. JAMA 2005; 294: 229-237 (Pubitemid 41043793)
29. Curley MA, Harris SK, Fraser KA, et al: State Behavioral Scale: A sedation assessment instrument for infants and young children supported on mechanical ventilation. Pediatr Crit Care Med 2006; 7:107-114
30. Darnell CM, Thompson J, Stromberg D, et al: Effect of low-dose naloxone infusion on fentanyl requirements in critically ill children. Pediatrics 2008; 121:e1363-e1371
31. Pollack MM, Patel KM, Ruttimann UE: PRISM III: An updated Pediatric Risk of Mortality score. Crit Care Med 1996; 24: 743-752 (Pubitemid 26155716)
32. Dominguez KD, Lomako DM, Katz RW, et al: Opioid withdrawal in critically ill neonates. Ann Pharmacother 2003; 37:473-477 (Pubitemid 36389651)
33. Yaster M, Kost-Byerly S, Berde C, et al: The management of opioid and benzodiazepine dependence in infants, children, and adolescents. Pediatrics 1996; 98:135-140 (Pubitemid 26226991)
34. Robertson RC, Darsey E, Fortenberry JD, et al: Evaluation of an opiate-weaning protocol using methadone in pediatric intensive care unit patients. Pediatr Crit Care Med 2000; 1:119-123
35. Williams PI, Sarginson RE, Ratcliffe JM: Use of methadone in the morphine-tolerant burned paediatric patient. Br J Anaesth 1998; 80:92-95 (Pubitemid 28029733)
36. Varga EV, Yamamura HI, Rubenzik MK, et al: Molecular mechanisms of excitatory signaling upon chronic opioid agonist treatment. Life Sci 2003; 74:299-311 (Pubitemid 37357061)
37. Kieffer BL, Evans CJ: Opioid tolerance-in search of the holy grail. Cell 2002; 108:587-590 (Pubitemid 34241419)
38. Raith K, Hochhaus G: Drugs used in the treatment of opioid tolerance and physical dependence: A review. Int J Clin Pharmacol Ther 2004; 42:191-203 (Pubitemid 38477435)
39. Inturrisi CE: Pharmacology of methadone and its isomers. Minerva Anestesiol 2005; 71: 435-437 (Pubitemid 43932968)
40. Mendez IA, Trujillo KA: NMDA receptor antagonists inhibit opiate antinociceptive tolerance and locomotor sensitization in rats. Psychopharmacology (Berl) 2008; 196:497-509
41. Kasai S, Hayashida M, Sora I, et al: Candidate gene polymorphisms predicting individual sensitivity to opioids. Naunyn Schmiedebergs Arch Pharmacol 2008; 377:269-281
42. Nishizawa D, Hayashida M, Nagashima M, et al: Genetic polymorphisms and human sensitivity to opioid analgesics. Methods Mol Biol 2010; 617:395-420
43. Befort K, Filliol D, Decaillot FM, et al: A single nucleotide polymorphic mutation in the human mu-opioid receptor severely impairs receptor signaling. J Biol Chem 2001; 276: 3130-3137
44. Mayer P, Höllt V: Pharmacogenetics of opioid receptors and addiction. Pharmacogenet Genomics 2006; 16:1-7 (Pubitemid 41803871)
45. Dumas EO, Pollack GM: Opioid tolerance development: A pharmacokinetic/pharmacodynamic perspective. AAPS J 2008; 10:537-551
46. Cunliffe M, McArthur L, Dooley F: Managing sedation withdrawal in children who undergo prolonged PICU admission after discharge to the ward. Paediatr Anaesth 2004; 14:293-298 (Pubitemid 38534981)
47. Hoder EL, Leckman JF, Ehrenkranz R, et al: Clonidine in neonatal narcotic-abstinence syndrome. N Engl J Med 1981; 305:1284 (Pubitemid 12234855)
48. Tobias JD: Dexmedetomidine: Applications in pediatric critical care and pediatric anesthesiology. Pediatr Crit Care Med 2007; 8:115-131 (Pubitemid 46568561)