Adherent endotoxin mediates biological responses of titanium particles without stimulating their phagocytosis

Journal of Orthopaedic Research

Volumn 20, Issue 4, 2002, Pages 696-703

  Bi, Yanming ^a,b   Collier, Terry O ^b   Goldberg, Victor M ^a   Anderson, James M ^b   Greenfield, Edward M ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

Confocal microscopy; Endotoxin; Fluorescence microscopy; Osteolysis; Phagocytosis; Wear particles

Indexed keywords

FLUORESCENCE; IMMUNOLOGY; IMPLANTS (SURGICAL); MICROSCOPIC EXAMINATION; PARTICLES (PARTICULATE MATTER); TITANIUM; WEAR OF MATERIALS;

BIOLOGICAL RESPONSES;

ORTHOPEDICS;

CYTOKINE; ENDOTOXIN; TITANIUM; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL STRAIN; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLUORESCENCE MICROSCOPY; IMPLANT; INTERNALIZATION; MOUSE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; PHAGOCYTOSIS; PRIORITY JOURNAL; PROSTHESIS LOOSENING; RELIABILITY;

ANIMALS; CELL ADHESION; CELL DIFFERENTIATION; ENDOTOXINS; MICE; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; ORTHOPEDIC PROCEDURES; OSTEOCLASTS; PHAGOCYTOSIS; TITANIUM; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0036316534     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0736-0266(01)00176-0     Document Type: Article

References (41)

1. Mechanisms of phagocytosis in macrophages
2. The effect of particle wear debris on nuclear factor kappa B activation and pro-inflammatory cytokine release in differentiated THP-1 cells
3. Adherent endotoxins are necessary for particle-induced bone resorption in a rat model
4. Quantitation of phagocytosis by confocal microscopy
5. Adherent endotoxin on orthopaedic wear particles stimulates cytokine production and osteoclast differentiation
6. Titanium particles stimulate bone resorption by inducing differentiation of murine osteoclasts
7. Studies of the macrophage complement receptor. Alteration of receptor function upon macrophage activation
8. Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
9. Flow cytometric analysis of macrophage response to ceramic and polyethylene particles: Effects of size, concentration, and composition
10. Adsorbed endotoxin mediates differential effects on particle-induced stimulation of cytokine and chemokine release
11. Macrophage cytokine response to particles and lipopolysaccharide in vitro
12. Current concepts in orthopaedic biomaterials and implant fixation
13. In vivo inflammatory response to polymethylmethacrylate particulate debris: Effect of size, morphology, and surface area
14. Effect of size, concentration, surface area, and volume of polymethylmethacrylate particles on human macrophages in vitro
15. Tissue ingrowth and differentiation in the bone-harvest chamber in the presence of cobalt-chromium-alloy and high-density-polyethylene particles
16. Effect of size and dose on bone resorption activity of macrophages by in vitro clinically relevant ultrahigh molecular weight polyethylene particles
17. A fluorescence technique to distinguish attached from ingested erythrocytes and zymosan particles in phagocytosing macrophages
18. The role of osteoclast differentiation in aseptic loosening
19. Drug inhibition of the macrophage response to metal wear particles in vitro
20. Bacterial modulins: A novel class of virulence factors which cause host tissue pathology by inducing cytokine synthesis
21. Decontaminating particles exposed to bacterial endotoxin (LPS)
22. Studies of the mechanism by which the mechanical failure of polymethylmethacrylate leads to bone resorption
23. Rapid repair of titanium particle-induced osteolysis is dramatically reduced in aged mice
24. Bone formation and bone resorption in failed total joint arthroplasties: Histomorphometric analysis with histochemical and immunohistochemical technique
25. Role of integrins in regulation of collagen phagocytosis by human fibroblasts
26. Human macrophage response to retrieved titanium alloy particles in vitro
27. Effects of serum protein opsonization on cytokine release by titanium-alloy particles
28. Macrophages stimulate bone resorption when they phagocytose particles
29. Signaling pathways for tumor necrosis factor-α and interluekin-6 expression in human macrophages exposed to titanium-alloy particulate debris in vitro
30. Osteoclast differentiation requires ascorbic acid
31. Stimulation of cytokine production by titanium wear particles is due to adherent endotoxin
32. Conditionally immortalized murine calvaria (CIMC) cells support osteoclast differentiation induced by bone resorptive cytokines
33. Measurement and removal of adherent endotoxin from titanium particles and implant surfaces
34. A quantitative flow cytometric assay of murine macrophage uptake of particulate debris
35. Nitric oxide release by macrophages in response to particulate wear debris
36. Endocytosis
37. Lipopolysaccharide-coated erythrocytes activate human neutrophils via CD14 while subsequent binding is through CD11b/CD18
38. Macrophage phagocytosis of polyethylene particulate in vitro
39. Function and regulation of a murine macrophage-specific IgG Fc receptor, Fc gamma R-alpha
40. Methods for the study of receptor-mediated phagocytosis
41. Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing particles for recognition by a novel receptor on macrophages