Targeted mutation of the talpid3 gene in zebrafish revealsits conserved requirement for ciliogenesis and hedgehog signalling across the vertebrates

Development

Volumn 138, Issue 22, 2011, Pages 4969-4978

  Ben, Jin ^a   Elworthy, Stone ^b   Ng, Ashley Shu Mei ^a   van Eeden, Freek ^b   Ingham, Philip W ^a,b,c  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Ciliopathy; Cystic kidney; Gli2 processing; Hedgehog signalling; Primary cilium; Talpid3; Zebrafish

Indexed keywords

NUCLEASE; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI2; TRANSCRIPTION FACTOR NKX2.2; ZINC FINGER PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ECTOPIA LENTIS; EMBRYO; EMBRYO DEVELOPMENT; EUKARYOTIC FLAGELLUM; FIN (ORGAN); GENE; GENE ACTIVITY; GENE EXPRESSION; GENE FUNCTION; GENE MUTATION; HATCHING; HOMOZYGOTE; KIDNEY POLYCYSTIC DISEASE; KINETOSOME; LARVAL STAGE; MUTAGENESIS; NEURAL TUBE; NONHUMAN; NUCLEOTIDE SEQUENCE; NULL ALLELE; ORTHOLOGY; PHENOTYPE; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; SOMITE; TALPID3 GENE; VERTEBRATE; WESTERN BLOTTING; ZEBRA FISH; ZYGOTE;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BASE SEQUENCE; CHICKENS; CILIA; CONSERVED SEQUENCE; EMBRYO, NONMAMMALIAN; FEMALE; HEDGEHOG PROTEINS; MALE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; ORGANOGENESIS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; VERTEBRATES; ZEBRAFISH; ZEBRAFISH PROTEINS;

ANIMALIA; DANIO RERIO; ERINACEIDAE; VERTEBRATA;

EID: 80054962146     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.070862     Document Type: Article

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