Indomethacin decreases arachidonic acid uptake in HCA-7 human colon cancer cells

Journal of Pharmacological Sciences

Volumn 108, Issue 3, 2008, Pages 389-392

  Orido, Takashi ^a   Fujino, Hiromichi ^a   Hasegawa, Yuta ^a   Toyomura, Kaori ^a   Kawashima, Tatsuo ^b   Murayama, Toshihiko ^a  

^a CHIBA UNIVERSITY   (Japan)

^b TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Arachidonic acid; Human HCA 7 colon cancer cell; Indomethacin

Indexed keywords

ACETYLSALICYLIC ACID; ARACHIDONIC ACID; CYCLOOXYGENASE 2; DICLOFENAC; INDOMETACIN; SULINDAC;

ANTINEOPLASTIC ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; CANCER CELL CULTURE; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL;

EID: 56649116081     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.08167SC     Document Type: Article

References (11)

1. Brown JR, DuBois RN. COX-2: a molecular target for colorectal cancer prevention. J Clin Oncol. 2005;23:2840-2855.
2. Tegeder I, Pfeilschifter J, Geisslinger G. Cyclooxygenase-independent actions of cyclooxygenase inhibitors. FASEB J. 2001;15:2057-2072.
3. Shao J, Sheng H, Inoue H, Morrow JD, DuBois RN. Regulation of constitutive cyclooxygenase-2 expression in colon carcinoma cells. J Biol Chem. 2000;275:33951-33956.
4. Fujino H, Chen XB, Regan JW, Murayama T. Indomethacin decreases EP2 prostanoid receptor expression in colon cancer cells. Biochem Biophys Res Commun. 2007;359:568-573.
5. Lehmann JM, Lenhard JM, Oliver BB, Ringold GM, Kliewer SA. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem. 1997;272:3406-3410.
6. 2 receptor subtype EP2 by PPARγ ligands inhibits human lung carcinoma cell growth. Biochem Biophys Res Commun. 2004;314:1093-1099.
7. 2) production by arachidonic acid, oestrogen and parathyroid hormone in MG-63 and MC3T3-E1 osteoblast-like cells. Prostaglandins Leukot Essent Fatty Acids. 2005;73:423-430.
8. 2 synthase that are in concert with cyclooxygenese-2. J Biol Chem. 2000;275:32783-32792.
9. 4 signaling pathway induces apoptosis and suppress cell proliferation in colon cancer. J Pharmacol Sci. 2007;103:24-32.
10. Martin G, Schoonjans K, Lefebvre AM, Staels B, Auwerx J. Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARα and PPARγ activators. J Biol Chem. 1997;272:28210-28217.
11. Festuccia WT, Laplante M, Berthiaume M, Gelinas Y, Deshaies Y. PPARγ agonism increases rat adipose tissue lipolysis, expression of glyceride lipases, and the response of lipolysis to hormonal control. Diabetologia. 2006;49:2427-2436.