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Volumn 121, Issue 5, 2008, Pages

Effect of low-dose naloxone infusion on fentanyl requirements in critically ill children

Author keywords

Controlled trial; Critically ill children; Opiate dependent neonate; Pain management; Randomized; Sedation

Indexed keywords

FENTANYL; MIDAZOLAM; NALOXONE; PLACEBO; HYPNOTIC SEDATIVE AGENT; NARCOTIC ANALGESIC AGENT; NARCOTIC ANTAGONIST;

EID: 44449168790     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2007-1468     Document Type: Article
Times cited : (20)

References (58)
  • 1
    • 0032943972 scopus 로고    scopus 로고
    • Intravenous analgesia
    • McArdle P. Intravenous analgesia. Crit Care Clin. 1999;15(1): 89-104
    • (1999) Crit Care Clin , vol.15 , Issue.1 , pp. 89-104
    • McArdle, P.1
  • 3
    • 0028096126 scopus 로고
    • Opioid tolerance and dependence in infants and children
    • Anand KJ, Arnold JH. Opioid tolerance and dependence in infants and children. Crit Care Med. 1994;22(2):334-342
    • (1994) Crit Care Med , vol.22 , Issue.2 , pp. 334-342
    • Anand, K.J.1    Arnold, J.H.2
  • 4
    • 0033919614 scopus 로고    scopus 로고
    • Tolerance, withdrawal, and physical dependency after long-term sedation and analgesia of children in the pediatric intensive care unit
    • Tobias JD. Tolerance, withdrawal, and physical dependency after long-term sedation and analgesia of children in the pediatric intensive care unit. Crit Care Med. 2000;28(6):2122-2132
    • (2000) Crit Care Med , vol.28 , Issue.6 , pp. 2122-2132
    • Tobias, J.D.1
  • 5
    • 0025600408 scopus 로고
    • Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation
    • Arnold JH, Truog RD, Orav EJ, Scavone JM, Hershenson MB. Tolerance and dependence in neonates sedated with fentanyl during extracorporeal membrane oxygenation. Anesthesiology. 1990;73(6):1136-1140
    • (1990) Anesthesiology , vol.73 , Issue.6 , pp. 1136-1140
    • Arnold, J.H.1    Truog, R.D.2    Orav, E.J.3    Scavone, J.M.4    Hershenson, M.B.5
  • 7
    • 0037040389 scopus 로고    scopus 로고
    • Opioid tolerance-in search of the holy grail
    • Kieffer BL, Evans CJ. Opioid tolerance-in search of the holy grail. Cell. 2002;108(5):587-590
    • (2002) Cell , vol.108 , Issue.5 , pp. 587-590
    • Kieffer, B.L.1    Evans, C.J.2
  • 8
    • 0035726443 scopus 로고    scopus 로고
    • Opioid tolerance in neonates: A state-of-the-art review
    • Suresh S, Anand KJ. Opioid tolerance in neonates: a state-of-the-art review. Paediatr Anaesth. 2001;11(5):511-521
    • (2001) Paediatr Anaesth , vol.11 , Issue.5 , pp. 511-521
    • Suresh, S.1    Anand, K.J.2
  • 9
    • 0242352647 scopus 로고    scopus 로고
    • New approaches to study the development of morphine tolerance and dependence
    • Ueda H, Inoue M, Mizuno K. New approaches to study the development of morphine tolerance and dependence. Life Sci. 2003;74(2-3):313-320
    • (2003) Life Sci , vol.74 , Issue.2-3 , pp. 313-320
    • Ueda, H.1    Inoue, M.2    Mizuno, K.3
  • 10
    • 1842788763 scopus 로고    scopus 로고
    • Drugs used in the treatment of opioid tolerance and physical dependence: A review
    • Raith K, Hochhaus G. Drugs used in the treatment of opioid tolerance and physical dependence: a review. Int J Clin Pharmacol Ther. 2004;42(4):191-203
    • (2004) Int J Clin Pharmacol Ther , vol.42 , Issue.4 , pp. 191-203
    • Raith, K.1    Hochhaus, G.2
  • 11
    • 0029957393 scopus 로고    scopus 로고
    • Modulatory effects of Gs-coupled excitatory opioid receptor functions on opioid analgesia, tolerance, and dependence
    • Crain SM, Shen KF. Modulatory effects of Gs-coupled excitatory opioid receptor functions on opioid analgesia, tolerance, and dependence. Neurochem Res. 1996;21(11):1347-1351
    • (1996) Neurochem Res , vol.21 , Issue.11 , pp. 1347-1351
    • Crain, S.M.1    Shen, K.F.2
  • 12
    • 0029810024 scopus 로고    scopus 로고
    • Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma
    • Avidor-Reiss T, Nevo I, Levy R, Pfeuffer T, Vogel Z. Chronic opioid treatment induces adenylyl cyclase V superactivation. Involvement of Gbetagamma. J Biol Chem. 1996;271(35): 21309-21315
    • (1996) J Biol Chem , vol.271 , Issue.35 , pp. 21309-21315
    • Avidor-Reiss, T.1    Nevo, I.2    Levy, R.3    Pfeuffer, T.4    Vogel, Z.5
  • 13
    • 0031848833 scopus 로고    scopus 로고
    • Regulation of adenylyl cyclase isozymes on acute and chronic activation of inhibitory receptors
    • Nevo I, Avidor-Reiss T, Levy R, Bayewitch M, Heldman E, Vogel Z. Regulation of adenylyl cyclase isozymes on acute and chronic activation of inhibitory receptors. Mol Pharmacol. 1998;54(2):419-426
    • (1998) Mol Pharmacol , vol.54 , Issue.2 , pp. 419-426
    • Nevo, I.1    Avidor-Reiss, T.2    Levy, R.3    Bayewitch, M.4    Heldman, E.5    Vogel, Z.6
  • 14
    • 0027761786 scopus 로고
    • Drug addiction: A model for the molecular basis of neural plasticity
    • Nestler EJ, Hope BT, Widnell KL. Drug addiction: a model for the molecular basis of neural plasticity. Neuron. 1993;11(6):995-1006
    • (1993) Neuron , vol.11 , Issue.6 , pp. 995-1006
    • Nestler, E.J.1    Hope, B.T.2    Widnell, K.L.3
  • 15
    • 0029417219 scopus 로고
    • Adenylylcyclase supersensitization in mu-opioid receptor-transfected Chinese hamster ovary cells following chronic opioid treatment
    • Avidor-Reiss T, Bayewitch M, Levy R, Matus-Leibovitch N, Nevo I, Vogel Z. Adenylylcyclase supersensitization in mu-opioid receptor-transfected Chinese hamster ovary cells following chronic opioid treatment. J Biol Chem. 1995;270(50): 29732-29738
    • (1995) J Biol Chem , vol.270 , Issue.50 , pp. 29732-29738
    • Avidor-Reiss, T.1    Bayewitch, M.2    Levy, R.3    Matus-Leibovitch, N.4    Nevo, I.5    Vogel, Z.6
  • 16
    • 0011276168 scopus 로고
    • Dual regulation of ade-nylate cyclase accounts for narcotic dependence and tolerance
    • Sharma SK, Klee WA, Nirenberg M. Dual regulation of ade-nylate cyclase accounts for narcotic dependence and tolerance.Proc Natl Acad Sci USA. 1975;72(8):3092-3096
    • (1975) Proc Natl Acad Sci USA , vol.72 , Issue.8 , pp. 3092-3096
    • Sharma, S.K.1    Klee, W.A.2    Nirenberg, M.3
  • 17
    • 0033957306 scopus 로고    scopus 로고
    • Antagonists of excitatory opioid receptor functions enhance morphine's analgesic potency and attenuate opioid tolerance/dependence liability
    • Crain SM, Shen KF. Antagonists of excitatory opioid receptor functions enhance morphine's analgesic potency and attenuate opioid tolerance/dependence liability. Pain. 2000;84(2-3): 121-131
    • (2000) Pain , vol.84 , Issue.2-3 , pp. 121-131
    • Crain, S.M.1    Shen, K.F.2
  • 18
    • 0024341553 scopus 로고
    • Dual opioid modulation of the action potential duration of mouse dorsal root ganglion neurons in culture
    • Shen KF, Crain SM. Dual opioid modulation of the action potential duration of mouse dorsal root ganglion neurons in culture. Brain Res. 1989;491(2):227-242
    • (1989) Brain Res , vol.491 , Issue.2 , pp. 227-242
    • Shen, K.F.1    Crain, S.M.2
  • 19
    • 0031712776 scopus 로고    scopus 로고
    • Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-regulated opioid receptor functions
    • Crain SM, Shen KF. Modulation of opioid analgesia, tolerance and dependence by Gs-coupled, GM1 ganglioside-regulated opioid receptor functions. Trends Pharmacol Sci. 1998;19(9): 358-365
    • (1998) Trends Pharmacol Sci , vol.19 , Issue.9 , pp. 358-365
    • Crain, S.M.1    Shen, K.F.2
  • 20
    • 0018835939 scopus 로고
    • Analgesia and hyperalgesia produced in the rat by intrathecal naloxone
    • Woolf CJ. Analgesia and hyperalgesia produced in the rat by intrathecal naloxone. Brain Res. 1980;189(2):593-597
    • (1980) Brain Res , vol.189 , Issue.2 , pp. 593-597
    • Woolf, C.J.1
  • 21
    • 0028804902 scopus 로고
    • Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreat-ment
    • Crain SM, Shen KF. Ultra-low concentrations of naloxone selectively antagonize excitatory effects of morphine on sensory neurons, thereby increasing its antinociceptive potency and attenuating tolerance/dependence during chronic cotreat-ment. Proc Natl Acad Sci USA. 1995;92(23):10540-10544
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.23 , pp. 10540-10544
    • Crain, S.M.1    Shen, K.F.2
  • 22
    • 0030945699 scopus 로고    scopus 로고
    • Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice
    • Shen KF, Crain SM. Ultra-low doses of naltrexone or etorphine increase morphine's antinociceptive potency and attenuate tolerance/dependence in mice. Brain Res. 1997;757(2): 176-190
    • (1997) Brain Res , vol.757 , Issue.2 , pp. 176-190
    • Shen, K.F.1    Crain, S.M.2
  • 23
    • 0023943662 scopus 로고
    • Opioids excite rather than inhibit sensory neurons after chronic opioid exposure of spinal cord-ganglion cultures
    • Crain SM, Shen KF, Chalazonitis A. Opioids excite rather than inhibit sensory neurons after chronic opioid exposure of spinal cord-ganglion cultures. Brain Res. 1988;455(1):99-109
    • (1988) Brain Res , vol.455 , Issue.1 , pp. 99-109
    • Crain, S.M.1    Shen, K.F.2    Chalazonitis, A.3
  • 24
    • 0025553738 scopus 로고
    • Opioids can evoke direct receptor-mediated excitatory as well as inhibitory effects on sensory neuron action potentials
    • Crain SM, Shen KF. Opioids can evoke direct receptor-mediated excitatory as well as inhibitory effects on sensory neuron action potentials. NIDA Res Monogr. 1990;105:34-39
    • (1990) NIDA Res Monogr , vol.105 , pp. 34-39
    • Crain, S.M.1    Shen, K.F.2
  • 25
    • 0032925452 scopus 로고    scopus 로고
    • Effects of prophylactic nalmefene on the incidence of morphine-related side effects in patients receiving intravenous patient-controlled analgesia
    • Joshi GP, Duffy L, Chehade J, Wesevich J, Gajraj N, Johnson ER. Effects of prophylactic nalmefene on the incidence of morphine-related side effects in patients receiving intravenous patient-controlled analgesia. Anesthesiology. 1999;90(4): 1007-1011
    • (1999) Anesthesiology , vol.90 , Issue.4 , pp. 1007-1011
    • Joshi, G.P.1    Duffy, L.2    Chehade, J.3    Wesevich, J.4    Gajraj, N.5    Johnson, E.R.6
  • 26
    • 0030730101 scopus 로고    scopus 로고
    • Opioid-sparing effects of a low-dose infusion of naloxone in patient-administered morphine sulfate
    • Gan TJ, Ginsberg B, Glass PS, Fortney J, Jhaveri R, Perno R. Opioid-sparing effects of a low-dose infusion of naloxone in patient-administered morphine sulfate. Anesthesiology. 1997; 87(5):1075-1081
    • (1997) Anesthesiology , vol.87 , Issue.5 , pp. 1075-1081
    • Gan, T.J.1    Ginsberg, B.2    Glass, P.S.3    Fortney, J.4    Jhaveri, R.5    Perno, R.6
  • 27
    • 0024207694 scopus 로고
    • Potentiation of pentazocine analgesia by low-dose naloxone
    • Levine JD, Gordon NC, Taiwo YO, Coderre TJ. Potentiation of pentazocine analgesia by low-dose naloxone. J Clin Invest. 1988;82(5):1574-1577
    • (1988) J Clin Invest , vol.82 , Issue.5 , pp. 1574-1577
    • Levine, J.D.1    Gordon, N.C.2    Taiwo, Y.O.3    Coderre, T.J.4
  • 28
    • 33846283029 scopus 로고    scopus 로고
    • Cheung CL, van Dijk M, Green JW, Tibboel D, Anand KJ. Effects of low-dose naloxone on opioid therapy in pediatric patients: a retrospective case-control study. Intensive Care Med. 2007;33(1):190-
    • Cheung CL, van Dijk M, Green JW, Tibboel D, Anand KJ. Effects of low-dose naloxone on opioid therapy in pediatric patients: a retrospective case-control study. Intensive Care Med. 2007;33(1):190-
  • 29
    • 0028222406 scopus 로고
    • Prospective study on the occurrence of withdrawal in critically ill children who receive fentanyl by continuous infusion
    • Katz R, Kelly HW, Hsi A. Prospective study on the occurrence of withdrawal in critically ill children who receive fentanyl by continuous infusion. Crit Care Med. 1994;22(5):763-767
    • (1994) Crit Care Med , vol.22 , Issue.5 , pp. 763-767
    • Katz, R.1    Kelly, H.W.2    Hsi, A.3
  • 30
    • 63749083795 scopus 로고    scopus 로고
    • 59th ed. Montvale, NJ: Thomson PDR;
    • Murray L. Physicians' Desk Reference 2005. 59th ed. Montvale, NJ: Thomson PDR; 2005
    • (2005) Physicians' Desk
    • Murray, L.1
  • 31
    • 0032813749 scopus 로고    scopus 로고
    • Motor Activity Assessment Scale: A valid and reliable sedation scale for use with mechanically ventilated patients in an adult surgical intensive care unit
    • Devlin JW, Boleski G, Mlynarek M, et al. Motor Activity Assessment Scale: a valid and reliable sedation scale for use with mechanically ventilated patients in an adult surgical intensive care unit. Crit Care Med. 1999;27(7):1271-1275
    • (1999) Crit Care Med , vol.27 , Issue.7 , pp. 1271-1275
    • Devlin, J.W.1    Boleski, G.2    Mlynarek, M.3
  • 32
    • 22144483419 scopus 로고    scopus 로고
    • Effect of prone positioning on clinical outcomes in children with acute lung injury: A randomized controlled trial
    • Curley MA, Hibberd PL, Fineman LD, et al. Effect of prone positioning on clinical outcomes in children with acute lung injury: a randomized controlled trial. JAMA. 2005;294(2): 229-237
    • (2005) JAMA , vol.294 , Issue.2 , pp. 229-237
    • Curley, M.A.1    Hibberd, P.L.2    Fineman, L.D.3
  • 33
    • 0033847545 scopus 로고    scopus 로고
    • Origins of the Motor Activity Assessment Scale score: A multi-institutional process
    • Clemmer TP, Wallace JC, Spuhler VJ, Bailey PP, Devlin JW. Origins of the Motor Activity Assessment Scale score: a multi-institutional process. Crit Care Med. 2000;28(8):3124
    • (2000) Crit Care Med , vol.28 , Issue.8 , pp. 3124
    • Clemmer, T.P.1    Wallace, J.C.2    Spuhler, V.J.3    Bailey, P.P.4    Devlin, J.W.5
  • 34
    • 33645547324 scopus 로고    scopus 로고
    • State Behavioral Scale: A sedation assessment instrument for infants and young children supported on mechanical ventilation
    • Curley MA, Harris SK, Fraser KA, Johnson RA, Arnold JH. State Behavioral Scale: a sedation assessment instrument for infants and young children supported on mechanical ventilation. Pediatr Crit Care Med. 2006;7(2):107-114
    • (2006) Pediatr Crit Care Med , vol.7 , Issue.2 , pp. 107-114
    • Curley, M.A.1    Harris, S.K.2    Fraser, K.A.3    Johnson, R.A.4    Arnold, J.H.5
  • 35
    • 0038390593 scopus 로고    scopus 로고
    • Clinical validation of FLACC: Pre-verbal patient pain scale
    • Manworren RC, Hynan LS. Clinical validation of FLACC: pre-verbal patient pain scale. Pediatr Nurs. 2003;29(2):140-146
    • (2003) Pediatr Nurs , vol.29 , Issue.2 , pp. 140-146
    • Manworren, R.C.1    Hynan, L.S.2
  • 36
    • 0036828487 scopus 로고    scopus 로고
    • The reliability and validity of the Face, Legs, Activity, Cry, Con-solability observational tool as a measure of pain in children with cognitive impairment
    • Voepel-Lewis T, Merkel S, Tait AR, Trzcinka A, Malviya S. The reliability and validity of the Face, Legs, Activity, Cry, Con-solability observational tool as a measure of pain in children with cognitive impairment. Anesth Analg. 2002;95(5): 1224-1229
    • (2002) Anesth Analg , vol.95 , Issue.5 , pp. 1224-1229
    • Voepel-Lewis, T.1    Merkel, S.2    Tait, A.R.3    Trzcinka, A.4    Malviya, S.5
  • 38
    • 0038783334 scopus 로고    scopus 로고
    • Validation of the paediatric logistic organ dysfunction (PELOD) score: Prospective, observational, multi-centre study
    • Leteurtre S, Martinot A, Duhamel A, Proulx F, Grandbastien B, Cotting J, et al. Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multi-centre study. Lancet. 2003;362(9379):192-197
    • (2003) Lancet , vol.362 , Issue.9379 , pp. 192-197
    • Leteurtre, S.1    Martinot, A.2    Duhamel, A.3    Proulx, F.4    Grandbastien, B.5    Cotting, J.6
  • 39
    • 0036217546 scopus 로고    scopus 로고
    • The combination of low dose of naloxone and morphine in PCA does not decrease opioid requirements in the postoperative period
    • Cepeda MS, Africano JM, Manrique AM, Fragoso W, Carr DB. The combination of low dose of naloxone and morphine in PCA does not decrease opioid requirements in the postoperative period. Pain. 2002;96(1-2):73-79
    • (2002) Pain , vol.96 , Issue.1-2 , pp. 73-79
    • Cepeda, M.S.1    Africano, J.M.2    Manrique, A.M.3    Fragoso, W.4    Carr, D.B.5
  • 40
    • 63749123100 scopus 로고    scopus 로고
    • Facts & Comparisons 4.0: Administration and dosage. Available at: http://online.factsandcomparisons.com/printsection.aspx?id=662859§ion= admin-dosage. Accessed March 17, 2008
    • Facts & Comparisons 4.0: Administration and dosage. Available at: http://online.factsandcomparisons.com/printsection.aspx?id=662859§ion= admin-dosage. Accessed March 17, 2008
  • 41
    • 0030071224 scopus 로고    scopus 로고
    • Naloxone versus nalbuphine infusion for prophylaxis of epi-dural morphine-induced pruritus
    • Kendrick WD, Woods AM, Daly MY, Birch RF, DiFazio C. Naloxone versus nalbuphine infusion for prophylaxis of epi-dural morphine-induced pruritus. Anesth Analg. 1996;82(3):641-647
    • (1996) Anesth Analg , vol.82 , Issue.3 , pp. 641-647
    • Kendrick, W.D.1    Woods, A.M.2    Daly, M.Y.3    Birch, R.F.4    DiFazio, C.5
  • 42
    • 0022448737 scopus 로고
    • A combination of buprenorphine and naloxone compared with buprenorphine administered intramuscularly in postoperative patients
    • Rolly G, Poelaert J, Mungroop H, Paelinck H. A combination of buprenorphine and naloxone compared with buprenorphine administered intramuscularly in postoperative patients. J Int Med Res. 1986;14(3):148-152
    • (1986) J Int Med Res , vol.14 , Issue.3 , pp. 148-152
    • Rolly, G.1    Poelaert, J.2    Mungroop, H.3    Paelinck, H.4
  • 43
    • 0035084767 scopus 로고    scopus 로고
    • Stoller KB, Bigelow GE, Walsh SL, Strain EC. Effects of buprenorphine/naloxone in opioid-dependent humans. Psy-chopharmacology (Berl). 2001;154(3):230-242
    • Stoller KB, Bigelow GE, Walsh SL, Strain EC. Effects of buprenorphine/naloxone in opioid-dependent humans. Psy-chopharmacology (Berl). 2001;154(3):230-242
  • 44
    • 0022576624 scopus 로고
    • Influence of naloxone infusion on analgesia and respiratory depression following epi-dural morphine
    • Rawal N, Schott U, Dahlstrom B, et al. Influence of naloxone infusion on analgesia and respiratory depression following epi-dural morphine. Anesthesiology. 1986;64(2):194-1201
    • (1986) Anesthesiology , vol.64 , Issue.2 , pp. 194-1201
    • Rawal, N.1    Schott, U.2    Dahlstrom, B.3
  • 45
    • 0037219290 scopus 로고    scopus 로고
    • Mehlisch DR. The combination of low dose of naloxone and morphine in patient-controlled (PCA) does not decrease opioid requirements in the postoperative period. Pain. 2003;101(1-2): 209-211, author reply 211-212
    • Mehlisch DR. The combination of low dose of naloxone and morphine in patient-controlled (PCA) does not decrease opioid requirements in the postoperative period. Pain. 2003;101(1-2): 209-211, author reply 211-212
  • 46
    • 23644451619 scopus 로고    scopus 로고
    • Sedation and analgesia in the pediatric intensive care unit
    • Tobias JD. Sedation and analgesia in the pediatric intensive care unit. Pediatr Ann. 2005;34(8):636-645
    • (2005) Pediatr Ann , vol.34 , Issue.8 , pp. 636-645
    • Tobias, J.D.1
  • 47
    • 0037015528 scopus 로고    scopus 로고
    • Analgesics for the treatment of pain in children
    • Berde CB, Sethna NF. Analgesics for the treatment of pain in children. N Engl J Med. 2002;347(14):1094-1103
    • (2002) N Engl J Med , vol.347 , Issue.14 , pp. 1094-1103
    • Berde, C.B.1    Sethna, N.F.2
  • 48
    • 33748806564 scopus 로고    scopus 로고
    • Sedation in the mechanically ventilated patient
    • Kress JP, Hall JB. Sedation in the mechanically ventilated patient. Crit Care Med. 2006;34(10):2541-2546
    • (2006) Crit Care Med , vol.34 , Issue.10 , pp. 2541-2546
    • Kress, J.P.1    Hall, J.B.2
  • 49
    • 0034050331 scopus 로고    scopus 로고
    • Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil, and sufentanil
    • Ummenhofer WC, Arends RH, Shen DD, Bernards CM. Comparative spinal distribution and clearance kinetics of intrathecally administered morphine, fentanyl, alfentanil, and sufentanil. An-esthesiology. 2000;92(3):739-753
    • (2000) An-esthesiology , vol.92 , Issue.3 , pp. 739-753
    • Ummenhofer, W.C.1    Arends, R.H.2    Shen, D.D.3    Bernards, C.M.4
  • 50
    • 0037023101 scopus 로고    scopus 로고
    • Possible involvement of mu1-opioid receptors in the fentanyl-or morphine-induced antinociception at supraspinal and spinal sites
    • Narita M, Imai S, Itou Y, Yajima Y, Suzuki T. Possible involvement of mu1-opioid receptors in the fentanyl-or morphine-induced antinociception at supraspinal and spinal sites. Life Sci. 2002;70(20):2341-2354
    • (2002) Life Sci , vol.70 , Issue.20 , pp. 2341-2354
    • Narita, M.1    Imai, S.2    Itou, Y.3    Yajima, Y.4    Suzuki, T.5
  • 51
    • 33645846309 scopus 로고    scopus 로고
    • Comparison of the relative efficacy and potency of mu-opioid agonists to activate Galpha(i/o) proteins containing a pertussis toxin-insensitive mutation
    • Clark MJ, Furman CA, Gilson TD, Traynor JR. Comparison of the relative efficacy and potency of mu-opioid agonists to activate Galpha(i/o) proteins containing a pertussis toxin-insensitive mutation. J Pharmacol Exp Ther. 2006;317(2): 858-864
    • (2006) J Pharmacol Exp Ther , vol.317 , Issue.2 , pp. 858-864
    • Clark, M.J.1    Furman, C.A.2    Gilson, T.D.3    Traynor, J.R.4
  • 52
    • 33645102976 scopus 로고    scopus 로고
    • Differential activation of G-proteins by mu-opioid receptor agonists
    • Saidak Z, Blake-Palmer K, Hay DL, Northup JK, Glass M.Differential activation of G-proteins by mu-opioid receptor agonists. Br J Pharmacol. 2006;147(6):671-680
    • (2006) Br J Pharmacol , vol.147 , Issue.6 , pp. 671-680
    • Saidak, Z.1    Blake-Palmer, K.2    Hay, D.L.3    Northup, J.K.4    Glass, M.5
  • 54
    • 33750967055 scopus 로고    scopus 로고
    • Tramadol, fentanyl and sufentanil but not morphine block voltage-operated sodium channels
    • Haeseler G, Foadi N, Ahrens J, Dengler R, Hecker H, Leuwer M. Tramadol, fentanyl and sufentanil but not morphine block voltage-operated sodium channels. Pain. 2006;126(1-3): 234-244
    • (2006) Pain , vol.126 , Issue.1-3 , pp. 234-244
    • Haeseler, G.1    Foadi, N.2    Ahrens, J.3    Dengler, R.4    Hecker, H.5    Leuwer, M.6
  • 55
    • 0347355442 scopus 로고    scopus 로고
    • Addition of ul-tralow dose naloxone to postoperative morphine PCA: Unchanged analgesia and opioid requirement but decreased incidence of opioid side effects
    • Cepeda MS, Alvarez H, Morales O, Carr DB. Addition of ul-tralow dose naloxone to postoperative morphine PCA: unchanged analgesia and opioid requirement but decreased incidence of opioid side effects. Pain. 2004;107(1-2):41-46
    • (2004) Pain , vol.107 , Issue.1-2 , pp. 41-46
    • Cepeda, M.S.1    Alvarez, H.2    Morales, O.3    Carr, D.B.4
  • 56
    • 33747152472 scopus 로고    scopus 로고
    • Consensus guidelines on sedation and analgesia in critically ill children
    • Playfor S, Jenkins I, Boyles C, et al. Consensus guidelines on sedation and analgesia in critically ill children. Intensive Care Med. 2006;32(8):1125-1136
    • (2006) Intensive Care Med , vol.32 , Issue.8 , pp. 1125-1136
    • Playfor, S.1    Jenkins, I.2    Boyles, C.3
  • 57
    • 33747194655 scopus 로고    scopus 로고
    • Sedation and analgesia in the PICU: Many questions remain
    • Prins S, van Dijk M, Tibboel D. Sedation and analgesia in the PICU: many questions remain. Intensive Care Med.2006;32(8): 1103-1105
    • (2006) Intensive Care Med , vol.32 , Issue.8 , pp. 1103-1105
    • Prins, S.1    van Dijk, M.2    Tibboel, D.3
  • 58
    • 1842867176 scopus 로고    scopus 로고
    • Naloxone reversal of opioid anesthesia revisited: Clinical evaluation and plasma concentration analysis of continuous nalox-one infusion after anesthesia with high-dose fentanyl
    • Takahashi M, Sugiyama K, Hori M, Chiba S, Kusaka K. Naloxone reversal of opioid anesthesia revisited: clinical evaluation and plasma concentration analysis of continuous nalox-one infusion after anesthesia with high-dose fentanyl. JAnesth. 2004;18(1):1-8
    • (2004) JAnesth , vol.18 , Issue.1 , pp. 1-8
    • Takahashi, M.1    Sugiyama, K.2    Hori, M.3    Chiba, S.4    Kusaka, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.