Glucose and lipid metabolism in spontaneously diabetic Torii rat

Open Diabetes Journal

Volumn 4, Issue SPEC. ISSUE 1, 2011, Pages 55-59

  Mera, Yasuko ^a   Morinaga, Hisayo ^a   Ohta, Takeshi ^a   Sasase, Tomohiko ^a  

^a JAPAN TOBACCO INC   (Japan)

Author keywords

Hyperglycemia; Hypertriglyceridemia; Intestine; Liver; SDT rat

Indexed keywords

ACYLGLYCEROL PALMITOYLTRANSFERASE; CHYLOMICRON; DIACYLGLYCEROL ACYLTRANSFERASE 1; GLUCOKINASE; GLUCOSE; GLYCOGEN; GLYCOGEN PHOSPHORYLASE; INSULIN; LEPTIN; LIPOPROTEIN LIPASE; MESSENGER RNA; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; PHLORIZIN; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ACYL COA DIACYLGLYCEROL ACYLTRANSFERASE 1 GENE; ACYL COA MONOACYLGLYCEROL ACYLTRANSFERASE 2 GENE; ARTICLE; BIOACCUMULATION; DISEASE ASSOCIATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; GENE; GENE EXPRESSION REGULATION; GLUCOKINASE GENE; GLUCONEOGENESIS; GLUCOSE METABOLISM; GLYCOGEN ANALYSIS; GLYCOGEN PHOSPHORYLASE GENE; GLYCOGEN SYNTHASE GENE; HYPERGLYCEMIA; HYPERTRIGLYCERIDEMIA; HYPOINSULINEMIA; INSULIN LIKE ACTIVITY; INSULIN TREATMENT; LIPID ABSORPTION; LIPID METABOLISM; LIPID STORAGE; LIPOLYSIS; LIVER METABOLISM; METABOLIC SYNDROME X; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT STRAIN; SPONTANEOUSLY DIABETIC TORII RAT;

EID: 80455125724     PISSN: None     EISSN: 18765246     Source Type: Journal    
DOI: 10.2174/1876524601104010055     Document Type: Article

References (46)

1. Howard BV. Lipoprotein metabolism in diabetes mellitus. J Lipid Res 1987; 28: 613-28.
2. Garcia MJ, McNamara PM, Gordon T, Kannel WB. Morbidity and mortality in diabetics in the Framingham population. Sixteen year follow-up study. Diabetes 1974; 23: 105-11.
3. Steiner G. Diabetes and atherosclerosis: an overview. Diabetes 1981; 30: 1-7.
4. Morinaga H, Yamamoto H, Sakata K, et al. Characterization of hepatic glucose metabolism disorder with the progress of diabetes in male Spontaneously Diabetic Torii rats. J Vet Med Sci 2008; 70: 1239-45.
5. Sasase T, Morinaga H, Yamamoto H, et al. Increased fat absorption and impaired fat clearance cause postprandial hypertriglyceridemia in Spontaneously Diabetic Torii rat. Diabetes Res Clin Pract 2007; 78: 8-15.
6. Shinohara M, Masuyama T, Kakehashi A. The Spontaneously Diabetic Torii (SDT) rat with retinopathy lesions resembling those of humans. In: Shafrir E, Eds. Animal models of diabetes: frontiers in research. 2nd ed. Boca Raton (FL): CRC Press 2007; pp. 311-21.
7. Shinohara M, Masuyama T, Shoda T, et al. A new spontaneously diabetic non-obese Torii rat strain with severe ocular complications. Int J Exp Diabetes Res 2000; 1: 89-100.
8. Masuyama T, Komeda K, Hara A, et al. Chronological characterization of diabetes development in male Spontaneously Diabetic Torii rats. Biochem Biophys Res Commun 2004; 314: 870-7.
9. Ferre T, Riu E, Bosch F, Valera A. Evidence from transgenic mice that glucokinase is rate limiting for glucose utilization in the liver. FASEB J 1996; 10: 1213-8.
10. Basu A, Basu R, Shah P, et al. Type 2 diabetes impairs splanchnic uptake of glucose but does not alter intestinal glucose absorption during enteral glucose feeding: additional evidence for a defect in hepatic glucokinase activity. Diabetes 2001; 50: 1351-62.
11. Basu A, Basu R, Shah P, et al. Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: evidence for a defect in hepatic glucokinase activity. Diabetes 2000; 49: 272-83.
12. Munoz MC, Barbera A, Dominguez J, et al. Effects of tungstate, a new potential oral antidiabetic agent, in Zucker diabetic fatty rats. Diabetes 2001; 50: 131-8.
13. Lavoie L, Dimitrakoudis D, Marette A, et al. Opposite effects of hyperglycemia and insulin deficiency on liver glycogen synthase phosphatase activity in the diabetic rat. Diabetes 1993; 42: 363-6.
14. Aiston S, Peak M, Agius L. Impaired glycogen synthesis in hepatocytes from Zucker fatty fa/fa rats: the role of increased phosphorylase activity. Diabetologia 2000; 43: 589-97.
15. Toyoda Y, Ito Y, Tanigawa K, Miwa I. Impairment of glucokinase translocation in cultured hepatocytes from OLETF and GK rats, animal models of type 2 diabetes. Arch Histol Cytol 2000; 63: 243-8.
16. Yen TT, Stamm NB. Constitutive hepatic glucokinase activity in db/db and ob/ob mice. Biochim Biophys Acta 1981; 657: 195-202.
17. Bollen M, Keppens S, Stalmans W. Specific features of glycogen metabolism in the liver. Biochem J 1998; 336 (Pt 1): 19-31.
18. Gomis RR, Ferrer JC, Guinovart JJ. Shared control of hepatic glycogen synthesis by glycogen synthase and glucokinase. Biochem J 2000; 351 Pt 3: 811-6.
19. Roesler WJ, Khandelwal RL. Regulation of rat liver glycogen phosphorylase concentration by in vivo relative levels of glucagon and insulin. Endocrinology 1987; 121: 227-32.
20. Ohta T, Matsui K, Miyajima K, et al. Effect of insulin therapy on renal changes in spontaneously diabetic Torii rats. Exp Anim 2007; 56: 355-62.
21. Sasase T, Morinaga H, Abe T, et al. Protein kinase C beta inhibitor prevents diabetic peripheral neuropathy, but not histopathological abnormalities of retina in Spontaneously Diabetic Torii rat. Diabetes Obes Metab 2009; 11: 1084-7.
22. Sasase T, Ohta T, Ogawa N, et al. Preventive effects of glycaemic control on ocular complications of Spontaneously Diabetic Torii rat. Diabetes Obes Metab 2006; 8: 501-7.
23. Sasase T, Ohta T, Ogawa N, et al. Diabetic complications of Spontaneously Diabetic Torii rat. Diabetes 2005; 54 (Suppl 1): A221.
24. Blondel O, Bailbe D, Portha B. Insulin resistance in rats with non-insulin-dependent diabetes induced by neonatal (5 days) streptozotocin: evidence for reversal following phlorizin treatment. Metabolism 1990; 39: 787-93.
25. Khan A, Efendic S. Evidence that increased glucose cycling in islets of diabetic ob/ob mice is a primary feature of the disease. Am J Physiol 1995; 269: E623-6.
26. Barzilai N, Rossetti L. Role of glucokinase and glucose-6-phosphatase in the acute and chronic regulation of hepatic glucose fluxes by insulin. J Biol Chem 1993; 268: 25019-25.
27. Hanson RW, Patel YM. Phosphoenolpyruvate carboxykinase (GTP): the gene and the enzyme. Adv Enzymol Relat Areas Mol Biol 1994; 69: 203-81.
28. Pilkis SJ, Granner DK. Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis. Annu Rev Physiol 1992; 54: 885-909.
29. Havel PJ, Uriu-Hare JY, Liu T, et al. Marked and rapid decreases of circulating leptin in streptozotocin diabetic rats: reversal by insulin. Am J Physiol 1998; 274: R1482-91.
30. Young NL, Saudek CD, Walters L, Lapeyrolerie J, Chang V. Preventing hyperphagia normalizes 3-hydroxy-3-methylglutaryl-CoA reductase activity in small intestine and liver of diabetic rats. J Lipid Res 1982; 23: 831-8.
31. Popper DA, Shiau YF, Reed M. Role of small intestine in pathogenesis of hyperlipidemia in diabetic rats. Am J Physiol 1985; 249: G161-7.
32. Risser TR, Reaven GM, Reaven EP. Intestinal very low density lipoprotein secretion in insulin-deficient rats. Diabetes 1978; 27: 902-8.
33. Steiner G, Poapst M, Davidson JK. Production of chylomicron-like lipoproteins from endogenous lipid by the intestine and liver of diabetic dogs. Diabetes 1975; 24: 263-71.
34. Yamada K, Hosokawa M, Fujimoto S, et al. The spontaneously diabetic Torii rat with gastroenteropathy. Diabetes Res Clin Pract 2007; 75: 127-34.
35. Chen HC, Smith SJ, Ladha Z, et al. Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J Clin Invest 2002; 109: 1049-55.
36. Meegalla RL, Billheimer JT, Cheng D. Concerted elevation of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) activity through independent stimulation of mRNA expression of DGAT1 and DGAT2 by carbohydrate and insulin. Biochem Biophys Res Commun 2002; 298: 317-23.
37. Mostafa N, Bhat BG, Coleman RA. Increased hepatic monoacylglycerol acyltransferase activity in streptozotocin-induced diabetes: characterization and comparison with activities from adult and neonatal rat liver. Biochim Biophys Acta 1993; 1169: 189-95.
38. Bar-On H, Roheim PS, Eder HA. Serum lipoproteins and apolipoproteins in rats with streptozotocin-induced diabetes. J Clin Invest 1976; 57: 714-21.
39. Brown DF. Triglyceride metabolism in the alloxan-diabetic rat. Diabetes 1967; 16: 90-5.
40. Reaven EP, Reaven GM. Mechanisms for development of diabetic hypertriglyceridemia in streptozotocin-treated rats. Effect of diet and duration of insulin deficiency. J Clin Invest 1974; 54: 1167-78.
41. Staprans I, Pan XM, Rapp JH, Feingold KR. Chylomicron and chylomicron remnant metabolism in STZ-induced diabetic rats. Diabetes 1992; 41: 325-33.
42. Redgrave TG, Callow MJ. The effect of insulin deficiency on the metabolism of lipid emulsion models of triacylglycerol-rich lipoproteins in rats. Metabolism 1990; 39: 1-10.
43. Hirano T, Mamo JC, Takeuchi H, Nagano S, Takahashi T. Correlation of insulin deficiency and hypertriglyceridemia in diabetic rats. Diabetes Res Clin Pract 1991; 12: 173-80.
44. Mason TM, Chan B, El-Bahrani B, et al. The effect of chronic insulin delivery via the intraperitoneal versus the subcutaneous route on hepatic triglyceride secretion rate in streptozotocin diabetic rats. Atherosclerosis 2002; 161: 345-52.
45. Kalopissis AD, Griffaton G, Fau D. Inhibition of hepatic very-low-density lipoprotein secretion in obese Zucker rats adapted to a high-protein diet. Metabolism 1995; 44: 19-29.
46. Hirano T, Mamo JC, Furukawa S, Nagano S, Takahashi T. Effect of acute hyperglycemia on plasma triglyceride concentration and triglyceride secretion rate in non-fasted rats. Diabetes Res Clin Pract 1990; 9: 231-8.