-
1
-
-
54949144309
-
Functional pharmacogenetics/ genomics of human cytochromes P450 involved in drug biotransformation
-
Zanger UM, Turpeinen M, Klein K, Schwab M. Functional pharmacogenetics/ genomics of human cytochromes P450 involved in drug biotransformation. Anal. Bioanal. Chem. 392, 1093-1108 (2008).
-
(2008)
Anal. Bioanal. Chem.
, vol.392
, pp. 1093-1108
-
-
Zanger, U.M.1
Turpeinen, M.2
Klein, K.3
Schwab, M.4
-
2
-
-
3142519666
-
Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response
-
Kirchheiner J, Nickchen K, Bauer M et al. Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response. Mol. Psychiatry 9, 442-472 (2004).
-
(2004)
Mol. Psychiatry
, vol.9
, pp. 442-472
-
-
Kirchheiner, J.1
Nickchen, K.2
Bauer, M.3
-
3
-
-
47249097440
-
The impact of CYP2D6 and CYP2C19 polymorphisms on suicidal behavior and substance abuse disorder among patients with schizophrenia: A retrospective study
-
Kobylecki CJ, Hansen T, Timm S et al. The impact of CYP2D6 and CYP2C19 polymorphisms on suicidal behavior and substance abuse disorder among patients with schizophrenia: a retrospective study. Ther. Drug Monit. 30, 265-270 (2008).
-
(2008)
Ther. Drug Monit.
, vol.30
, pp. 265-270
-
-
Kobylecki, C.J.1
Hansen, T.2
Timm, S.3
-
4
-
-
35248854448
-
Testing for cytochrome P450 polymorphisms in adults with non-psychotic depression treated with selective serotonin reuptake inhibitors (SSRIs)
-
Matchar DB, Thakur ME, Grossman I et al. Testing for cytochrome P450 polymorphisms in adults with non-psychotic depression treated with selective serotonin reuptake inhibitors (SSRIs). Evid. Rep. Technol. Assess. (Full Rep.) (146), 1-77 (2007).
-
(2007)
Evid. Rep. Technol. Assess. (Full Rep.)
, vol.146
, pp. 1-77
-
-
Matchar, D.B.1
Thakur, M.E.2
Grossman, I.3
-
6
-
-
0742286803
-
Cytochrome P450 2D6: Overview and update on pharmacology, genetics, biochemistry
-
Zanger UM, Raimundo S, Eichelbaum M. Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry. Naunyn-Schmiedebergs Arch. Pharmacol. 369, 23-37 (2004).
-
(2004)
Naunyn-Schmiedebergs Arch. Pharmacol.
, vol.369
, pp. 23-37
-
-
Zanger, U.M.1
Raimundo, S.2
Eichelbaum, M.3
-
7
-
-
29544449443
-
Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19
-
de Leon J, Armstrong SC, Cozza KL. Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19. Psychosomatics 47, 75-85 (2006).
-
(2006)
Psychosomatics
, vol.47
, pp. 75-85
-
-
De Leon, J.1
Armstrong, S.C.2
Cozza, K.L.3
-
9
-
-
62449286261
-
DNA microarray technology in the clinical environment: The AmpliChip CYP450 test for CYP2D6 and CYP2C19 genotyping
-
de Leon J, Susce MT, Johnson M et al. DNA microarray technology in the clinical environment: the AmpliChip CYP450 test for CYP2D6 and CYP2C19 genotyping. CNS Spectr. 14, 19-34 (2009).
-
(2009)
CNS Spectr.
, vol.14
, pp. 19-34
-
-
De Leon, J.1
Susce, M.T.2
Johnson, M.3
-
10
-
-
59149096567
-
The AmpliChip CYP450 test: Cytochrome P450 2D6 genotype assessment and phenotype prediction
-
Rebsamen MC, Desmeules J, Daali Y et al. The AmpliChip CYP450 test: cytochrome P450 2D6 genotype assessment and phenotype prediction. Pharmacogenomics J. 9, 34-41 (2009).
-
(2009)
Pharmacogenomics J.
, vol.9
, pp. 34-41
-
-
Rebsamen, M.C.1
Desmeules, J.2
Daali, Y.3
-
11
-
-
77956188003
-
Discovery of the nonfunctional CYP2D6*31 allele in Spanish, Puerto Rican, and US Hispanic populations
-
Gaedigk A, Isidoro-Garcia M, Pearce RE et al. Discovery of the nonfunctional CYP2D6*31 allele in Spanish, Puerto Rican, and US Hispanic populations. Eur. J. Clin. Pharmacol. 66, 859-864 (2010).
-
(2010)
Eur. J. Clin. Pharmacol.
, vol.66
, pp. 859-864
-
-
Gaedigk, A.1
Isidoro-Garcia, M.2
Pearce, R.E.3
-
12
-
-
33846643134
-
Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: Characterization of gene duplication events
-
Gaedigk A, Ndjountché L, Divakaran K et al. Cytochrome P4502D6 (CYP2D6) gene locus heterogeneity: characterization of gene duplication events. Clin. Pharmacol. Ther. 81, 242-251 (2007).
-
(2007)
Clin. Pharmacol. Ther.
, vol.81
, pp. 242-251
-
-
Gaedigk, A.1
Ndjountché, L.2
Divakaran, K.3
-
13
-
-
38349132802
-
The CYP2D6 activity score: Translating genotype information into a qualitative measure of phenotype
-
Gaedigk A, Simon SD, Pearce RE, Bradford LD, Kennedy MJ, Leeder JS. The CYP2D6 activity score: Translating genotype information into a qualitative measure of phenotype. Clin. Pharmacol. Ther. 83, 234-242 (2008).
-
(2008)
Clin. Pharmacol. Ther.
, vol.83
, pp. 234-242
-
-
Gaedigk, A.1
Simon, S.D.2
Pearce, R.E.3
Bradford, L.D.4
Kennedy, M.J.5
Leeder, J.S.6
-
14
-
-
83755207557
-
CYP2D6, SULT1A1 and UGT2B17 copy number variation: Quantitative detection by multiplex PCR
-
doi: 10.2217/ PGS.11.135 In Press
-
Gaedigk A, Twist GP, Leeder JS. CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR. Pharmacogenomics doi: 10.2217/ PGS.11.135 (2011) (In Press).
-
(2011)
Pharmacogenomics
-
-
Gaedigk, A.1
Twist, G.P.2
Leeder, J.S.3
-
15
-
-
73549100850
-
CYP2D7-2D6 hybrid tandems: Identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction
-
Gaedigk A, Fuhr U, Johnson C, Berard LA, Bradford D, Leeder JS. CYP2D7-2D6 hybrid tandems: identification of novel CYP2D6 duplication arrangements and implications for phenotype prediction. Pharmacogenomics 11, 43-53 (2010).
-
(2010)
Pharmacogenomics
, vol.11
, pp. 43-53
-
-
Gaedigk, A.1
Fuhr, U.2
Johnson, C.3
Berard, L.A.4
Bradford, D.5
Leeder, J.S.6
-
16
-
-
80455175971
-
Identification of novel CYP2D7-2D6 hybrids: Non-functional and functional variants
-
Gaedigk A, Montane Jaime LK, Bertino JS et al. Identification of novel CYP2D7-2D6 hybrids: non-functional and functional variants. Front Pharmacol. 1, 121 (2010).
-
(2010)
Front Pharmacol.
, vol.1
, pp. 121
-
-
Gaedigk, A.1
Montane Jaime, L.K.2
Bertino, J.S.3
-
17
-
-
79953249419
-
Gene copy number variations: It is important to determine which allele is affected
-
Ramamoorthy A, Skaar TC. Gene copy number variations: it is important to determine which allele is affected. Pharmacogenomics 12, 299-301 (2011).
-
(2011)
Pharmacogenomics
, vol.12
, pp. 299-301
-
-
Ramamoorthy, A.1
Skaar, T.C.2
-
19
-
-
0026240145
-
Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: Possible association with the poor metabolizer phenotype
-
Tyndale R, Aoyama T, Broly F et al. Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype. Pharmacogenetics 1, 26-32 (1991).
-
(1991)
Pharmacogenetics
, vol.1
, pp. 26-32
-
-
Tyndale, R.1
Aoyama, T.2
Broly, F.3
-
20
-
-
0027273757
-
Debrisoquine oxidation polymorphism: Phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene
-
Broly F, Meyer UA. Debrisoquine oxidation polymorphism: phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene. Pharmacogenetics 3, 123-130 (1993).
-
(1993)
Pharmacogenetics
, vol.3
, pp. 123-130
-
-
Broly, F.1
Meyer, U.A.2
-
21
-
-
77958476379
-
Assessment of activity levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 genes by population pharmacokinetics of dextromethorphan
-
Abduljalil K, Frank D, Gaedigk A et al. Assessment of activity levels for CYP2D6*1, CYP2D6*2, and CYP2D6*41 genes by population pharmacokinetics of dextromethorphan. Clin. Pharmacol. Ther. 88, 643-651 (2010).
-
(2010)
Clin. Pharmacol. Ther.
, vol.88
, pp. 643-651
-
-
Abduljalil, K.1
Frank, D.2
Gaedigk, A.3
-
22
-
-
7744246753
-
Molecular diversity at the CYP2D6 locus in the Mediterranean region
-
Fuselli S, Dupanloup I, Frigato E et al. Molecular diversity at the CYP2D6 locus in the Mediterranean region. Eur. J. Hum. Genet. 12, 916-924 (2004).
-
(2004)
Eur. J. Hum. Genet.
, vol.12
, pp. 916-924
-
-
Fuselli, S.1
Dupanloup, I.2
Frigato, E.3
-
23
-
-
33847031732
-
CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure
-
Sistonen J, Sajantila A, Lao O, Corander J, Barbujani G, Fuselli S. CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure. Pharmacogenet. Genomics 17, 93-101 (2007).
-
(2007)
Pharmacogenet. Genomics
, vol.17
, pp. 93-101
-
-
Sistonen, J.1
Sajantila, A.2
Lao, O.3
Corander, J.4
Barbujani, G.5
Fuselli, S.6
-
24
-
-
13944266054
-
Limited association of the 2988G≥A single nucleotide polymorphism with CYP2D6*41 in black subjects
-
Gaedigk A, Ndjountché L, Leeder JS, Bradford LD. Limited association of the 2988G≥A single nucleotide polymorphism with CYP2D6*41 in black subjects. Clin. Pharmacol. Ther. 77, 228-230 (2005).
-
(2005)
Clin. Pharmacol. Ther.
, vol.77
, pp. 228-230
-
-
Gaedigk, A.1
Ndjountché, L.2
Leeder, J.S.3
Bradford, L.D.4
-
25
-
-
3543014421
-
A novel intronic mutation, 2988G≥A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects
-
Raimundo S, Toscano C, Klein K et al. A novel intronic mutation, 2988G≥A, with high predictivity for impaired function of cytochrome P450 2D6 in white subjects. Clin. Pharmacol. Ther. 76, 128-138 (2004).
-
(2004)
Clin. Pharmacol. Ther.
, vol.76
, pp. 128-138
-
-
Raimundo, S.1
Toscano, C.2
Klein, K.3
-
26
-
-
77957801199
-
-
Allele Nomenclature Committee Accessed 18 May
-
Human Cytochrome P450 (CYP) Allele Nomenclature Committee www.cypalleles.ki.se/cyp2d6.htm (Accessed 18 May 2011)
-
(2011)
Human Cytochrome P450 (CYP)
-
-
-
28
-
-
84873079618
-
-
AmpliChip CYP450 test http://molecular.roche.com/assays/Pages/ AmpliChipCYP450Test.aspx
-
AmpliChip CYP450 Test
-
-
|