TREM-1 expression on neutrophils and monocytes of septic patients: relation to the underlying infection and the implicated pathogen

BMC Infectious Diseases

Volumn 11, Issue , 2011, Pages

  Poukoulidou, Thekla ^a   Spyridaki, Aikaterini ^a   Mihailidou, Ira ^a   Kopterides, Petros ^a   Pistiki, Aikaterini ^a   Alexiou, Zoi ^b   Chrisofos, Michael ^c   Dimopoulou, Ioanna ^a   Drimoussis, Panagiotis ^d   Giamarellos Bourboulis, Evangelos J ^a   Koutelidakis, Ioannis ^e   Marioli, Androniki ^c   Mega, Anna ^f   Orfanos, Stylianos E ^a   Theodorakopoulou, Maria ^a   Tsironis, Christos ^d   Maggina, Nina ^d   Polychronopoulos, Vlassios ^g   Tsangaris, Iraklis ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b Thriasion Elefsina General Hospital   (Greece)

^c Sismanogleion Athens Hospital   (Greece)

^d IASO GENERAL HOSPITAL   (Greece)

^e ARISTOTLE UNIVERSITY MEDICAL SCHOOL   (Greece)

^f LAIKO GENERAL HOSPITAL   (Greece)

^g Sismanoglion Athens Hospital   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TREM1 PROTEIN, HUMAN;

ABDOMINAL INFECTION; ACUTE PYELONEPHRITIS; ADULT; ARTICLE; BACTERIUM ISOLATE; BLOOD SAMPLING; CELL ISOLATION; COHORT ANALYSIS; COMMUNITY ACQUIRED PNEUMONIA; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HOSPITAL ACQUIRED PNEUMONIA; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MONOCYTE; MULTICENTER STUDY; NEUTROPHIL; PATHOGENESIS; PROSPECTIVE STUDY; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEPSIS; SEPTIC SHOCK; AGED; CHEMISTRY; FLOW CYTOMETRY; HOSPITALIZATION; IMMUNOLOGY; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; MONOCYTES; NEUTROPHILS; PROSPECTIVE STUDIES; RECEPTORS, IMMUNOLOGIC; SEPSIS; SEVERITY OF ILLNESS INDEX;

EID: 80155137263     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-11-309     Document Type: Article

References (28)

1. Vincent JL, Sun Q, Dubois MJ. Clinical trials of immunomodulatory therapies in severe sepsis and septic shock. Clin Infect Dis 2002, 34:1084-1093. 10.1086/339549, 11914997.
2. Gogos C, Kotsaki A, Pelekanou A, Giannikopoulos G, Vaki I, Maravitsa P, Adamis S, Alexiou Z, Andrianopoulos G, Antonopoulou A, Athanasia S, Baziaka F, Charalambous A, Christodoulou S, Dimopoulou I, Floros I, Giannitsioti E, Gkanas P, Ioakeimidou A, Kanellakopoulou K, Karabela N, Karagianni V, Katsarolis I, Kontopithari G, Kopterides P, Koutelidakis I, Koutoukas P, Kranidioti H, Lignos M, Louis K, et al. Early alterations of the innate and adaptive immune statuses in sepsis according to the type of underlying infection. Crit Care 2010, 14:R96. 10.1186/cc9031, 2911733, 20504311.
3. Bouchon A, Facchetti F, Welgant MA, Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 2001, 410:1103-1107. 10.1038/35074114, 11323674.
4. Colonna M, Facchetti F. TREM-1 (trigerring receptor expressed on myeloid cells): a new player in acute inflammatory responses. J Infect Dis 2003, 187(Suppl 2):397-401.
5. Ford JW, McVicar DW. TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol 2009, 21:38-46. 10.1016/j.coi.2009.01.009, 2723941, 19230638.
6. Tessarz A, Cerwenka A. The TREM-1/DAP12 pathway. Immunoogy Letters 2008, 116:111-116.
7. Sharif O, Knapp S. From expression to signaling: Roles of TREM-1 and TREM-2 in innate immunity and bacterial infection. Immunology 2008, 213:701-713.
8. Klesney-Tait J, Turnbull IR, Cilonna M. The TREM receptor family and signal integration. Nat Immunol 2006, 7:1266-1273. 10.1038/ni1411, 17110943.
9. Radsak MP, Salih HR, Rammensee HR, Schild H. Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival. J Immunol 2004, 172:4956-4963.
10. Giamarellos-Bourboulis EJ, Tsangaris I, Kanni T, Mouktaroudi M, Pantelidou I, Adamis G, Atmatzidis S, Chrisofos M, Evangelopoulou V, Frantzeskaki F, et al. Procalcitonin as an early indicator of outcome in sepsis: a prospective observational study. J Hosp Infect 2011, 77:58-63. 10.1016/j.jhin.2010.07.026, 21131099.
11. Georgopoulou AP, Savva A, Giamarellos-Bourboulis EJ, Georgitsi M, Raftogiannis M, Antonakos N, et al. Early changes of procalcitonin may advise about prognosis and appropriateness of antimicrobial therapy in sepsis. J Crit Care 2011 26:331.e1-331.e7.
12. Levy M, Fink M, Marshall J, Abraham E, Angus D, Cook D, Cohen J, Opal S, Vincent J, Ramsay G, . SCCM/ESICM/ACCP/ATS/SIS 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definition conference. Crit Care Med 2003, 31:1250-1256. 10.1097/01.CCM.0000050454.01978.3B, 12682500, SCCM/ESICM/ACCP/ATS/SIS.
13. Christ-Crain M, Stolz D, Bingisser R, Müller C, Miedinger D, Huber PR, Zimmerli W, Harbath S, Tamm M, Müller B. Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia. A randomized trial. Am J Resp Crit Care Med 2006, 174:84-93. 10.1164/rccm.200512-1922OC, 16603606.
14. Chastre J, Fagon JY. Ventilator-associated pneumonia. Am J Respir Crit Care Med 2002, 165:867-903.
15. Vincent JL. Ventilator-associated pneumonia. J Hosp Infect 2004, 57:272-280. 10.1016/j.jhin.2003.06.001, 15262388.
16. Pinson AG, Philbrick JT, Lindbeck GH, Schorling JB. Fever in the clinical diagnosis of acute pyelonephritis. Am J Emerg Med 1997, 15:148-151. 10.1016/S0735-6757(97)90087-5, 9115515.
17. Calandra T, Cohen J. The international Sepsis Forum Consensus definitions of infections in the intensive care unit. Crit Care Med 2005, 33:1639-48.
18. Vincent JL. Clinical sepsis and septic shock definition, diagnosis and management principles. Langenbecks Arch Surg 2008, 393:817-824. 10.1007/s00423-008-0343-1, 18584205.
19. Remick DJ. Pathophysiology of sepsis. Am J Pathol 2007 170:1435-1444.
20. Bouchon A, Dietrich J, Colonna M. Cutting edge. Inflammatory responses can be trigerred by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol 2000, 164:4991-4995.
21. Gibot S, Le Renard PE, Bollaert PE, Kolopp-Sarda MN, Bene MC, Faure GC, Levy B. Surface trigerring receptor expressed on myeloid cells 1 expression patterns in septic shock. Intensive Care Med 2005, 31:594-597. 10.1007/s00134-005-2572-x, 15754199.
22. Dimopoulou I, Orfanos SE, Pelekanou A, Kotanidou A, Livaditi O, Augustatou C, Zervou M, Douka E, Theodorakopoulou M, Karagianni V, Douzinas E, Armaganidis A, Giamarellos-Bourboulis EJ. Serum of patients with septic shock stimulates the expression of TREM-1 on U937 monocytes. Inflamm Res 2009, 58:127-132. 10.1007/s00011-008-7039-4, 19109693.
23. Gibot S, Kolopp-Sarda MN, Béné MC, Cravoisy A, Levy B, Faure GC, Bollaert PE. Plasma level of a trigerring receptor expressed on myeloid cells-1: its diagnostic accuracy in patients with suspected sepsis. Ann Intern Med 2004, 141:9-15.
24. Barati M, Bashar FR, Shahrami R, Zadeh MH, Taher MT, Nojomi M. Soluble triggering receptor expressed on myeloid cells 1 and the diagnosis of sepsis. J Crit Care 2010, 25:362.e1-e6.
25. Barraud D, Gibot S. Triggering receptor expressed on myeloid cells 1. Crit Care Clin 2011, 27:265-279. 10.1016/j.ccc.2010.12.006, 21440201.
26. Porfiridis I, Plachouras D, Karagianni V, Kotanidou A, Papiris S, Giamarellou H, Giamarellos-Bourboulis EJ. Diagnostic value of triggering receptor expressed on myeloid cells-1 and C-reactive protein for patients with lung infiltrates: an observational study. BMC Infectious Diseases 2010, 10:286. 10.1186/1471-2334-10-286, 2955686, 20920231.
27. Pelekanou A, Tsangaris I, Kotsaki A, Karagianni V, Giamarellou H, Armaganidis A, Giamarellos-Bourboulis EJ. Decrease of CD4-lymphocytes and apoptosis of CD14-monocytes are characteristic alterations in sepsis caused by ventilator-associated pneumonia: results from an observational study. Crit Care 2009, 13:R172. 10.1186/cc8148, 2811921, 19883512.
28. Giamarelos-Bourboulis EJ, Zakynthinos S, Baziaka F, Papadomichelakis E, Virtzili S, Koutoukas P, Armaganidis A, Giamarellou H, Roussos C. Soluble trigerring receptor expressed on myeloid cells-1 as an anti-inflammatory mediator in sepsis. Intensive Care Med 2006, 32:237-243. 10.1007/s00134-005-0017-1, 16450102.