Editorial: Anesthetic-induced neurotoxicity of the neonate: Time for clinical guidelines?

Paediatric Anaesthesia

Volumn 19, Issue 12, 2009, Pages 1141-1146

  Sanders, Robert D ^a   Davidson, Andrew ^b  

^a CHELSEA AND WESTMINSTER HOSPITAL   (United Kingdom)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ANESTHETIC AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; CARNITINE; DEXMEDETOMIDINE; DIAZEPAM; ERYTHROPOIETIN; ISOFLURANE; KETAMINE; LITHIUM; MELATONIN; MIDAZOLAM; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTROPHIN RECEPTOR P75; POTASSIUM CHLORIDE COTRANSPORTER; PROPOFOL; PROTEIN KINASE B; SEVOFLURANE; THIOPENTAL; TISSUE PLASMINOGEN ACTIVATOR; XENON;

ANESTHESIA COMPLICATION; APOPTOSIS; BRAIN DEVELOPMENT; EDITORIAL; ELECTIVE SURGERY; FOOD AND DRUG ADMINISTRATION; GENERAL ANESTHESIA; HEART ARREST; HUMAN; HYPERCAPNIA; MONKEY; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; PEDIATRIC ANESTHESIA; PRIORITY JOURNAL; RAT; RISK ASSESSMENT; RODENT; SYNAPTIC TRANSMISSION; THERAPY DELAY; AGE; ANIMAL; BRAIN; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; PRACTICE GUIDELINE; STANDARD; TOXICITY AND INTOXICATION;

AGE FACTORS; ANESTHETICS, GENERAL; ANIMALS; BRAIN; HUMANS; INFANT, NEWBORN; NEUROTOXICITY SYNDROMES; PRACTICE GUIDELINES AS TOPIC; SURGICAL PROCEDURES, ELECTIVE;

EID: 70450196055     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/j.1460-9592.2009.03141.x     Document Type: Editorial

References (36)

1. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research: Anesthetic and Life Support Drugs Advisory Committee Meeting Minutes March 29th 2007. Available at http://www.fda.gov/ohrms/dockets/ac/07/minutes/2007-4285m1-Final.pdf.
2. McGowan FX Jr., Davis PJ. Anesthetic-related neurotoxicity in the developing infant: of mice, rats, monkeys and, possibly, humans. Anesth Analg 2008 106 : 1599 1602.
3. Morray JP, Geiduschek JM, Ramamoorthy C et al. Anesthesia-related cardiac arrest in children: initial findings of the Pediatric Perioperative Cardiac Arrest (POCA) Registry. Anesthesiology 2000 93 : 6 14.
4. Bhananker SM, Ramamoorthy C, Geiduschek JM et al. Anesthesia-related cardiac arrest in children: update from the Pediatric Perioperative Cardiac Arrest Registry. Anesth Analg 2007 105 : 344 350.
5. Ikonomidou C, Bosch F, Miksa M et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 1999 283 : 70 74. (Pubitemid 29044848)
6. Sanders RD, Ma D, Brooks P et al. Balancing paediatric anaesthesia: preclinical insights into analgesia, hypnosis, neuroprotection, and neurotoxicity. Br J Anaesth 2008 101 : 597 609.
7. Mellon RD, Simone AF, Rappaport BA. Use of anesthetic agents in neonates and young children. Anesth Analg 2007 104 : 509 520.
8. Slikker W Jr., Zou X, Hotchkiss CE et al. Ketamine-induced neuronal cell death in the perinatal rhesus monkey. Toxicol Sci 2007 98 : 145 158.
9. Jevtovic-Todorovic V, Hartman RE, Izumi Y et al. Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits. J Neurosci 2003 23 : 876 882.
10. Satomoto M, Satoh Y, Terui K et al. Neonatal exposure to sevoflurane induces abnormal social behaviors and deficits in fear conditioning in mice. Anesthesiology 2009 110 : 628 637.
11. Cattano D, Young C, Straiko MM et al. Subanesthetic doses of propofol induce neuroapoptosis in the infant mouse brain. Anesth Analg 2008 106 : 1712 1714.
12. Young C, Jevtovic-Todorovic V, Qin YQ et al. Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain. Br J Pharmacol 2005 146 : 189 197.
13. Fredriksson A, Ponten E, Gordh T et al. Neonatal exposure to a combination of N-methyl-D-aspartate and gamma-aminobutyric acid type A receptor anesthetic agents potentiates apoptotic neurodegeneration and persistent behavioral deficits. Anesthesiology 2007 107 : 427 436.
14. Bittigau P, Sifringer M, Ikonomidou C. Antiepileptic drugs and apoptosis in the developing brain. Ann N Y Acad Sci 2003 993 : 103 114.
15. Ma D, Williamson P, Januszewski A et al. Xenon mitigates isoflurane-induced neuronal apoptosis in the developing rodent brain. Anesthesiology 2007 106 : 746 753.
16. Sanders RD, Xu J, Shu Y et al. Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Anesthesiology 2009 110 : 1077 1085.
17. Sanders RD, Xu J, Shu Y et al. General anesthetics induce apoptotic neurodegeneration in the neonatal rat spinal cord. Anesth Analg 2008 106 : 1708 1711.
18. Rivera C, Voipio J, Payne JA et al. The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation. Nature 1999 397 : 251 255.
19. Olney JW, Young C, Wozniak DF et al. Anesthesia-induced developmental neuroapoptosis. Does it happen in humans? Anesthesiology 2004 101 : 273 275.
20. Franks NP, Lieb WR. Molecular and cellular mechanisms of general anaesthesia. Nature 1994 367 : 607 614.
21. Head BP, Patel HH, Niesman IR et al. Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology 2009 110 : 813 825.
22. Patel P, Sun L. Update on neonatal anesthetic neurotoxicity: insight into molecular mechanisms and relevance to humans. Anesthesiology 2009 110 : 703 708.
23. Cattano D, Williamson P, Fukui K et al. Potential of xenon to induce or to protect against neuroapoptosis in the developing mouse brain. Can J Anaesth 2008 55 : 429 436.
24. Yon JH, Carter LB, Reiter RJ et al. Melatonin reduces the severity of anesthesia-induced apoptotic neurodegeneration in the developing rat brain. Neurobiol Dis 2006 21 : 522 530.
25. Straiko MM, Young C, Cattano D et al. Lithium protects against anesthesia-induced developmental neuroapoptosis. Anesthesiology 2009 110 : 862 868.
26. Zou X, Sadovova N, Patterson TA et al. The effects of L-carnitine on the combination of, inhalation anesthetic-induced developmental, neuronal apoptosis in the rat frontal cortex. Neuroscience 2008 151 : 1053 1065.
27. Dzietko M, Felderhoff-Mueser U, Sifringer M et al. Erythropoietin protects the developing brain against N-methyl-D-aspartate receptor antagonist neurotoxicity. Neurobiol Dis 2004 15 : 177 187.
28. Anand KJ, Sippell WG, Aynsley-Green A. Randomised trial of fentanyl anaesthesia in preterm babies undergoing surgery: effects on the stress response. Lancet 1987 1 : 62 66.
29. Stratmann G, May LD, Sall JW et al. Effect of hypercarbia and isoflurane on brain cell death and neurocognitive dysfunction in 7-day-old rats. Anesthesiology 2009 110 : 849 861.
30. Loepke AW, Soriano SG. An assessment of the effects of general anesthetics on developing brain structure and neurocognitive function. Anesth Analg 2008 106 : 1681 1707.
31. Wilder RT, Flick RP, Sprung J et al. Early exposure to anesthesia and learning disabilities in a population-based birth cohort. Anesthesiology 2009 110 : 796 804.
32. Moller JT, Cluitmans P, Rasmussen LS et al. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. Lancet 1998 351 : 857 861.
33. Kalkman CJ, Peelen L, Moons KG et al. Behavior and development in children and age at the time of first anesthetic exposure. Anesthesiology 2009 110 : 805 812.
34. Bartels M, Althoff RR, Boomsma DI. Anesthesia and cognitive performance in children: no evidence for a causal relationship. Twin Res Hum Genet 2009 12 : 246 253.
35. Di Maggio C, Sun LS, Kakavuoli A et al. A retrospective cohort study of the Association of Anesthesia and Hernia Repair Surgery with Behavioral and Developmental Disorders in Young Children. J Neurosurg Anesthesiol (in press).
36. Sprung J, Flick RP, Wilder RT et al. Anesthesia for cesarean delivery and learning disabilities in a population-based birth cohort. Anesthesiology 2009 111 : 302 310.