Progesterone receptor variant increases ovarian cancer risk in BRCA1 and BRCA2 mutation carriers who were never exposed to oral contraceptives

Pharmacogenetics

Volumn 11, Issue 7, 2001, Pages 635-638

  Runnebaum, I B ^a   Wang Gohrke, S ^a   Vesprini, D ^a   Kreienberg, R ^a   Lynch, H ^a   Moslehi, R ^a   Ghadirian, P ^a   Weber, B ^a   Godwin, A K ^a   Risch, H ^a   Garber, J ^a   Lerman, C ^a   Olopade, O I ^a   Foulkes, W D ^a   Karlan, B ^a   Warner, E ^a   Rosen, B ^a   Rebbeck, T ^a   Tonin, P ^a   Dube M P ^a   Kieback, D G ^a   Narod, S A ^a   more..

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Hereditary breast cancer; Hereditary ovarian cancer; Oral contraception; Progesterone receptor

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; ORAL CONTRACEPTIVE AGENT; PROGESTERONE RECEPTOR;

ADULT; ALLELE; ALU SEQUENCE; ARTICLE; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; DISEASE ACTIVITY; DRUG EXPOSURE; DRUG USE; EXON; FEMALE; GENE MUTATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; HETEROZYGOTE; HUMAN; INTRON; MAJOR CLINICAL STUDY; ORAL CONTRACEPTION; OVARY CANCER; PRIORITY JOURNAL;

ADULT; ALLELES; BREAST NEOPLASMS; CONTRACEPTIVES, ORAL; FEMALE; GENES, BRCA1; GENES, BRCA2; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HETEROZYGOTE DETECTION; HUMANS; MIDDLE AGED; OVARIAN NEOPLASMS; RECEPTORS, PROGESTERONE; RISK FACTORS;

EID: 0034791490     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200110000-00010     Document Type: Article

References (8)

1. A genetic mutation in the progesterone receptor (PROGINS) leads to an increased risk of non-familial breast and ovarian cancer causing inadequate control of estrogen receptor driven proliferation
2. Oral contraceptives and the risk of hereditary ovarian cancer
3. Ovarian cancer risk in BRCA1 carriers is modified by the HRAS1 variable number of tandem repeat (VNTR) locus
4. Modification of BRCA1-associated breast cancer risk by the polymorphic androgen-receptor CAG repeat
5. Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone
6. A case-control study of oral contraceptive use and invasive epithelial ovarian cancer
7. Ovarian carcinoma-associated TaqI restriction fragment length polymorphism in intron G of the progesterone receptor gene is due to an Alu sequence insertion
8. Progesterone receptor gene polymorphism is associated with decreased risk for breast cancer by age 50