RNA polymerase II associated factor 1/PD2 maintains self-renewal by its interaction with Oct3/4 in mouse embryonic stem cells

Stem Cells

Volumn 27, Issue 12, 2009, Pages 3001-3011

  Ponnusamy, Moorthy P ^a   Deb, Shonali ^a   Dey, Parama ^a   Chakraborty, Subhankar ^a   Rachagani, Satyanarayana ^a   Senapati, Shantibhusan ^a   Batra, Surinder K ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Embryonic stem cells; Oct3 4; PAF complex; Paf1 PD2; Self renewal

Indexed keywords

CELL PROTEIN; FIBROBLAST GROWTH FACTOR 8; OCTAMER TRANSCRIPTION FACTOR 4; RNA POLYMERASE II ASSOCIATED FACTOR 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR GATA 6; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; EMBRYONAL CARCINOMA STEM CELL; EMBRYONIC STEM CELL; ENDODERM; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; BIOLOGICAL MARKERS; CARRIER PROTEINS; CELL LINEAGE; CELLS, CULTURED; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION; MICE; MICE, KNOCKOUT; NUCLEAR REPROGRAMMING; OCTAMER TRANSCRIPTION FACTOR-3; PROTEIN BINDING;

EID: 73349104918     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.237     Document Type: Article

References (49)

1. Boiani M, Scholer HR. Regulatory networks in embryo-derived pluripotent stem cells. Nat Rev Mol Cell Biol 2005;6:872-884.
2. Mimeault M, Batra SK. Concise review: recent advances on the significance of stem cells in tissue regeneration and cancer therapies. Stem Cells 2006;24:2319-2345.
3. Weissman IL, Anderson DJ, Gage F. Stem and progenitor cells: origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol 2001;17:387-403.
4. Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature 1981;292:154-156.
5. Moorthy PP, Kumar AA, Devaraj H. Expression of the Gas7 gene and Oct4 in embryonic stem cells of mice. Stem Cells Dev 2005;14:664-670.
6. Thomson JA, Itskovitz-Eldor J, Shapiro SS et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-1147.
7. Boyer LA, Lee TI, Cole MF et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005;122:947-956.
8. Chambers I, Smith A. Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene 2004;20:23:7150-7160.
9. Wang J, Rao S, Chu J et al. A protein interaction network for pluripotency of embryonic stem cells. Nature 2006;444:364-368.
10. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663-676.
11. Ying QL, Nichols J, Chambers I et al. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell selfrenewal in collaboration with STAT3. Cell 2003;115:281-292.
12. Ivanova N, Dobrin R, Lu R et al. Dissecting self-renewal in stem cells with RNA interference. Nature 2006;442:533-538.
13. Zhu B, Mandal SS, Pham AD et al. The human PAF complex coordinates transcription with events downstream of RNA synthesis. Genes Dev 2005;19:1668-1673.
14. Moniaux N, Nemos C, Schmied BM et al. The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis. Oncogene 2006;25:3247-3257.
15. Wang P, Bowl MR, Bender S et al. Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice. Mol Cell Biol 2008;28:2930-2940.
16. Stryke D, Kawamoto M, Huang CC et al. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res 2003;31:278-281.
17. Burridge PW, Anderson D, Priddle H et al. Improved human embryonic stem cell embryoid body homogeneity and cardiomyocyte differentiation from a novel V-96 plate aggregation system highlights interline variability. Stem Cells 2007;25:929-938.
18. Furlan-Magaril M, Rincon-Arano H, Recillas-Targa F. Sequential chromatin immunoprecipitation protocol: ChIP-reChIP. Methods Mol Biol 2009;543:253-266.
19. Rozenblatt-Rosen O, Hughes CM, Nannepaga SJ et al. The parafibromin tumor suppressor protein is part of a human Paf1 complex. Mol Cell Biol 2005;25:612-620.
20. Pan G, Thomson JA. Nanog and transcriptional networks in embryonic stem cell pluripotency. Cell Res 2007;17:42-49.
21. Avilion AA, Nicolis SK, Pevny LH et al. Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 2003;17:126-140.
22. Chambers I, Colby D, Robertson M et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 2003;113:643-655.
23. Nichols J, Zevnik B, Anastassiadis K et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 1998;95:379-391.
24. Pritsker M, Ford NR, Jenq HT et al. Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells. Proc Natl Acad Sci U S A 2006;103:6946-6951.
25. Strickland S, Mahdavi V. The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Cell 1978;15:393-403.
26. Schöler HR, Balling R, Hatzopoulos AK et al. Octamer binding proteins confer transcriptional activity in early mouse embryogenesis. EMBO J 1989;8:2551-2557.
27. Lewin B. Commitment and activation at pol II promoters: a tail of protein-protein interactions. Cell 1990;61:1161-1164.
28. Ptashne M, Gann AA. Activators and targets. Nature 1990;346:329-331.
29. Schöler HR, Ciesiolka T, Gruss P. A nexus between Oct-4 and E1A: implications for gene regulation in embryonic stem cells. Cell 1991;66:291-304.
30. Esteban MA, Xu J, Yang J et al. Generation of induced pluripotent stem cell lines from Tibetan miniature pig. J Biol Chem 2009;284: 17634-17640.
31. Kim JB, Sebastiano V, Wu G et al. Oct4-induced pluripotency in adult neural stem cells. Cell 2009;136:411-419.
32. Loh YH, Agarwal S, Park IH et al. Generation of induced pluripotent stem cells from human blood. Blood 2009;113:5476-5479.
33. Pei D. The magic continues for the iPS strategy. Cell Res 2008;18: 221-223.
34. Tweedell KS. New paths to pluripotent stem cells. Curr Stem Cell Res Ther 2008;3:151-162.
35. Woltjen K, Michael IP, Mohseni P et al. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature 2009;458: 766-770.
36. Thomson JA, Kalishman J, Golos TG et al. Isolation of a primate embryonic stem cell line. Proc Natl Acad Sci U S A 1995;92:7844-7848.
37. Wilmut I, Schnieke AE, McWhir J et al. Viable offspring derived from fetal and adult mammalian cells. Nature 1997;385:810-813.
38. Ebert AD, Yu J, Rose FF Jr. et al. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature 2009;457:277-280.
39. Park IH, Arora N, Huo H et al. Disease-specific induced pluripotent stem cells. Cell 2008;134:877-886.
40. Dejosez M, Krumenacker JS, Zitur LJ et al. Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell 2008;133:1162-1174.
41. Ema M, Mori D, Niwa H et al. Kruppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Cell Stem Cell 2008;3:555-567.
42. Galan-Caridad JM, Harel S, Arenzana TL et al. Zfx controls the selfrenewal of embryonic and hematopoietic stem cells. Cell 2007;20:129: 345-357.
43. Singh SK, Kagalwala MN, Parker-Thornburg J et al. REST maintains self-renewal and pluripotency of embryonic stem cells. Nature 2008; 453:223-227.
44. Zhang J, Tam WL, Tong GQ et al. Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1. Nat Cell Biol 2006;8:1114-1123.
45. Ding L, Paszkowski-Rogacz M, Nitzsche A et al. A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. Cell Stem Cell 2009;4:403-415.
46. Liang J, Wan M, Zhang Y et al. Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat Cell Biol 2008;10:731-739.
47. Saxe JP, Tomilin A, Scholer HR et al. Post-translational regulation of Oct4 transcriptional activity. Plos One 2009;4:4467.
48. Tolkunova E, Malashicheva A, Parfenov VN et al. PIAS proteins as repressors of Oct4 function. J Mol Biol 2007;374:1200-1212.
49. Reményi A, Lins K, Nissen LJ et al. Crystal structure of a POU/ HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. Genes Dev 2003;17:2048-2059.