Liquid chromatographic-mass spectrometric analysis of phospholipids. Chromatography, ionization and quantification

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1811, Issue 11, 2011, Pages 763-775

  Brouwers, Jos F ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Ionization; Liquid chromatography; Mass spectrometry; Quantification

Indexed keywords

CONJUGATED LINOLEIC ACID; GLYCEROPHOSPHOLIPID; PHOSPHOLIPID; SOLVENT; TRANS FATTY ACID;

ATMOSPHERIC MOISTURE; ATMOSPHERIC PRESSURE; CARCINOGENESIS; COLLISIONALLY ACTIVATED DISSOCIATION; ELECTROSPRAY; ELECTROSPRAY MASS SPECTROMETRY; FATTY ACID DESATURATION; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROPHOBICITY; LIMIT OF QUANTITATION; LIPID COMPOSITION; LIPIDOMICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; REVIEW; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VAPORIZATION;

ANIMALS; CHROMATOGRAPHY, LIQUID; HUMANS; IONS; MASS SPECTROMETRY; PHOSPHOLIPIDS;

EID: 80255129324     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2011.08.001     Document Type: Review

References (151)

1. M.S. Bretscher Membrane structure: some general principles Science 181 1973 622 629
2. W. Renooij, L.M. Van Golde, R.F. Zwaal, and L.L. Van Deenen Topological asymmetry of phospholipid metabolism in rat erythrocyte membranes. Evidence for flip-flop of lecithin Eur. J. Biochem. 61 1976 53 58
3. A.J. Verkleij, R.F.A. Zwaal, B. Roelofsen, P. Comfurius, D. Kastelijn, and L.L.M. van Deenen The asymmetric distribution of phospholipids in the human red cell membrane. A combined study using phospholipases and freeze-etch electron microscopy Biochim. Biophys. Acta (BBA) - Biomembranes 323 1973 178 193
4. K. Simons, and E. Ikonen Functional rafts in cell membranes Nature 387 1997 569 572 (Pubitemid 27248754)
5. M. Zhang, E. Mileykovskaya, and W. Dowhan Gluing the respiratory chain together. Cardiolipin is required for supercomplex formation in the inner mitochondrial membrane J. Biol. Chem. 277 2002 43553 43556 (Pubitemid 36157767)
6. K. Pfeiffer, V. Gohil, R.A. Stuart, C. Hunte, U. Brandt, and M.L. Greenberg Cardiolipin stabilizes respiratory chain supercomplexes J. Biol. Chem. 278 2003 52873 52880 (Pubitemid 38035887)
7. R.A. van Gestel, P.J. Rijken, S. Surinova, M. O'Flaherty, A.J.R. Heck, and J.A. Killian The influence of the acyl chain composition of cardiolipin on the stability of mitochondrial complexes; an unexpected effect of cardiolipin in alpha-ketoglutarate dehydrogenase and prohibitin complexes J. Proteomics 73 2010 806 814
8. C.A. Demopoulos, R.N. Pinckard, and D.J. Hanahan Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators) J. Biol. Chem. 254 1979 9355 9358 (Pubitemid 10248704)
9. D.J. Hanahan, C.A. Demopoulos, J. Liehr, and R.N. Pinckard Identification of platelet activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphorylcholine J. Biol. Chem. 255 1980 5514 5516 (Pubitemid 10023580)
10. G. Di Paolo, and P. De Camilli Phosphoinositides in cell regulation and membrane dynamics Nature 443 2006 651 657 (Pubitemid 44564702)
11. S.J. Leevers, B. Vanhaesebroeck, and M.D. Waterfield Signalling through phosphoinositide 3-kinases: the lipids take centre stage Curr. Opin. Cell Biol. 11 1999 219 225 (Pubitemid 29164037)
12. C.D. Funk Prostaglandins and leukotrienes: advances in eicosanoid biology Science 294 2001 1871 1875 (Pubitemid 33101574)
13. R. Bittman, N.M. Witzke, T.C. Lee, M.L. Blank, and F. Snyder Synthesis and biochemical studies of analogs of platelet-activating factor bearing a methyl group at C2 of the glycerol backbone J. Lipid Res. 28 1987 733 738 (Pubitemid 17085972)
14. M.L. Blank, E.A. Cress, T.C. Lee, B. Malone, J.R. Surles, and C. Piantadosi Structural features of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) required for hypotensive and platelet serotonin responses Res. Commun. Chem. Pathol. Pharmacol. 38 1982 3 20 (Pubitemid 12004578)
15. K. Satouchi, R.N. Pinckard, L.M. McManus, and D.J. Hanahan Modification of the polar head group of acetyl glyceryl ether phosphorylcholine and subsequent effects upon platelet activation J. Biol. Chem. 256 1981 4425 4432 (Pubitemid 11089706)
16. L. Yetukuri, K. Ekroos, A. Vidal-Puig, and M. Oresic Informatics and computational strategies for the study of lipids Mol. Biosyst. 4 2008 121 127 (Pubitemid 351147792)
17. N.U. Olsson, and N.J. Salem Molecular species analysis of phospholipids J. Chromatogr. B Biomed. Appl. 692 1997 245 256 (Pubitemid 27217826)
18. E.A. Dennis, R.A. Deems, R. Harkewicz, O. Quehenberger, H.A. Brown, and S.B. Milne A mouse macrophage lipidome J. Biol. Chem. 285 2010 39976 39985
19. Z. Guan, S. Li, D.C. Smith, W.A. Shaw, and C.R.H. Raetz Identification of N-acylphosphatidylserine molecules in eukaryotic cells Biochemistry 46 2007 14500 14513 (Pubitemid 350276356)
20. O. Quehenberger, A.M. Armando, A.H. Brown, S.B. Milne, D.S. Myers, and A.H. Merrill Lipidomics reveals a remarkable diversity of lipids in human plasma J. Lipid Res. 51 2010 3299 3305
21. A. Singh, T. Prasad, K. Kapoor, A. Mandal, M. Roth, and R. Welti Phospholipidome of Candida: each species of Candida has distinctive phospholipid molecular species Omics 14 2010 665 677
22. S. Milne, P. Ivanova, J. Forrester, and B.H. Alex Lipidomics: an analysis of cellular lipids by ESI-MS Methods 39 2006 92 103 (Pubitemid 44107707)
23. E.J. Want, C.A. Smith, C. Qin, K.C. Horne, and G. Siuzdak Phospholipid capture combined with non-linear chromatographic correction for improved serum metabolite profiling Metabolomics 2 2006 145 154 (Pubitemid 44473573)
24. Y.-Q. Xia, and M. Jemal Phospholipids in liquid chromatography/mass spectrometry bioanalysis: comparison of three tandem mass spectrometric techniques for monitoring plasma phospholipids, the effect of mobile phase composition on phospholipids elution and the association of phospholipids with matrix effects Rapid Commun. Mass Spectrom. 23 2009 2125 2138
25. O.A. Ismaiel, T. Zhang, R.G. Jenkins, and H.T. Karnes Investigation of endogenous blood plasma phospholipids, cholesterol and glycerides that contribute to matrix effects in bioanalysis by liquid chromatography/mass spectrometry J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 878 2010 3303 3316
26. N. Mazzella, J. Molinet, A.D. Syakti, A. Dodi, P. Doumenq, and J. Artaud Bacterial phospholipid molecular species analysis by ion-pair reversed-phase HPLC/ESI/MS J. Lipid Res. 45 2004 1355 1363 (Pubitemid 38802639)
27. J.F. Brouwers, E.A. Vernooij, A.G.M. Tielens, and L.M.G. van Golde Rapid separation and identification of phosphatidylethanolamine molecular species J. Lipid Res. 40 1999 164 169 (Pubitemid 29022599)
28. E.A. Vernooij, J.F. Brouwers, J.J. Kettenes-van den Bosch, and D.J.A. Crommelin RP-HPLC/ESI MS determination of acyl chain positions in phospholipids J. Sep. Sci. 25 2002 285 289 (Pubitemid 34467060)
29. X. Han, and R.W. Gross Structural determination of picomole amounts of phospholipids via electrospray ionization tandem mass spectrometry J. Am. Soc. Mass Spectrom. 6 1995 1202 1210
30. W. Hou, H. Zhou, M.B. Khalil, D. Seebun, S.A.L. Bennett, and D. Figeys Lyso-form fragment ions facilitate the determination of stereospecificity of diacyl glycerophospholipids Rapid Commun. Mass Spectrom. 25 2011 205 217
31. E. Hvattum, G. Hagelin, and A. Larsen Study of mechanisms involved in the collision-induced dissociation of carboxylate anions from glycerophospholipids using negative ion electrospray tandem quadrupole mass spectrometry Rapid Commun. Mass Spectrom. 12 1998 1405 1409 (Pubitemid 28450985)
32. C. Beermann, M. Möbius, N. Winterling, J.J. Schmitt, and G. Boehm sn-position determination of phospholipid-linked fatty acids derived from erythrocytes by liquid chromatography electrospray ionization ion-trap mass spectrometry Lipids 40 2005 211 218 (Pubitemid 40530226)
33. Y.P. Ho, P.C. Huang, and K.H. Deng Metal ion complexes in the structural analysis of phospholipids by electrospray ionization tandem mass spectrometry Rapid Commun. Mass Spectrom. 17 2003 114 121
34. K. Ekroos, C.S. Ejsing, U. Bahr, M. Karas, K. Simons, and A. Shevchenko Charting molecular composition of phosphatidylcholines by fatty acid scanning and ion trap MS3 fragmentation J. Lipid Res. 44 2003 2181 2192 (Pubitemid 37509634)
35. F.F. Hsu, A. Bohrer, and J. Turk Formation of lithiated adducts of glycerophosphocholine lipids facilitates their identification by electrospray ionization tandem mass spectrometry J. Am. Soc. Mass Spectrom. 9 1998 516 526
36. Y.P. Ho, and P.C. Huang A novel structural analysis of glycerophosphocholines as TFA/K(+) adducts by electrospray ionization ion trap tandem mass spectrometry Rapid Commun. Mass Spectrom. 16 2002 1582 1589
37. H. Nakanishi, Y. Iida, T. Shimizu, and R. Taguchi Separation and quantification of sn-1 and sn-2 fatty acid positional isomers in phosphatidylcholine by RPLC-ESIMS/MS J. Biochem. 147 2010 245 256
38. K. Retra, O.B. Bleijerveld, R.A. van Gestel, A.G. Tielens, J.J. van Hellemond, and J.F. Brouwers A simple and universal method for the separation and identification of phospholipid molecular species Rapid Commun. Mass Spectrom. 22 2008 1853 1862 (Pubitemid 351947751)
39. K.L. Ritzenthaler, M.K. McGuire, R. Falen, T.D. Shultz, N. Dasgupta, and M.A. McGuire Estimation of conjugated linoleic acid intake by written dietary assessment methodologies underestimates actual intake evaluated by food duplicate methodology J. Nutr. 131 2001 1548 1554 (Pubitemid 32422981)
40. S.F. Chin, W. Liu, J.M. Storkson, Y.L. Ha, and M.W. Pariza Dietary sources of conjugated dienoic isomers of linoleic acid, a newly recognized class of anticarcinogens J. Food Compos. Anal. 5 1992 185 197
41. J.R.R. Fritsche, and H. Steinhart Formation, contents, and estimation of daily intake of conjugated linoleic acid isomers and trans-fatty acids in foods Adv. Conjug. Linoleic Acid Res. 1 1999 378 396
42. A. Bhattacharya, J. Banu, M. Rahman, J. Causey, and G. Fernandes Biological effects of conjugated linoleic acids in health and disease J. Nutr. Biochem. 17 2006 789 810 (Pubitemid 44738517)
43. D.S. Kelley, G.L. Bartolini, J.W. Newman, M. Vemuri, and B.E. Mackey Fatty acid composition of liver, adipose tissue, spleen, and heart of mice fed diets containing t10, c12-, and c9, t11-conjugated linoleic acid Prostaglandins Leukot. Essent. Fatty Acids 74 2006 331 338
44. A.H.M. Terpstra Effect of conjugated linoleic acid on body composition and plasma lipids in humans: an overview of the literature Am. J. Clin. Nutr. 79 2004 352 361 (Pubitemid 41115576)
45. W.W. Christie, G. Dobson, and R.O. Adlof A practical guide to the isolation, analysis and identification of conjugated linoleic acid Lipids 42 2007 1073 1084 (Pubitemid 350303590)
46. V. Santercole, R. Mazzette, E.P.L. Santis, S. Banni, L. Goonewardene, and J.K.G. Kramer Total lipids of sarda sheep meat that include the fatty acid and alkenyl composition and the CLA and trans-18:1 isomers Lipids 42 2007 361 382 (Pubitemid 46668932)
47. R. Micha, and D. Mozaffarian Trans fatty acids: effects on metabolic syndrome, heart disease and diabetes Nat. Rev. Endocrinol. 5 2009 335 344
48. S. Stender, J. Dyerberg, and A. Astrup High levels of industrially produced trans fat in popular fast foods N. Engl. J. Med. 354 2006 1650 1652
49. R. Micha, I.B. King, R.N. Lemaitre, E.B. Rimm, F. Sacks, and X. Song Food sources of individual plasma phospholipid trans fatty acid isomers: the Cardiovascular Health Study Am. J. Clin. Nutr. 91 2010 883 893
50. D.B. Allison, S.K. Egan, L.M. Barraj, C. Caughman, M. Infante, and J.T. Heimbach Estimated intakes of trans fatty and other fatty acids in the US population J. Am. Diet. Assoc. 99 1999 166 174 quiz 175-176. (Pubitemid 29077342)
51. D. Mozaffarian, and R. Clarke Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils Eur. J. Clin. Nutr. 63 2009 S22 S33
52. P. Juanéda, M. Ledoux, and J.-L. Sébédio Analytical methods for determination of trans fatty acid content in food Eur. J. Lipid Sci. Technol. 109 2007 901 917 (Pubitemid 47523731)
53. P. Juanéda Utilisation of reversed-phase high-performance liquid chromatography as an alternative to silver-ion chromatography for the separation of cis- and trans-C18:1 fatty acid isomers J. Chromatogr. A. 954 2002 285 289 (Pubitemid 34310201)
54. P.C. Calder, P. Yaqoob, F. Thies, F.A. Wallace, and E.A. Miles Fatty acids and lymphocyte functions Br. J. Nutr. 87 2002 S31 S48
55. J.F. Brouwers, C. Versluis, L.M.G. van Golde, and A.G.M. Tielens 5-Octadecenoic acid: evidence for a novel type of fatty acid modification in schistosomes Biochem. J. 334 1998 315 319 (Pubitemid 28448573)
56. J.-T. Lin, T.A. McKeon, C.L. Woodruff, and J.A. Singleton Separation of synthetic phosphatidylcholine molecular species by high-performance liquid chromatography on a C8 column J. Chromatogr. A 824 1998 169 174 (Pubitemid 28477497)
57. M.C. Thomas, T.W. Mitchell, D.G. Harman, J.M. Deeley, J.R. Nealon, and S.J. Blanksby Ozone-induced dissociation: elucidation of double bond position within mass-selected lipid ions Anal. Chem. 80 2008 303 311 (Pubitemid 351448435)
58. T. Covey, B. Thomson, and B. Schneider Atmospheric pressure ion sources Mass Spectrom. Rev. 28 2009 870 897
59. B. Thomson, and J. Iribarne Field induced ion evaporation from liquid surfaces at atmospheric pressure J. Chem. Phys. 71 1979 4451 4463
60. S. Nguyen, and J.B. Fenn Gas-phase ions of solute species from charged droplets of solutions Proc. Natl. Acad. Sci. U S A 104 2007 1111 1117 (Pubitemid 46183969)
61. M.H. Amad, N.B. Cech, G.S. Jackson, and C.G. Enke Importance of gas-phase proton affinities in determining the electrospray ionization response for analytes and solvents J. Mass Spectrom. 35 2000 784 789 (Pubitemid 30479520)
62. M. Yamashita, and J. Fenn Electrospray ion-source-another variation on the free-jet theme J. Phys. Chem. 88 1984 4451 4459
63. A.P. Bruins, T.R. Covey, and J.D. Henion Ion spray interface for combined liquid chromatography/atmospheric pressure ionization mass spectrometry Anal. Chem. 59 1987 2642 2646
64. M.S. Wilm, and M. Mann Electrospray and Taylor-Cone theory, Dole's beam of macromolecules at last? Int. J. Mass Spectrom. Ion Processes 136 1994 167 180
65. H.Y. Kim, T.C. Wang, and Y.C. Ma Liquid chromatography/mass spectrometry of phospholipids using electrospray ionization Anal. Chem. 66 1994 3977 3982
66. H.Y. Kim, and N. Salem Phospholipid molecular species analysis by thermospray liquid chromatography/mass spectrometry Anal. Chem. 58 1986 9 14
67. H.Y. Kim, and N. Salem Jr. Liquid chromatography-mass spectrometry of lipids Prog. Lipid Res. 32 1993 221 245 (Pubitemid 24020882)
68. F. Sugnaux, and C. Djerassi Liquid chromatography-mass spectrometry of polar lipids-comparison of online method using direct liquid introduction interface with off-line method using desorption chemical ionization J. Chromatogr. 251 1982 189 201
69. F. Jungalwala, J. Evans, and R. McCluer Compositional and molecular-species analysis of phospholipids by high-performance liquid-chromatography coupled with chemical ionization mass-spectrometry J. Lipid Res. 25 1984 738 749 (Pubitemid 14067556)
70. G. Odham, A. Valeur, P. Michelsen, E. Aronsson, and M. McDowall Highly sensitive determination and characterization of intact cellular ester-linked phospholipids using liquid-chromatography plasma spray mass-spectrometry J. Chromatogr.-Biomed. Appl. 434 1988 31 41 (Pubitemid 19036858)
71. A. Valeur, P. Michelsen, and G. Odham Online straight-phase liquid-chromatography plasmaspray tandem mass-spectrometry of glycerolipids Lipids 28 1993 255 259 (Pubitemid 23086579)
72. R. Kostiainen, and A.P. Bruins Effect of solvent on dynamic range and sensitivity in pneumatically-assisted electrospray (ion spray) mass spectrometry Rapid Commun. Mass Spectrom. 10 1996 1393 1399 (Pubitemid 26352582)
73. R. Kostiainen, and T.J. Kauppila Effect of eluent on the ionization process in liquid chromatography-mass spectrometry J. Chromatogr. A. 1216 2009 685 699
74. M. Yamashita, and J.B. Fenn Negative ion production with the electrospray ion source J. Phys. Chem. 88 1984 4671 4675
75. K. Hiraoka, and I. Kudaka Negative-mode electrospray-mass spectrometry using nonaqueous solvents Rapid Commun. Mass Spectrom. 6 1992 265 268
76. R. Straub, and R. Voyksner Negative-ion formation in electrospray mass-spectrometry J. Am. Soc. Mass Spectrom. 4 1993 578 587
77. P. Kebarle, and L. Tang From ions in solution to ions in the gas phase-the mechanism of electrospray mass spectrometry Anal. Chem. 65 1993 972A 986A
78. R. King, R. Bonfiglio, C. Fernandez-Metzler, C. Miller-Stein, and T. Olah Mechanistic investigation of ionization suppression in electrospray ionization J. Am. Soc. Mass Spectrom. 11 2000 942 950 (Pubitemid 34546664)
79. A.P. Bruins Mechanistic aspects of electrospray ionization J. Chromatogr. A 794 1998 345 357 (Pubitemid 28083620)
80. T.M. Annesley Ion suppression in mass spectrometry Clin. Chem. 49 2003 1041 1044 (Pubitemid 36751088)
81. C.R. Mallet, Z. Lu, and J.R. Mazzeo A study of ion suppression effects in electrospray ionization from mobile phase additives and solid-phase extracts Rapid Commun. Mass Spectrom. 18 2004 49 58 (Pubitemid 38031417)
82. J.D. Henion, B.A. Thomson, and P.H. Dawson Determination of sulfa drugs in biological fluids by liquid chromatography/mass spectrometry/mass spectrometry Anal. Chem. 54 1982 451 456 (Pubitemid 12140222)
83. A. Good, D.A. Durden, and P. Kebarle Ion-molecule reactions in pure nitrogen and nitrogen containing traces of water at total pressures 0.5-4 torr. Kinetics of clustering reactions forming H (H2O)n J. Chem. Phys. 52 1970 212 221
84. W.C. Byrdwell Atmospheric pressure chemical ionization mass spectrometry for analysis of lipids Lipids 36 2001 327 346 (Pubitemid 32433866)
85. G. Singh, A. Gutierrez, K. Xu, and I.A. Blair Liquid chromatography/ electron capture atmospheric pressure chemical ionization/mass spectrometry: analysis of pentafluorobenzyl derivatives of biomolecules and drugs in the attomole range Anal. Chem. 72 2000 3007 3013 (Pubitemid 30482464)
86. D. Robb, and M. Blades State-of-the-art in atmospheric pressure photoionization for LC/MS Anal. Chim. Acta 627 2008 34 49
87. W. Schaefer, and F. Dixon Effect of high-performance liquid chromatography mobile phase components on sensitivity in negative atmospheric pressure chemical ionization liquid chromatography mass spectrometry J. Am. Soc. Mass Spectrom. 7 1996 1059 1069
88. W.C. Byrdwell Dual parallel mass spectrometers for analysis of sphingolipid, glycerophospholipid and plasmalogen molecular species Rapid Commun. Mass Spectrom. 12 1998 256 272
89. A.Å. Karlsson, P. Michelsen, Å. Larsen, and G. Odham Normal-phase liquid chromatography class separation and species determination of phospholipids utilizing electrospray mass spectrometry/tandem mass spectrometry Rapid Commun. Mass Spectrom. 10 1996 775 780 (Pubitemid 126680242)
90. O.A. Ismaiel, M.S. Halquist, M.Y. Elmamly, A. Shalaby, and H. Thomas Karnes Monitoring phospholipids for assessment of ion enhancement and ion suppression in ESI and APCI LC/MS/MS for chlorpheniramine in human plasma and the importance of multiple source matrix effect evaluations J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 875 2008 333 343
91. A.H. Merrill Jr., M.C. Sullards, J.C. Allegood, S. Kelly, and E. Wang Sphingolipidomics: High-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry Methods 36 2005 207 224 (Pubitemid 40726151)
92. A.A. Karlsson, P. Michélsen, and G. Odham Molecular species of sphingomyelin: determination by high-performance liquid chromatography/mass spectrometry with electrospray and high-performance liquid chromatography/tandem mass spectrometry with atmospheric pressure chemical ionization J. Mass Spectrom. 33 1998 1192 1198 (Pubitemid 29004872)
93. D.B. Robb, T.R. Covey, and A.P. Bruins Atmospheric pressure photoionization: an ionization method for liquid chromatography-mass spectrometry Anal. Chem. 72 2000 3653 3659 (Pubitemid 30614945)
94. J.A. Syage, M.D. Evans, and K.A. Hanold Photoionization mass spectrometry Am. Lab. 32 2000 24 29
95. J.A. Syage Mechanism of [M + H] + formation in photoionization mass spectrometry J. Am. Soc. Mass Spectrom. 15 2004 1521 1533 (Pubitemid 39433846)
96. T.J. Kauppila, T. Kotiaho, R. Kostiainen, and A.P. Bruins Negative ion-atmospheric pressure photoionization-mass spectrometry J. Am. Soc. Mass Spectrom. 15 2004 203 211 (Pubitemid 38183209)
97. editorial, In the news TrAC Trends Anal. Chem. 27 2008 iii x
98. D.B. Robb, and M.W. Blades An electropneumatic-heated nebulizer for enhancing spray ionization in PhotoSpray atmospheric pressure photoionization sources for liquid chromatography/mass spectrometry Rapid Commun. Mass Spectrom. 23 2009 3394 3400
99. D. Smith, D. Robb, and M. Blades Comparison of dopants for charge exchange ionization of nonpolar polycyclic aromatic hydrocarbons with reversed-phase LC-APPI-MS J. Am. Soc. Mass Spectrom. 20 2009 73 79
100. D.B. Robb, and M.W. Blades Atmospheric pressure photoionization for ionization of both polar and nonpolar compounds in reversed-phase LC/MS Anal. Chem. 78 2006 8162 8164 (Pubitemid 44871786)
101. A. Muñoz-Garcia, J. Ro, J.C. Brown, and J.B. Williams Identification of complex mixtures of sphingolipids in the stratum corneum by reversed-phase high-performance liquid chromatography and atmospheric pressure photospray ionization mass spectrometry J. Chromatogr. A 1133 2006 58 68 (Pubitemid 44573154)
102. J. Lembcke, U. Ceglarek, G.M. Fiedler, S. Baumann, A. Leichtle, and J. Thiery Rapid quantification of free and esterified phytosterols in human serum using APPI-LC-MS/MS J. Lipid Res. 46 2005 21 26 (Pubitemid 40066667)
103. A. Delobel, D. Touboul, and O. Laprévote Structural characterization of phosphatidylcholines by atmospheric pressure photoionization mass spectrometry Eur. J. Mass Spectrom. (Chichester, Eng) 11 2005 409 417 (Pubitemid 41571740)
104. F.B. Jungalwala, V. Hayssen, J.M. Pasquini, and R.H. McCluer Separation of molecular species of sphingomyelin by reversed-phase high-performance liquid chromatography J. Lipid Res. 20 1979 579 587 (Pubitemid 9230549)
105. G.M. Patton, J.M. Fasulo, and S.J. Robins Separation of phospholipids and individual molecular species of phospholipids by high-performance liquid chromatography J. Lipid Res. 23 1982 190 196 (Pubitemid 12112627)
106. J. McHowat, J. Jones, and M. Creer Gradient elution reversed-phase chromatographic isolation of individual glycerophospholipid molecular species J. Chromatogr. B 702 1997 21 32 (Pubitemid 28008055)
107. A.D. Postle Method for the sensitive analysis of individual molecular species of phosphatidylcholine by high-performance liquid chromatography using post-column fluorescence detection J. Chromatogr. B Biomed. Appl. 415 1987 241 251 (Pubitemid 17073951)
108. J. Lin, and T. McKeon Separation of intact phosphatidylcholine molecular species by high performance liquid chromatography J. Liq. Chromatogr. Relat. Technol. 23 2000 813 829 (Pubitemid 30180904)
109. S. Abidi, and T. Mounts Reversed-phase high-performance liquid chromatography of molecular species of phospholipid derivatives J. Chromatogr. A 741 1996 213 222 (Pubitemid 26276221)
110. J.F. Brouwers, B.M. Gadella, L.M.G. van Golde, and A.G.M. Tielens Quantitative analysis of phosphatidylcholine molecular species using HPLC and light scattering detection J. Lipid Res. 39 1998 344 353 (Pubitemid 28100672)
111. N. Khaselev, and R.C. Murphy Structural characterization of oxidized phospholipid products derived from arachidonate-containing plasmenyl glycerophosphocholine J. Lipid Res. 41 2000 564 572 (Pubitemid 30220660)
112. R. Taguchi, T. Houjou, H. Nakanishi, T. Yamazaki, M. Ishida, and M. Imagawa Focused lipidomics by tandem mass spectrometry J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 823 2005 26 36 (Pubitemid 41073986)
113. R. Laaksonen, M. Katajamaa, H. Päivä, M. Sysi-Aho, L. Saarinen, and P. Junni A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle PLoS ONE 1 2006 e97
114. C. Hu, J. van Dommelen, R. van der Heijden, G. Spijksma, T.H. Reijmers, and M. Wang RPLC-ion-trap-FTMS method for lipid profiling of plasma: method validation and application to p53 mutant mouse model J. Proteome Res. 7 2008 4982 4991
115. R. Taguchi, and M. Ishikawa Precise and global identification of phospholipid molecular species by an Orbitrap mass spectrometer and automated search engine Lipid Search J. Chromatogr. A 1217 2010 4229 4239
116. K. Sandra, A. Pereira, G. Vanhoenacker, F. David, and P. Sandra Comprehensive blood plasma lipidomics by liquid chromatography/quadrupole time-of-flight mass spectrometry J. Chromatogr. A 1217 2010 4087 4099
117. E.J. Ahn, H. Kim, B.C. Chung, G. Kong, and M.H. Moon Quantitative profiling of phosphatidylcholine and phosphatidylethanolamine in a steatosis/fibrosis model of rat liver by nanoflow liquid chromatography/tandem mass spectrometry J. Chromatogr. A. 1194 2008 96 102
118. H.K. Min, G. Kong, and M.H. Moon Quantitative analysis of urinary phospholipids found in patients with breast cancer by nanoflow liquid chromatography-tandem mass spectrometry: II. Negative ion mode analysis of four phospholipid classes Anal. Bioanal. Chem. 396 2010 1273 1280
119. H.D. Meiring, E. van der Heeft, G.J. ten Hove, and A.P.J.M. de Jong Nanoscale LC-MS(n): technical design and applications to peptide and protein analysis J. Sep. Scie. 25 2002 557
120. W.S. Letter A rapid method for phospholipid class separation by HPLC using an evaporative light scattering detector J. Liquid Chrom. 15 1992 253 266
121. B.L. Peterson, and B.S. Cummings A review of chromatographic methods for the assessment of phospholipids in biological samples Biomed. Chromatogr. 20 2006 227 243
122. Z. Guan, J. Grünler, S. Piao, and P.J. Sindelar Separation and quantitation of phospholipids and their ether analogues by high-performance liquid chromatography Anal. Biochem. 297 2001 137 143 (Pubitemid 32989343)
123. M.F. Caboni, S. Menotta, and G. Lercker High-performance liquid chromatography separation and light-scattering detection of phospholipids from cooked beef J. Chromatogr. A 683 1994 59 65 (Pubitemid 24320480)
124. C. Silversand, and C. Haux Improved high-performance liquid chromatographic method for the separation and quantification of lipid classes: application to fish lipids J. Chromatogr. B Biomed. Sci. Appl. 703 1997 7 14 (Pubitemid 28011239)
125. M. Hermansson, A. Uphoff, R. Kakela, and P. Somerharju Automated quantitative analysis of complex lipidomes by liquid chromatography/mass spectrometry Anal. Chem. 77 2005 2166 2175 (Pubitemid 40463834)
126. U. Sommer LC-MS-based method for the qualitative and quantitative analysis of complex lipid mixtures J. Lipid Res. 47 2006 804 814
127. P.T. Ivanova, S.B. Milne, M.O. Byrne, Y. Xiang, and H.A. Brown Glycerophospholipid Identification and Quantitation by Electrospray Ionization Mass Spectrometry Lipidomics and Bioactive Lipids: Mass[hyphen (true graphic)]Spectrometry-Based Lipid Analysis 2007 Academic Press 21 57
128. M. Scherer, G. Schmitz, and G. Liebisch Simultaneous quantification of cardiolipin, Bis(monoacylglycero)phosphate and their precursors by hydrophilic interaction LC-MS/MS including correction of isotopic overlap Anal. Chem. 82 2010 8794 8799
129. L. Zheng, R. T'Kind, S. Decuypere, S.J. von Freyend, G.H. Coombs, and D.G. Watson Profiling of lipids in Leishmania donovani using hydrophilic interaction chromatography in combination with Fourier transform mass spectrometry Rapid Commun. Mass Spectrom. 24 2010 2074 2082
130. R. Bonfiglio, R.C. King, T.V. Olah, and K. Merkle The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds Rapid Commun. Mass Spectrom. 13 1999 1175 1185 (Pubitemid 29285118)
131. S. Beißmann, W. Buchberger, R. Hertsens, and C.W. Klampfl High-performance liquid chromatography coupled to direct analysis in real time mass spectrometry: investigations on gradient elution and influence of complex matrices on signal intensities J. Chromatogr. A 1218 2011 5180 5186
132. M. Koivusalo, P. Haimi, L. Heikinheimo, R. Kostiainen, and P. Somerharju Quantitative determination of phospholipid compositions by ESI-MS. Effects of acyl chain length, unsaturation, and lipid concentration on instrument response J. Lipid Res. 42 2001 663 672 (Pubitemid 32367010)
133. V. Kainu, M. Hermansson, and P. Somerharju Electrospray ionization mass spectrometry and exogenous heavy isotope-labeled lipid species provide detailed information on aminophospholipid acyl chain remodeling J. Biol. Chem. 283 2007 3676 3687
134. H. Kim, E. Ahn, and M.H. Moon Profiling of human urinary phospholipids by nanoflow liquid chromatography/tandem mass spectrometry Analyst 133 2008 1656 1663
135. C.A. Smith, E.J. Want, G. O'Maille, R. Abagyan, and G. Siuzdak XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification Anal. Chem. 78 2006 779 787 (Pubitemid 43228585)
136. M. Katajamaa, J. Miettinen, and M. Oresic MZmine: toolbox for processing and visualization of mass spectrometry based molecular profile data Bioinformatics 22 2006 634 636 (Pubitemid 43372832)
137. T. Pluskal, S. Castillo, A. Villar-Briones, and M. Oresic MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data BMC Bioinforma. 11 2010 395
138. J. Hartler, M. Trötzmüller, C. Chitraju, F. Spener, H.C. Köfeler, and G.G. Thallinger Lipid data analyzer: unattended identification and quantitation of lipids in LC-MS data Bioinformatics 27 2011 572 577
139. E. Hein, B. Bodeker, J. Nolte, and H. Hayen Software tool for mining liquid chromatography/multi-stage mass spectrometry data for comprehensive glycerophospholipid profiling Rapid Commun. Mass Spectrom. 24 2010 2083 2092
140. P. Haimi, A. Uphoff, M. Hermansson, and P. Somerharju Software tools for analysis of mass spectrometric lipidome data Anal. Chem. 78 2006 8324 8331 (Pubitemid 44932100)
141. P. Haimi, K. Chaithanya, V. Kainu, M. Hermansson, and P. Somerharju Instrument-independent software tools for the analysis of MS-MS and LC-MS lipidomics data Methods Mol. Biol. 580 2009 285 294
142. P. Östman, S.J. Marttila, T. Kotiaho, S. Franssila, and R. Kostiainen Microchip atmospheric pressure chemical ionization source for mass spectrometry Anal. Chem. 76 2004 6659 6664 (Pubitemid 39507257)
143. P. Keski-Rahkonen, M. Haapala, V. Saarela, S. Franssila, T. Kotiaho, and R. Kostiainen Atmospheric pressure thermospray ionization using a heated microchip nebulizer Rapid Commun. Mass Spectrom. 23 2009 3313 3322
144. J. Pol, T. Kauppila, M. Haapala, V. Saarela, S. Franssila, and R. Ketola Microchip sonic spray ionization Anal. Chem. 79 2007 3519 3523 (Pubitemid 46717186)
145. J. Pól, T.J. Kauppila, S. Franssila, T. Kotiaho, and R. Kostiainen Ionspray microchip Rapid Commun. Mass Spectrom. 24 2010 2584 2590
146. M. Haapala, V. Saarela, J. Pol, K. Kolari, T. Kotiaho, and S. Franssila Integrated liquid chromatography-heated nebulizer microchip for mass spectrometry Anal. Chim. Acta 662 2010 163 169
147. L. Ahonen, M. Haapala, V. Saarela, S. Franssila, T. Kotiaho, and R. Kostiainen Feasibility of capillary liquid chromatography/microchip atmospheric pressure photoionization mass spectrometry in analyzing anabolic steroids in urine samples Rapid Commun. Mass Spectrom. 24 2010 958 964
148. H. Tian, J. Xu, Y. Xu, and Y. Guan Multidimensional liquid chromatography system with an innovative solvent evaporation interface J. Chromatogr. A 1137 2006 42 48 (Pubitemid 44792123)
149. H. Nie, R. Liu, Y. Yang, Y. Bai, Y. Guan, and D. Qian Lipid profiling of rat peritoneal surface layers by online normal- and reversed-phase 2D LC QToF-MS J. Lipid Res. 51 2010 2833 2844
150. M. Pulfer, and R.C. Murphy Electrospray mass spectrometry of phospholipids Mass Spectrom. Rev. 22 2003 332 364
151. H. Kim, H.K. Min, G. Kong, and M.H. Moon Quantitative analysis of phosphatidylcholines and phosphatidylethanolamines in urine of patients with breast cancer by nanoflow liquid chromatography/tandem mass spectrometry Anal. Bioanal. Chem. 393 2009 1649 1656