Antigenotoxicity activity of natural chlorophylls

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 376, Issue 1-2, 1997, Pages 97-100

  Negishi, Tomoe ^a   Rai, Haruki ^a   Hayatsu, Hikoya ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

4 Nitroquinoline 1 oxide; Antigenotoxicity; Chlorophyll; Drosophila wing spots

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; ANTIMUTAGENIC AGENT; CHLOROPHYLL; ANTINEOPLASTIC AGENT; CHLOROPHYLLIDE; MUTAGENIC AGENT;

ANIMAL EXPERIMENT; ARTICLE; CHLORELLA; CONTROLLED STUDY; DROSOPHILA; GENOTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SPINACH; VEGETABLE; ANIMAL; DROSOPHILA MELANOGASTER; DRUG EFFECT; MUTAGEN TESTING;

ANIMALIA; CHLORELLA VULGARIS; SALMONELLA; SPINACIA OLERACEA;

4-NITROQUINOLINE-1-OXIDE; ANIMALS; ANTICARCINOGENIC AGENTS; CHLOROPHYLL; CHLOROPHYLLIDES; DROSOPHILA MELANOGASTER; MUTAGENICITY TESTS; MUTAGENS; SPINACIA OLERACEA;

EID: 0030976823     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(97)00030-4     Document Type: Article

References (22)

1. Arimoto, S., S. Fukuoka, C. Itome, H. Nakano, H. Rai and H. Hayatsu (1993) Binding of polycyclic planar mutagens to chlorophyllin resulting in the inhibition of the mutagenic activity, Mutation Res., 287, 293-305.
2. Association of Official Analytical Chemists (1990) Chlorophyll in Plants: Spectrophotometric Method for Total Chlorophyll and the a and b Components, in: K. Helrich (Ed.), Official Methods of Analysis, 15th Edition, AOAC Inc., Arlington, VA, pp. 62-63.
3. Bailleul, B., P. Daubersies, S. Galiègue-Zouitina and M.-H. Loucheux-Lefebvre (1989) Molecular basis of 4-nitroquinoline 1-oxide carcinogenesis, Jpn. J. Cancer Res., 80, 691-697.
4. 1 hepatocarcinogenesis in rainbow trout, Cancer Res., 55, 57-62.
5. Chipchase, M.I.H. (1961) Chemical components in plant tissues. In Long, C. (ed.), Biochemists' Handbook. E. & F.N. Spon Ltd, London, pp. 1032-1033.
6. Committee on Diet (1982) Nutrition and Cancer, Diet Nutrition and Cancer, National Academy Press, Washington, D.C.
7. Frei, H. and F.E. Würgler (1988) Statistical methods to decide whether mutagenicity test data from Drosophila assays indicate a positive, negative, or inconclusive result, Mutation Res., 203, 297-308.
8. Graf, U., H. Juon, A.J. Katz, H. Frei and F.E. Würgler (1983) A pilot study on a new Drosophila spot test, Mutation Res., 120, 233-239.
9. Graf, U., F.E. Würgler, A.J. Katz, H. Frei, H. Juon, C.B. Hall and P.G. Kale (1984) Somatic mutation and recombination test in Drosophila melanogaster, Environ. Mutagenesis, 6, 153-188.
10. Guo, D., D.T. Horio, J.S. Grove and R.H. Dashwood (1995) Inhibition by chlorophyllin of 2-amino-3-methyl-imidazo[4,5-f]quinoline-induced tumorigenesis in the male F344 rat, Cancer Lett., 95, 161-165.
11. Hasegawa, R., M. Hirose, T. Kato, A. Hagiwara, P. Boonyaphiphat, M. Nagao, N. Ito and T. Shirai (1995) Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats, Carcinogenesis, 16, 2243-2246.
12. Hayatsu, H., S. Arimoto and T. Negishi (1988) Dietary inhibitors of mutagenesis and carcinogenesis, Mutat. Res., 202, 429-446.
13. Kephart, J.C. (1955) Chlorophyll derivatives - their chemistry, commercial preparation and uses, Economic Botany, 9, 3-38.
14. Lai, C.-N., M.A. Butler and T.S. Matney (1980) Antimutagenic activities of common vegetables and their chlorophyll content, Mutation Res., 77, 245-250.
15. Negishi, T., S. Arimoto, C. Nishizaki and H. Hayatsu (1989) Inhibitory effect of chlorophyll on the genotoxicity of 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2), Carcinogenesis, 10, 145-149.
16. Negishi, T., T., Shiotani, K. Fujikawa and H. Hayatsu (1991) The genotoxicities of N-nitrosamines in Drosophila melanogaster in vivo: the correlation of mutagenicity in the wing spot test with the DNA damages detected by the DNA-repair test, Mutation Res., 252, 119-128.
17. Park, K.K. and Y.J. Surh (1996) Chemopreventive activity of chlorophyllin against mouse skin carcinogenesis by benzo[a]pyrene and benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide, Cancer Lett., 102, 1-7.
18. Phillips, R.L. (1975) Role of life-style and dietary habits in risk of cancer among Seventh-Day Adventists, Cancer Res., 35, 3513-3522.
19. Sarkar, D., A. Sharma and G. Talukder (1994) Chlorophylll and chlorophyllin as modifiers of genotoxic effects, Mutation Res., 318, 239-247.
20. Terwel, L. and C.M. van der Hoeven (1985) Antimutagenic activity of some naturally occurring compounds towards cigarette-smoke condensate and benzo[a]pyrene in Salmonella/microsome assay, Mutation Res., 152, 1-4.
21. Würgler, F.E. and E.W. Vogel (1986) In vivo mutagenicity testing using somatic cells of Drosophila melanogaster. In: de Serres, F.J. (ed.), Chemical Mutagens, Vol. 10, Plenum Press, New York, pp. 10-72.
22. Yun, C.-H., H.G. Jeong, J.W. Jhoun and F.P. Guengerich (1995) Non-specific inhibition of cytochrome P-450 activities by chlorophyllin in human and rat liver microsomes, Carcinogenesis, 16, 1437-1440.