CD4+-T-cell counts, spontaneous apoptosis, and Fas expression in peripheral blood mononuclear cells obtained from human immunodeficiency virus type 1-infected subjects

Clinical and Diagnostic Laboratory Immunology

Volumn 4, Issue 6, 1997, Pages 736-741

  Patki, Abhay H ^a   Georges, Daniel L ^a   Lederman, Michael M ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; FAS ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ETIOLOGY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MONONUCLEAR CELL; PRIORITY JOURNAL;

EID: 0030728210     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/cdli.4.6.736-741.1997     Document Type: Article

References (36)

1. Alderson, M. R., T. W. Tough, T. Davis-Smith, S. Braddy, B. Falk, K. A. Schooley, R. G. Goodwin, C. A. Smith, F. Ramsdell, and D. H. Lynch. 1995. Fas ligand mediates activation-induced cell death in human T lymphocytes. J. Exp. Med. 181:71-77.
2. Ameisen, J. C., and A. Capron. 1991. Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis. Immunol. Today 12:102-105.
3. Badley, A. D., J. A. McElhinny, P. J. Leibson, D. H. Lynch, M. R. Alderson, and C. V. Paya. 1996. Upregulation of Fas ligand expression by human immunodeficiency virus in human macrophages mediates apoptosis of unin-fected T lymphocytes. J. Virol. 70:199-206.
4. + T lymphocytes during HIV infection. J. Immunol. 156:2282-2293.
5. Brunner, T., R. Mogul, D. LaFace, N. J. Yoo, A. Mahboul, F. Echeverri, S. J. Martin, W. R. Force, D. H. Lynch, C. F. Ware, and D. R. Green. 1995. Cell-autonomous Fas (CD95)/FasL interaction mediates activation-induced apoptosis in T-cell hybridoma. Nature 373:441-444.
6. Buhl, R., K. J. Holroyd, A. Mastrangeli, A. M. Cantin, H. A. Jaffee, F. B. Wells, C. Saltini, and R. G. Crystal. 1989. Systematic glutathione deficiency in symptom free HIV seropositive individuals. Lancet ii:1294-1297.
7. Buttke, T. M., and P. A. Sandstrom. 1994. Oxidative stress as a mediator of apoptosis. Immunol. Today 15:7-10.
8. Cheng, J., T. Zhou, C. Liu, J. P. Shapiro, M. J. Brauer, M. C. Kiefer, P. J. Barr, and J. D. Mounz. 1994. Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science 263:1759-1762.
9. Clerici, M., N. Stocks, R. A. Zajac, R. N. Boswell, D. R. Lucey, C. S. Via, and G. M. Shearer. 1989. Detection of three different patterns of T helper cell dysfunction in asymptomatic, human immunodeficiency virus-seropositive patients. J. Clin. Invest. 84:1892-1899.
10. Debatin, K. M., A. Fahrig-Faaissner, S. Enenkel-Stodt, W. Kreuz, A. Benner, and P. H. Krammer. 1996. High expression of Apo-1 (CD95) on T lymphocytes from human immunodeficiency virus-1-infected children. Blood 83: 3101-3103.
11. Dhein, J., H. Walczac, C. Baumler, K. M. Debatin, and P. H. Krammer. 1995. Autocrine T-cell suicide mediated by Apo-1/(Fas/CD95). Nature 373: 438-441.
12. + T cells from human immunodeficiency virus-infected persons: differential in vitro preventive effect of cytokines and protease antagonists. Blood 87:4959-4966.
13. Gougeon, M. L., S. Garcia, J. Heeny, R. Tschopp, H. Lecoeur, D. Guetard, V. Rame, R. Dauguet, and L. Montagnier. 1993. Programmed cell death in AIDS related HIV and SIV infections. AIDS Res. Hum. Retroviruses 9: 553-563.
14. Gougeon, M.-L., H. Lecoeur, A. Dulioust, M.-G. Enouf, M. Crouvoisier, C. Goujard, T. Debord, and L. Montagnier. 1996. Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression. J. Immunol. 156:3509-3520.
15. Graters, R. A., F. G. Terpstra, R. De Jong, C. J. M. Van Noesel, R. A. W. Van Lier, and F. Miedema. 1990. Selective loss of T cell function in different stages of HIV infection: early loss of anti-CD-3-induced T cell proliferation followed by decreased anti-CD-3-induced cytotoxic T lymphocyte generation in AIDS-related complex and AIDS. Eur. J. Immunol. 20:1039-1044.
16. Ho, D. D., A. U. Neumann, A. S. Perelson, W. Chen, J. M. Leonard, and M. Markowitz. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373:123-126.
17. Ju, S.-T., D. J. Panka, H. Cui, R. Ettinger, M. El-Khatib, D. H. Sherr, B. Z. Stanger, and A. Marshak-Rothstein. 1995. Fas (CD95)/FasL interactions required for programmed cell death after T-cell activation. Nature 373:444-448.
18. Katsikis, P. D., E. S. Wunderlich, C. A. Craig, L. A. Herzenberg, and L. A. Herzenberg. 1995. Fas antigen stimulation induced marked apoptosis of T lymphocytes in HIV-virus infected individuals. J. Exp. Med. 181:2029-2036.
19. + T cells from HIV-infected persons. J. Immunol. 153:412-418.
20. McCloskey, T., N. Oyaizu, M. Coronesi, and S. Pahwa. 1994. Use of a flow cytometric assay to quantitate apoptosis in human lymphocytes. Clin. Immunol. Immunopathol. 71:14-18.
21. McCloskey, T. W., N. Oyaizu, M. Kaplan, and S. Pahwa. 1995. Expression of the Fas antigen in patients infected with human immunodeficiency virus. Cytometry 22:111-114.
22. Meyaard, L., S. A. Otto, R. R. Jonker, M. J. Mijnster, R. P. Keet, and F. Miedema. 1992. Programmed cell death of T cells in HIV-1 infection. Science 257:217-219.
23. Meyaard, L., S. A. Otto, I. P. M. Keet, M. T. L. Roos, and F. Miedema. 1994. Programmed death of T cells in human immunodeficiency virus infection: no correlation with progression to disease. J. Clin. Invest. 93:982-988.
24. + T helper cell depletion occurs. J. Clin. Invest. 82:1908-1914.
25. Muro-Cacho, C. A., G. Pantaleo, and A. S. Fauci. 1995. Analysis of apoptosis in lymph nodes of HIV-infected persons: intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with the stage of disease or viral burden. J. Immunol. 155:5555-5566.
26. Nicoletti, I., G. Migliorati, M. C. Pagliacci, F. Grignani, and C. Riccardi. 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139: 271-279.
27. Oyaizu, N., T. W. McCloskey, S. Than, R. Hu, V. S. Kalyanaraman, and S. Pahwa. 1994. Cross-linking of CD4 molecules upregulates Fas antigen expression in lymphocytes by inducing interferon-gamma and tumor necrosis factor-alpha secretion. Blood 84:2622-2631.
28. Patki, A. H., and M. M. Lederman. 1996. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell. Immunol. 169:40-46.
29. 3H]thymidine-labelled DNA. Clin. Diagn. Lab. Immunol. 3:1-4.
30. Purvis, S. F., J. W. Jacobberger, R. M. Sramkoski, A. H. Patki, and M. M. Lederman. 1995. The HIV-1 Tat protein induces apoptosis and death in Jurkat cells. AIDS Res. Hum. Retroviruses 11:443-450.
31. Schimenti, K. J., and J. W. Jacobberger. 1992. Fixation of mammalian cells for flow cytometric evaluation of DNA content and nuclear immunofluorescence. Cytometry 13:48-59.
32. + T cells, and monocytes. Cell. Immunol. 163:303-308.
33. Silvestris, F., P. Cafforio, M. A. Frassanito, M. Tucci, A. Romito, S. Nagata, and Dammacco. 1996. Ovcrexpression of Fas antigen on T cells in advanced HIV-1 infection: differential ligation constantly induces apoptosis. AIDS 10:131-141.
34. Van Noesel, C. J. M., R. A. Gruters, F. G. Terpstra, P. T. A. Schellekens, R. A. W. Van Lier, and F. Miedema. 1990. Functional and phenotypic evidence for a selective loss of memory T cells in asymptomatic human immunodeficiency virus-infected men. J. Clin. Invest. 86:293-299.
35. Wei, X., S. K. Ghosh, M. E. Taylor, V. A. Johnson, E. A. Emini, P. Deutsch, J. D. Lifson, S. Bonhoeffer, M. A. Nowak, M. S. Saag, and G. M. Shaw. 1995. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373:117-122.
36. Westendorp, M. O., R. Frank, C. Ochsenbauer, K. Stricker, J. Dhein, H. Walczak, K. M. Debatin, and P. H. Krammer. 1995. Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature 375:497-500.