Human rna polymerase ii-association factor 1 (hpaf1/pd2) regulates histone methylation and chromatin remodeling in pancreatic cancer

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Dey, Parama ^a   Ponnusamy, Moorthy P ^a   Deb, Shonali ^a   Batra, Surinder K ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; DNA BINDING PROTEIN; HISTONE METHYLTRANSFERASE; HUMAN RNA POLYMERASE II ASSOCIATION FACTOR 1; LYSINE; RNA; RNA POLYMERASE II; UNCLASSIFIED DRUG; CHD1 PROTEIN, HUMAN; HELICASE; HISTONE; MIXED LINEAGE LEUKEMIA PROTEIN; MLL PROTEIN, HUMAN; NUCLEAR PROTEIN; PAF1 PROTEIN, HUMAN;

ARTICLE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN STRUCTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GENE EXPRESSION; HISTONE METHYLATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; METHYLATION; NUCLEOSOME; PANCREAS CANCER; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA ISOLATION; RNA TRANSLATION; TRANSCRIPTION REGULATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PANCREAS TUMOR; PATHOLOGY; PHYSIOLOGY; TUMOR CELL CULTURE;

CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA HELICASES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONES; HUMANS; METHYLATION; MYELOID-LYMPHOID LEUKEMIA PROTEIN; NUCLEAR PROTEINS; PANCREATIC NEOPLASMS; RNA POLYMERASE II; TUMOR CELLS, CULTURED;

EID: 80055047728     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026926     Document Type: Article

References (37)

1. Shilatifard A, (2008) Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation. Curr Opin Cell Biol 20: 341-348.
2. Shi X, Hong T, Walter KL, Ewalt M, Michishita E, et al. (2006) ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature 442: 96-99.
3. Wang P, Lin C, Smith ER, Guo H, Sanderson BW, et al. (2009) Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II. Mol Cell Biol 29: 6074-6085.
4. Krogan NJ, Dover J, Wood A, Schneider J, Heidt J, et al. (2003) The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell 11: 721-729.
5. Lusser A, Urwin DL, Kadonaga JT, (2005) Distinct activities of CHD1 and ACF in ATP-dependent chromatin assembly. Nat Struct Mol Biol 12: 160-166.
6. Marfella CG, Imbalzano AN, (2007) The Chd family of chromatin remodelers. Mutat Res 618: 30-40.
7. Sims RJ III, Chen CF, Santos-Rosa H, Kouzarides T, Patel SS, et al. (2005) Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem 280: 41789-41792.
8. Esteller M, (2007) Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 8: 286-298.
9. Omura N, Goggins M, (2009) Epigenetics and epigenetic alterations in pancreatic cancer. Int J Clin Exp Pathol 2: 310-326.
10. Rozenblatt-Rosen O, Hughes CM, Nannepaga SJ, Shanmugam KS, Copeland TD, et al. (2005) The parafibromin tumor suppressor protein is part of a human Paf1 complex. Mol Cell Biol 25: 612-620.
11. Yart A, Gstaiger M, Wirbelauer C, Pecnik M, Anastasiou D, et al. (2005) The HRPT2 tumor suppressor gene product parafibromin associates with human PAF1 and RNA polymerase II. Mol Cell Biol 25: 5052-5060.
12. Zhu B, Mandal SS, Pham AD, Zheng Y, Erdjument-Bromage H, et al. (2005) The human PAF complex coordinates transcription with events downstream of RNA synthesis. Genes Dev 19: 1668-1673.
13. Krogan NJ, Kim M, Tong A, Golshani A, Cagney G, et al. (2003) Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II. Mol Cell Biol 23: 4207-4218.
14. Wood A, Schneider J, Dover J, Johnston M, Shilatifard A, (2003) The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p. J Biol Chem 278: 34739-34742.
15. Warner MH, Roinick KL, Arndt KM, (2007) Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification. Mol Cell Biol 27: 6103-6115.
16. Miller T, Krogan NJ, Dover J, Erdjument-Bromage H, Tempst P, et al. (2001) COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98: 12902-12907.
17. Rozenblatt-Rosen O, Nagaike T, Francis JM, Kaneko S, Glatt KA, et al. (2009) The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3′ mRNA processing factors. Proc Natl Acad Sci U S A 20;106: 755-760.
18. Jaehning JA, (2010) The Paf1 complex: platform or player in RNA polymerase II transcription? Biochim Biophys Acta 1799: 379-388.
19. Chaudhary K, Deb S, Moniaux N, Ponnusamy MP, Batra SK, (2007) Human RNA polymerase II-associated factor complex: dysregulation in cancer. Oncogene 26: 7499-7507.
20. Marton HA, Desiderio S, (2008) The Paf1 complex promotes displacement of histones upon rapid induction of transcription by RNA polymerase II. BMC Mol Biol 9:4: 4.
21. Mueller CL, Porter SE, Hoffman MG, Jaehning JA, (2004) The Paf1 complex has functions independent of actively transcribing RNA polymerase II. Mol Cell 14: 447-456.
22. Ponnusamy MP, Deb S, Dey P, Chakraborty S, Rachagani S, et al. (2009) RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells. Stem Cells 27: 3001-3011.
23. Chu Y, Simic R, Warner MH, Arndt KM, Prelich G, (2007) Regulation of histone modification and cryptic transcription by the Bur1 and Paf1 complexes. EMBO J 26: 4646-4656.
24. Laribee RN, Krogan NJ, Xiao T, Shibata Y, Hughes TR, et al. (2005) BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex. Curr Biol 15: 1487-1493.
25. Mulder KW, Brenkman AB, Inagaki A, van den Broek NJ, Timmers HT, (2007) Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex. Nucleic Acids Res 35: 2428-2439.
26. Milne TA, Kim J, Wang GG, Stadler SC, Basrur V, et al. (2010) Multiple interactions recruit MLL1 and MLL1 fusion proteins to the HOXA9 locus in leukemogenesis. Mol Cell 38: 853-863.
27. Muntean AG, Tan J, Sitwala K, Huang Y, Bronstein J, et al. (2010) The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis. Cancer Cell 17: 609-621.
28. Delmas V, Stokes DG, Perry RP, (1993) A mammalian DNA-binding protein that contains a chromodomain and an SNF2/SWI2-like helicase domain. Proc Natl Acad Sci U S A 90: 2414-2418.
29. Stokes DG, Perry RP, (1995) DNA-binding and chromatin localization properties of CHD1. Mol Cell Biol 15: 2745-2753.
30. Flanagan JF, Mi LZ, Chruszcz M, Cymborowski M, Clines KL, et al. (2005) Double chromodomains cooperate to recognize the methylated histone H3 tail. Nature 438: 1181-1185.
31. Simic R, Lindstrom DL, Tran HG, Roinick KL, Costa PJ, et al. (2003) Chromatin remodeling protein Chd1 interacts with transcription elongation factors and localizes to transcribed genes. EMBO J 22: 1846-1856.
32. Moniaux N, Nemos C, Deb S, Zhu B, Dornreiter I, et al. (2009) The human RNA polymerase II-associated factor 1 (hPaf1): a new regulator of cell-cycle progression. PLoS One 4: e7077.
33. Feuerbach F, Galy V, Trelles-Sticken E, Fromont-Racine M, Jacquier A, et al. (2002) Nuclear architecture and spatial positioning help establish transcriptional states of telomeres in yeast. Nat Cell Biol 4: 214-221.
34. Jones PA, Baylin SB, (2007) The epigenomics of cancer. Cell 128: 683-692.
35. Huo H, Magro PG, Pietsch EC, Patel BB, Scotto KW, (2010) Histone methyltransferase MLL1 regulates MDR1 transcription and chemoresistance. Cancer Res 70: 8726-8735.
36. Renault L, Kuhlmann J, Henkel A, Wittinghofer A, (2001) Structural basis for guanine nucleotide exchange on Ran by the regulator of chromosome condensation (RCC1). Cell 20;105: 245-255.
37. Gaspar-Maia A, Alajem A, Polesso F, Sridharan R, Mason MJ, et al. (2009) Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature 460: 863-868.