Assessment of neurotoxicity of monocrotaline, an alkaloid extracted from Crotalaria retusa in astrocyte/neuron co-culture system

NeuroToxicology

Volumn 32, Issue 6, 2011, Pages 776-784

  Pitanga, Bruno P S ^a   Silva, Victor Diógenes A ^a   Souza, Cleide S ^a   Junqueira, Huiara A ^a   Fragomeni, Breno O N ^a   Nascimento, Ravena P ^a   Silva, Ana Rita ^a   Costa, Maria de Fátima D ^a   El Bachá, Ramon S ^a   Costa, Silvia L ^a  

^a FEDERAL UNIVERSITY OF BAHIA   (Brazil)

Author keywords

Astrocyte; Crotalaria retusa; GSH; Monocrotaline; Neuron

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALKALOID; BETA III TUBULIN; BETA TUBULIN; CYTOCHROME P450; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTATHIONE; LACTATE DEHYDROGENASE; MONOCROTALINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN NERVE CELL; CELL VACUOLE; CELL VIABILITY; COCULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROTALARIA; CROTALARIA RETUSA; CYTOTOXICITY TEST; DOWN REGULATION; EMBRYO; ENZYME ACTIVITY; IMMUNOCYTOCHEMISTRY; LONG TERM EXPOSURE; MICROMORPHOLOGY; NERVE CELL MEMBRANE STEADY POTENTIAL; NEUROTOXICITY; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; STEADY STATE; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; BLOTTING, WESTERN; CELL SHAPE; CELL SURVIVAL; CELLS, CULTURED; CEREBRUM; COCULTURE TECHNIQUES; CROTALARIA; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTATHIONE; IMMUNOHISTOCHEMISTRY; L-LACTATE DEHYDROGENASE; MONOCROTALINE; NEURONS; RATS; RATS, WISTAR; TIME FACTORS; TUBULIN;

ANIMALIA; CROTALARIA; CROTALARIA RETUSA; FABACEAE; RATTUS;

EID: 80055084586     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2011.07.002     Document Type: Article

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