Exogenous IL-7 induces Fas-mediated human neuronal apoptosis: Potential effects during human immunodeficiency virus type 1 infection

Journal of NeuroVirology

Volumn 11, Issue 4, 2005, Pages 319-328

  Nunnari, Giuseppe ^a   Xu, Yan ^a   Acheampong, Edward A ^a   Fang, Jianhua ^a   Daniel, Rene ^a   Zhang, Chune ^a   Zhang, Hui ^a   Mukhtar, Muhammad ^a   Pomerantz, Roger J ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Apoptosis; CNS; HIV 1; IL 7; Neurons

Indexed keywords

CASPASE 10; FAS ANTIGEN; GLYCOPROTEIN GP 120; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; MESSENGER RNA; PROTEIN BCL 2; PROTEIN KINASE; TUMOR NECROSIS FACTOR RECEPTOR; DNA BINDING PROTEIN; INTERLEUKIN 7 RECEPTOR, ALPHA CHAIN; INTERLEUKIN-7 RECEPTOR, ALPHA CHAIN; MILK PROTEIN; STAT5 PROTEIN; TRANSACTIVATOR PROTEIN;

APOPTOSIS; ARTICLE; ASTROCYTE; CELL SURVIVAL; CONTROLLED STUDY; DEMENTIA; DNA MICROARRAY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VIVO STUDY; NERVE CELL; NICK END LABELING; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; UPREGULATION; WESTERN BLOTTING; CELL CULTURE; CYTOLOGY; GENE EXPRESSION; GENETICS; GENOMICS; IMMUNOLOGY; METABOLISM; VIROLOGY; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTIGENS, CD95; APOPTOSIS; ASTROCYTES; CELLS, CULTURED; DNA-BINDING PROTEINS; GENE EXPRESSION; GENOMICS; HIV ENVELOPE PROTEIN GP120; HIV INFECTIONS; HIV-1; HUMANS; INTERLEUKIN-7; MILK PROTEINS; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, INTERLEUKIN-7; RNA, MESSENGER; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; VIRUS REPLICATION;

EID: 27144546784     PISSN: 13550284     EISSN: None     Source Type: Journal    
DOI: 10.1080/13550280500187005     Document Type: Article

References (46)

1. Alper O, Hacker NF, et al (1999). Protein kinase A-Ialpha subunit-directed antisense inhibition of ovarian cancer cell growth: crosstalk with tyrosine kinase signaling pathway. Oncogene 18: 4999-5004.
2. Becker EB, Howell J, et al (2004). Characterization of the c-Jun N-terminal kinase-BimEL signaling pathway in neuronal apoptosis. J Neurosci 24: 8762-8770.
3. Bellacosa A, Testa JR, et al (1991). A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254: 274-277.
4. Brooks DG, Kitchen SG, et al (2001). Generation of HIV latency during thymopoiesis. Nat Med 7: 459-464.
5. Chun TW, Engel D, et al (1998). Induction of HIV-1 replication in latently infected CD4+ T cells using a combination of cytokines. J Exp Med 188: 83-91.
6. Cosenza L, Gorgun G, et al (2002). Interleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines. Cell Signal 14: 317-325.
7. Cross TG, Scheel-Toellner D, et al (2000). Serine/threonine protein kinases and apoptosis. Exp Cell Res 256: 34-41.
8. Deacon EM, Pongracz J, et al (1997). PKC isoenzymes: differential involvement in apoptosis and pathogenesis. J Clin Pathol Mol Pathol 50: 124-131.
9. Dudley AC, Thomas D, et al (2004). The STATs in cell stress-type responses. Cell Communi Signal 2: 1478-1481.
10. Dus D, Krawczenko A, et al (2003). IL-7 receptor is present on human microvascular endothelial cells. Immunol Lett 86: 163-168.
11. Ellison M, Povlishock JN, et al (1987). Blood-brain barrier dysfunction in cats following recombinant interleukin-2 infusion. Cancer Res 47: 5765-5770.
12. Fry AS, Connick E, et al (2001). A potential role for interleukin-7 in T-cell homeostasis. Blood 97: 2983-2990.
13. Goodwin RG, Friend DJ, et al (1990). Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. Cell 60: 941-951.
14. Grabstein KH, Namen AE, et al (1990). Regulation of T cell proliferation by IL-7. J Immunol 144: 3015-3020.
15. Herskovits AZ, Davies P, et al (2004). Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain. Gene 328: 59-67.
16. Heufler C, Tppar G, et al (1993). Interleukin 7 is produced by murine and human keratinocytes. J Exp Med 178: 1109-1114.
17. Ichijo H (1999). From receptor to stress-activated MAP kinases. Oncogene 18: 6087-6093.
18. Jaleco S, Swainson L, et al (2003). Homeostasis of naïve and memory CD4+ T-cell: IL-2 and IL-7 differentially regulate the balance between proliferation and Fas-mediated apoptosis. J Immunol 171: 61-68.
19. Kaul M, Garden GA, et al (2001). Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410: 988-994.
20. Lai SY, Molden J, et al (1997). Shared Υc subunit within the human interleukin-7 receptor complex. J Clin Invest 99: 169-177.
21. Lelievre JD, Petit F (2005). Interleukin 7 increases human immunodeficiency HIV-1 LAI-mediated Fas-induced T cell death. J Virol In press.
22. Le-Niculescu H, Bonfoco E, et al (1999). Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol. Cell Biol 19: 751-763.
23. Leonard WJ (2001). Cytokines and immunodeficiency disease. Nat Rev Immunol 1: 200-208.
24. Lin JX, Migone TS, et al (1995). The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2: 331-339.
25. Llano A, Barretina J, et al (2001). Interleukin-7 in plasma correlates with CD4 T-cell depletion and may be associated with emergence of syncytium-inducing variants human immunodeficiency virus type 1-positive individuals. J Virol 75: 10319-10325.
26. Marte BM, Downward J (1997). PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem Sci 22: 355-358.
27. Macaluso M, Russo G, et al (2002). Ras family genes: an interesting link between cell cycle and cancer. J Cell Physiol 192: 125-130.
28. Michaelson MD, Mehler MF, et al (1996). Interleukin-7 is trophic for embryonic neurons and is expressed in developing brain. Dev Biol 179: 251-263.
29. Miyazaki T, Kawahara A, et al (1994). Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 266: 1045-1047.
30. Napolitano LA, Grant RM, et al (2001). Increased production of IL-7 accompanies HIV-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med 7: 73-79.
31. Pimentel-Muinos FX, Seed B (1999). Regulated commitment of TNF receptor signaling: a molecular switch for death or activation. Immunity 11: 783-793.
32. Pollock PM, Harper UL, et al (2003). High frequency of BRAF mutations in nevi. Nat Genet 33: 19-20.
33. Porter BO, Scibelli P, et al (2001). Control of T cell development in vivo by subdomains within the IL-7 receptor alpha-chain cytoplasmic tail. J Immunol 106, 262-269.
34. Raber J, Merlo PE, et al (1994). IL-1β potentiates the acetycholine-induced release of vasopressin from the hypothalamus in vitro, but not from the amygdala. Neuroendocrinology 59: 208-217.
35. Rethi B, Fluur C, et al (2004). Decreased IL-7Rα expression of T cell is associated with CD4+ T cell depletion and high levels of serum IL-7 during HIV infection. Immuno 2004 online abstracts 840.
36. Sasson S, Zanetti G, et al IL-7 Down-regplates Surface Expression of IL-7Ralpha in vitro and in vivo. The 11th Conference on Retroviruses and Opportunistic Infections, San Francisco, CA, USA, Abstract N 249.
37. Schmitz I, Krueger A, et al (2003). An IL-2-dependent switch between CD95 signaling pathways sensitize primary human T cells toward CD95-mediated activation-induced cell death. J Immunol 171: 2930-2936.
38. Scripture-Adams DD, Brooks DG, et al (2002). Interleukin-7 induces expression of latent human immunodeficiency virus type 1 with minimal effects on T-cell phenotype, J Virol 76: 13077-13082.
39. Smiers FJ, van Paassen M, et al (1995). Heterogeneity of proliferative responses of human B cell precursor acute lymphoblastic leukemia (BCP-ALL) cells to interleukin 7 (IL-7): no correlation with immunoglobulin gene status and expression of IL-7 receptor or IL-2/IL-4/IL-7 receptor common gamma chain genes. Leukemia 9: 1039-1045.
40. Sudo T, Ito M, et al (1989). Interleukin 7 production and function in stromal cell-dependent B cell development. J Exp Med 170: 333-338.
41. Wang J, Chun HJ, et al (2001). Caspase-10 is an initiator caspase in death receptor signaling. Proc Natl Acad Sci U S A 98: 13884-13888.
42. Wang FX, Xu Y, et al (2005). IL-7 is a potent and proviral strain-specific inducer of latent, in vivo HIV-1 cellular reservoirs of infected individuals on virally-suppressive HAART. J Clin Inves 115: 128-137.
43. Wilks AF, Harpur AG, et al (1994). Cytokine signal transduction and the JAK family of protein tyrosine kinase. Bioassays 16: 313-320.
44. Wolf SS, Cohen A, et al (1992). Expression of cytokines and their receptors by human thymocytes and thymic stromal cells. Immunology 77: 362-368.
45. Xia Z, Dickens M, et al (1995). Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331.
46. Xu Y, Kulkosky J, et al (2004). HIV-1 mediated apoptosis of neuronal cells: proximal molecular mechanisms of HIV-1-induced encephalopathy. Proc Natl Acad Sci U S A 101: 7070-7075.