Netrin-1 overexpression in kidney proximal tubular epithelium ameliorates cisplatin nephrotoxicity

Laboratory Investigation

Volumn 91, Issue 12, 2011, Pages 1717-1726

  Rajasundari, Amala ^a   Pays, Laurent ^b   Mehlen, Patrick ^b   Ramesh, Ganesan ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b CENTRE LÉON BÉRARD   (France)

Author keywords

calcineurin NFAT; GF b1; iabetic nephropathy; orcantharidin; ubulointerstitial fibrosis; xtracellular matrix

Indexed keywords

CASPASE 3; CISPLATIN; COMPLEMENT COMPONENT C3; CXCL9 CHEMOKINE; EOTAXIN; GAMMA INTERFERON; HEME OXYGENASE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; NETRIN 1; OSTEOPONTIN; PROTEIN P53; RANTES; SECONDARY LYMPHOID TISSUE CHEMOKINE; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE SEVERITY; KIDNEY DYSFUNCTION; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE EPITHELIUM; MALE; MOUSE; NEPHRITIS; NEPHROTOXICITY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; RENAL PROTECTION; REPERFUSION INJURY;

ACUTE KIDNEY INJURY; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOLOGICAL MARKERS; CELL ADHESION MOLECULES; CELLS, CULTURED; CISPLATIN; CYTOKINES; KIDNEY TUBULES, PROXIMAL; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE GROWTH FACTORS; NEUTROPHIL INFILTRATION; OXIDATIVE STRESS; TUMOR SUPPRESSOR PROTEIN P53; TUMOR SUPPRESSOR PROTEINS;

EID: 80055025757     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2011.126     Document Type: Article

References (39)

1. Hartmann Jr T, Lipp HP. Toxicity of platinum compounds. Expert Opin Pharmacother 2003;4:889-901.
2. Sastry J, Kellie SJ. Severe neurotoxicity, ototoxicity and nephrotoxicity following high-dose cisplatin and amifostine. Pediatr Hematol Oncol 2005;22:441-445. (Pubitemid 40993608)
3. Arany I, Safirstein RL. Cisplatin nephrotoxicity. Semin Nephrol 2003; 23:460-464. (Pubitemid 37176691)
4. Lau AH. Apoptosis induced by cisplatin nephrotoxic injury. Kidney Int 1999;56:1295-1298. (Pubitemid 29451234)
5. Pabla N, Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int 2008;73:994-1007. (Pubitemid 351543900)
6. Zhang B, Ramesh G, Uematsu S, et al. TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity. J Am Soc Nephrol 2008;19:923-932.
7. Ramesh G, Reeves WB. TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity. J Clin Invest 2002;110:835-842.
8. Wang W, Brian RW, Ramesh G. Netrin-1 and kidney injury. I. Netrin-1 protects against ischemia-reperfusion injury of the kidney. Am J Physiol Renal Physiol 2008;294:F739-F747.
9. Ly NP, Komatsuzaki K, Fraser IP, et al. Netrin-1 inhibits leukocyte migration in vitro and in vivo. PNAS 2005;102:14729-14734. (Pubitemid 41457124)
10. Nguyen A, Cai H. Netrin-1 induces angiogenesis via a DCCdependent ERK1/2-eNOS feed-forward mechanism. PNAS 2006;103: 6530-6535.
11. Wilson BD, Ii M, Park KW, et al. Netrins promote developmental and therapeutic angiogenesis. Science 2006;313:640-644. (Pubitemid 44201136)
12. Navankasattusas S, Whitehead KJ, Suli A, et al. The netrin receptor UNC5B promotes angiogenesis in specific vascular beds. Development 2008;135:659-667. (Pubitemid 351405019)
13. Hebrok M, Reichardt LF. Brain meets pancreas: netrin, an axon guidance molecule, controls epithelial cell migration. Trends Cell Biol 2004;14:153-155. (Pubitemid 38447113)
14. Liu Y, Stein E, Oliver T, et al. Novel role for netrins in regulating epithelial behavior during lung branching morphogenesis. Curr Biol 2004;14:897-905. (Pubitemid 38800912)
15. Lu X, Le Noble F, Yuan L, et al. The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2004;432:179-186. (Pubitemid 39545842)
16. Arakawa H. Netrin-1 and its receptors in tumorigenesis. Nat Rev Cancer 2004;4:978-987. (Pubitemid 39626221)
17. Fitamant J, Guenebeaud C, Coissieux MM, et al. Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer. Proc Natl Acad Sci USA 2008;105:4850-4855. (Pubitemid 351753835)
18. Mazelin L, Bernet A, Bonod-Bidaud C, et al. Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 2004; 431:80-84. (Pubitemid 39215111)
19. Wang W, Reeves WB, Pays L, et al. Netrin-1 overexpression protects kidney from ischemia reperfusion injury by suppressing apoptosis. Am J Pathol 2009;175:1010-1018.
20. Ernest S, Bello-Reuss E. Expression and function of P-glycoprotein in a mouse kidney cell line. Am J Physiol 1995;269:C323-C333.
21. Wang W, Li C, Summer SN, et al. Role of AQP1 in endotoxemiainduced acute kidney injury. Am J Physiol Renal Physiol 2008;294: F1473-F1480.
22. Ramesh G, Zhang B, Uematsu S, et al. Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice. Am J Physiol Renal Physiol 2007;293:F325-F332. (Pubitemid 47345033)
23. Ramesh G, Reeves WB. p38 MAP kinase inhibition ameliorates cisplatin nephrotoxicity in mice. Am J Physiol Renal Physiol 2005;289: F166-F174. (Pubitemid 40863584)
24. Bredesen DE, Mehlen P, Rabizadeh S. Apoptosis and dependence receptors: a molecular basis for cellular addiction. Physiol Rev 2004; 84:411-430. (Pubitemid 38365489)
25. Mehlen P, Bredesen DE. The dependence receptor hypothesis. Apoptosis 2004;9:37-49. (Pubitemid 38270427)
26. Wei Q, Dong G, Yang T, et al. Activation and involvement of p53 in cisplatin-induced nephrotoxicity. Am J Physiol Renal Physiol 2007;293: F1282-F1291. (Pubitemid 47583963)
27. Reeves WB, Kwon O, Ramesh G. Netrin-1 and kidney injury. II. Netrin-1 is an early biomarker of acute kidney injury. Am J Physiol Renal Physiol 2008;294:F731-F738.
28. Fan Y, Shen F, Chen Y, et al. Overexpression of netrin-1 induces neovascularization in the adult mouse brain. J Cereb Blood Flow Metab 2008;28:1543-1551.
29. Llambi F, Causeret F, Bloch-Gallego E, et al. Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J 2001;20:2715-2722. (Pubitemid 32938556)
30. Wu TW, Li WW, Li H. Netrin-1 attenuates ischemic stroke-induced apoptosis. Neuroscience 2008;156:475-482.
31. Guenebeaud C, Goldschneider D, Castets M, et al. The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Mol Cell 2010;40:863-876.
32. Forcet C, Ye X, Granger L, et al. The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation. PNAS 2001;98:3416-3421. (Pubitemid 32220860)
33. Jiang M, Dong Z. Regulation and pathological role of p53 in cisplatin nephrotoxicity. J Pharmacol Exp Ther 2008;327:300-307.
34. Tanikawa C, Matsuda K, Fukuda S, et al. p53RDL1 regulates p53-dependent apoptosis. Nat Cell Biol 2003;5:216-223. (Pubitemid 36322248)
35. Ramesh G, Kimball SR, Jefferson LS, et al. Endotoxin and cisplatin synergistically stimulate TNF-alpha production by renal epithelial cells. Am J Physiol Renal Physiol 2007;292:F812-F819. (Pubitemid 46220550)
36. Tadagavadi RK, Wang W, Ramesh G. Netrin-1 regulates Th1/Th2/Th17 cytokine production and inflammation through UNC5B receptor and protects kidney against ischemia-reperfusion injury. J Immunol 2010; 185:3750-3758.
37. Matsukawa A, Hogaboam CM, Lukacs NW, et al. Expression and contribution of endogenous IL-13 in an experimental model of sepsis. J Immunol 2000;164:2738-2744. (Pubitemid 30115507)
38. Manna SK, Aggarwal BB. IL-13 suppresses TNF-induced activation of nuclear factor-{kappa}B, activation protein-1, apoptosis. J Immunol 1998;161:2863-2872. (Pubitemid 28425708)
39. Sandovici M, Henning RH, van Goor H, et al. Systemic gene therapy with interleukin-13 attenuates renal ischemia-reperfusion injury. Kidney Int 2008;73:1364-1373. (Pubitemid 351770490)