Protein kinase B (Akt) and mitogen-activated protein kinase p38α in retinal ischemic post-conditioning

Journal of Molecular Neuroscience

Volumn 45, Issue 2, 2011, Pages 309-320

  Dreixler, John C ^a   Sampat, Ajay ^b   Shaikh, Afzhal R ^a   Alexander, Michael ^a   Marcet, Marcus M ^a   Roth, Steven ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Akt; p38; Post conditioning; Retinal ischemia

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 14; PROTEIN KINASE B; PROTEIN KINASE B 1; PROTEIN KINASE B 2; PROTEIN KINASE B 3; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; GENE SILENCING; HISTOPATHOLOGY; IN VIVO STUDY; ISCHEMIC POSTCONDITIONING; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; REPERFUSION; RETINA CELL; RETINA ISCHEMIA; RNA SEQUENCE;

ANIMALS; BIOLOGICAL MARKERS; DUAL SPECIFICITY PHOSPHATASE 1; ELECTRORETINOGRAPHY; ISCHEMIC POSTCONDITIONING; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RETINA; RNA, SMALL INTERFERING;

RATTUS;

EID: 80054965106     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9523-5     Document Type: Article

References (36)

1. BV Bui B Edmunds GA Cioffi B Fortune 2005 The gradient of retinal functional changes during acute intraocular pressure elevation Invest Ophthalmol Vis Sci 46 202 213 15623775 10.1167/iovs.04-0421 (Pubitemid 40041199)
2. LR Coulthard DE White DL Jones MF McDermott SA Burchill 2009 p38(MAPK): stress responses from molecular mechanisms to therapeutics Trends Mol Med 15 369 379 19665431 10.1016/j.molmed.2009.06.005 1:CAS:528:DC%2BD1MXhtVehur%2FM
3. Y Dorsett T Tuschl 2004 siRNAs: applications in functional genomics and potential as therapeutics Nat Rev 3 318 329 10.1038/nrd1345 1:CAS:528: DC%2BD2cXis1Gkt74%3D (Pubitemid 38499759)
4. JC Dreixler AR Shaikh SK Shenoy Y Shen S Roth 2008 Protein kinase C subtypes and retinal ischemic preconditioning Exp Eye Res 87 300 311 18722601 10.1016/j.exer.2008.05.015 1:CAS:528:DC%2BD1cXhtFCgur7M
5. JC Dreixler FC Barone AR Shaikh E Du S Roth 2009 Mitogen-activated protein kinase p38alpha and retinal ischemic preconditioning Exp Eye Res 89 782 790 19631642 10.1016/j.exer.2009.07.006 1:CAS:528:DC%2BD1MXht1aisbrF
6. JC Dreixler S Hagevik JW Hemmert AR Shaikh DM Rosenbaum S Roth 2009 Involvement of erythropoietin in retinal ischemic preconditioning Anesthesiology 110 774 780 19322943 10.1097/ALN.0b013e31819c4601
7. JC Dreixler JW Hemmert SK Shenoy Y Shen HT Lee AR Shaikh DM Rosenbaum S Roth 2009 The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning Exp Eye Res 88 512 521 19084003 10.1016/j.exer.2008.11.013 1:CAS:528:DC%2BD1MXjt1Sksbo%3D
8. J Dreixler A Shaikh B Savoie M Alexander M Marcet S Roth 2010 Retinal ischemic postconditioning is not additive with ischemic preconditioning Exp Eye Res 91 844 852 20599964 10.1016/j.exer.2010.06.015 1:CAS:528:DC%2BC3cXhsV2jtrvM
9. Dreixler JC, Bratton A, Du E, Shaikh AR, Marcet MM, Roth S (2011) Mitogen activated protein kinase phosphatase-1 (MKP-1) in retinal ischemic preconditioning. Experimental Eye Research in press, doi: 10.1016/j.exer.2010. 10.011
10. N Faberowski E Stefansson RC Davidson 1989 Local hypothermia protects the retina from ischemia. A quantitative study in the rat Invest Ophthalmol Vis Sci 30 2309 2313 2807788 1:STN:280:DyaK3c%2FjsFyrug%3D%3D (Pubitemid 20004229)
11. KK Farh A Grimson C Jan BP Lewis WK Johnston LP Lim CB Burge DP Bartel 2005 The widespread impact of mammalian MicroRNAs on mRNA repression and evolution Science 310 1817 1821 16308420 10.1126/science.1121158 1:CAS:528:DC%2BD2MXhtlSntbzL (Pubitemid 41814382)
12. DC Fernandez MP Bordone MS Chianelli RE Rosenstein 2009 Retinal neuroprotection against ischemia-reperfusion damage induced by postconditioning Investig Ophthalmol Vis Sci 50 3922 3930 10.1167/iovs.08-3344
13. X Gao H Zhang T Takahashi J Hsieh J Liao GK Steinberg H Zhao 2008 The Akt signaling pathway contributes to postconditioning's protection against stroke; the protection is associated with the MAPK and PKC pathways J Neurochem 105 943 955 18182053 10.1111/j.1471-4159.2008.05218.x 1:CAS:528:DC%2BD1cXlsl2gsrY%3D (Pubitemid 351562746)
14. S Genc TF Koroglu K Genc 2004 RNA interference in neuroscience Mol Brain Res 132 260 270 15582163 10.1016/j.molbrainres.2004.02.004 1:CAS:528: DC%2BD2cXhtVCktLbF (Pubitemid 39586765)
15. CA Hazzalin LC Mahadevan 2001 MAPK-regulated transcription: a continuously variable gene switch Nat Rev 3 30 40 10.1038/nrm715 (Pubitemid 135709916)
16. AA Hirano JH Brandstatter A Vila NC Brecha 2007 Robust syntaxin-4 immunoreactivity in mammalian horizontal cell processes Vis Neurosci 24 489 502 17640443 10.1017/S0952523807070198 (Pubitemid 47509566)
17. V Hornung M Guenthner-Biller C Bourquin A Ablasser M Schlee S Uematsu A Noronha M Manoharan S Akira A de Fougerolles S Endres G Hartmann 2005 Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7 Nat Med 11 263 270 15723075 10.1038/nm1191 1:CAS:528:DC%2BD2MXhvVSru7o%3D (Pubitemid 40460553)
18. D Huesken J Lange C Mickanin J Weiler F Asselbergs J Warner B Meloon S Engel A Rosenberg D Cohen M Labow M Reinhardt F Natt J Hall 2005 Design of a genome-wide siRNA library using an artificial neural network Nat Biotechnol 23 995 1001 16025102 10.1038/nbt1118 1:CAS:528:DC%2BD2MXntVSrtrg%3D (Pubitemid 41114034)
19. C Jomary J Cullen SE Jones 2006 Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse Invest Ophthalmol Vis Sci 47 1620 1629 16565401 10.1167/iovs.05-1176 (Pubitemid 46780774)
20. AD Judge V Sood JR Shaw D Fang K McClintock I MacLachlan 2005 Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA Nat Biotechnol 23 457 462 15778705 10.1038/nbt1081 1:CAS:528:DC%2BD2MXivFOhtLk%3D (Pubitemid 41724921)
21. AK Junk A Mammis SI Savitz M Singh S Roth S Malhotra PS Rosenbaum A Cerami M Brines DM Rosenbaum 2002 Erythropoietin administration protects retinal neurons from acute ischemia-reperfusion injury Proc Natl Acad Sci USA 99 10659 10664 12130665 10.1073/pnas.152321399 1:CAS:528:DC%2BD38Xmt1ChsbY%3D
22. H Kamada C Nito H Endo PH Chan 2007 Bad as a converging signaling molecule between survival PI3-K/Akt and death JNK in neurons after transient focal cerebral ischemia in rats J Cereb Blood Flow Metab 27 521 533 16820799 10.1038/sj.jcbfm.9600367 1:CAS:528:DC%2BD2sXjtlKitb8%3D
23. M Kikuchi L Tenneti SA Lipton 2000 Role of p38 mitogen-activated protein kinase in axotomy-induced apoptosis of rat retinal ganglion cells J Neurosci 20 5037 5044 10864961 1:CAS:528:DC%2BD3cXksF2jt7o%3D (Pubitemid 30421707)
24. B Lehner AG Fraser CM Sanderson 2004 How to use RNA interference Brief Funct Genomics Proteomics 3 68 83 10.1093/bfgp/3.1.68 1:CAS:528: DC%2BD2cXlsFWitrk%3D
25. G Li RE Anderson H Tomita R Adler X Liu DJ Zack RVS Rajala 2007 Nonredundant role of Akt2 for neuroprotection of rod photoreceptor cells from light-induced cell death J Neurosci 27 203 211 17202487 10.1523/JNEUROSCI.0445- 06.2007 (Pubitemid 46091607)
26. BD Manning LC Cantley 2007 Akt/Pkb signaling: navigating downstream Cell 129 1261 1274 17604717 10.1016/j.cell.2007.06.009 1:CAS:528:DC%2BD2sXotV2hs7g%3D (Pubitemid 46962095)
27. CC Mello D Conte 2004 Revealing the world of RNA interference Nature 431 338 342 15372040 10.1038/nature02872 1:CAS:528:DC%2BD2cXnsFaiu7k%3D (Pubitemid 39265673)
28. T Nakazawa M Shimura S Endo H Takahashi N Mori M Tamai 2005 N-Methyl-D-aspartic acid suppresses Akt activity through protein phosphatase in retinal ganglion cells Mol Vis 11 1173 1182 16402025 1:CAS:528: DC%2BD28XitFelsrs%3D (Pubitemid 43020064)
29. S Roth B Li PS Rosenbaum H Gupta IM Goldstein KM Maxwell JM Gidday 1998 Preconditioning provides complete protection against retinal ischemic injury in rats Invest Ophthalmol Vis Sci 39 775 785
30. S Roth AR Shaikh MM Hennelly Q Li V Bindokas CE Graham 2003 Mitogen-activated protein kinases and retinal ischemia Invest Ophthalmol Vis Sci 44 5383 5395 14638742 10.1167/iovs.03-0451 (Pubitemid 37475414)
31. S Roth JC Dreixler AR Shaikh KH Lee V Bindokas 2006 Mitochondrial potassium ATP channels and retinal ischemic preconditioning Invest Ophthalmol Vis Sci 47 2114 2124 16639023 10.1167/iovs.05-1068 (Pubitemid 46768296)
32. T Scartabelli E Gerace E Landucci F Moroni DE Pellegrini-Giampietro 2008 Neuroprotection by group I mGlu receptors in a rat hippocampal slice model of cerebral ischemia is associated with the PI3K-Akt signaling pathway: a novel postconditioning strategy? Neuropharmacology 55 509 516 18606174 10.1016/j.neuropharm.2008.06.019 1:CAS:528:DC%2BD1cXhtVKisrbK
33. O Tschopp Z-Z Yang D Brodbeck BA Dummler M Hemmings-Mieszczak T Watanabe T Michaelis J Frahm BA Hemmings 2005 Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis Development 132 2943 2954 15930105 10.1242/dev.01864 1:CAS:528: DC%2BD2MXnvVWmtrs%3D (Pubitemid 41086730)
34. MR Verardo GP Lewis M Takeda KA Linberg J Byun G Luna U Wilhelmsson M Pekny D-F Chen SK Fisher 2008 Abnormal reactivity of Muller cells after retinal detachment in mice deficient in GFAP and vimentin Invest Ophthalmol Vis Sci 49 3659 3665 18469190 10.1167/iovs.07-1474
35. NA Whitlock N Agarwal J-X Ma CE Crosson 2005 Hsp27 upregulation by HIF-1 signaling offers protection against retinal ischemia in rats Invest Ophthalmol Vis Sci 46 1092 1098 15728570 10.1167/iovs.04-0043 (Pubitemid 41321050)
36. Y Zhu Y Zhang BA Ojwang MA Brantley Jr JM Gidday 2007 Long-term tolerance to retinal ischemia by repetitive hypoxic preconditioning: role of HIF-1alpha and heme oxygenase-1 Invest Ophthalmol Vis Sci 48 1735 1743 17389506 10.1167/iovs.06-1037 (Pubitemid 351261360)