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Volumn 47, Issue 44, 2011, Pages 12062-12064

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity

(10) Pors, Klaus a Loadman, Paul M a Shnyder, Steven D a Sutherland, Mark a Sheldrake, Helen M a Guino, Meritxell b Kiakos, Konstantinos c Hartley, John A c Searcey, Mark b Patterson, Laurence H a

a UNIVERSITY OF BRADFORD (United Kingdom)

b UNIVERSITY COLLEGE LONDON (United Kingdom)

c UNIVERSITY OF EAST ANGLIA (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROMETHYLINDOLINE; CYTOCHROME P450 1A1; DUOCARMYCIN A; ICT 2700; ICT 2740; PHENOL; RACHELMYCIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CYCLIZATION; CYTOTOXICITY; DNA DAMAGE; DRUG BINDING; DRUG MECHANISM; DRUG SYNTHESIS; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; NONHUMAN; PHARMACOPHORE; PROTEIN EXPRESSION;

EID: 80155209663 PISSN: 13597345 EISSN: 1364548X Source Type: Journal
DOI: 10.1039/c1cc15638a Document Type: Article

Times cited : (34)

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