Systemic chemical desensitization of peptidergic sensory neurons with resiniferatoxin inhibits experimental periodontitis

Open Dentistry Journal

Volumn 5, Issue 1, 2011, Pages 1-6

  Breivik, Torbjorn ^a,b   Gundersen, Yngvar ^b   Gjermo, Per ^a   Fristad, Inge ^c   Opstad, Per Kristian ^b  

^a UNIVERSITY OF OSLO   (Norway)

^b NORWEGIAN DEFENCE RESEARCH ESTABLISHMENT FFI   (Norway)

^c UNIVERSITY OF BERGEN   (Norway)

Author keywords

Cytokines; Glucocorticoids; Peptidergic nerves and neurons; Periodontitis; Resiniferatoxin

Indexed keywords

EID: 80054957054     PISSN: 18742106     EISSN: None     Source Type: Journal    
DOI: 10.2174/1874210601105010001     Document Type: Article

References (62)

1. Medzhitov R. Recognition of microorganisms and activation of the immune response. Nature 2007; 449: 819-26.
2. Berzci I, Chalmers I M, Nagy E, Warrington R J. Immune effects of neuropeptides. Baillière's Clin Rheumatol 1996; 10: 227-57.
3. Black PH. Stress and the inflammatory response: A review of neurogenic inflammation. Brain Behav Immun 2002; 16: 622-53.
4. Breivik T, Thrane PS, Murison R, Gjermo P. Emotional stress effects on immunity, gingivitis and periodontitis. Eur J Oral Sci 1996; 104: 327-34.
5. Straub RH, Westerman J, Schoelmerich J, Falk W. Dialog between the CNS and the immune system in lymphoid organs. Immunol Today 1998; 166: 232-13.
6. Eskandari F, Sternberg EM. Neural immune interaction in health and disease. Ann NY Acad Sci 2002; 966: 20-7.
7. Pavlov VA, Tracey KJ. Neural regulators of innate immune responses and inflammation. CMLS 2004; 61: 2322-31.
8. Andersson J. The inflammatory reflex--introduction. J Int Med 2005; 257: 122-5.
9. Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. The sympathetic nerve: an intergrative interface between two systems: the brain and the immune system. Pharmacol Rev 2000; 52: 595-638.
10. Czura CJ, Tracey KJ. Autonomic neural regulation of immunity. J Int Med 2005; 247: 156-66.
11. Korrow NA. Activation of the hypothalamic-pituitary-adrenal axis and the autonomic nervous system during inflammation and altered programming of the neuroendocrine-immune axis during fetal and neonatal development: Lessons learned from the model inflammagen, lipopolysaccharide. Brain Behav Immun 2006; 20: 144-58.
12. Nance DM, Sanders VM. Autonomic innervation and regulation of the immune system (1987-2007). Brain Behav Immun 2007; 21: 736-45.
13. Palm NW, Medzhitov R. Pattern recognition receptors and control of adaptive immunity. Immunol Rev 2009; 227: 221-33.
14. Elekes K, Helyes Z, Németh J, et al. Role of capsaisin-sensitive afferents and sensory neuropeptides in endotoxin-induced airway inflammation and consequent bronchial hyperactivity in the mouse. Reg Pept 2007; 141: 44-54.
15. Szallasi A, Blumberg PM. Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev 1999; 51: 159-212.
16. Wadachi R, Hargreaves KM. Trigeminal nociceptors express TLR-4 and CD14: a mechanism for pain due to infection. J Dent Res 2006; 85: 49-53.
17. Breivik T, Opstad PK, Gjermo P, Thrane PS. Effects of hypothalamic-pituitary-adrenal axis reactivity on periodontal tissue destruction in rats. Eur J Oral Sci 2000; 108: 115-22.
18. Breivik T, Thrane PS, Gjermo P, Opstad PK. Glucocorticoid receptor antagonist RU-486 treatment reduces periodontitis in Fischer 344 rats. J Periodont Res 2000; 35: 285-90.
19. Breivik T, Thrane PS, Gjermo P, Opstad PK, Pabst R, von Horsten S. Hypothalamic-pituitary-adrenal axis activation by experimental periodontal disease in rats. J Periodont Res 2001; 36: 295-300.
20. Breivik T, Thrane PS, Gjermo P, Fonnum F. Postnatal glutamateinduced central nervous system lesions alter periodontal disease susceptibility in adult Wistar rats. J Clin Periodontol 2001; 28: 904-9.
21. Breivik T, Stephan M, Brabant GE, Straub RH, Pabst R, von Horsten S. Postnatal lipopolysaccharide-induced illness predisposes to periodontal disease in adulthood. Brain Behav Immun 2002; 16: 421-38.
22. Breivik T, Thrane PS, Gjermo P, Cools A, Myhrer T. Effects of hippocampal lesioning on experimental periodontal disease in Wistar rats. J Periodont Res 2002; 37: 360-5.
23. Breivik T, Gundersen Y, Osmundsen H, Opstad PK, Fonnum F. Chronic treatment with the glutamate receptor antagonist MK-801 alters periodontal disease susceptibility. J Periodont Res 2005; 40: 28-35.
24. Breivik T, Gundersen Y, Opstad PK, Fonnum F. Chemical sympathectomy inhibits periodontal disease in Fischer 344 rats. J Periodont Res 2005; 40: 325-30.
25. Breivik T, Gundersen G, Osmundsen H, Fonnum F, Opstad PK. Neonatal dexamathasone and chronic tianeptine treatment inhibit ligature-induced periodontitis in adult rats. J Periodont Res 2006; 41: 23-32.
26. Breivik T, Gundersen Y, Myhrer T, et al. Enhanced susceptibility to periodontitis in an animal model of depression: reversed by chronic treatment with the antidepressant tianeptine. J Clin Periodontol 2006; 33: 469-77.
27. Breivik T, Gundersen Y, Gjermo P, von Hörsten S, Opstad PK. Nicotinic acetylcholine receptor activation mediates nicotineinduced enhancement of experimental periodontitis. J Periodont Res 2009; 44: 297-303.
28. Szallasi A, Blumberg PM. Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor. Life Sci 1990; 47: 1399-408.
29. Szallasi A, Nilsson S, Farkas-Szallasi T, Blumberg PM, Hökfelt T, Lundberg JM. Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery, and depletion by systemic vanilloid treatment. Brain Res 1995; 703: 175-83.
30. Szallasi A, Cruz F, Geppetti P. TRPV1: a therapeutic target for novel analgesic drugs? Trends Molecul Med 2006; 12: 545-54.
31. Neubert JK, Mannes AJ, Karai LJ, et al. Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia. Mol Pain 2008; 4: pp. 3.
32. Breivik T, Thrane PS. Psychoneuroimmune interactions in periodontal disease. In: Psychneuroimmunology 2001; Eds. Ader R, Felten L, Cohen N. 3rd ed, San Diego, CA: Academic Press, chapter 63, pp. 627-44.
33. Long NC, Frevert CW, Shore SA. Role of C fibers in the inflammatory response to intratracheal lipopolysaccharide. Am J Physiol 1996; 271: 425-31.
34. Murai M, Tsuji F, Nose M, et al. SA13353 (1-[2-(1-Adamantyl) ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea) inhibits TNF-alpha production through the activation of capsaicin-sensitive afferent neurons mediated via transient receptor potential vanilloid 1 in vivo. Eur J Pharmacol 2008; 588: 309-15.
35. Socransky SS, Haffajee AD. The bacterial aetiology of destructive periodontal disease. J Periodontol 1992; 63: 322-31.
36. Breivik T, Rook GA. Oral treatment with SR299 (killed Mycobacterium vaccae) inhibits experimental periodontal disease in Wistar rats. J Clin Periodontal 2003; 30: 931-6.
37. Breivik T, Opstad PK, Engstad R, Gundersen G, Gjermo P, Preus H. Soluble HH-1,3/1,6-glucan from yeast inhibits experimental periodontal disease in Wistar rats. J Clin Periodontal 2005; 32: 347-52.
38. Tokoro Y, Matsuki Y, Yamamoto T, Suzuki T, Hara K. Relevance of local Th2-type cytokine mRNA expression in immunocompetent infiltrates in inflamed gingival tissue to periodontal diseases. Clin Exp Immunol 1997; 107: 166-74.
39. Chapple CC, Srivastava M, Hunter N. Failure of macrophage activation in destructive periodontal disease. J Pathol 1998; 186: 281-6.
40. Fokkema SJ, Loos BG, Slegte C, van der Velden U. A type 2 response in lipopolysaccharide (LPS)-stimulated whole blood cell cultures from periodontitis patients. Clin Exp Immunol 2002: 127: 374-8.
41. Weiss SJ. Tissue destruction by neutrophils. N Eng J Med 1989; 6: 365-76.
42. Ding Y, Haapasalo M, Kerosuo E, Lounatmaa K, Kotiranta A, Sorsa T. Release and activation of human neutrophil matrix metallo-and serine proteinases during phagocytosis of Fusobacterium nucleatum, Porphyromonas gingivalis and Treponema denticola. J Clin Periodontol 1997; 24: 237-48.
43. Lohinai Z, Benedek P, Feher E, et al. Protective effects of mercaptoethylguanidine, a selective inhibitor of inducible nitric oxide synthase, in ligature-induced periodontitis in the rat. Br J Pharmacol 1998; 123: 353-60.
44. Fredriksson MI, Gustavsson AK, Bergstrøm KG, Åsmand BE. Constitutionally hyperactive neutrophils in periodontitis. J Periodontol 2003; 74: 219-24.
45. Van Dyke TE, Serhan CN. Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseases. J Dent Res 2003; 82: 82-90.
46. Van Dyke TE. Control of inflammation and periodontitis. Periodontol 2000 2007; 45: 158-66.
47. Gustafsson A, Ito H, Asman B, Bergström K. Hyper-reactive mononuclear cells and neutrophils in chronic periodontitis. J Clin Periodontol 2006; 33:126-9.
48. Mourtzoukou EG, Iavazzo C, Falagas ME. Resiniferatoxin in the treatment of interstitial cystitis: a systematic review. Internat Urogynecol J Pelv Fl Dysf 2008; 19: 1571-6.
49. Lee HR, Ho WZ, Douglas SD. Substance P augments tumor necrosis factor release in human monocyte-derived macrophages. Clin Diagnost Lab Immunol 1994; 1: 419-23.
50. Schäfers M, Sommer C, Geis C, Hagenacker T, Vandenabeele P, Sorkin LS. Selective stimulation of either tumor necrosis factor receptor differentially induces pain behavior in vivo and ectopic activity in sensory neurons in vitro. Neuroscience 2008; 157: 414-23.
51. Landa JI, Alvarez Sánchez J, Grau M, Sánchez JA, Balibrea JL. Somatostatin reduces the levels of tumor necrosis factor alpha in a rat model of endotoxemia induced by lipopolysaccharide. Res Exp Med 1995; 195: 317-25.
52. Feng Y, Tang Y, Guo J, Wang X. Inhibition of LPS-induced TNFalpha production by calcitonin gene-related peptide (CGRP) in cultured mouse peritoneal macrophages. Life Sci 1997; 61: 281-7.
53. Gomes RN, Castro-Faria-Neto HC, Bozza PT, et al. Calcitonin gene-related peptide inhibits local acute inflammation and protects mice against lethal endotoxemia. Shock 2005; 24: 59059-64.
54. Hugoson A, Ljungquist B, Breivik T. The relationship of some negative events and psychological factors to periodontal disease in an adult Swedish population 50 to 80 years of age. J Clin Periodontol 2002; 29: 247-53.
55. Vettore MV, Leoa ATT, Monteiro da Silva AM, Quintanilha RS, Lamarca GA. The relationship of stress and anxiety with chronic periodontitis. J Clin Periodontol 2003; 30: 394-402.
56. Nemeroff CB, Vale WW. The neurobiology of depression: inroads to treatment and new drug discovery. J Clin Psychiat 2005; 66: 5-13.
57. Heim C, Newport DJ, Mletzko T, Miller AH, Nemeroff CB. The link between childhood trauma and depression: insights from HPA axis studies in humans. Psychoneuroendocrinol 2008; 33: 693-710.
58. Salvi GE, Lang NP. The effects of non-steroidal anti-inflammatory drugs (selective and non-selective) on the treatment of periodontal diseases. Cur Pharmacotherapeut Des 2005; 11: 1757-69.
59. Materazzi S, Nassini R, Andrè E, et al. Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1. Proc Nat Acad Scie USA 2008; 105: 12045-50.
60. Gadek-Michalska A, Bugajski AJ, Bugajski J. Prostaglandins and interleukin-1beta in the hypothalamic-pituitary-adrenal response to systemic phenylephrine under basal and stress conditions. J Phys Pharmacol 2008: 59: 563-75.
61. Sjöström L, Laurell L, Hugoson A, Håkansson JP. Periodontal conditions in adults with rheumatoid arthritis. Com Dent Oral Epidemiol 1989; 17: 234-6.
62. Marotte H, Farge P, Gaudin P, Alexandre C, Mougin B, Miossec P. The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction. An Rheumat Dis 2006: 65: 905-9.