Macrophage response to high number of titanium particles is cytotoxic and COX-2 mediated and it is not affected by the particle's endotoxin content or the cleaning treatment

Journal of Biomedical Materials Research - Part A

Volumn 99 A, Issue 4, 2011, Pages 630-637

  Schwab, Luciana P ^a   Marlar, Justin ^a   Hasty, Karen A ^a   Smith, Richard A ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

cytotoxicity; endotoxins; macrophage; particles; titanium

Indexed keywords

CELL VIABILITY; CLEANING PROCEDURES; CLEANING TREATMENT; CYTOKINE RESPONSE; CYTOTOXIC; ENDOTOXINS; ENVIRONMENTAL FACTORS; IMPLANT MATERIALS; MACROPHAGE ACTIVATION; PARTICULATE MATERIALS; PERIPROSTHETIC OSTEOLYSIS; TI PARTICLES; TITANIUM PARTICLES; WEAR DEBRIS;

BONE; CLEANING; CYTOTOXICITY; DEBRIS; TITANIUM;

MACROPHAGES;

CYCLOOXYGENASE 2 INHIBITOR; ENDOTOXIN; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; TITANIUM; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL DEATH; CELL VIABILITY; CLEANING; CONTAMINATION; CONTROLLED STUDY; CYTOTOXICITY; IMPLANT; MACROPHAGE; MACROPHAGE ACTIVATION; NONHUMAN;

ANIMALS; BONE AND BONES; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; DINOPROSTONE; ENDOTOXINS; MACROPHAGE ACTIVATION; MACROPHAGES; MATERIALS TESTING; MICE; OSTEOLYSIS; PARTICLE SIZE; PROSTHESIS FAILURE; TITANIUM; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80255141927     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.33222     Document Type: Article

References (32)

1. Sierra RJ, Cooney WP, Pagnano MW, Trousdale RT, Rand JA,. Reoperations after 3200 revision TKAs: Rates, etiology, and lessons learned. Clin Orthop Relat Res 2004; 425: 200-206. (Pubitemid 39062770)
2. Lie SA, Havelin LI, Furnes ON, Engesaeter LB, Vollset SE,. Failure rates for 4762 revision total hip arthroplasties in the Norwegian Arthroplasty Register. J Bone Joint Surg Br 2004; 86: 504-509. (Pubitemid 38660051)
3. Goodman SB, Lind M, Song Y, Smith RL,. In vitro, in vivo, and tissue retrieval studies on particulate debris. Clin Orthop Relat Res 1998; 352: 25-34. (Pubitemid 28326281)
4. Amstutz HC, Campbell P, Kossovsky N, Clarke IC,. Mechanism and clinical significance of wear debris-induced osteolysis. Clin Orthop Relat Res 1992; 276: 7-18.
5. Jacobs JJ, Hallab NJ, Urban RM, Wimmer MA,. Wear particles. J Bone Joint Surg Am 2006; 88 (Suppl 2): 99-102.
6. Sabokbar A, Kudo O, Athanasou NA,. Two distinct cellular mechanisms of osteoclast formation and bone resorption in periprosthetic osteolysis. J Orthop Res 2003; 21: 73-80. (Pubitemid 36157622)
7. Wang ML, Nesti LJ, Tuli R, Lazatin J, Danielson KG, Sharkey PF, Tuan RS,. Titanium particles suppress expression of osteoblastic phenotype in human mesenchymal stem cells. J Orthop Res 2002; 20: 1175-1184. (Pubitemid 35363974)
8. Vermes C, Chandrasekaran R, Jacobs JJ, Galante JO, Roebuck KA, Glant TT,. The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts. J Bone Joint Surg Am 2001; 83A: 201-211. (Pubitemid 32163714)
9. Pioletti DP, Leoni L, Genini D, Takei H, Du P, Corbeil J,. Gene expression analysis of osteoblastic cells contacted by orthopedic implant particles. J Biomed Mater Res 2002; 61: 408-420. (Pubitemid 34666054)
10. Petit A, Catelas I, Antoniou J, Zukor DJ, Huk OL,. Differential apoptotic response of J774 macrophages to alumina and ultra-high-molecular-weight polyethylene particles. J Orthop Res 2002; 20: 9-15. (Pubitemid 34071415)
11. Greenfield EM, Bechtold J,. What other biologic and mechanical factors might contribute to osteolysis? J Am Acad Orthop Surg 2008; 16 (Suppl 1): S561-S62.
12. Greenfield EM, Bi Y, Ragab AA, Goldberg VM, Nalepka JL, Seabold JM,. Does endotoxin contribute to aseptic loosening of orthopedic implants? J Biomed Mater Res B Appl Biomater 2005; 72: 179-185. (Pubitemid 40039625)
13. Cho DR, Shanbhag AS, Hong CY, Baran GR, Goldring SR,. The role of adsorbed endotoxin in particle-induced stimulation of cytokine release. J Orthop Res 2002; 20: 704-713. (Pubitemid 34822989)
14. Daniels AU, Barnes FH, Charlebois SJ, Smith RA,. Macrophage cytokine response to particles and lipopolysaccharide in vitro. J Biomed Mater Res 2000; 49: 469-478. (Pubitemid 30030466)
15. Glant TT, Jacobs JJ, Molnar G, Shanbhag AS, Valyon M, Galante JO,. Bone resorption activity of particulate-stimulated macrophages. J Bone Miner Res 1993; 8: 1071-1079. (Pubitemid 23261100)
16. Bi Y, Collier TO, Goldberg VM, Anderson JM, Greenfield EM,. Adherent endotoxin mediates biological responses of titanium particles without stimulating their phagocytosis. J Orthop Res 2002; 20: 696-703. (Pubitemid 34822988)
17. Grandjean-Laquerriere A, Tabary O, Jacquot J, Richard D, Frayssinet P, Guenounou M, Laurent-Maquin D, Laquerriere P, Gangloff S,. Involvement of toll-like receptor 4 in the inflammatory reaction induced by hydroxyapatite particles. Biomaterials 2007; 28: 400-404. (Pubitemid 44754702)
18. Bi Y, Seabold JM, Kaar SG, Ragab AA, Goldberg VM, Anderson JM, Greenfield EM,. Adherent endotoxin on orthopedic wear particles stimulates cytokine production and osteoclast differentiation. J Bone Miner Res 2001; 16: 2082-2091. (Pubitemid 32995400)
19. Xing Z, Pabst MJ, Hasty KA, Smith RA,. Accumulation of LPS by polyethylene particles decreases bone attachment to implants. J Orthop Res 2006; 24: 959-966. (Pubitemid 43804930)
20. Chapekar MS, Zaremba TG, Kuester RK, Hitchins VM,. Synergistic induction of tumor necrosis factor alpha by bacterial lipopolysaccharide and lipoteichoic acid in combination with polytetrafluoroethylene particles in a murine macrophage cell line RAW 264.7. J Biomed Mater Res 1996; 31: 251-256.
21. Greenfield EM, Beidelschies MA, Tatro JM, Goldberg VM, Hise AG,. Bacterial pathogen-associated molecular patterns stimulate biological activity of orthopaedic wear particles by activating cognate Toll-like receptors. J Biol Chem 2010; 285: 32378-32384.
22. Ragab AA, Van De Motter R, Lavish SA, Goldberg VM, Ninomiya JT, Carlin CR, Greenfield EM,. Measurement and removal of adherent endotoxin from titanium particles and implant surfaces. J Orthop Res 1999; 17: 803-809. (Pubitemid 30033279)
23. Hitchins VM, Merritt K,. Decontaminating particles exposed to bacterial endotoxin (LPS). J Biomed Mater Res 1999; 46: 434-437. (Pubitemid 29293768)
24. Nishiguchi S, Kato H, Fujita H, Oka M, Kim HM, Kokubo T, Nakamura T,. Titanium metals form direct bonding to bone after alkali and heat treatments. Biomaterials 2001; 22: 2525-2533. (Pubitemid 32706455)
25. Schwab LP, Xing Z, Hasty KA, Smith RA,. Titanium particles and surface-bound LPS activate different pathways in IC-21 macrophages. J Biomed Mater Res B Appl Biomater 2006; 79: 66-73. (Pubitemid 44477475)
26. Bukata SV, Gelinas J, Wei X, Rosier RN, Puzas JE, Zhang X, Schwarz EM, Song XY, Griswold DE, O'Keefe RJ,. PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway. J Orthop Res 2004; 22: 6-12. (Pubitemid 38035439)
27. Niikura T, Saegusa Y, Nishikawa T, Yoshiya S, Kurosaka M,. Titanium-alloy particles induced cyclooxygenase-2 in human macrophage-like cells in vitro. Kobe J Med Sci 2002; 48: 115-123. (Pubitemid 36305727)
28. Lee DH, Park JC, Suh H,. Synergistic induction of cyclooxygenase-II by bacterial lipopolysaccharide in combination with particles of medical device materials in a murine macrophage cell line J774A.1. J Biomed Mater Res 2001; 55: 547-553. (Pubitemid 32336285)
29. Raisz LG, Pilbeam CC, Fall PM,. Prostaglandins: Mechanisms of action and regulation of production in bone. Osteoporos Int 1993; 3 (Suppl 1): 136-140. (Pubitemid 23099913)
30. Kawaguchi H, Pilbeam CC, Harrison JR, Raisz LG,. The role of prostaglandins in the regulation of bone metabolism. Clin Orthop Relat Res 1995; 313: 36-46.
31. Li X, Pilbeam CC, Pan L, Breyer RM, Raisz LG,. Effects of prostaglandin E2 on gene expression in primary osteoblastic cells from prostaglandin receptor knockout mice. Bone 2002; 30: 567-573. (Pubitemid 34270493)
32. Pioletti DP, Takei H, Kwon SY, Wood D, Sung KL,. The cytotoxic effect of Ti particles phagocytosed by osteoblasts. J Biomed Mater Res 1999; 46: 399-407. (Pubitemid 29293764)