Serum levels of IGF-I and BRCA penetrance: A case control study in breast cancer families

Familial Cancer

Volumn 10, Issue 3, 2011, Pages 521-528

  Pasanisi, Patrizia ^a   Bruno, Eleonora ^a   Venturelli, Elisabetta ^a   Manoukian, Siranoush ^a   Barile, Monica ^b   Peissel, Bernard ^a   De Giacomi, Clelia ^c   Bonanni, Bernardo ^b   Berrino, Jacopo ^a   Berrino, Franco ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

Author keywords

BRCA genes; Breast cancer; IGF I; Penetrance; Primary prevention

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; GONADORELIN DERIVATIVE; SOMATOMEDIN C; TAMOXIFEN;

ADULT; BREAST CANCER; CANCER RISK; CANCER SUSCEPTIBILITY; CASE CONTROL STUDY; CONFERENCE PAPER; CONTROLLED STUDY; FAMILIAL CANCER; FEMALE; GENE MUTATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; PENETRANCE; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL;

ADOLESCENT; ADULT; AGED; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; INSULIN-LIKE GROWTH FACTOR I; MIDDLE AGED; MUTATION; ODDS RATIO; PENETRANCE; POSTMENOPAUSE; PROGNOSIS; PROSPECTIVE STUDIES; RISK FACTORS; YOUNG ADULT;

EID: 80054980132     PISSN: 13899600     EISSN: 15737292     Source Type: Journal    
DOI: 10.1007/s10689-011-9437-y     Document Type: Conference Paper

References (71)

1. Endogenous Hormones and Breast Cancer Collaborative Group 2010 Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies Lancet Oncol 11 530 542 10.1016/S1470-2045(10)70095-4
2. Campagnoli C, Pasanisi P, Peris C, Berrino F (2008) Insulin-like growth factor-I and breast cancer: epidemiological and clinical data. In: Pasqualini JR (ed) Breast cancer: prognosis, treatment and prevention 2nd Edn. Paris: INFORMA-Healthcare. New York, London
3. Dickson R (1996) Biochemical control of breast development. In: Harris JR, Lippman ME, Morrow M, Hellman S (eds) Diseases of the breast. Lippincott-Raven, Philadelphia
4. CE Stewart P Rotwein 1996 Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors Physiol Rev 76 1005 1026 8874492 1:CAS:528:DyaK28XntVSjtL4%3D (Pubitemid 26346814)
5. JS Oh JE Kucab PR Bushel, et al. 2002 Insulin-like growth factor-1 inscribes a gene expression profile for angiogenic factors and cancer progression in breast epithelial cells Neoplasia 4 204 217 11988840 10.1038/sj.neo.7900229 1:CAS:528:DC%2BD38XksFGnu7w%3D (Pubitemid 34525252)
6. RC Baxter AJ Butt LJ Schedlich, et al. 2000 Antiproliferative and pro-apoptotic activities of insulin-like growth factor-binding protein-3 Growth Horm IGF Res 10 (Suppl A) S10 S11 10984273 10.1016/S1096-6374(00)90004-2 (Pubitemid 30641915)
7. CA Conover 1996 Regulation and physiological role of insulin-like growth factor binding proteins Endocr J 43 Suppl S43 S48 9076341 10.1507/endocrj.43. Suppl-S43 1:CAS:528:DyaK2sXhtVSnurc%3D
8. R Kaaks 1996 Nutrition, hormones, and breast cancer: is insulin the missing link? Cancer Causes Control 7 605 625 8932921 10.1007/BF00051703 1:STN:280:DyaK2s%2Fos1yqsA%3D%3D (Pubitemid 26377730)
9. AH Eliassen SA Missmer SS Tworoger, et al. 2006 Endogenous steroid hormone concentrations and risk of breast cancer among premenopausal women J Natl Cancer Inst 98 1406 1415 17018787 10.1093/jnci/djj376 1:CAS:528: DC%2BD28XhtVOmurjL (Pubitemid 44530717)
10. R Kaaks S Rinaldi TJ Key, et al. 2005 Postmenopausal serum androgens, oestrogens and breast cancer risk: the European prospective investigation into cancer and nutrition Endocr Relat Cancer 12 1071 1082 16322344 10.1677/erc.1.01038 1:CAS:528:DC%2BD28XnvVyhsA%3D%3D (Pubitemid 41815798)
11. R Kaaks F Berrino T Key, et al. 2005 Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) J Natl Cancer Inst 97 755 765 15900045 10.1093/jnci/dji132 1:CAS:528:DC%2BD2MXksVSjsbk%3D (Pubitemid 40879595)
12. T Key P Appleby I Barnes, et al. 2002 Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies J Natl Cancer Inst 94 606 616 11959894 1:CAS:528:DC%2BD38Xjs1eit7w%3D (Pubitemid 34498648)
13. A Micheli P Muti G Secreto, et al. 2004 Endogenous sex hormones and subsequent breast cancer in premenopausal women Int J Cancer 112 312 318 15352045 10.1002/ijc.20403 1:CAS:528:DC%2BD2cXnvVejsb8%3D (Pubitemid 39244371)
14. A Lautenbach A Budde CD Wrann, et al. 2009 Obesity and the associated mediators leptin, estrogen and IGF-I enhance the cell proliferation and early tumorigenesis of breast cancer cells Nutr Cancer 61 484 491 19838920 10.1080/01635580802610115 1:CAS:528:DC%2BD1MXhtVGrtbbE
15. FP Liebens B Carly A Pastijn, et al. 2007 Management of BRCA1/2 associated breast cancer: a systematic qualitative review of the state of knowledge in 2006 Eur J Cancer 43 238 257 17095205 10.1016/j.ejca.2006.07.019 1:CAS:528:DC%2BD2sXpvVKkuw%3D%3D (Pubitemid 46123983)
16. The Breast Cancer Linkage Consortium (1999) Cancer risks in BRCA2 mutation carriers. J Natl Cancer Inst 91:1310-1316
17. MS Brose TR Rebbeck KA Calzone, et al. 2002 Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program J Natl Cancer Inst 94 1365 1372 12237282 1:CAS:528:DC%2BD38Xnt1Gnurg%3D (Pubitemid 35154141)
18. DF Easton DT Bishop D Ford, et al. 1993 Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium Am J Hum Genet 52 678 701 8460634 1:CAS:528: DyaK2cXhtVemurs%3D (Pubitemid 23310135)
19. D Ford DF Easton M Stratton, et al. 1998 Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium Am J Hum Genet 62 676 689 9497246 10.1086/301749 1:CAS:528:DyaK1MXlvFeh (Pubitemid 28164626)
20. S Narod D Ford P Devilee, et al. 1995 Genetic heterogeneity of breast-ovarian cancer revisited. Breast Cancer Linkage Consortium Am J Hum Genet 57 957 958 7573057 1:STN:280:DyaK28%2FivFaqsg%3D%3D
21. Prevalence and penetrance of BRCA1 and BRCA2 mutations in a population-based series of breast cancer cases (2000) Anglian Breast Cancer Study Group. Br J Cancer 83:1301-1308
22. V Bonadona OM Sinilnikova S Chopin, et al. 2005 Contribution of BRCA1 and BRCA2 germ-line mutations to the incidence of breast cancer in young women: results from a prospective population-based study in France Genes Chromosomes Cancer 43 404 413 15887246 10.1002/gcc.20199 1:CAS:528:DC%2BD2MXlvFCku78%3D (Pubitemid 40946475)
23. JL Hopper MC Southey GS Dite, et al. 1999 Population-based estimate of the average age-specific cumulative risk of breast cancer for a defined set of protein-truncating mutations in BRCA1 and BRCA2. Australian Breast Cancer Family Study Cancer Epidemiol Biomarkers Prev 8 741 747 10498392 1:CAS:528: DyaK1MXmsFGktL4%3D (Pubitemid 29445010)
24. N Loman A Bladstrom O Johannsson, et al. 2003 Cancer incidence in relatives of a population-based set of cases of early-onset breast cancer with a known BRCA1 and BRCA2 mutation status Breast Cancer Res 5 R175 R186 14580253 10.1186/bcr632
25. J Peto N Collins R Barfoot, et al. 1999 Prevalence of BRCA1 and BRCA2 gene mutations in patients with early-onset breast cancer J Natl Cancer Inst 91 943 949 10359546 10.1093/jnci/91.11.943 1:CAS:528:DyaK1MXjvFOmtb4%3D (Pubitemid 29272520)
26. HA Risch JR McLaughlin DE Cole, et al. 2006 Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada J Natl Cancer Inst 98 1694 1706 17148771 10.1093/jnci/djj465 1:CAS:528:DC%2BD28XhtlCru7nJ (Pubitemid 44942707)
27. S Thorlacius JP Struewing P Hartge, et al. 1998 Population-based study of risk of breast cancer in carriers of BRCA2 mutation Lancet 352 1337 1339 9802270 10.1016/S0140-6736(98)03300-5 1:STN:280:DyaK1M%2FhslamtA%3D%3D (Pubitemid 28510913)
28. A Nkondjock A Robidoux Y Paredes, et al. 2006 Diet, lifestyle and BRCA-related breast cancer risk among French-Canadians Breast Cancer Res Treat 98 285 294 16541324 10.1007/s10549-006-9161-8 1:STN:280:DC%2BD28nktF2qtQ%3D%3D (Pubitemid 44195598)
29. F Berrino P Pasanisi J Berrino, et al. 2002 A European case-only study on familial breast cancer IARC Sci Publ 156 63 65 12484126 1:STN:280: DC%2BD38jit1eqsQ%3D%3D
30. P Pasanisi J Berrino E Fusconi, et al. 2005 A European Case-Only Study (COS) on familial breast cancer J Nutr 135 3040S 3041S
31. P Pasanisi G Hedelin J Berrino, et al. 2009 Oral contraceptive use and BRCA penetrance: a case-only study Cancer Epidemiol Biomarkers Prev 18 2107 2113 19549808 10.1158/1055-9965.EPI-09-0024 1:CAS:528:DC%2BD1MXosFWjs7w%3D
32. C Hoppe TR Udam L Lauritzen, et al. 2004 Animal protein intake, serum insulin-like growth factor I, and growth in healthy 2.5-year-old Danish children Am J Clin Nutr 80 447 452 15277169 1:CAS:528:DC%2BD2cXmtFKis7g%3D
33. C Hoppe C Molgaard A Vaag, et al. 2005 High intakes of milk, but not meat, increase s-insulin and insulin resistance in 8-year-old boys Eur J Clin Nutr 59 393 398 15578035 10.1038/sj.ejcn.1602086 1:CAS:528:DC%2BD2MXhslWqsrw%3D (Pubitemid 40403293)
34. T Norat L Dossus S Rinaldi, et al. 2007 Diet, serum insulin-like growth factor-I and IGF-binding protein-3 in European women Eur J Clin Nutr 61 91 98 16900085 10.1038/sj.ejcn.1602494 1:CAS:528:DC%2BD28Xht12ktbbM (Pubitemid 44921120)
35. MD Holmes MN Pollak WC Willett, et al. 2002 Dietary correlates of plasma insulin-like growth factor I and insulin-like growth factor binding protein 3 concentrations Cancer Epidemiol Biomarkers Prev 11 852 861 12223429 1:CAS:528:DC%2BD38XnvVSksbc%3D (Pubitemid 35014888)
36. S Maor MZ Papa RI Yarden, et al. 2007 Insulin-like growth factor-I controls BRCA1 gene expression through activation of transcription factor Sp1 Horm Metab Res 39 179 185 17373631 10.1055/s-2007-970415 1:CAS:528: DC%2BD2sXltVamtrs%3D (Pubitemid 46580615)
37. S Maor A Yosepovich MZ Papa, et al. 2007 Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutation Cancer Lett 257 236 243 17766039 10.1016/j.canlet.2007.07.019 1:CAS:528:DC%2BD2sXhtFGkt7bN (Pubitemid 47538827)
38. G Hudelist T Wagner M Rosner, et al. 2007 Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations Endocr Relat Cancer 14 1053 1062 18045956 10.1677/ERC-06-0075 1:CAS:528:DC%2BD1cXivFagurw%3D (Pubitemid 351252436)
39. DA Berry G Parmigiani J Sanchez, et al. 1997 Probability of carrying a mutation of breast-ovarian cancer gene BRCA1 based on family history J Natl Cancer Inst 89 227 238 9017003 10.1093/jnci/89.3.227 1:CAS:528: DyaK2sXhtlGktrs%3D (Pubitemid 27073760)
40. G Parmigiani D Berry O Aguilar 1998 Determining carrier probabilities for breast cancer-susceptibility genes BRCA1 and BRCA2 Am J Hum Genet 62 145 158 9443863 10.1086/301670 1:CAS:528:DyaK1cXhsVGrsrc%3D (Pubitemid 28093844)
41. R Capocaccia A Verdecchia A Micheli, et al. 1990 Breast cancer incidence and prevalence estimated from survival and mortality Cancer Causes Control 1 23 29 2102272 10.1007/BF00053180 1:STN:280:DyaK3MzjvVelsA%3D%3D
42. A Antoniou PD Pharoah S Narod, et al. 2003 Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case Series unselected for family history: a combined analysis of 22 studies Am J Hum Genet 72 1117 1130 12677558 10.1086/375033 1:CAS:528:DC%2BD3sXjslagtbg%3D (Pubitemid 36530000)
43. J Chang-Claude H Becher N Eby, et al. 1997 Modifying effect of reproductive risk factors on the age at onset of breast cancer for German BRCA1 mutation carriers J Cancer Res Clin Oncol 123 272 279 9201250 1:STN:280:DyaK2szksVyrsQ%3D%3D (Pubitemid 27230903)
44. SA Narod D Goldgar L Cannon-Albright, et al. 1995 Risk modifiers in carriers of BRCA1 mutations Int J Cancer 64 394 398 8550241 10.1002/ijc. 2910640608 1:STN:280:DyaK287ksVOqtw%3D%3D (Pubitemid 26051675)
45. SA Narod 2006 Modifiers of risk of hereditary breast cancer Oncogene 25 5832 5836 16998497 10.1038/sj.onc.1209870 1:CAS:528:DC%2BD28XhtVSgurvK (Pubitemid 44453438)
46. G De Angelis R De Angelis L Frova, et al. 1994 MIAMOD: a computer package to estimate chronic disease morbidity using mortality and survival data Comput Methods Programs Biomed 44 99 107 7988122 10.1016/0169-2607(94)90091-4 (Pubitemid 24281294)
47. A Verdecchia R Capocaccia V Egidi, et al. 1989 A method for the estimation of chronic disease morbidity and trends from mortality data Stat Med 8 201 216 2784863 10.1002/sim.4780080207 1:STN:280:DyaL1M3gtlSnsg%3D%3D (Pubitemid 19064812)
48. H Roudgari ZH Miedzybrodzka NE Haites 2008 Probability estimation models for prediction of BRCA1 and BRCA2 mutation carriers: COS compares favourably with other models Fam Cancer 7 199 212 18097771 10.1007/s10689-007-9176-2 1:CAS:528:DC%2BD1cXptVKksbk%3D
49. A Decensi S Gandini D Serrano, et al. 2007 Randomized dose-ranging trial of tamoxifen at low doses in hormone replacement therapy users J Clin Oncol 25 4201 4209 17709798 10.1200/JCO.2006.09.4318 1:CAS:528:DC%2BD2sXhtFyis7vJ (Pubitemid 47548559)
50. H Jernstrom T Sandberg E Bageman, et al. 2005 Insulin-like growth factor-1 (IGF1) genotype predicts breast volume after pregnancy and hormonal contraception and is associated with circulating IGF-1 levels: implications for risk of early-onset breast cancer in young women from hereditary breast cancer families Br J Cancer 92 857 866 15756256 10.1038/sj.bjc.6602389 1:STN:280:DC%2BD2M7isVKgtA%3D%3D (Pubitemid 40462630)
51. CM Phelan TR Rebbeck BL Weber, et al. 1996 Ovarian cancer risk in BRCA1 carriers is modified by the HRAS1 variable number of tandem repeat (VNTR) locus Nat Genet 12 309 311 8589723 10.1038/ng0396-309 1:CAS:528:DyaK28XhvVSgtb4%3D (Pubitemid 26080091)
52. TR Rebbeck PW Kantoff K Krithivas, et al. 1999 Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat Am J Hum Genet 64 1371 1377 10205268 10.1086/302366 1:CAS:528: DyaK1MXlt1ajt78%3D (Pubitemid 30468755)
53. IB Runnebaum S Wang-Gohrke D Vesprini, et al. 2001 Progesterone receptor variant increases ovarian cancer risk in BRCA1 and BRCA2 mutation carriers who were never exposed to oral contraceptives Pharmacogenetics 11 635 638 11668223 10.1097/00008571-200110000-00010 1:CAS:528:DC%2BD3MXotFWltLg%3D (Pubitemid 32953589)
54. P Pasanisi E Venturelli D Morelli, et al. 2008 Serum insulin-like growth factor-I and platelet-derived growth factor as biomarkers of breast cancer prognosis Cancer Epidemiol Biomarkers Prev 17 1719 1722 18628423 10.1158/1055-9965.EPI-07-0654 1:CAS:528:DC%2BD1cXosFGhsbg%3D
55. R Kurek UW Tunn O Eckart, et al. 2000 The significance of serum levels of insulin-like growth factor-1 in patients with prostate cancer BJU Int 85 125 129 10619960 10.1046/j.1464-410x.2000.00350.x 1:CAS:528:DC%2BD3cXptVKrsQ%3D%3D (Pubitemid 30072463)
56. J Muller A Juul AM Andersson, et al. 2000 Hormonal changes during GnRH analogue therapy in children with central precocious puberty J Pediatr Endocrinol Metab 13 Suppl 1 739 1746 10969916 10.1515/JPEM.2000.13.S1.739
57. S Chen ES Iversen T Friebel, et al. 2006 Characterization of BRCA1 and BRCA2 mutations in a large United States sample J Clin Oncol 24 863 871 16484695 10.1200/JCO.2005.03.6772 1:CAS:528:DC%2BD28Xitl2qtrg%3D (Pubitemid 46638837)
58. Jatoi I, Anderson WF (2008) Management of women who have a genetic predisposition for breast cancer. Surg Clin North Am 88:845-861
59. DH Roukos E Briasoulis 2007 Individualized preventive and therapeutic management of hereditary breast ovarian cancer syndrome Nat Clin Pract Oncol 4 578 590 17898808 10.1038/ncponc0930 1:CAS:528:DC%2BD2sXhtV2isb7N (Pubitemid 47534757)
60. J Gronwald N Tung WD Foulkes, et al. 2006 Tamoxifen and contralateral breast cancer in BRCA1 and BRCA2 carriers: an update Int J Cancer 118 2281 2284 16331614 10.1002/ijc.21536 1:CAS:528:DC%2BD28XjsVCgt7Y%3D
61. KW Reding JL Bernstein BM Langholz, et al. 2010 Adjuvant systemic therapy for breast cancer in BRCA1/BRCA2 mutation carriers in a population-based study of risk of contralateral breast cancer Breast Cancer Res Treat 23 491 498 10.1007/s10549-010-0769-3
62. J Kotsopoulos SA Narod 2005 Towards a dietary prevention of hereditary breast cancer Cancer Causes Control 16 125 138 15868454 10.1007/s10552-004-2593- 8 (Pubitemid 40691208)
63. A Nkondjock A Robidoux Y Paredes, et al. 2006 Diet, lifestyle and BRCA-related breast cancer risk among French-Canadians Breast Cancer Res Treat 98 2852 2894 10.1007/s10549-006-9161-8 (Pubitemid 44195598)
64. MC King JH Marks JB Mandell 2003 Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2 Science 302 643 646 14576434 10.1126/science.1088759 1:CAS:528:DC%2BD3sXotlWqt7Y%3D (Pubitemid 37310920)
65. F Berrino A Villarini M De Petris, et al. 2006 Adjuvant diet to improve hormonal and metabolic factors affecting breast cancer prognosis Ann N Y Acad Sci 1089 110 118 17261760 10.1196/annals.1386.023 1:CAS:528:DC%2BD2sXhsFertLw%3D (Pubitemid 47092078)
66. L Fontana S Klein JO Holloszy 2006 Long-term low-protein, low-calorie diet and endurance exercise modulate metabolic factors associated with cancer risk Am J Clin Nutr 84 1456 1462 17158430 1:CAS:528:DC%2BD28XhtlGrurnO (Pubitemid 44912831)
67. ML Irwin K Varma M Alvarez-Reeves, et al. 2009 Randomized controlled trial of aerobic exercise on insulin and insulin-like growth factors in breast cancer survivors: the Yale Exercise and Survivorship study Cancer Epidemiol Biomarkers Prev 18 306 313 19124513 10.1158/1055-9965.EPI-08-0531 1:CAS:528:DC%2BD1MXhvFCjsg%3D%3D
68. F Berrino C Bellati G Secreto, et al. 2001 Reducing bioavailable sex hormones through a comprehensive change in diet: the diet and androgens (DIANA) randomized trial Cancer Epidemiol Biomarkers Prev 10 25 33 11205485 1:STN:280:DC%2BD3M7nvVyjsg%3D%3D (Pubitemid 32106041)
69. F Berrino P Pasanisi C Bellati, et al. 2005 Serum testosterone levels and breast cancer recurrence Int J Cancer 113 499 502 15455345 10.1002/ijc.20582 1:CAS:528:DC%2BD2MXhsFar (Pubitemid 40038721)
70. R Kaaks C Bellati E Venturelli, et al. 2003 Effects of dietary intervention on IGF-I and IGF-binding proteins, and related alterations in sex steroid metabolism: the Diet and Androgens (DIANA) Randomised Trial Eur J Clin Nutr 57 1079 1088 12947426 10.1038/sj.ejcn.1601647 1:CAS:528: DC%2BD3sXmslemtb8%3D (Pubitemid 37121004)
71. P Pasanisi F Berrino M De Petris, et al. 2006 Metabolic syndrome as a prognostic factor for breast cancer recurrences Int J Cancer 119 236 238 16450399 10.1002/ijc.21812 1:CAS:528:DC%2BD28Xkslyisr8%3D