Efficacy of an enteral 10-day methadone wean to prevent opioid withdrawal in fentanyl-tolerant pediatric intensive care unit patients

Pediatric Critical Care Medicine

Volumn 2, Issue 4, 2001, Pages 329-333

  Meyer, Michael T ^a,b   Berens, Richard J ^b  

^a AIR FORCE INSTITUTE OF TECHNOLOGY   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

abstinence; fentanyl; methadone; narcotic abstinence syndrome; neonatal abstinence score; opioids; physical dependency; tolerance; withdrawal

Indexed keywords

EID: 85016388732     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/00130478-200110000-00009     Document Type: Article

References (21)

1. Anand K, Arnold J; Opioid tolerance and dependance in infants and children. Crit Care Med 1994; 22; 334-342
2. Epstein J, Breslow M; The stress response of critical illness. Crit Care Clin 1999; 15; 17-33
3. Katz R, Kelly H, Hsi A; Prospective study on the occurrence of withdrawal in critically ill children who receive fentanyl by continuous infusion. Crit Care Med 1994; 22; 763-767
4. Marx C, Rosenberg D, Ambuel B, et al; Pediatric intensive care sedation; Survey of fellowship training programs. Pediatrics 1993; 91; 369-378
5. Tobias J, Schleien C, Haun S; Methadone as treatment for iatrogenic narcotic dependency in pediatric intensive care unit patients. Crit Care Med 1990; 18; 1292-1293
6. Robertson R, Darsey E, Fortenberry J, et al; Evaluation of an opiate-weaning protocol using methadone in pediatric intensive care unit patients. Pediatr Crit Care Med 2000; 1; 119-123
7. Finnegan L, Kron R, Connaughton J, et al; Neonatal abstinence syndrome; Assessment and management. Addict Dis 1975; 2; 141-158
8. Inturrisi C, Colburn W, Kaiko R, et al; Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain. Clin Pharmacol Ther 1986; 41; 392-401
9. Foley K, Houde R; Methadone in cancer pain management; individualize dose and titrate to effect. J Clin Oncol 1998; 16; 3213-3215
10. Macfadyen A, Buckmaster M; Pain management in the pediatric intensive care unit. Crit Care Clin 1999; 15; 185-200
11. French J, Nocera M; Drug withdrawal symptoms in children after continuous infusions of fentanyl. J Pediatr Nurs 1994; 9; 107-113
12. Franck L, Vilardi J, Durand D, et al; Opioid withdrawal in neonates after continuous infusions of morphine or fentanyl during extracorpeal membrane oxygenation. Am J Crit Care 1998; 7; 364-369
13. Franck L, Vilardi J; Assessment and management of opioid withdrawal in ill neonates. Neonatal Netw 1995; 14; 39-48
14. Arnold J, Truog R, Orav E, et al; Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation. Anesthesiology 1990; 73; 1136-1140
15. Cammarano W, Pittet J, Weitz S, et al; Acute withdrawal syndrome related to the administration of analgesic and sedative medications in adult intensive care unit patients. Crit Care Med 1998; 26; 676-684
16. Tobias J; Subcutaneous administration of fentanyl and midazolam to prevent withdrawal after prolonged sedation in children. Crit Care Med 1999; 27; 2262-2321
17. Tobias J; Tolerance, withdrawal, and physical dependency after long-term sedation and analgesia of children in the pediatric intensive care unit. Crit Care Med 2000; 28; 2122-2132
18. Anand K., Ingraham J; Tolerance, dependence, and strategies for compassionate withdrawal of analgesics and anxiolytics in the pediatric ICU. Crit Care Nurse 1996; 16; 87-93
19. Fonsmark L, Rasmussen Y, Car P; Occurrence of withdrawal in critically ill sedated children. Crit Care Med 1999; 27; 196-199
20. Chiang W, Goldfrank L; Substance withdrawal. Emerg Med Clin North Am 1990; 8; 613-631
21. Sawe J; High-dose morphine and methadone in cancer patients. Clinical pharmacokinetic considerations of oral therapy. Clin Pharmacokinet 1986; 11; 87-106