Effect of aqueous extract of the leaves of Acalypha wilkesiana 'Godseffiana' Muell Arg (Euphorbiaceae) on the hematology, plasma biochemistry and ocular indices of oxidative stress in alloxan induced diabetic rats

Journal of Ethnopharmacology

Volumn 137, Issue 3, 2011, Pages 1415-1424

  Ikewuchi, Jude C ^a   Onyeike, Eugene N ^a   Uwakwe, Augustine A ^a   Ikewuchi, Catherine C ^a  

^a UNIVERSITY OF PORT HARCOURT   (Nigeria)

Author keywords

Acalypha wilkesiana; Apigenin; Hypoglycemia; Lipid profile; Ocular oxidative stress

Indexed keywords

ACALYPHA WILKESIANA EXTRACT; ANTIDIABETIC AGENT; APIGENIN; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CALCIUM; CATECHIN; EPICATECHIN; GLUCOSE; KAEMPFEROL; MALONALDEHYDE; METFORMIN; NARINGENIN; PLANT EXTRACT; QUERCETIN; SITOSTEROL; TANNIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UREA;

ACALYPHA WILKESIANA; ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENIC INDEX; BILIRUBIN BLOOD LEVEL; CALCIUM BLOOD LEVEL; CARDIOVASCULAR PARAMETERS; CELL VOLUME; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG SCREENING; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; LYMPHOCYTE COUNT; MEDICINAL PLANT; MONOCYTE; NONHUMAN; OXIDATIVE STRESS; PHYTOCHEMISTRY; PLANT LEAF; RAT; THROMBOCYTE COUNT; TRIACYLGLYCEROL BLOOD LEVEL; UREA BLOOD LEVEL; UREA NITROGEN BLOOD LEVEL;

ANIMALS; ANTIOXIDANTS; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; BIOLOGICAL MARKERS; BLOOD CELL COUNT; BLOOD CELLS; BLOOD GLUCOSE; BLOOD UREA NITROGEN; CALCIUM; CHOLESTEROL, HDL; CHOLESTEROL, VLDL; CHROMATOGRAPHY, GAS; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EUPHORBIACEAE; EYE; HYPOGLYCEMIC AGENTS; KIDNEY; LIVER; MALONDIALDEHYDE; METFORMIN; OXIDATIVE STRESS; PLANT EXTRACTS; PLANT LEAVES; PLANTS, MEDICINAL; RATS; RATS, WISTAR; SOLVENTS; TRIGLYCERIDES; UREA;

ACALYPHA WILKESIANA; EUPHORBIACEAE; RATTUS;

EID: 80054941407     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.08.015     Document Type: Article

References (85)

1. O. Ademuyiwa, R.N. Ugbaja, F. Idumebor, and O. Adebawo Plasma lipid profiles and risk of cardiovascular disease in occupational lead exposure in Abeokuta, Nigeria Lipids in Health and Disease 4 2005 19
2. K.O. Akinyemi, O. Oladapo, C.E. Okwara, C.C. Ibe, and K.A. Fasure Screening of crude extracts of six medicinal plants used in south-west Nigerian unorthodox medicine for anti-methicillin resistant Staphylococcus aureus activity BMC Complementary and Alternative Medicine 5 2005 6
3. Association of Official Analytical Chemists Cholesterol in Foods. Direct Saponification - Gas Chromatograpphic Method. AOAC Official Method 994.10 2000 AOAC International Gaithersberg, USA
4. Association of Official Analytical Chemists Oil in Seeds. Supercritical Fluid Extraction (SFE) Method. AOAC Official Method 999.02 2002 AOAC International Gaithersberg, USA
5. G. Assmann, and A.M. Gotto Jr. HDL cholesterol and protective factors in atherosclerosis Circulation 109 2004 III-8 III-14
6. M. Atalay, and D.E. Laaksonen Diabetes, oxidative stress and physical exercise Journal of Sports Science and Medicine 1 2002 1 14
7. E.S Baginsky, S.S. Marie, W.L. Clark, and B. Zak Direct microdetermination of calcium Clinica Chimiya Acta 46 1973 49 54
8. C.J. Bailey, and C. Day Traditional plant medicines as treatments for diabetes Diabetes Care 12 1989 553 564
9. S.K. Basu, J.E. Thomas, and S.N. Acharya Prospects for growth in global nutraceutical and functional food markets: a Canadian perspective Australian Journal of Basic and Applied Science 1 2007 637 649
10. R.F. Beers, and I.W. Sizer A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase Biological Chemistry 195 1952 130 140
11. A. Berger, P.J.H. Jones, and S.S. Abumweis Plant sterols: factors affecting their efficacy and safety as functional food ingredients Lipids in Health and Disease 3 2004 5
12. A. Brehm, G. Pfeiler, G. Pacini, H. Vierhapper, and M. Roden Relationship between serum lipoprotein ratios and insulin resistance in obesity Clinical Chemistry 50 2004 2316 2322
13. E.M. Brown, and S.C. Hebert Calcium-receptor-regulated parathyroid and renal function Bone 20 1997 303 309
14. J.D. Brunzell, M. Davidson, C.D. Furberg, R.D. Goldberg, B.V. Howard, J.H. Stein, and J.L. Witztum Lipoprotein management in patients with cardiometabolic risk: consensus conference report from the American Diabetes Association and the American College of Cardiology Foundation Journal of the American College of Cardiology 51 2008 1512 1524
15. R. Burcelin, M. Eddouks, J. Maury, J. Kande, R. Assan, and J. Girard Excessive glucose production, rather than Insulin resistance, account for hyperglycemia in recent onset streptozocin-diabetic rats Diabetologia 385 1995 283 290
16. A. Bussing, G.M. Stein, I. Herterich-Akinpelu, and U. Pfuller Apoptosis-associated generation of reactive oxygen intermediates and release of pro-inflammatory cytokines in human lymphocytes and granulocytes by extracts from the seeds of Acalypha wilkesiana Journal of Ethnopharmacology 66 1999 301 309
17. M. Cheesbrough District Laboratory Practice in Tropical Countries, Part 2 2004 Cambridge University Press UK
18. Christman, S., 2004. Acalypha wilkesiana. Floridata.com LC, FL. < http://www.floridata.com/ref/A/acal-wil.cfm >.
19. K.O. Chu, C.C. Wang, C.Y. Chu, M.S. Rogers, K.W. Choy, and C.P. Pang Determination of catechins and catechin gallates in tissues by liquid chromatography with coulometric array detection and selective solid phase extraction Journal of Chromatography B 810 2004 187 195
20. K.T. Chung, T.Y. Wong, C.I. Wei, Y.W. Huang, and Y. Lin Tannins and human health: a review Critical Review of Food Science and Nutrition 38 1998 421 464
21. M.A. Crook Clinical Chemistry and Metabolic Medicine 7th edn 2006 Holder Arnold London
22. C.J. Dillard, and J.B. German Phytochemicals: nutraceuticals and human health Journal of the Science of Food and Agriculture 80 2000 1744 1756
23. M. Dobiásová Atherogenic index of plasma [log(triglyceride/HDL-Cholesterol)]: theoretical and practical implications Clinical Chemistry 50 2004 1113 1115
24. European Food Safety Authority Scientific Opinion of the Panel on Contaminants in the Food Chain on a request from the European Commission on Saponins in Madhuca longifolia L. as undesirable substances in animal feed The EFSA Journal 979 2009 1 36
25. W.C. Evans Trease and Evans Pharmacognosy 15th edn 2005 Elsevier India
26. FAO, 2004. Vitamin and mineral requirements in human nutrition (2nd edn). A report of a Joint FAO/WHO Expert Consultation, Bangkok, Thailand. ISBN: 92 4 154612 3. < http://whqlibdoc.who.int/publications/2004/9241546123.pdf >.
27. M.J. Franz, J.P. Bantle, C.A. Beebe, J.D. Brunzell, J.L. Chiasson, A. Garg, L.A. Holzeister, B. Hoogwerf, E. Mayer-Davies, A.D. Mooradian, J.Q. Purnell, and M. Wheeler Evidence-based nutrition principles and recommendations for the treatment and prevention of diabetes and related complications Diabetes Care 25 2002 148 198
28. W.T. Friedewald, R.I. Levy, and D.S. Friedrickson Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge Clinical Chemistry 18 1972 499 502
29. Gilman, E.F., 1999. Acalypha wilkesiana. Environmental Horticulture Department, Florida Cooperative Extension Service, Institute of Food and Agricultural Sciences, University of Florida. Fact Sheet FPS-6. October 1999. 3 pp.
30. J.M.C. Gutteridge, and C. Wilkins Copper-dependent hydroxyl radical damage to ascorbic acid. Formation of a thiobarbituric acid reactive products FEBS Letters 137 1982 327 340
31. M.E. Hartnett, R.D. Stratton, R.W. Browne, B.A. Rosner, R.J. Lanham, and D. Armstrong Serum markers of oxidative stress and severity of diabetic retinopathy Diabetes Care 23 2000 234 240
32. R. Hemalatha Anti-hepatotoxic and anti-oxidant defense potential of Tridax procumbens International Journal of Green Pharmacy 2 2008 164 169
33. M.C. Houston The role of vascular biology, nutrition and nutraceuticals in the prevention and treatment of hypertension Journal of American Nutraceutical Association 2002 5 71
34. M.C. Houston Nutraceuticals, vitamins, antioxidants, and minerals in the prevention and treatment of hypertension Progress in Cardiovascular Diseases 47 2005 396 449
35. M.C. Houston Treatment of hypertension with nutraceuticals, vitamins, antioxidants and minerals Expert Reviews in Cardiovascular Therapy 5 2007 681 691
36. F.E. Hunter, J.M. Gebicki, P.E. Hoffstein, J. Weinstein, and A. Scott Swelling and lysis of rat liver mitochondria induced by ferrous ions Journal of Biological Chemistry 238 1963 828 835
37. J.C. Ikewuchi Changes in the weight, plasma lipid profile, and atherogenic indices of salt-loaded rats by aqueous extract of Acalypha wilkesiana Muell Arg: potential for cardiovascular risk reduction Pacific Journal of Science and Technology 11 2010 516 523
38. J.C. Ikewuchi, and C.C. Ikewuchi Alteration of plasma lipid profiles and atherogenic indices by Stachytarpheta jamaicensis L (Vahl) Biokemistri 21 2009 71 77
39. J.C. Ikewuchi, and C.C. Ikewuchi Alteration of plasma lipid profile and atherogenic indices of cholesterol loaded rats by Tridax procumbens Linn: implications for the management of obesity and cardiovascular diseases Biokemistri 21 2009 95 99
40. C.C. Ikewuchi, and J.C. Ikewuchi Comparative study on the vitamin composition of some common Nigerian medicinal plants Pacific Journal of Science and Technology 10 2009 367 371
41. J.C. Ikewuchi, and C.C. Ikewuchi Hypocholesterolaemic effect of aqueous extract of Acalypha wilkesiana 'Godseffiana' Muell Arg on rats fed egg yolk supplemented diet: implications for cardiovascular risk management Research Journal of Science and Technology 2 2010 78 81
42. J.C. Ikewuchi, and C.C. Ikewuchi Iodometric determination of the ascorbic acid (vitamin C) content of some fruits consumed in a university community in Nigeria Global Journal of Pure and Applied Sciences 17 2011 47 49
43. J.C. Ikewuchi, C.C. Ikewuchi, and F.C. Onwuka Acalypha wilkesiana Muell Arg induced diuresis in salt-loaded rats: implication for the management of edema, obesity and hypertension Journal of Applied Science and Environmental Management 13 2009 51 54
44. J.C Ikewuchi, C.C. Ikewuchi, E.N. Onyeike, and A.A. Uwakwe Nutritional potential of the leaves of Acalypha wilkesiana 'Godseffiana' Muell Arg Journal of Applied Science and Environmental Management 14 2010 21 24
45. K. Imai, T. Aimoto, M. Sato, and R. Kimura Antioxidative effect of protoporphyrin on lipid peroxidation in tissue homogenates of intravenously administered rats Journal of Pharmacobio-dynamics 14 1991 20 24
46. M. Jyoti, T.V. Vihas, A. Ravikumar, and G. Sarita Glucose lowering effect of aqueous extract of Enicostemma littorale Blume in diabetes: a possible mechanism of action Journal of Ethnopharmacology 81 2002 317 320
47. K. Kaushansky Determinants of platelet number and regulation of thrombopoiesis Hematology 1 2009 147 152
48. R.M. Krauss, P.J. Blanche, R.S. Rawlings, H.S. Fernstrom, and P.T. Williams Separate effects of reduced carbohydrate intake and weight loss on atherogenic dyslipidemia American Journal of Clinical Nutrition 83 2006 1025 1031
49. Lau, T., 2008. "A healthy way to live": the occurrence, bioactivity, biosynthesis, and synthesis of kaempferol. Chemistry 150. < http://chemgroups.ucdavis.edu/∼shaw/CHE-150-2008/DHC-Website/ Kaempferol-LauT.pdf > (retrieved 25.04.11).
50. S.H. Lee, Y.B. Park, K.H. Bae, S.H. Bok, Y.K. Kwon, E.S. Lee, and M.S. Choi Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme a reductase and acyl coenzyme A: cholesterol acyltransferase in rats Annals of Nutrition and Metabolism 43 1999 173 180
51. P. Libby Current concepts of the pathogenesis of the acute coronary syndromes Circulation 104 2001 365 372
52. A.H. Lichtennstein, L.J. Appel, M. Brands, M. Carnethon, S. Daniels, B. Franklin, P. Kris-Etherton, W.S. Harris, B. Howard, N. Karanja, M. Lefevre, L. Rudel, F. Sacks, L. van Horn, M. Winston, J. Wylie-Rosett, and H.A. Franch Diet and lifestyle recommendations revision 2006. A Scientific Statement from the American Heart Association Nutrition Committee Circulation 114 2006 82 96
53. F. Liu, J. Kim, Y. Li, X. Liu, J. Li, and X. Chen An extract of Lagerstroemia speciosa L. has insulin-like glucose uptake-stimulatory and adipocyte differentiation-inhibitory activities in 3T3-L1 cells Journal of Nutrition 131 2001 2242 2247
54. X. Liu, J.-K. Kim, Y. Li, J. Li, F. Liu, and X. Chen Tannic acid stimulates glucose transport and inhibits adipocyte differentiation in 3T3-L1 cells Journal of Nutrition 135 2005 165 171
55. F.H. Lopes, H. Bernardes Silva, J.A. Soares, B. Filho, F.M. Consolim-Colombo, D.M.A. Giorgi, and M.E. Krieger Lipid metabolism alterations in normotensive subjects with positive family history of hypertension Hypertension 30 1997 629 631
56. Z. Luthar Polyphenol classification and tannin content of buckwheat seeds (Fagopyrum esculentum Moench) Fagopyrum 12 1992 36 42
57. A.C. Maritim, R.A. Sanders, and J.B. Watkins III Diabetes, oxidative stress, and antioxidants: a review Journal Biochemistry and Molecular Toxicology 17 2003 24 38
58. D.M. Martirosyan, L.A. Miroshnichenko, S.N. Kulokawa, A.V. Pogojeva, and V.I. Zoloedov Amaranth oil application for heart disease and hypertension Lipids in Health and Disease 6 2007 1
59. P.E. McBride Triglycerides and risk for coronary heart disease Journal of American Medical Association 298 2007 336 338
60. E. Middleton Jr. , C. Kandaswami, and T.C. Theoharides The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer Pharmacology Reviews 52 2000 673 751
61. H. Millogo-Kone, M. Lompo, F. Kini, S. Asimi, I.P. Guissou, and O. Nacoulma Evaluation of flavonoids and total phenolic contents of stem bark and leaves of Parkia biglobosa (Jacq.) Benth (Mimosaceae)-free radical scavenging and antimicrobial activities Research Journal of Medical Science 3 2009 70 74
62. H.P. Misra, and I. Fridovich The role of superoxide anion in the auto-oxidation of epinephrine and a single assay for superoxide dismutase Journal of Biological Chemistry 247 1989 3170 3175
63. P.R. Moreno, E. Falk, I.F. Palacios, J.B. Newell, V. Fuster, and J.T. Fallon Macrophage infiltration in acute coronary syndromes: implications for plaque rupture Circulation 90 1994 775 778
64. V.S. Muthusamy, S. Anand, K.N. Sangeetha, S. Sujatha, and B.A.B.S. Lakshmi Tannins present in Cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B inhibition Chemical and Biological Interactions 174 2008 69 78
65. A.O. Ogundaini From greens into medicine: taking a lead from nature. An inaugural lecture delivered at Oduduwa Hall, Obafemi Awolowo University, Ile-Ife, Nigeria Inaugural Lecture Series 176 2005 OAU Press Limited Ile-Ife, Nigeria http://www.oauife.edu.ng/faculties/pharmacy/aogund.pdf
66. M.K. Oladunmoye Comparative evaluation of antimicrobial activities and phytochemical screening of two varieties of Acalypha wilkesiana International Journal of Tropical Medicine 1 2006 134 136
67. D.M. Pereira, P. Valentão, J.A. Pereira, and P.B. Andrade Phenolics: from chemistry to biology Molecules 14 2009 2202 2211
68. V. Piironen, D.G. Lindsay, T.A. Miettinen, J. Toivo, and A.-M. Lampi Plant sterols: biosynthesis, biological function and their importance to human nutrition Journal of the Science of Food & Agriculture 80 2000 939 966
69. M.A Radwan Enhancement of absorption of insulin-loaded polyisobutylcyanoacrylate nanospheres by sodium cholate after oral and subcutaneous administration in diabetic rats Drug Development and Industrial Pharmacy 27 2001 383 391
70. D. Rajdl, J. Racek, A. Steinerová, Z. Novotný, F. Stožický, L. Trefil, and K. Siala Markers of oxidative stress in diabetic mothers and their infants during delivery Physiology Research 54 2005 429 436
71. H.P. Rang, M.M. Dale, J.M. Ritter, and P.K. Moore Pharmacology 5th edn 2005 Elsevier India
72. V.T. Samuel, D.S. Jayaprakash Murthy, K. Dattatreya, P.S. Babu, and S.S. Johncy Impaired antioxidant defence mechanism in diabetic retinopathy Journal of Clinical and Diagnostic Research (serial online) 4 2010 3430 3436
73. G.X. Shen Lipid disorders in diabetes mellitus and current management Current Pharmaceutical Analysis 3 2007 17 24
74. K.O. Soetan Pharmacological and other beneficial effects of antinutritional factors in plants: a review African Journal of Biotechnology 7 2008 4713 4721
75. Y. Takeda, S. Suzuki, T. Fukutomi, H. Kondo, M. Sugiura, H. Suzumura, G. Murasaki, H. Okutani, and M. Itoh Elevated white blood cell count as a risk factor of coronary artery disease: inconsistency between forms of the disease Japanese Heart Journal 44 2003 201 211
76. A. Taniguchi, M. Fukushima, Y. Seino, M. Sakai, S. Yoshii, S. Nagasaka, I. Yamauchi, T. Okumura, K. Nin, K. Tokuyama, N. Yamadori, M. Ogura, A. Kuroe, and Y. Nakai Platelet count is independently associated with insulin resistance in nonobese Japanese type 2 diabetic patients Metabolism: Clinical and Experimental 52 2003 1246 1249
77. A.R. Tapas, D.M. Sakarkar, and R.B. Kakde Flavonoids as nutraceuticals: a review Tropical Journal of Pharmaceutical Research 7 2008 1089 1099
78. A.K. Taraphdar, M. Roy, and R.K. Bhattacharya Natural products as inducers of apoptosis: implication for cancer therapy and prevention Current Science 80 2001 1387 1396
79. A. Taylor Relationship between nutrition and oxidation Journal of the American College of Nutrition 12 1993 138 146
80. C.A.O. Usoro, C.C. Adikwuru, I.N. Usoro, and A.C. Nsonwu Lipid profile of postmenopausal women in Calabar, Nigeria Pakistan Journal of Nutrition 5 2006 79 82
81. A.C. Van der Wal, A.E. Becker, C.M. van der Loos, and P.K. Das Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology Circulation 89 1994 36 44
82. S.D. Varma Scientific basis of medical therapy of cataracts by antioxidants American Journal of Clinical Nutrition 53 1991 335S 345S
83. M. Vessal, M. Hemmati, and M. Vasei Antidiabetic effects of quercetin in streptozocin induced diabetic rats Comparative Biochemistry and Physiology C 135 2003 357 364
84. S.P. Wolff Diabetes mellitus and free radicals: free radicals, transition metals and oxidative stress in the aetiology of diabetes mellitus and complications British Medical Bulletin 49 1993 432 642
85. J. Zicha, J. Kunes, and M.A. Devynck Abnormalities of membrane function and lipid metabolism in hypertension: a review American Journal of Hypertension 12 1999 315 331