Hepatitis C coinfection enhances sensitization of CD4 +T-cells towards Fas-induced apoptosis in viraemic and HAART-controlled HIV-1-positive patients

Antiviral Therapy

Volumn 16, Issue 7, 2011, Pages 1047-1055

  Körner, Christian ^a   Tolksdorf, Felix ^a   Riesner, Katarina ^a   Kram̈er, Benjamin ^a   Schulte, Daniela ^a   Nattermann, Jacob ^a   Rockstroh, Jur̈gen K ^a   Spengler, Ulrich ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; DEATH RECEPTOR; FAS ANTIGEN; FAS LIGAND;

ADOLESCENT; ADULT; AGED; APOPTOSIS; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; HEPATITIS C; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; UPREGULATION; VIREMIA;

ADULT; AGED; ANTIGENS, CD95; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES; COINFECTION; FAS LIGAND PROTEIN; FEMALE; HEPACIVIRUS; HEPATITIS C; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED;

EID: 80055080338     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: 10.3851/IMP1882     Document Type: Article

References (46)

1. Ameisen JC, Capron A. Cell dysfunction and depletion in AIDS: the programmed celldeath hypothesis. Immunol Today 1991; 12:102-105.
2. Krammer PH. CD95's deadly mission in the immune system. Nature 2000; 407:789-795.
3. Sun EW, Shi YF. Apoptosis: the quiet death silences the immune system. Pharmacol Ther 2001; 92:135-145. (Pubitemid 34251131)
4. Hildeman D, Jorgensen T, Kappler J, Marrack P. Apoptosis and the homeostatic control of immune responses. Curr Opin Immunol 2007; 19:516-521. (Pubitemid 47464912)
5. Gougeon ML. T cell apoptosis as a consequence of chronic activation of the immune system in HIV infection. Adv Exp Med Biol 1995; 374:121-127.
6. Gougeon ML, Lecoeur H, Dulioust A, et al. Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T-cells correlates with lymphocyte activation and with disease progression. J Immunol 1996; 156:3509-3520.
7. Westendorp MO, Frank R, Ochsenbauer C, et al. Sensitization of T-cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature 1995; 375:497-500.
8. Luciani F, Matarrese P, Giammarioli AM, et al. CD95/phosphorylated ezrin association underlies HIV-1 GP120/IL-2-induced susceptibility to CD95(APO-1/Fas)-mediated apoptosis of human resting CD4(+)T lymphocytes. Cell Death Differ 2004; 11:574-582. (Pubitemid 38660142)
9. Poonia B, Pauza CD, Salvato MS. Role of the Fas/FasL pathway in HIV or SIV disease. Retrovirology 2009; 6:91.
10. Anderson KB, Guest JL, Rimland D. Hepatitis C virus coinfection increases mortality in HIV-infected patients in the highly active antiretroviral therapy era: data from the HIV Atlanta VA Cohort Study. Clin Infect Dis 2004; 39:1507-1513. (Pubitemid 39518216)
11. Greub G, Ledergerber B, Battegay M, et al. Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV Cohort Study. Lancet 2000; 356:1800-1805.
12. Giordano TP, Kramer JR, Souchek J, Richardson P, El-Serag HB. Cirrhosis and hepatocellular carcinoma in HIV-infected veterans with and without the hepatitis C virus: a cohort study, 1992-2001. Arch Intern Med 2004; 164:2349-2354. (Pubitemid 39532246)
13. Pineda JA, Romero-Gómez M, Díaz-García F, et al. HIV coinfection shortens the survival of patients with hepatitis C virus-related decompensated cirrhosis. Hepatology 2005; 41:779-789. (Pubitemid 40462940)
14. Kramer JR, Giordano TP, Souchek J, El-Serag HB. Hepatitis C coinfection increases the risk of fulminant hepatic failure in patients with HIV in the HAART era. J Hepatol 2005; 42:309-314. (Pubitemid 40254243)
15. El-Serag HB, Giordano TP, Kramer J, Richardson P, Souchek J. Survival in hepatitis C and HIV co-infection: a cohort study of hospitalized veterans. Clin Gastroenterol Hepatol 2005; 3:175-183. (Pubitemid 40220313)
16. Martín JC, Castilla J, López M, Arranz R, Gonzalez-Lahoz J, Soriano V. Impact of chronic hepatitis C on HIV-1 disease progression. HIV Clin Trials 2004; 5:125-131. (Pubitemid 39136305)
17. Rockstroh JK, Mocroft A, Soriano V, et al. Influence of hepatitis C virus infection on HIV-1 disease progression and response to highly active antiretroviral therapy. J Infect Dis 2005; 192:992-1002. (Pubitemid 41266795)
18. Taya N, Torimoto Y, Shindo M, Hirai K, Hasebe C, Kohgo Y. Fas-mediated apoptosis of peripheral blood mononuclear cells in patients with hepatitis C. Br J Haematol 2000; 110:89-97. (Pubitemid 30625597)
19. Fischer R, Baumert T, Blum H. Hepatitis C virus infection and apoptosis. World J Gastroenterol 2007; 13:4865-4872. (Pubitemid 47496752)
20. Körner C, Krämer B, Schulte D, et al. Effects of HCV co-infection on apoptosis of CD4+ T-cells in HIV-positive patients. Clin Sci 2009; 116:861-870.
21. Dianzani U, Bensi T, Savarino A, et al. Role of FAS in HIV infection. Curr HIV Res 2003; 1:405-417.
22. Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA, Herzenberg LA. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med 1995; 181:2029-2036.
23. Aries SP, Schaaf B, Müller C, Dennin RH, Dalhoff K. Fas (CD95) expression on CD4+ T-cells from HIV-infected patients increases with disease progression. J Mol Med 1995; 73:591-593. (Pubitemid 26015288)
24. Patki AH, Georges DL, Lederman MM. CD4+-T-cell counts, spontaneous apoptosis, and Fas expression in peripheral blood mononuclear cells obtained from human immunodeficiency virus type 1-infected subjects. Clin Diagn Lab Immunol 1997; 4:736-741. (Pubitemid 27501417)
25. Mitra D, Steiner M, Lynch DH, Staiano-Coico L, Laurence J. HIV-1 upregulates Fas ligand expression in CD4+ T-cells in vitro and in vivo: association with Fas-mediated apoptosis and modulation by aurintricarboxylic acid. Immunology 1996; 87:581-585. (Pubitemid 26116467)
26. Hosaka N, Oyaizu N, Than S, Pahwa S. Correlation of loss of CD4 T-cells with plasma levels of both soluble form Fas (CD95) Fas ligand (FasL) in HIV-infected infants. Clin Immunol 2000; 95:20-25. (Pubitemid 30202813)
27. Hosaka N, Oyaizu N, Kaplan MH, Yagita H, Pahwa S. Membrane and soluble forms of Fas (CD95) and Fas ligand in peripheral blood mononuclear cells and in plasma from human immunodeficiency virus-infected persons. J Infect Dis 1998; 178:1030-1039. (Pubitemid 28452195)
28. Llano A, Barretina J, Gutiérrez A, et al. Interleukin-7 in plasma correlates with CD4 T-cell depletion and may be associated with emergence of syncytium-inducing variants in human immunodeficiency virus type 1-positive individuals. J Virol 2001; 75:10319-10325.
29. Fluur C, De Milito A, Fry TJ, et al. Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection. J Immunol 2007; 178:5340-5350. (Pubitemid 46595320)
30. Nunnari G, Xu Y, Acheampong EA, et al. Exogenous IL-7 induces Fas-mediated human neuronal apoptosis: potential effects during human immunodeficiency virus type 1 infection. J Neurovirol 2005; 11:319-328. (Pubitemid 41614511)
31. Cianci R, De Luca A, Cammarota G, Cauda R, Pandolfi F. HCV co-infection does not affect the TREC/IL-7 pathway in HIV disease. Eur Rev Med Pharmacol Sci 2008; 12:67-69. (Pubitemid 351425358)
32. Soriano-Sarabia N, Vallejo A, Molina-Pinelo S, et al. HIV-hepatitis C virus co-infection is associated with decreased plasmatic IL-7 levels. AIDS 2007; 21:253-255. (Pubitemid 46036940)
33. Hayashi N, Mita E. Involvement of Fas system-mediated apoptosis in pathogenesis of viral hepatitis. J Viral Hepat 1999; 6:357-365. (Pubitemid 29470165)
34. Calabrese F, Pontisso P, Pettenazzo E, et al. Liver cell apoptosis in chronic hepatitis C correlates with histological but not biochemical activity or serum HCV-RNA levels. Hepatology 2000; 31:1153-1159. (Pubitemid 30233241)
35. Zignego AL, Giannini C, Monti M, Gragnani L. Hepatitis C virus lymphotropism: lessons from a decade of studies. Dig Liver Dis 2007; 39 Suppl 1:S38-S45. (Pubitemid 47528193)
36. Núñez M, Soriano V, López M, et al. Coinfection with hepatitis C virus increases lymphocyte apoptosis in HIV-infected patients. Clin Infect Dis 2006; 43:1209-1212. (Pubitemid 44632808)
37. Macías J, Japón MA, Sáez C, et al. Increased hepatocyte fas expression and apoptosis in HIV and hepatitis C virus coinfection. J Infect Dis 2005; 192:1566-1576. (Pubitemid 41504692)
38. Munshi N, Balasubramanian A, Koziel M, Ganju RK, Groopman JE. Hepatitis C and human immunodeficiency virus envelope proteins cooperatively induce hepatocytic apoptosis via an innocent bystander mechanism. J Infect Dis 2003; 188:1192-1204. (Pubitemid 37338984)
39. Roger PM, Breittmayer JP, Arlotto C, et al. Highly active anti-retroviral therapy (HAART) is associated with a lower level of CD4+ T cell apoptosis in HIV-infected patients. Clin Exp Immunol 1999; 118:412-416.
40. Dieye TN, Van Vooren JP, Delforge ML, Liesnard C, Devleeschouwer M, Farber CM. Spontaneous apoptosis and highly active antiretroviral therapy (HAART). Biomed Pharmacother 2000; 54:16-20. (Pubitemid 30126195)
41. Qurishi N, Kreuzberg C, Lüchters G, et al. Effect of antiretroviral therapy on liver-related mortality in patients with HIV and hepatitis C virus coinfection. Lancet 2003; 362:1708-1713. (Pubitemid 37468321)
42. Dyrhol-Riise AM, Stent G, Røsok BI, Voltersvik P, Olofsson J, Asjö B. The Fas/FasL system and T cell apoptosis in HIV-1-infected lymphoid tissue during highly active antiretroviral therapy. Clin Immunol 2001; 101:169-179.
43. Herbeuval JP, Nilsson J, Boasso A, et al. HAART reduces death ligand but not death receptors in lymphoid tissue of HIV-infected patients and simian immunodeficiency virus-infected macaques. AIDS 2009; 23:35-40.
44. Caggiari L, Zanussi S, Bortolin MT, et al. Effects of therapy with highly active anti-retroviral therapy (HAART) and IL-2 on CD4+ and CD8+ lymphocyte apoptosis in HIV+ patients. Clin Exp Immunol 2000; 120:101-106. (Pubitemid 30176906)
45. Ohnimus H, Heinkelein M, Jassoy C. Apoptotic cell death upon contact of CD4+ T lymphocytes with HIV glycoprotein-expressing cells is mediated by caspases but bypasses CD95 (Fas/Apo-1) and TNF receptor 1. J Immunol 1997; 159:5246-5252. (Pubitemid 127470050)
46. Roggero R, Robert-Hebmann V, Harrington S, et al. Binding of human immunodeficiency virus type 1 gp120 to CXCR4 induces mitochondrial transmembrane depolarization and cytochrome c-mediated apoptosis independently of Fas signaling. J Virol 2001; 75:7637-7650. (Pubitemid 32738022)