Glucocorticoids: Do we know how they work?

Arthritis Research

Volumn 4, Issue 3, 2002, Pages 146-150

  Saklatvala, Jeremy ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Glucocorticoid; Inflammation; JNK; MAP kinase; NF B

Indexed keywords

ACYLTRANSFERASE; CORTICOSTEROID; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYCLOOXYGENASE 2; CYTOPLASMIC RECEPTOR; DEXAMETHASONE; DNA; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HISTONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 8; LIGAND; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN C FOS; PROTEIN C JUN; PROTEIN INHIBITOR; PROTEIN KINASE; PROTEIN P300; STEROID; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; THREONINE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TYROSINE; UNINDEXED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG TARGETING; ENZYME INHIBITION; GENE EXPRESSION; GENE INDUCTION; GENETIC CODE; HORMONE ACTION; HUMAN; INFLAMMATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

ANTI-INFLAMMATORY AGENTS; DEXAMETHASONE; ENZYME INHIBITORS; GLUCOCORTICOIDS; HUMANS; INFLAMMATION; MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EID: 0036242607     PISSN: 14659905     EISSN: None     Source Type: Journal    
DOI: 10.1186/ar398     Document Type: Article

References (26)

1. The effect of a hormone of the adrenal cortex, 17-hydroxy-11-dehydrocorticosterone (compound E), on the acute phase of rheumatic fevers
2. Control of transcription by steroid hormones
3. New twists in gene regulation by glucocorticoid receptor: Is DNA binding dispensable?
4. Molecular mechanisms of glucocorticoid action: What is important?
5. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor
6. Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors
7. A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors
8. Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1
9. Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1 beta-induced histone H4 acetylation on lysines 8 and 12
10. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids
11. Immunosuppression by glucocorticoids: Inhibition of NF-kappa B activity through induction of I kappa B synthesis
12. Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38
13. Organization and regulation of mitogen-activated protein kinase signaling pathways
14. Protein phosphatases and the regulation of mitogen-activated protein kinase signalling
15. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
16. A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA
17. p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes
18. Regulation of interleukin-1 beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase
19. Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade
20. Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade
21. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism
22. Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: Evidence for post-transcriptional regulation
23. Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: Glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK
24. Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway
25. Activation of the mitogen-activated protein kinase cascade is suppressed by low concentrations of dexamethasone in mast cells
26. Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1