Novel tricyclic inhibitors of IKK2: Discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6- dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066)

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 23, 2011, Pages 7006-7012

  Watterson, Scott H ^a   Langevine, Charles M ^a   Van Kirk, Katy ^a   Kempson, James ^a   Guo, Junquing ^a   Spergel, Steven H ^a   Das, Jagabandhu ^a   Moquin, Robert V ^a   Dyckman, Alaric J ^a   Nirschl, David ^a   Gregor, Kurt ^a   Pattoli, Mark A ^a   Yang, Xiaoxia ^a   McIntyre, Kim W ^a   Yang, Guchen ^a   Galella, Michael A ^a   Booth Lute, Hollie ^a   Chen, Laishun ^a   Yang, Zheng ^a   Wang Iverson, David ^a   McKinnon, Murray ^a   Dodd, John H ^a   Barrish, Joel C ^a   Burke, James R ^a   Pitts, William J ^a   more..

^a BRISTOL MYERS SQUIBB RESEARCH AND DEVELOPMENT   (United States)

Author keywords

BMS 066; IKK; IKK ; IKK2; NF B

Indexed keywords

2 METHOXY N [[6 (1 METHYL 4 (METHYLAMINO) 1,6 DIHYDROIMIDAZO[4,5 D]PYRROLO[2,3 B]PYRIDIN 7 YL)PYRIDIN 2 YL]METHYL]ACETAMIDE; BMS 066; DEXAMETHASONE; I KAPPA B KINASE INHIBITOR; INDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENTERITIS; HISTOPATHOLOGY; IN VITRO STUDY; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; RAT; STRUCTURE ACTIVITY RELATION; TISSUE DISTRIBUTION;

ACETAMIDES; ADMINISTRATION, ORAL; ANIMALS; DRUG DISCOVERY; ENZYME ACTIVATION; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; I-KAPPA B KINASE; INFLAMMATORY BOWEL DISEASES; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR STRUCTURE; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80255129403     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.09.111     Document Type: Article

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