Genes, microbes, and T cells - New therapeutic targets in Crohn's disease

New England Journal of Medicine

Volumn 346, Issue 8, 2002, Pages 614-616

  Elson, Charles O ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; GENE PRODUCT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN NOD1; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG;

ARTICLE; CROHN DISEASE; ENTERITIS; ESSENTIAL GENE; GENETIC ANALYSIS; HUMAN; INTESTINE FLORA; NOD2 GENE; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; ULCERATIVE COLITIS; UNITED STATES;

APOPTOSIS; CARRIER PROTEINS; CROHN DISEASE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NF-KAPPA B; NOD2 SIGNALING ADAPTOR PROTEIN; PROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037148940     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM200202213460812     Document Type: Article

References (6)

1. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
2. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
3. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB
4. Autoimmunity and apoptosis: The Crohn's connection
5. NF-κB signalling proteins as therapeutic targets for inflammatory bowel diseases
6. Experimental models of intestinal inflammation: New insights into mechanisms of mucosal homeostasis