Adjuvant properties of a biocompatible thermo-responsive polymer of N-isopropylacrylamide in autoimmunity and arthritis

Journal of the Royal Society Interface

Volumn 8, Issue 65, 2011, Pages 1748-1759

  Shakya, Akhilesh Kumar ^a   Kumar, Ashok ^a   Nandakumar, Kutty Selva ^b  

^a INDIAN INSTITUTE OF TECHNOLOGY KANPUR   (India)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Arthritis; Autoimmunity; Biocompatibility; Collagen; Thermo responsive polymer

Indexed keywords

ACRYLIC MONOMERS; ADSORPTION; AMIDES; ANTIBODIES; ANTIGENS; BIOCOMPATIBILITY; BODY FLUIDS; CELL CULTURE; COLLAGEN; FREE RADICALS; IMMUNIZATION; MAMMALS; POLYMERS;

ANTIBODY RESPONSE; ARTHRITIS; AUTOIMMUNITY; IMMUNE CELLS; IMMUNOSTAINING; IN-VITRO; N-ISOPROPYLACRYLAMIDES; NATIVE CONFIGURATION; OVALBUMINS; PHYSICAL ADSORPTION; PNIPAAM; POLY-N-ISOPROPYL ACRYLAMIDE; THERMO-RESPONSIVE; THERMORESPONSIVE POLYMER; TYPE II;

FREE RADICAL POLYMERIZATION;

COLLAGEN TYPE 2; FREUND ADJUVANT; GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 4; OVALBUMIN; POLY(N ISOPROPYLACRYLAMIDE);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTHRITIS; ARTICLE; AUTOIMMUNITY; BIOCOMPATIBILITY; CELL INFILTRATION; IMMUNOCOMPETENT CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; POLYMERIZATION; SPLEEN CELL; SYNTHESIS;

EID: 80055005618     PISSN: 17425689     EISSN: 17425662     Source Type: Journal    
DOI: 10.1098/rsif.2011.0114     Document Type: Article

References (49)

1. Monach, P. A., Benoist, C. & Mathis, D. 2004 The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease. Adv. Immunol. 82, 217-248. (doi:10.1016/S0065-2776(04)82005-4)
2. Kannan, K., Ortmann, R. A. & Kimpel, D. 2005 Animal models of rheumatoid arthritis and their relevance to human disease. Pathophysiology 12, 167-181. (doi:10.1016/j.pathophys.2005.07.011)
3. Reed, S. G., Bertholet, S., Coler, R. N. & Friede, M. 2009 New horizons in adjuvants for vaccine development. Trends Immunol. 30, 23-32. (doi:10.1016/j.it.2008.09.006)
4. Wilson-Welder, J. H., Torres, M. P., Kipper, M. J., Mallapragada, S. K., Wannemuehler, M. J. & Narasimhan, B. 2009 Vaccine adjuvants: current challenges and future approaches. J. Pharm. Sci. 98, 1278-1316. (doi:10.1002/jps.21523)
5. Edelman, R. 2002 The development and use of vaccine adjuvants. Mol. Biotechnol. 21, 129-148. (doi:10.1385/ MB:21:2:129)
6. Galaev, I. Y. & Mattiasson, B. 1999 'Smart' polymers and what they could do in biotechnology and medicine. Trends Biotechnol. 17, 335-340. (doi:10.1016/S0167-7799(99)01345-1)
7. Jeong, B. & Gutowska, A. 2002 Lessons from nature: stimuli-responsive polymers and their biomedical applications. Trends Biotechnol. 20, 305-311. (doi:10.1016/ S0167-7799(02)01962-5)
8. Cooperstein, M. A. & Canavan, H. E. 2010 Biological cell detachment from poly(N-isopropyl acrylamide) and its applications. Langmuir 26, 7695-7707. (doi:10.1021/la902587p)
9. Kumar, A., Srivastava, A., Galaev, I. Y. & Mattiasson, B. 2007 Smart polymers: physical forms and bioengineering applications. Prog. Polym. Sci. 32, 1205-1237. (doi:10.1016/j.progpolymsci.2007.05.003)
10. Shin, B. C., Jhon, M. S., Lee, H. B. & Yuk, S. H. 1998 Temperature-induced phase transition of semi-interpenetrating polymer networks composed of poly(N-isopropyl acrylamide) and hydrophilic polymers. Eur. Polym. J. 34, 171-174. (doi:10.1016/S0014-3057(98)00025-1)
11. Grab, B., Miles, A. J., Furcht, L. T. & Fields, G. B. 1996 Promotion of fibroblast adhesion by triple-helical peptide models of type I collagen-derived sequences. J. Biol. Chem. 271, 12 234-12 240. (doi:10.1074/jbc.271.21.12234)
12. Mo, J. A., Bona, C. A. & Holmdahl, R. 1993 Variable region gene selection of immunoglobulin G-expressing B cells with specificity for a defined epitope on type II collagen. Eur. J. Immunol. 23, 2503-2510. (doi:10.1002/eji.1830231019)
13. Uysal, H. et al. 2009 Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J. Exp. Med. 206, 449-462. (doi:10.1084/jem.20081862)
14. Kumar, A., Kamihira, M., Galaev, I. Y., Mattiasson, B. & Iijima, S. 2001 Type-specific separation of animal cells in aqueous two-phase systems using antibody conjugates with temperature-sensitive polymers. Biotechnol. Bioeng. 75, 570-580. (doi:10.1002/bit.10080)
15. Shakya, A. K., Sharma, P. & Kumar, A. 2010 Synthesis and characterization of thermo-responsive poly(N-isopropylacrylamide)- bovine liver catalase bioconjugate. Enzyme Microb. Tech. 47, 277-282. (doi:10.1016/j.enz mictec.2010.07.018)
16. Mosmann, T. 1983 Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63. (doi:10. 1016/0022-1759(83)90303-4)
17. Holmdahl, R., Rubin, K., Klareskog, L., Larsson, E. & Wigzell, H. 1986 Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II collagen antibodies. Arthritis Rheum. 29, 400-410. (doi:10.1002/art.1780290314)
18. Morgado, M. G., Cam, P., Gris-Liebe, C., Cazenave, P. A. & Jouvin-Marche, E. 1989 Further evidence that BALB/c and C57BL/6 gamma 2a genes originate from two distinct isotypes. EMBO J. 8, 3245-3251. (Pubitemid 19273550)
19. Holmdahl, R., Carlsen, S., Mikulowska, A., Vestberg, M., Brunsberg, U., Hansson, A.-S., Sundvall, M., Jansson, L. & Pettersson, U. 1998 Genetic analysis of murine models for rheumatoid arthritis. In Human genome methods (ed. K.W. Adolpho), pp. 215-238. New York, NY: CRC Press.
20. Svensson, L., Jirholt, J., Holmdahl, R. & Jansson, L. 1998 B cell-deficient mice do not develop type II collageninduced arthritis (CIA). Clin. Exp. Immunol. 111, 521-526. (doi:10.1046/j.1365-2249.1998.00529.x)
21. Schild, H. G. 1992 Poly(N-isopropylacrylamide): experiment, theory and application. Prog. Polym. Sci. 17, 163-249. (doi:10.1016/0079-6700(92)90023-R)
22. Shakya, A. K., Sami, H., Srivastava, A. & Kumar, A. 2010 Stability of responsive polymer-protein bioconjugates. Prog. Polym. Sci. 35, 459-486. (doi:10.1016/j.progpolymsci. 2010.01.003)
23. Bettelli, E., Korn, T., Oukka, M. & Kuchroo, V. K. 2008 Induction and effector functions of T(H)17 cells. Nature 453, 1051-1057. (doi:10.1038/ nature07036)
24. HogenEsch, H. 2002 Mechanisms of stimulation of the immune response by aluminum adjuvants. Vaccine 20 (Suppl. 3), S34-S39. (doi:10.1016/S0264-410X(02) 00169-X)
25. Aimanianda, V., Haensler, J., Lacroix-Desmazes, S., Kaveri, S. V. & Bayry, J. 2009 Novel cellular and molecular mechanisms of induction of immune responses by aluminum adjuvants. Trends Pharmacol. Sci. 30, 287-295. (doi:10.1016/j.tips.2009.03.005)
26. Trentham, D. E., Townes, A. S. & Kang, A. H. 1977 Autoimmunity to type II collagen: an experimental model of arthritis. J. Exp. Med. 146, 857-868. (doi:10.1084/jem. 146.3.857)
27. Mauri, C., Williams, R. O., Walmsley, M. & Feldmann, M. 1996 Relationship between Th1/Th2 cytokine patterns and the arthritogenic response in collagen-induced arthritis. Eur. J. Immunol. 26, 1511-1518. (doi:10.1002/eji. 1830260716)
28. Brand, D. D., Kang, A. H. & Rosloniec, E. F. 2003 Immunopathogenesis of collagen arthritis. Springer Semin. Immunopathol. 25, 3-18. (doi:10.1007/s00281- 003-0127-1)
29. Doncarli, A., Stasiuk, L. M., Fournier, C. & Abehsira-Amar, O. 1997 Conversion in vivo from an early dominant Th0/Th1 response to a Th2 phenotype during the development of collagen-induced arthritis. Eur. J. Immunol. 27, 1451-1458. (doi:10.1002/eji.1830270623)
30. Svensson, L.,Nandakumar, K. S., Johansson,A., Jansson, L. & Holmdahl, R. 2002 IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis. Eur. J. Immunol. 32, 2944-2953. (doi:10.1002/1521- 4141(2002010)32:10,2944::AID-IMMU2944.3.0.CO;2-4)
31. Nandakumar, K. S. & Holmdahl, R. 2006 Arthritis induced with cartilage-specific antibodies is IL-4-dependent. Eur. J. Immunol. 36, 1608-1618. (doi:10.1002/eji.200535633)
32. Weaver, C. T., Hatton, R. D., Mangan, P. R. & Harrington, L. E. 2007 IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25, 821-852. (doi:10.1146/annurev.immunol. 25.022106.141557)
33. Ito, Y. et al. 2009 Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis. Arthritis Rheum. 60, 2294-2303. (doi:10.1002/art.24687)
34. Nellore, R. V., Pande, P. G., Young, D. & Bhagat, H. R. 1992 Evaluation of biodegradable microspheres as vaccine adjuvant for hepatitis B surface antigen. J. Parenter. Sci. Technol. 46, 176-180.
35. Eldridge, J. H., Staas, J. K., Meulbroek, J. A., Tice, T. R. & Gilley, R. M. 1991 Biodegradable and biocompatible poly(DL-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies. Infect. Immun. 59, 2978-2986.
36. Mutsumi, Y., Jessica, M. & Julia, E. B. 2007 Effect of poly(lactic-co-glycolic acid) contact on maturation of murine bone marrow-derived dendritic cells. J. Biomed. Mater. Res. A 80, 7-12.
37. Hartikka, J., Geall, A., Bozoukova, V., Kurniadi, D., Rusalov, D., Enas, J., Yi, J. H., Nanci, A. & Rolland, A. 2008 Physical characterization and in vivo evaluation of poloxamer-based DNA vaccine formulations. J. Gene Med. 10, 770-782. (doi:10.1002/jgm.1199)
38. Mutwiri, G., Benjamin, P., Soita, H., Townsend, H., Yost, R., Roberts, B., Andrianov, A. K. & Babiuk, L. 2007 Poly[di(sodium carboxylatoethylphenoxy)phosphazene] (PCEP) is a potent enhancer of mixed Th1/Th2 immune responses in mice immunized with influenza virus antigens. Vaccine 25, 1204-1213. (doi:10.1016/j.vaccine. 2006.10.011)
39. Kleine, B., Rapp, W., Wiesmuller, K. H., Edinger, M., Beck, W., Metzger, J., Ataulakhanov, R., Jung, GR.&Bessler,W. G. 1994 Lipopeptide- polyoxyethylene conjugates as mitogens and adjuvants. Immunobiology 190, 53-66. (Pubitemid 24124498)
40. Boonyo, W., Junginger, H. E., Waranuch, N., Polnok, A. & Pitaksuteepong, T. 2007 Chitosan and trimethyl chitosan chloride (TMC) as adjuvants for inducing immune responses to ovalbumin in mice following nasal administration. J. Control Release 121, 168-175. (doi:10.1016/j. jconrel.2007.05.025)
41. Eldridge, J. H., Staas, J. K., Meulbroek, J. A., McGhee, J. R., Tice, T. R. & Gilley, R. M. 1991 Biodegradable microspheres as a vaccine delivery system. Mol. Immunol. 28, 287-294. (doi:10.1016/0161-5890(91)90076-V)
42. Eyles, J. E., Carpenter, Z. C., Alpar, H. O. & Williamson, E. D. 2003 Immunological aspects of polymer microsphere vaccine delivery systems. J. Drug Target. 11, 509-514. (doi:10.1080/10611860410001670017)
43. Khaled, K. A., Sarhan, H. A., Ibrahim, M. A., Ali, A. H. & Naguib, Y. W. 2010 Prednisolone-loaded PLGA microspheres. In vitro characterization and in vivo application in adjuvant-induced arthritis in mice. AAPS PharmSci Tech 11, 859-869. (doi:10.1208/s12249-010-9445-5)
44. Sutterwala, F. S. et al. 2006 Critical role for NALP3/ CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24, 317-327. (doi:10.1016/j.immuni.2006.02.004)
45. Li, H., Nookala, S. & Re, F. 2007 Aluminum hydroxide adjuvants activate caspase-1 and induce IL-1beta and IL-18 release. J. Immunol. 178, 5271-5276. (Pubitemid 46595312)
46. Eisenbarth, S. C., Colegio, O. R., O'Connor, W., Sutterwala, F. S. & Flavell, R. A. 2008 Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 453, 1122-1126. (doi:10. 1038/nature06939)
47. Arend, W. P., Palmer, G. & Gabay, C. 2008 IL-1, IL-18, and IL-33 families of cytokines. Immunol. Rev. 223, 20-38. (doi:10.1111/j.1600-065X.2008. 00624.x)
48. Mullazehi, M., Mathsson, L., Lampa, J. & Ronnelid, J. 2006 Surface-bound anti-type II collagen-containing immune complexes induce production of tumor necrosis factor alpha, interleukin-1beta, and interleukin-8 from peripheral blood monocytes via Fc gamma receptor IIA: a potential pathophysiologic mechanism for humoral anti-type II collagen immunity in arthritis. Arthritis Rheum. 54, 1759-1771. (doi:10.1002/art.21892)
49. Kagari, T., Doi, H. & Shimozato, T. 2002 The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. J. Immunol. 169, 1459-1466. (Pubitemid 34809191)