-
1
-
-
52949108830
-
Anticancer alkylphospholipids: Mechanisms of action, cellular sensitivity and resistance, and clinical prospects
-
van Blitterswijk, W. J. and Verheij, M. (2008) Anticancer alkylphospholipids: mechanisms of action, cellular sensitivity and resistance, and clinical prospects. Curr. Pharm. Des. 14, 2061-2074
-
(2008)
Curr. Pharm. Des.
, vol.14
, pp. 2061-2074
-
-
Van Blitterswijk, W.J.1
Verheij, M.2
-
2
-
-
0025177753
-
Antitumoral and other biomedical activities of synthetic ether lysophospholipids
-
Munder, P. G. and Westphal, O. (1990) Antitumoral and other biomedical activities of synthetic ether lysophospholipids. Chem. Immunol. 49, 206-235
-
(1990)
Chem. Immunol.
, vol.49
, pp. 206-235
-
-
Munder, P.G.1
Westphal, O.2
-
3
-
-
0033563010
-
Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis
-
Ruiter, G. A., Zerp, S. F., Bartelink, H., van Blitterswijk, W. J. and Verheij, M. (1999) Alkyl-lysophospholipids activate the SAPK/JNK pathway and enhance radiation-induced apoptosis. Cancer Res. 59, 2457-2463 (Pubitemid 29242297)
-
(1999)
Cancer Research
, vol.59
, Issue.10
, pp. 2457-2463
-
-
Ruiter, G.A.1
Zerp, S.F.2
Bartelink, H.3
Van Blitterswijk, W.J.4
Verheij, M.5
-
4
-
-
0037331989
-
Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway
-
DOI 10.1097/00001813-200302000-00011
-
Ruiter, G. A., Zerp, S. F., Bartelink, H., van Blitterswijk, W. J. and Verheij, M. (2003) Anti-cancer alkyl-lysophospholipids inhibit the phosphatidylinositol 3-kinase-Akt/PKB survival pathway. Anti-Cancer Drugs 2, 167-173 (Pubitemid 36269756)
-
(2003)
Anti-Cancer Drugs
, vol.14
, Issue.2
, pp. 167-173
-
-
Ruiter, G.A.1
Zerp, S.F.2
Bartelink, H.3
Van Blitterswijk, W.J.4
Verheij, M.5
-
5
-
-
0023501959
-
Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion
-
DOI 10.1007/BF02535537
-
van Blitterswijk, W. J., Hilkmann, H. and Storme, G. A. (1987) Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion. Lipids 22, 820-823 (Pubitemid 18001383)
-
(1987)
Lipids
, vol.22
, Issue.11
, pp. 820-823
-
-
Van Blitterswijk, W.J.1
Hilkmann, H.2
Storme, G.A.3
-
6
-
-
0037131168
-
Alkyl-lysophospholipid accumulates in lipid rafts and induces apoptosis via raft-dependent endocytosis and inhibition of phosphatidylcholine synthesis
-
DOI 10.1074/jbc.M203176200
-
van der Luit, A. H., Budde, M., Ruurs, P., Verheij, M. and van Blitterswijk, W. J. (2002) Alkyl-lysophospholipid accumulates in lipid rafts and induces apoptosis via raft-dependent endocytosis and inhibition of phosphatidylcholine synthesis. J. Biol. Chem. 277, 39541-39547 (Pubitemid 35190932)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.42
, pp. 39541-39547
-
-
Van Der, L.A.H.1
Budde, M.2
Ruurs, P.3
Verheij, M.4
Van Blitterswijk, W.J.5
-
7
-
-
34548073046
-
A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells
-
van der Luit, A. H., Vink, S. R., Klarenbeek, J. B., Perrissoud, D., Solary, E., Verheij, M. and van Blitterswijk, W. J. (2007) A new class of anticancer alkylphospholipids uses lipid rafts as membrane gateways to induce apoptosis in lymphoma cells. Mol. Cancer Ther. 6, 2337-2344
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 2337-2344
-
-
Van Der Luit, A.H.1
Vink, S.R.2
Klarenbeek, J.B.3
Perrissoud, D.4
Solary, E.5
Verheij, M.6
Van Blitterswijk, W.J.7
-
8
-
-
1842290345
-
3 (edelfosine): Molecular structure requirements, cellular uptake, and protection by bcl-2 and bcl-x(L)
-
Mollinedo, F., Fernandez-Luna, J. L., Gajate, C., Martin-Martin, B., Benito, A., Martinez-Dalmau, R. and Modolell, M. (1997) Selective induction of apoptosis in cancer cells by the ether lipid ET-18-OCH3 (edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-XL. Cancer Res. 57, 1320-1328 (Pubitemid 27152558)
-
(1997)
Cancer Research
, vol.57
, Issue.7
, pp. 1320-1328
-
-
Mollinedo, F.1
Fernandez-Luna, J.L.2
Gajate, C.3
Martin-Martin, B.4
Benito, A.5
Martinez-Dalmau, R.6
Modolell, M.7
-
9
-
-
0035254650
-
Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis
-
DOI 10.1016/S0360-3016(00)01476-0, PII S0360301600014760
-
Ruiter, G. A., Verheij, M., Zerp, S. F. and van Blitterswijk, W. J. (2001) Alkyllysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis. Int. J. Radiat. Oncol. Biol. Phys. 49, 415-419 (Pubitemid 32120238)
-
(2001)
International Journal of Radiation Oncology Biology Physics
, vol.49
, Issue.2
, pp. 415-419
-
-
Ruiter, G.A.1
Verheij, M.2
Zerp, S.F.3
Van Blitterswijk, W.J.4
-
10
-
-
33645047901
-
Radiosensitization of squamous cell carcinoma by the alkylphospholipid perifosine in cell culture and xenografts
-
Vink, S. R., Lagerwerf, S., Mesman, E., Schellens, J. H., Begg, A. C., van Blitterswijk, W. J. and Verheij, M. (2006) Radiosensitization of squamous cell carcinoma by the alkylphospholipid perifosine in cell culture and xenografts. Clin. Cancer Res. 12, 1615-1622
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 1615-1622
-
-
Vink, S.R.1
Lagerwerf, S.2
Mesman, E.3
Schellens, J.H.4
Begg, A.C.5
Van Blitterswijk, W.J.6
Verheij, M.7
-
11
-
-
33847289770
-
Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy
-
DOI 10.1016/j.ctrv.2006.12.001, PII S0305737206002386
-
Vink, S. R., van Blitterswijk, W. J., Schellens, J.H.M. and Verheij, M. (2007) Rationale and clinical application of alkylphospholipid analogues in combination with radiotherapy. Cancer Treat. Rev. 33, 191-202 (Pubitemid 46323398)
-
(2007)
Cancer Treatment Reviews
, vol.33
, Issue.2
, pp. 191-202
-
-
Vink, S.R.1
Van Blitterswijk, W.J.2
Schellens, J.H.M.3
Verheij, M.4
-
12
-
-
72449168537
-
Fas/CD95 down-regulation in lymphoma cells through acquired alkyl-lysophospholipid resistance: Partial role of sphingomyelin deficiency
-
van Blitterswijk, W. J., Klarenbeek, J. B., van der Luit, A. H., Alderliesten, M. C., van Lummel, M. and Verheij, M. (2010) Fas/CD95 down-regulation in lymphoma cells through acquired alkyl-lysophospholipid resistance: partial role of sphingomyelin deficiency. Biochem. J. 425, 225-234
-
(2010)
Biochem. J.
, vol.425
, pp. 225-234
-
-
Van Blitterswijk, W.J.1
Klarenbeek, J.B.2
Van Der Luit, A.H.3
Alderliesten, M.C.4
Van Lummel, M.5
Verheij, M.6
-
13
-
-
33846526677
-
Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts
-
DOI 10.1042/BJ20061178
-
van der Luit, A. H., Budde, M., Zerp, S., Caan, W., Klarenbeek, J. B., Verheij, M. and van Blitterswijk, W. J. (2007) Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin and cholesterol deficiency in lipid rafts. Biochem. J. 401, 541-549 (Pubitemid 46166435)
-
(2007)
Biochemical Journal
, vol.401
, Issue.2
, pp. 541-549
-
-
Van Der, L.A.H.1
Budde, M.2
Zerp, S.3
Caan, W.4
Klarenbeek, J.B.5
Verheij, M.6
Van Blitterswijk, W.J.7
-
14
-
-
0034163834
-
Structure function, and biology of SHIP proteins
-
Rohrschneider, L. R., Fuller, J. F., Wolf, I., Liu, Y. and Lucas, D. M. (2000) Structure, function, and biology of SHIP proteins. Genes Dev. 14, 505-520 (Pubitemid 30159771)
-
(2000)
Genes and Development
, vol.14
, Issue.5
, pp. 505-520
-
-
Rohrschneider, L.R.1
Fuller, J.F.2
Wolf, I.3
Liu, Y.4
Lucas, D.M.5
-
15
-
-
41449094548
-
Phosphoinositide lipid phosphatases: Natural regulators of phosphoinositide 3-kinases signalling in T lymphocytes
-
Harris, S. J., Parry, R. V., Westwick, J. and Ward, S. G. (2008) Phosphoinositide lipid phosphatases: natural regulators of phosphoinositide 3-kinases signalling in T lymphocytes. J. Biol. Chem. 283, 2465-2469
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 2465-2469
-
-
Harris, S.J.1
Parry, R.V.2
Westwick, J.3
Ward, S.G.4
-
16
-
-
62749155738
-
The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease
-
Ooms, L. M., Horan, K. A., Rahman, P., Seaton, G., Gurung, R., Kethesparan, D. S. and Mitchell, C. A. (2009) The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease. Biochem. J. 419, 29-49
-
(2009)
Biochem. J.
, vol.419
, pp. 29-49
-
-
Ooms, L.M.1
Horan, K.A.2
Rahman, P.3
Seaton, G.4
Gurung, R.5
Kethesparan, D.S.6
Mitchell, C.A.7
-
17
-
-
0032797269
-
Signaling steps in apoptosis by ether lipids
-
Smets, L. A., van Rooij, H. and Salomons, G. S. (1999) Signaling steps in apoptosis by ether lipids. Apoptosis 4, 419-427
-
(1999)
Apoptosis
, vol.4
, pp. 419-427
-
-
Smets, L.A.1
Van Rooij, H.2
Salomons, G.S.3
-
18
-
-
0025726216
-
A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
-
Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F. and Riccardi, C. (1991) A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods 139, 271-279
-
(1991)
J. Immunol. Methods
, vol.139
, pp. 271-279
-
-
Nicoletti, I.1
Migliorati, G.2
Pagliacci, M.C.3
Grignani, F.4
Riccardi, C.5
-
19
-
-
0025988995
-
Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation
-
Serunian, L. A., Auger, K. R. and Cantley, L. C. (1991) Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation. Methods Enzymol. 198, 78-87
-
(1991)
Methods Enzymol.
, vol.198
, pp. 78-87
-
-
Serunian, L.A.1
Auger, K.R.2
Cantley, L.C.3
-
20
-
-
0038959159
-
The identification of phosphatidylinositol 3,5-bisphosphate in T-lymphocytes and its regulation by interleukin-2
-
Jones, D. R., González-García, A., Díez, E., Martinez-A, C., Carrera, A. C. and Meŕida, I. (1999) The identification of phosphatidylinositol 3,5-bisphosphate in T-lymphocytes and its regulation by interleukin-2. J. Biol. Chem. 274, 18407-18413
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 18407-18413
-
-
Jones, D.R.1
González-García, A.2
Díez, E.3
Martinez-A, C.4
Carrera, A.C.5
Meŕida, I.6
-
21
-
-
58149175555
-
The life of a cell: Apoptosis regulated by the PI3K/PKB pathway
-
Duronio, V. (2008) The life of a cell: apoptosis regulated by the PI3K/PKB pathway. Biochem. J. 415, 333-344
-
(2008)
Biochem. J.
, vol.415
, pp. 333-344
-
-
Duronio, V.1
-
22
-
-
33644986197
-
Centaurin-α1 is a phosphatidylinositol 3-kinase-dependent activator of ERK1/2 mitogen-activated protein kinases
-
Hayashi, H., Matsuzaki, O., Muramatsu, S., Tsuchiya, Y., Harada, T., Suzuki, Y., Sugano, S., Matsuda, A. and Nishida, E. (2006) Centaurin-α1 is a phosphatidylinositol 3-kinase-dependent activator of ERK1/2 mitogen-activated protein kinases. J. Biol. Chem. 281, 1332-1337
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 1332-1337
-
-
Hayashi, H.1
Matsuzaki, O.2
Muramatsu, S.3
Tsuchiya, Y.4
Harada, T.5
Suzuki, Y.6
Sugano, S.7
Matsuda, A.8
Nishida, E.9
-
23
-
-
0141456089
-
Different modes of internalization of apoptotic alkyl-lysophospholipid and cell-rescuing lysophosphatidylcholine
-
DOI 10.1042/BJ20030179
-
van der Luit, A. H., Budde, M., Verheij, M. and van Blitterswijk, W. J. (2003) Different modes of internalization of apoptotic alkyl-lysophospholipid and cell-rescuing lysophosphatidylcholine. Biochem. J. 374, 747-53 (Pubitemid 37163920)
-
(2003)
Biochemical Journal
, vol.374
, Issue.3
, pp. 747-753
-
-
Van Der, L.A.H.1
Budde, M.2
Verheij, M.3
Van Blitterswijk, W.J.4
-
24
-
-
0036133127
-
Molecular ordering of the initial signaling events of CD95
-
DOI 10.1128/MCB.22.1.207-220.2002
-
Algeciras-Schimnich, A., Shen, L., Barnhart, B. C., Murmann, A. E., Burkhardt, J. K. and Peter, M. E. (2002) Molecular ordering of the initial signaling events of CD95. Mol. Cell Biol. 22, 207-220 (Pubitemid 33144269)
-
(2002)
Molecular and Cellular Biology
, vol.22
, Issue.1
, pp. 207-220
-
-
Algeciras-Schimnich, A.1
Shen, L.2
Barnhart, B.C.3
Murmann, A.E.4
Burkhardt, J.K.5
Peter, M.E.6
-
25
-
-
51549083000
-
Different roles of SHIP1 according to the cell context: The example of blood platelets
-
Gratacap, M.-P., Séverin, S., Chicanne, G., Plantavid, M. and Payrastre, B. (2008) Different roles of SHIP1 according to the cell context: the example of blood platelets. Adv. Enzyme Regul. 48, 240-252
-
(2008)
Adv. Enzyme Regul.
, vol.48
, pp. 240-252
-
-
Gratacap, M.-P.1
Séverin, S.2
Chicanne, G.3
Plantavid, M.4
Payrastre, B.5
-
26
-
-
78650191420
-
Role of SHIP in cancer
-
Hamilton, M. J., Ho, V. W., Kuroda, E., Ruschmann, J., Antignano, F., Lam, V. and Krystal, G. (2011) Role of SHIP in cancer. Exp. Hematol. 39, 2-13
-
(2011)
Exp. Hematol.
, vol.39
, pp. 2-13
-
-
Hamilton, M.J.1
Ho, V.W.2
Kuroda, E.3
Ruschmann, J.4
Antignano, F.5
Lam, V.6
Krystal, G.7
-
27
-
-
8844258034
-
Restoration of SHIP activity in a human leukemia cell line downregulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3β signaling and leads to an increased transit time through the G1 phase of the cell cycle
-
DOI 10.1038/sj.leu.2403529
-
Horn, S., Endl, E., Fehse, B., Weck, M. M., Mayr, G. W. and Jucker, M. (2004) Restoration of SHIP activity in human leukemia cell line down-regulates constitutively activated phosphatidylinositol 3-kinase/Akt/GSK-3β signalling and leads to an increased transit time through the G1 phase of the cell cycle. Leukemia 18, 1839-1849 (Pubitemid 39530015)
-
(2004)
Leukemia
, vol.18
, Issue.11
, pp. 1839-1849
-
-
Horn, S.1
Endl, E.2
Fehse, B.3
Weck, M.M.4
Mayr, G.W.5
Jucker, M.6
-
28
-
-
0029665083
-
p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity
-
Lioubin, M. N., Algate, P. A., Tsai, S., Carlberg, K., Aebersold, A. and Rohrschneider, L. R. (1996) p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity. Genes Dev. 10, 1084-1095
-
(1996)
Genes Dev.
, vol.10
, pp. 1084-1095
-
-
Lioubin, M.N.1
Algate, P.A.2
Tsai, S.3
Carlberg, K.4
Aebersold, A.5
Rohrschneider, L.R.6
-
29
-
-
33845889090
-
3 phosphatase SHIP1
-
DOI 10.1038/ncb1515, PII NCB1515
-
Nishio, M., Watanabe, K., Sasaki, J., Tayca, C., Takasuga, S., Iizuka, R., Balla, T., Yamazaki, M., Watanabe, H., Itoh, R. et al. (2007) Control of cell polarity and motility by the PtdIns(3,4,5)P 3 phosphatase SHIP1. Nat. Cell Biol. 9, 36-44 (Pubitemid 46024195)
-
(2007)
Nature Cell Biology
, vol.9
, Issue.1
, pp. 36-44
-
-
Nishio, M.1
Watanabe, K.2
Sasaki, J.3
Taya, C.4
Takasuga, S.5
Iizuka, R.6
Balla, T.7
Yamazaki, M.8
Watanabe, H.9
Itoh, R.10
Kuroda, S.11
Horie, Y.12
Forster, I.13
Mak, T.W.14
Yonekawa, H.15
Penninger, J.M.16
Kanaho, Y.17
Suzuki, A.18
Sasaki, T.19
-
30
-
-
77951624382
-
SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells
-
Brooks, R., Fuhler, G. M., Iyer, S., Smith, M. J., Park, M. Y., Paraiso, K. H., Engelman, R. W. and Kerr, W. G. (2010) SHIP1 inhibition increases immunoregulatory capacity and triggers apoptosis of hematopoietic cancer cells. J. Immunol. 184, 3582-3589
-
(2010)
J. Immunol.
, vol.184
, pp. 3582-3589
-
-
Brooks, R.1
Fuhler, G.M.2
Iyer, S.3
Smith, M.J.4
Park, M.Y.5
Paraiso, K.H.6
Engelman, R.W.7
Kerr, W.G.8
-
31
-
-
0034663568
-
Signal-dependent membrane targeting by pleckstrin homology (PH) domains
-
Lemmon, M. A. and Ferguson, K. M. (2000) Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem. J. 350, 1-18
-
(2000)
Biochem. J.
, vol.350
, pp. 1-18
-
-
Lemmon, M.A.1
Ferguson, K.M.2
-
32
-
-
35148857726
-
Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells
-
DOI 10.1016/j.cellsig.2007.07.020, PII S089865680700229X
-
Freeley, M., Park, J., Yang, K. J., Wange, R. L., Volkov, Y., Kelleher, D. and Long, A. (2007) Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells. Cell. Signalling 19, 2444-2457 (Pubitemid 47542296)
-
(2007)
Cellular Signalling
, vol.19
, Issue.12
, pp. 2444-2457
-
-
Freeley, M.1
Park, J.2
Yang, K.-J.3
Wange, R.L.4
Volkov, Y.5
Kelleher, D.6
Long, A.7
-
33
-
-
77950937721
-
SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity
-
Charlier, E., Condé, C., Zhang, J., Deneubourg, L., Di Valentin, E., Rahmouni, S., Chariot, A., Agostinis, P., Pang, P. C., Haslam, S. M. et al. (2010) SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity. Leukemia 24, 821-832
-
(2010)
Leukemia
, vol.24
, pp. 821-832
-
-
Charlier, E.1
Condé, C.2
Zhang, J.3
Deneubourg, L.4
Di Valentin, E.5
Rahmouni, S.6
Chariot, A.7
Agostinis, P.8
Pang, P.C.9
Haslam, S.M.10
-
34
-
-
0030975468
-
The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of ship, its association with Shc, and its induction of apoptosis
-
DOI 10.1074/jbc.272.14.8983
-
Liu, L., Damen, J. E., Hughes, M. R., Babic, I., Jirik, F. R. and Krystal, G. (1997) The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis. J. Biol. Chem. 272, 8983-8988 (Pubitemid 27154897)
-
(1997)
Journal of Biological Chemistry
, vol.272
, Issue.14
, pp. 8983-8988
-
-
Liu, L.1
Damen, J.E.2
Hughes, M.R.3
Babic, I.4
Jirik, F.R.5
Krystal, G.6
-
35
-
-
33748433789
-
Restoration of SHIP-1 activity in human leukemic cells modifies NF-κB activation pathway and cellular survival upon oxidative stress
-
DOI 10.1038/sj.onc.1209542, PII 1209542
-
Gloire, G., Charlier, E., Rahmouni, S., Volanti, C., Chariot, A., Erneux, C. and Piette, J. (2006) Restoration of SHIP-1 activity in human leukemic cells modifies NF-κB activation pathway and cellular survival upon oxidative stress. Oncogene 25, 5485-5494 (Pubitemid 44344099)
-
(2006)
Oncogene
, vol.25
, Issue.40
, pp. 5485-5494
-
-
Gloire, G.1
Charlier, E.2
Rahmouni, S.3
Volanti, C.4
Chariot, A.5
Erneux, C.6
Piette, J.7
|