IL-13 suppresses TNF-induced activation of nuclear factor-κB, activation protein-1, and apoptosis

Journal of Immunology

Volumn 161, Issue 6, 1998, Pages 2863-2872

  Manna, Sunil K ^a   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; CASPASE; CERAMIDE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 13; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NEOMYCIN; OKADAIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE C; PROTEIN KINASE; PROTEIN KINASE C; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; BIOASSAY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ASSAY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOMODULATION; MOUSE; NONHUMAN; ONCOGENE C JUN; PRIORITY JOURNAL;

APOPTOSIS; BIOLOGICAL TRANSPORT; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CASPASE 3; CASPASES; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; CYTOTOXICITY, IMMUNOLOGIC; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; I-KAPPA B PROTEINS; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-13; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OKADAIC ACID; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTOR RELA; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032530947     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Minty, A., P. Chalon, J. M. Derocq, X. Dumont, J. C. Guillmot, M. Kaghad, C. Labit, P. Leplatait, P. Liauzin, B. Miloux, C. Minty, P. Casallas, G. Loison, J. Lupker, D. Shire, P. Ferrara, and D. Caput. 1993. Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses. Nature 362:248.
2. McKenzie, A. N., J. A. Culpepper, R. de Waal Malefyt, F. Briere, J. Punnonen, G. Aversa, A. Sato, W. Dang, B. G. Cocks, S. Menon, G. Zurawski, and J. E. de Vries. 1993. Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function. Proc. Natl. Acad. Sci. USA 90:3735.
3. Cocks, B. G., R. de Waal Malefyt, J. Galizzi, J. E. de Vries, and G. Aversa. 1993. IL-13 induces proliferation and differentiation of human B cells activated by the CD40 ligand. Int. Immunol. 5:657.
4. Defrance, T., P. Carayon, G. Billian, J. C. Guillmot, A. Minty, D. Caput, and P. Ferrara. 1994. Interleukin 13 is a B cell stimulating factor. J. Exp. Med. 179: 135.
5. Punnonen, J., G. Avers, B. G. Cocks, A. N. McKenzie, S. Menon, B. Bennet, J. Culpepper, W. Dang, G. Zurawski, and J. E. de Vries. 1993. Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells. Proc. Natl. Acad. Sci. USA 90:3730.
6. de Waal Malefyt, R., R. Figdor, R. Huijbens, S. Mohen-Peterson, B. Bennet, J. Culpepper, W. Dang, G. Zurawski, and J. E. de Vries. 1993. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes: comparison with IL-4 and modulation by IFN-γ or IL-10. J. Immunol. 151:1.
7. Sozzani, P., C. Cambon, N. Vita, M. H. Seguelas, D. Caput, P. Ferrara, and B. Pipy. 1995. Interleukin-13 inhibits protein kinase C-triggered respiratory burst in human monocytes: role of calcium and cyclic AMP. J. Biol. Chem. 270:5084.
8. Bogdan, C., H. Thuring, M. Dlaska, M. Rollinghoff, and G. Weiss. 1997. Mechanism of suppression of macrophage nitric oxide release by IL-13 influence of the macrophage population. J. Immunol. 159:4506.
9. Muchamuel, T., S. Menon, P. Pisacane, M. C. Howard, and D. A. Cockayne. 1997. IL-13 protects mice from lipopolysaccharide-induced lethal endotoxemia: correlation with down-modulation of TNF-α, IFN-γ, and IL-12 production J. Immunol. 158:2898.
10. Mulligan, M. S., R. L. Warner, J. L. Foreback, T. P. Shanley, and P. A. Ward. 1997. Protective effects of IL-4, IL-10, IL-12, and IL-13 in IgG immune complexinduced lung injury: role of endogenous IL-12. J. Immunol. 159:3483.
11. Callard, R. E., D. J. Matthews, and L. Hibbert. 1996. IL-4 and IL-13 receptors: are they one and the same? Immunol. Today 17:108.
12. Zurawski, S. M., F. Vega, B. Huyghe, and G. Zurawski. 1993. Receptors for interleukin-13 and interleukin-4 are complex and share a novel component that functions in signal transduction. EMBO J. 12:2663.
13. Welham, M. J., L. Learmonth, H. Bone, and J. Schrader. 1995. Interleukin-13 signal transduction in lymphohemopoietic cells: similarities and differences in signal transduction with interleukin-4 and insulin. J. Biol. Chem. 270:12286.
14. Obiri, N. I., T. Murata, W. Debinski, and R. K. Puri. 1997. Modulation of interleukin (IL)-13 binding and signaling by the γ chain of the IL-2 receptor. J. Biol. Chem. 272:20251.
15. Caput, D., P. Laurent, M. Kaghad, J. M. Lelias, S. Lefort, N. Vita, and P. Ferrara. 1996. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. J. Biol. Chem. 271:16921.
16. Wright, K., G. S. Ward, G. Kolios, and J. Westwick. 1997. Activation of phosphatidylinositol 3-kinase by interleukin-13: an inhibitory signal for inducible nitric-oxide synthase expression in epithelial cell line HT-29. J. Biol. Chem. 272:12626.
17. Baeuerle, P. A., and V. R. Baichwal. 1997. NF-κB as a frequent target for immunosuppressive and anti-inflammatory molecules. Adv. Immunol. 65:111.
18. Liu, Z.-G., H. Hsu, D. V. Goeddel, and M. Karin. 1996. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87:565.
19. Zhou, G., and M. T. Kuo. 1997. NF-κB-mediated induction of mdr1b expression by insulin in rat hepatoma cells. J. Biol. Chem. 272:15174.
20. Chaturvedi, M., A. Kumar, B. Darnay, G. B. N. Chainy, S. Agarwal, and B. B. Aggarwal B. B. 1997. Sanguinarine (pseudochelerythrine) Is a potent inhibitor of NF-κB activation. J. Biol. Chem. 272:30129.
21. Schreiber, E., P. Matthias, M. M. Muller, and W. Schaffner. 1989. Rapid detection of octamer binding proteins with 'mini-extracts,' prepared from a small number of cells. Nucleic Acids Res. 17:6419.
22. Aarden, L. A., E. R. De Groot, O. L. Schaap, and P. M. Lansdorp. 1987. Production of hybridoma growth factor by human monocytes. Eur. J Immunol. 17:1411.
23. Sanceau, J., T. Kaisho, T. Hirano, and J. Wietzerbin. 1995. Triggering of the human interleukin-6 gene by interferon-γ and tumor necrosis factor-γ in monocytic cells involves cooperation between interferon regulatory factor-1. NpκB, and Sp1 transcription factors. J. Biol. Chem. 270:27920.
24. Cowley, S., H. Paterson, P. Kemp, and C. J. Marshall. 1994. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841.
25. Haridas, V., B. Damay, K. Natarajan, R. Heller, and B. B. Aggarwal. 1998. Overexpression of the p80 form of the TNF receptor induces apoptosis, NF-κB activation and c-Jun kinase activation: comparison with the endogenous receptor. J. Immunol. 160:3152.
26. Sambrook, J., E. E. Fritch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual, 2nd Ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
27. Chaturvedi, M. M., R. LaPushin, and B. B. Aggarwal. 1994. Tumor necrosis factor and lymphotoxin: qualitative and quantitative differences in the mediation of early and late cellular responses. J. Biol. Chem. 269:14575.
28. Brenner, D. A., M. O'Hara, P. Angel, M. Chojkier, and M. Karin. 1989. Prolonged activation of jun and collagenase genes by tumour necrosis factor-α. Nature 337:661.
29. 2 and antioxidants have opposite effects on activation of NF-κB and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J. 12:2005.
30. Minden, A., A. Lin, M. McMahon, C. Lange-Carter, B. Derijard, R. J. Davis, G. L. Johnson, and M. Karin. 1994. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266:1719.
31. Lee, F. S., J. Hagler, Z. J. Chen, and T. Maniatis. 1997. Activation of the IκBα kinase complex by MEKK1, a kinase of the JNK pathway. Cell 88:213.
32. Song, H. Y., C. H. Regnier, C. J. Kirschning, D. V. Goeddel, and M. Rothe. 1997. Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc. Natl. Acad. Sci. USA 94:9792.
33. Tewari, M., L. T. Quan, K. O'Rourke, S. Desnoyers, Z. Zeng, D. R. Beidler, G. G. Poirier, G. S. Salvesan, and V. M. Dixit. 1995. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81:801.
34. Montaner, L. J., A. G. Doyle, M. Collin, G. Herbein, P. Illei, W. James, A. Minty, D. Caput, P. Ferrara, and S. Gordon. 1993. Interleukin 13 inhibits human immunodeficiency virus type 1 production in primary blood-derived human macrophages in vitro. J. Exp. Med. 178:743.
35. Denis, M., and E. Ghadirian. 1994. Interleukin 13 and interleukin 4 protect bronchoalveolar macrophages from productive infection with human immunodeficiency virus type 1. AIDS Res. Hum. Retroviruses 10:795.
36. Stancovski, I., and D. Baltimore. 1997. NF-κB activation: the I κB kinase revealed? Cell 82:299.
37. Singh, S., and B. B. Aggarwal. 1995. Protein tyrosine phosphatase inhibitors block tumor necrosis factor-dependent activation of the nuclear transcription factor NF-κB. J. Biol. Chem. 270:10631.
38. Lee, S. Y., A. Reichlin, A. Santana, K. A. Sokol, M. C. Nussenzweig and Y. Choi. 1997. TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival. Immunity 7:703
39. Yeh, W.-C., A Shahinian, D. Speiser, J. Kraunus, F. Billia, A Wakeham, J. Luis de la Pompa, D. Ferrick, B. Hum, N. Iscove, P. Ohashi, M. Rothe, D. V. Goeddel and T. W. Mak. 1997. Early lethality, functional NF-κB activation, and increased sensitivity to TNF-induced cell death in TRAF2-defic,ent mice. Immunity 7:715.
40. Lomo, J., H. K. Blomhoff, S. E. Jacobsen, S. Krajewski, J. C. Reed, and E. B. Smeland. 1997. Interleukin-13 in combination with CD40 ligand potently inhibits apoptosis in human B lymphocytes: upregulation of Bcl-xL and Mcl-1. Blood 89:4415.
41. Chen, Y. R., W. Wang, A. N. T. Kong, and T.-H. Tan. 1998. Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinoeenic isothiocyanates. J. Biol. Chem. 273:1769.
42. Wang, C. Y., M. W. Mayo, and A. S. Baldwin, Jr. 1996. TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274:784.
43. Cai, Z. M. Korner, N. Tarantino, and S. Chouaib. 1997. IκB alpha overexpression in human breast carcinoma MCF7 cells inhibits nuclear factor-κB activation but not tumor necrosis factor-α-induced apoptosis. J. Biol. Chem. 272:96.
44. Grimm, S., M. K. Bauer, P. A. Baeuerle, and K. Osthoff. 1996. Bcl-2 down-regulates the activity of transcription factor NF-κB induced upon apoptosis. J. Cell. Biol. 134:13.
45. Sands, W. A., V. Bulut, A. Severn, D. Xu, and F. Y. Liew. 1994. Inhibition of nitric oxide synthesis by interleukin-4 may involve inhibiting the activation of protein kinase C epsilon. Eur. J. Immunol. 24:2345.
46. Debinski, W., N. I. Obiri, S. K. Powers, I. Pastan, and R. K. Puri. 1995. Human glioma cells overexpress receptors for interleukin-13 and are extremely sensitive to a novel chimeric protein composed of interleukin-13 and Pseudomonas exotoxin. Clin. Cancer Res. 1:1253.
47. Donnelly, R. P., L. J. Crofford, S. L. Freeman, J. Buras, E. Remmers, R. L. Wilder, and M. J. Fenton. 1993. Tissue-specific regulation of IL-6 production by 1L-4: differential effects of IL-4 on nuclear factor-κB activity in monocytes and fibroblasts. J. Immunol 151:5603.
48. Bennett, B. L., R. Cruz, R. G. Lacson, and A. M. Manning. 1997. Interleukin-4 suppression of tumor necrosis factor α-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-κB. J. Biol. Chem. 272:10212.
49. Pindolia, K. R., C. J. Noth, Y. X. Xu, N. Janakiraman, R. A. Chapman, and S. C. Gautam. 1996. IL-4 upregulates IL-1-induced chemokine gene expression in bone marrow stromal cells by enhancing NF-κB activation. Hematopathol. Mol. Hematol. 10:171.
50. Totpal, K. and B. B. Aggarwal. 1991. Interleukin-4 potentiates the anti-proliferative effects of tumor necrosis factor against different tumor cell lines. Cancer Res. 51:4266.