Erythropoietin attenuates isoflurane-induced neurodegeneration and learning deficits in the developing mouse brain

Paediatric Anaesthesia

Volumn 21, Issue 12, 2011, Pages 1209-1213

  Tsuchimoto, Teppei ^a   Ueki, Masaaki ^a   Miki, Takanori ^b   Morishita, Jun ^a   Maekawa, Nobuhiro ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

Author keywords

developing brain; erythropoietin; isoflurane; learning disability; neurodegeneration

Indexed keywords

GLUCOSE; ISOFLURANE; RECOMBINANT ERYTHROPOIETIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL OXYGEN TENSION; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; DENTATE GYRUS; GLUCOSE BLOOD LEVEL; HISTOPATHOLOGY; LEARNING DISORDER; MAZE TEST; MOUSE; NERVE DEGENERATION; NISSL STAINING; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL;

AIR; ANALYSIS OF VARIANCE; ANESTHETICS, INHALATION; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BRAIN; DISEASE MODELS, ANIMAL; ERYTHROPOIETIN; ISOFLURANE; MAZE LEARNING; MICE; MICE, INBRED C57BL; NERVE DEGENERATION; SODIUM CHLORIDE;

EID: 80055001443     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/j.1460-9592.2011.03657.x     Document Type: Article

References (23)

1. Jevtovic-Todorovic V, Hartman R, Izumi Y, et al. Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 2003; 23: 876-882. (Pubitemid 36206178)
2. Sanders R, Xu J, Shu Y, et al. Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Anesthesiology 2009; 110: 1077-1085.
3. Yon JH, Daniel-Johnson J, Carter LB, et al. Anesthesia induces neuronal cell death in the developing rat brain via the intrinsic and extrinsic apoptotic pathways. Neuroscience 2005; 135: 815-827.
4. Lu LX, Yon JH, Carter LB, et al. General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain. Apoptosis 2006; 11: 1603-1615. (Pubitemid 44253677)
5. Ma D, Williamson P, Januszewski A, et al. Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain. Anesthesiology 2007; 106: 746-753. (Pubitemid 46555618)
6. Ikonomidou C, Bosch F, Miksa M, et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 1999; 283: 70-74. (Pubitemid 29044848)
7. Scallet A, Schmued LC, Slikker W, et al. Developmental neurotoxicity of ketamine: morphometric confirmation, exposure parameters, and multiple fluorescent labeling of apoptotic neurons. Toxicol Sci 2004; 81: 364-370. (Pubitemid 39377966)
8. Wang C, Sadovova N, Fu X, et al. The role of NMDA receptors in ketamine-induced apoptosis in rat forebrain culture. Neuroscience 2005; 132: 967-977. (Pubitemid 40602532)
9. Sanders RD, Ma D, Brooks P, et al. Balancing paediatric anaesthesia: preclinical insights into analgesia, hypnosis, neuroprotection, and neurotoxicity. Br J Anaesth 2008; 101: 597-609.
10. McGowan FX Jr, Davis PJ,. Anesthetic-related neurotoxicity in the developing infant: of mice, rats, monkeys and, possibly, humans. Anesth Analg 2008; 106: 1599-1602.
11. Wilder RT, Flick RP, Sprung J, et al. Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology 2009; 110: 796-804.
12. Sanders RD, Davidson A,. Anesthetic-induced neurotoxicity of the neonate: time for clinical guidelines? Pediatr Anesth 2009; 19: 1141-1146.
13. Zou X, Sadovova N, Patterson TA, et al. The effects of L-carnitine on the combination of inhalation anesthetic-induced developmental neuronal apoptosis in the rat frontal cortex. Neuroscience 2009; 151: 1053-1065.
14. Kumral A, Ozer E, Yilmaz O, et al. Neuroprotective effect of erythropoietin on hypoxic-ischemic brain injury in neonatal rats. Biol Neonate 2003; 83: 224-228. (Pubitemid 36351232)
15. Chang YS, Mu D, Wendland M, et al. Erythropoietin improves functional and histological outcome in neonatal stroke. Pediatr Res 2005; 58: 106-111. (Pubitemid 40967438)
16. Dzietko M, Felderhoff-Mueser U, Sifringer M, et al. Erythropoietin protects the developing brain against N-methyl-D-aspartate receptor antagonist neurotoxicity. Neurobiol Dis 2004; 15: 177-187. (Pubitemid 38296748)
17. Fredriksson AA, Archer TT,. Alpha-phenyl-tert-butyl-nitrone (PBN) reverses age-related maze learning performance and motor activity deficits in C57BL/6 mice. Behav Pharmacol 1996; 7: 245-253.
18. Loepke AW, Istaphanous GK, McAuliffe JJ 3rd,. The effects of neonatal isoflurane exposure in mice on brain cell viability, adult behavior, learning, and memory. Anesth Analg 2009; 108: 90-104.
19. Yu X, Shacka JJ, Eells JB, et al. Erythropoietin receptor signalling is required for normal brain development. Development 2002; 129: 505-516. (Pubitemid 34863815)
20. Brines ML, Ghezzi P, Keenan S, et al. Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci U S A 2000; 97: 10526-10531.
21. Head B, Patel H, Niesman I, et al. Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology 2009; 110: 813-825.
22. Zhao Y, Liang G, Chen Q, et al. Anesthetic-induced neurodegeneration mediated via inositol 1, 4, 5-trisphosphate receptors. J Pharmacol Exp Ther 2010; 333: 14-22.
23. Marrero MB, Venema RC, Ma H, et al. Erythropoietin receptor-operated Ca2+ channels: activation by phospholipase C-gamma 1. Kidney Int 1998; 53: 1259-1268. (Pubitemid 28316887)