Identification of N-terminal extracellular domain determinants in nicotinic acetylcholine receptor (nAChR) α6 subunits that influence effects of wild-type or mutant β3 subunits on function of α6β2*- or α6β4*-nAChR

Journal of Biological Chemistry

Volumn 286, Issue 44, 2011, Pages 37976-37989

  Dash, Bhagirathi ^a,b   Bhakta, Minoti ^a   Chang, Yongchang ^a   Lukas, Ronald J ^a  

^a BARROW NEUROLOGICAL INSTITUTE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHANNEL OPENING; CO-EXPRESSION; EXTRACELLULAR DOMAINS; HETEROLOGOUS EXPRESSION; N-TERMINAL DOMAINS; N-TERMINALS; NICOTINIC ACETYLCHOLINE RECEPTORS; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHR); STRUCTURAL BASIS; SUBUNIT INTERFACES; WILD TYPES; XENOPUS OOCYTE;

AMINO ACIDS; MAMMALS;

TOBACCO;

ASPARAGINE; HYBRID PROTEIN; METHIONINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA6; NICOTINIC RECEPTOR ALPHA6BETA2; NICOTINIC RECEPTOR ALPHA6BETA4; NICOTINIC RECEPTOR BETA3; RECEPTOR SUBUNIT; SERINE; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CHIMERA; CONTROLLED STUDY; DOPAMINE RECEPTOR BLOCKING; FEMALE; GAIN OF FUNCTION MUTATION; HUMAN; MOUSE; MUTANT; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; WILD TYPE; XENOPUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIDEPRESSIVE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ION CHANNELS; LIGANDS; MICE; MOLECULAR SEQUENCE DATA; NEUROTRANSMITTER AGENTS; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, NICOTINIC; SEQUENCE HOMOLOGY, AMINO ACID; SMOKING CESSATION;

MAMMALIA;

EID: 80055068688     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.263673     Document Type: Article

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