Cardiac overexpression of 8-oxoguanine dna glycosylase 1 protects mitochondrial dna and reduces cardiac fibrosis following transaortic constriction

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 301, Issue 5, 2011, Pages

  Wang, Jianxun ^a   Wang, Qianwen ^b   Watson, Lewis J ^a,b   Jones, Steven P ^a,b   Epstein, Paul N ^b  

^a University of Louisville School of Medicine   (United States)

^b Department of Physiology ^*  (United States)

Author keywords

Mitochondria; Transgene

Indexed keywords

8 HYDROXYGUANINE; 8 OXOGUANINE DNA GLYCOSYLASE 1; COLLAGEN TYPE 1; COLLAGEN TYPE 3; DNA GLYCOSYLTRANSFERASE; DOXORUBICIN; GUANINE; MESSENGER RNA; MITOCHONDRIAL DNA; MYOSIN HEAVY CHAIN BETA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; AORTA SURGERY; ARTICLE; CONTROLLED STUDY; DNA REPAIR; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; HEART; HEART FUNCTION; HEART MUSCLE FIBROSIS; HEART WEIGHT; MALE; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING; TIBIA; TRANSAORTIC CONSTRICTION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; AORTA; COLLAGEN TYPE I; COLLAGEN TYPE III; CONSTRICTION; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA GLYCOSYLASES; DNA, MITOCHONDRIAL; DOXORUBICIN; FIBROSIS; GENE EXPRESSION REGULATION; GENOTYPE; GUANINE; HEART DISEASES; HUMANS; MALE; MICE; MICE, TRANSGENIC; MITOCHONDRIA, HEART; MYOCARDIUM; MYOSIN HEAVY CHAINS; OXIDATIVE STRESS; PHENOTYPE; RNA, MESSENGER; UP-REGULATION;

EID: 80355134487     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00157.2011     Document Type: Article

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