Monocrotaline pyrrol is cytotoxic and alters the patterns of GFAP expression on astrocyte primary cultures

Toxicology in Vitro

Volumn 22, Issue 5, 2008, Pages 1191-1197

  Barreto, R A ^a   Sousa, C S ^a   Silva, V D A ^a   Silva, A R ^a   Veloso, E S ^b   Cunha, S D ^b   Costa, M F D ^a   El Bacha R S ^a   Costa, S L ^a  

^a Instituto de Ciencias da Sau   (Brazil)

^b FEDERAL UNIVERSITY OF BAHIA   (Brazil)

Author keywords

Astrocytes; Dehydromonocrotaline; GFAP; Pyrrolizidine alkaloid

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; GLIAL FIBRILLARY ACIDIC PROTEIN; LACTATE DEHYDROGENASE; MONOCROTALINE PYRROLE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; ASTROCYTE; CELL CULTURE; CELL STRUCTURE; CHROMATIN; CHROMATIN CONDENSATION; CONTROLLED STUDY; CROTALARIA; CULTURE MEDIUM; CYTOTOXICITY; DOSE RESPONSE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; LABELING INDEX; NERVE CELL CULTURE; NERVOUS SYSTEM INJURY; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; RAT; STAINING; WESTERN BLOTTING;

ALKYLATING AGENTS; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; ASTROCYTES; CELL ENLARGEMENT; CELL MEMBRANE; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; GLIAL FIBRILLARY ACIDIC PROTEIN; MONOCROTALINE; RATS; RATS, WISTAR;

ANIMALIA; CROTALARIA; RATTUS;

EID: 44749088254     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.03.013     Document Type: Article

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