Relevance of local Th2-type cytokine mRNA expression in immunocompetent infiltrates in inflamed gingival tissue to periodontal diseases

Clinical and Experimental Immunology

Volumn 107, Issue 1, 1997, Pages 166-174

  Tokoro, Y ^a   Matsuki, Y ^a   Yamamoto, T ^b   Suzuki, T ^a   Hara, K ^a  

^a NIIGATA UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

Cytokine profile; Macrophage; Periodontal disease form; Principal component analysis; Th2

Indexed keywords

CYTOKINE; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CLINICAL ARTICLE; HELPER CELL; HUMAN; IN SITU HYBRIDIZATION; MACROPHAGE; PERIODONTAL DISEASE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

EID: 0031024348     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1997.d01-880.x     Document Type: Article

References (25)

1. Seymour GJ, Gemmell E, Reinhardt RA, Eastcott J, Taubman MA. Immunopathogenesis of chronic inflammatory periodontal disease: cellular and molecular mechanisms. J Periodont Res 1993; 28:478-86.
2. Romagnani S. Lymphokine production by human T cells in disease states. Ann Rev Immunol 1994; 12:227-57.
3. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol Today 1996; 17:138-46.
4. Stadecker MJ, Flores Villanueva PO. Accessory cell signals regulate Th-cell responses: from basic immunology to a model of helminthic disease. Immunol Today 1994; 15:571-4.
5. Fukuda R, Ishimura N, Nguyen TX et al. The expression of IL-2, IL-4 and interferon-gamma (IFN-gamma) mRNA using liver biopsies at different phases of acute exacerbation of chronic hepatitis B. Clin Exp Immunol 1995; 100:446-51.
6. Simon AK, Seipelt E, Wu P, Wenzel B, Braun J, Sieper J. Analysis of cytokine profiles in synovial T cell clones from chlamydial reactive arthritis patients: predominance of the Th1 subset. Clin Exp Immunol 1993; 94:122-6.
7. Yamazaki K, Nakujima T, Gemmell E, Polak B, Seymour GJ, Hara K. IL-4 and IL-6-producing cells in human penodontal disease tissue. J Oral Pathol Med 1994; 23:347-53.
8. Matsuki Y, Yamamoto T, Hara K. Detection of inflammatory cytokine messenger RNA (mRNA)-expressing cells in human inflamed gingiva by combined in situ hybridisation and immunohistochemistry. Immunology 1992; 76:42-47.
9. Tokoro Y, Yamamoto T, Hara K. IL-1β mRNA as the predominant inflammatory cytokine transcript: correlation with inflammatory cell infiltration into human gingiva. J Oral Pathol Med 1996; 25:225-31.
10. Fujihashi K, Beagley KW, Kono Y et al. Gingival mononuclear cells from chronic inflammatory periodontal tissues produce interleukin (IL)-5 and IL-6 but not IL-2 and IL-4. Am J Pathol 1993; 142:1239-50.
11. Joliffe IT, Morgan BJ. Principal component analysis and exploratory factor analysis. Stat Method Med Res 1992; 1:69-95.
12. Matsuki Y, Yamamoto T, Hara K. Localization of interleukin-1 (IL-1) mRNA-expressing macrophages in human inflamed gingiva and IL-1 activity in gingival crevicular fluid. J Periodont Res 1993; 28:35-42.
13. Goodman LA. Methods for statistical analysis of multivariate observations. New York: John Wiley & Sons, 1977.
14. Matsuki Y, Yamamoto T, Hara K. Interleukin-1 mRNA-expressing macrophages in human chronically inflamed gingival tissues. Am J Pathol 1991; 138:1299-305.
15. Dewhirst FE, Stashenko PP, Mole JE, Tsurumachi T. Purification and partial sequence of human osteoclast-activating factor: identity with interleukin 1β. J Immunol 1985; 135: 2562-8.
16. Yamazaki K, Nakajima T, Hara K. Immunohistological analysis of T cell functional subsets in chronic inflammatory periodontal disease. Clin Exp Immunol 1995; 99:384-91.
17. Aoyagi T, Sugawara-Aoyagi M, Yamazaki K, Hara K. Interleukin 4 (IL-4) and IL-6-producing memory T-cells in peripheral blood and gingival tissues in periodontitis patients with high serum antibody titers to Porphyromonas gingivalis. Oral Microbiol Immunol 1995; 10:304-10.
18. + T cells isolated from inflamed human gingival tissues. Clin Exp Immunol 1996; 103:422-8.
19. Seymour GJ. Possible mechanisms involved in the immunoregulation of chronic inflammatory periodontal disease. J Dent Res 1987; 66:2-9.
20. Yano N, Endoh M, Miyazaki M, Yamauchi F, Nomoto Y, Sakai H. Altered production of IgE and IgA induced by IL-4 in peripheral blood mononuclear cells from patients with IgA nephropathy. Clin Exp Immunol 1992; 88:295-300.
21. Yamazaki K, Nakajima T, Aoyagi T, Hara K. Immunohistological analysis of memory T lymphocytes and activated B lymphocytes in tissues with periodontal disease. J Periodont Res 1993; 28:324-34.
22. Hara Y, Maeda K, Akamine A, Miyatake S, Aono M. Immunohistological evidence for gingival IgE-bearing cells in human periodontitis. J Periodont Res 1987; 22:370-4.
23. Suzuki T, Sugita N, Yoshie H, Hara K. Presence of activated eosinophils, high IgE and sCD23 titers in gingival crevicular fluid of patients with adult periodontitis. J Periodont Res 1995; 30:159-66.
24. Akira S, Hirano T, Taga T, Kishimoto T. Biology of multifunctional cytokines: IL-6 and related molecules (IL-I and TNF). FASEB J 1990; 4:2860-7.
25. Ishimi Y, Miyaura C, Jin CH et al. IL-6 is produced by osteoblasts and induces hone resorption. J Immunol 1990; 145:3297-303.