A novel small molecule 1,2,3,4,6-penta-O-galloyl-α-D-glucopyranose mimics the antiplatelet actions of insulin

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Perveen, Rehana ^a,d   Funk, Kevin ^a   Thuma, Jean ^a   Wulf Ridge, Shelli ^a   Cao, Yanyan ^b,e   Akkerman, Jan Willem N ^c   Chen, Xiaozhuo ^a,b   Akbar, Huzoor ^a,b  

^a OHIO UNIVERSITY   (United States)

^b OHIO UNIVERSITY   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d BAQAI MEDICAL UNIVERSITY   (Pakistan)

^e NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4,6 PENTA O GALLOYL ALPHA DEXTRO GLUCOPYRANOSE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTITHROMBOCYTIC AGENT; CALCIUM; CYCLIC AMP; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR KINASE; INSULIN RECEPTOR SUBSTRATE 1; PADGEM PROTEIN; PROTEIN KINASE B; SOMATOMEDIN C RECEPTOR; THROMBIN; THROMBOCYTE RECEPTOR; UNCLASSIFIED DRUG; BETA PENTA O GALLOYL GLUCOSE; BETA-PENTA-O-GALLOYL-GLUCOSE; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, HUMAN; TANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIPLATELET ACTIVITY; ARTICLE; CELL GRANULE; COLLAGEN DEGRADATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOSOL; DRUG ACTIVITY; DRUG RECEPTOR BINDING; EX VIVO STUDY; HUMAN; HUMAN CELL; HYPOGLYCEMIA; MOUSE; NONHUMAN; PROTEIN AGGREGATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; METABOLISM; MOLECULAR MIMICRY; PHOSPHORYLATION;

MUS;

ADENOSINE TRIPHOSPHATE; CYCLIC AMP; HUMANS; HYDROLYZABLE TANNINS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; MOLECULAR MIMICRY; P-SELECTIN; PHOSPHORYLATION; PLATELET AGGREGATION INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN;

EID: 80355143314     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026238     Document Type: Article

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