메뉴 건너뛰기




Volumn 21, Issue 11, 2011, Pages 1693-1741

Recent patents of dipeptidyl peptidase IV inhibitors

Author keywords

CD26; DPP IV; DPP IV inhibitors; Incretin molecules; Type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; BENZOPYRAZOLE DERIVATIVE; CYCLOHEXANE DERIVATIVE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; INSULIN; ISOCARBOSTYRIL DERIVATIVE; ISOQUINOLINE DERIVATIVE; METFORMIN; NAPHTHYRIDINE DERIVATIVE; PIPERAZINE DERIVATIVE; PIPERAZINONE DERIVATIVE; PIPERIDINE DERIVATIVE; PYRAZINE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; QUINAZOLINONE DERIVATIVE; QUINOLINE DERIVATIVE; QUINOLONE DERIVATIVE; QUINOXALINE DERIVATIVE; QUINOZALINE DERIVATIVE; SHR 1039; SHR 1040; SITAGLIPTIN; THIAZOLIDINE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XANTHINE DERIVATIVE;

EID: 80054933500     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1517/13543776.2011.627325     Document Type: Article
Times cited : (27)

References (164)
  • 1
    • 0033619675 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides
    • DOI 10.1016/S0167-0115(99)00089-0, PII S0167011599000890
    • Mentlein R. Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides. Regul Pept 1999;85:9-24 (Pubitemid 29505281)
    • (1999) Regulatory Peptides , vol.85 , Issue.1 , pp. 9-24
    • Mentlein, R.1
  • 2
    • 0037219684 scopus 로고    scopus 로고
    • Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog
    • DOI 10.1038/nsb882
    • Rasmussen HB, Branner S, Wiberg FC, et al. Crystal s tructure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog. Nat Struct Biol 2003;10:19-25 (Pubitemid 36034172)
    • (2003) Nature Structural Biology , vol.10 , Issue.1 , pp. 19-25
    • Rasmussen, H.B.1    Branner, S.2    Wiberg, F.C.3    Wagtmann, N.4
  • 3
    • 0037787851 scopus 로고    scopus 로고
    • Dipeptidyl-peptidase IV from bench to bedside: An update on structural properties, functions, and clinical aspects of the enzyme DPP IV
    • Lambeir AM, Durinx C, Scharpe S, et al. Dipeptidylpeptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV. Crit Rev Clin Lab Sci 2003;40:209-94 (Pubitemid 36775376)
    • (2003) Critical Reviews in Clinical Laboratory Sciences , vol.40 , Issue.3 , pp. 209-294
    • Lambeir, A.-M.1    Durinx, C.2    Scharpe, S.3    De Meester, I.4
  • 4
    • 0035723325 scopus 로고    scopus 로고
    • CD26: A multifunctional integral membrane and secreted protein of activated lymphocytes
    • DOI 10.1046/j.1365-3083.2001.00984.x
    • Gorrell MD, Gysbers V, McCaughan GW. CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes. Scand J Immunol 2001;54:249-64 (Pubitemid 34205737)
    • (2001) Scandinavian Journal of Immunology , vol.54 , Issue.3 , pp. 249-264
    • Gorrell, M.D.1    Gysbers, V.2    McCaughan, G.W.3
  • 5
    • 0025915551 scopus 로고
    • Evidence that thymocyte-activating molecule is mouse CD26 (dipeptidyl peptidase IV)
    • Vivier I, Marguet D, Naquet P, et al. Evidence that thymocyte-activating molecule is mouse CD26 (dipeptidyl peptidase IV). J Immunol 1991;147:447-54
    • (1991) J Immunol , vol.147 , pp. 447-54
    • Vivier, I.1    Marguet, D.2    Naquet, P.3
  • 6
    • 78650799604 scopus 로고    scopus 로고
    • Soluble CD26 / dipeptidyl peptidase IV enhances human lymphocyte proliferation in vitro independent of dipeptidyl peptidase enzyme activity and adenosine deaminase binding
    • Yu DM, Slaitini L, Gysbers V, et al. Soluble CD26 / dipeptidyl peptidase IV enhances human lymphocyte proliferation in vitro independent of dipeptidyl peptidase enzyme activity and adenosine deaminase binding. Scand J Immunol 2011;73:102-11
    • (2011) Scand J Immunol , Issue.73 , pp. 102-11
    • Yu, D.M.1    Slaitini, L.2    Gysbers, V.3
  • 8
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • DOI 10.1053/j.gastro.2007.03.054, PII S001650850700580X
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007;132:2131-57 (Pubitemid 46711096)
    • (2007) Gastroenterology , vol.132 , Issue.6 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 9
    • 79961191559 scopus 로고    scopus 로고
    • Regulation of glucagon secretion by incretins
    • Holst JJ, Christensen M, Lund A, et al. Regulation of glucagon secretion by incretins. Diabetes Obes Metab 2011;13(Suppl 1):89-94
    • (2011) Diabetes Obes Metab , vol.13 , Issue.SUPPL. 1 , pp. 89-94
    • Holst, J.J.1    Christensen, M.2    Lund, A.3
  • 11
    • 79951576817 scopus 로고    scopus 로고
    • Trophic effects of PACAP on pancreatic islets: A mini-review
    • Sakurai Y, Shintani N, Hayata A, et al. Trophic effects of PACAP on pancreatic islets: a mini-review. J Mol Neurosci 2011;43:3-7
    • (2011) J Mol Neurosci , vol.43 , pp. 3-7
    • Sakurai, Y.1    Shintani, N.2    Hayata, A.3
  • 12
    • 78651383361 scopus 로고    scopus 로고
    • Secretin and body fluid homeostasis
    • Chu JY, Cheng CY, Lee VH, et al. Secretin and body fluid homeostasis. Kidney Int 2011;79:280-7
    • (2011) Kidney Int , Issue.79 , pp. 280-7
    • Chu, J.Y.1    Cheng, C.Y.2    Lee, V.H.3
  • 13
    • 0030819309 scopus 로고    scopus 로고
    • Regulation of the receptor specificity and function of the chemokine RANTES (regulated on activation, normal T cell expressed and secreted) by dipeptidyl peptidase IV (CD26)-mediated cleavage
    • DOI 10.1084/jem.186.11.1865
    • Oravecz T, Pall M, Roderiquez G, et al. Regulation of the receptor specificity and function of the chemokine RANTES (regulated on activation, normal T cell expressed and secreted) by dipeptidyl peptidase IV (CD26)-mediated cleavage. J Exp Med 1997;186:1865-72 (Pubitemid 27524596)
    • (1997) Journal of Experimental Medicine , vol.186 , Issue.11 , pp. 1865-1872
    • Oravecz, T.1    Pall, M.2    Roderiquez, G.3    Gorrell, M.D.4    Ditto, M.5    Nguyen, N.Y.6    Boykins, R.7    Unsworth, E.8    Norcross, M.A.9
  • 14
    • 70350328161 scopus 로고    scopus 로고
    • Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease?
    • Yazbeck R, Howarth GS, Abbott CA. Dipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease? Trends Pharmacol Sci 2009;30:600-7
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 600-7
    • Yazbeck, R.1    Howarth, G.S.2    Abbott, C.A.3
  • 15
    • 61549105354 scopus 로고    scopus 로고
    • DPP-IV inhibition enhances the antilipolytic action of NPY in human adipose tissue
    • Kos K, Baker AR, Jernas M, et al. DPP-IV inhibition enhances the antilipolytic action of NPY in human adipose tissue. Diabetes Obes Metab 2009;11:285-92
    • (2009) Diabetes Obes Metab , vol.11 , pp. 285-92
    • Kos, K.1    Baker, A.R.2    Jernas, M.3
  • 17
    • 4644275017 scopus 로고    scopus 로고
    • The role of substance P in inflammatory disease
    • O?Connor TM, O?Connell J, O?Brien DI, et al. The role of substance P in inflammatory disease. J Cell Physiol 2004;201:167-80
    • (2004) J Cell Physiol , vol.201 , pp. 167-80
    • Oconnor, T.M.1    Oconnell, J.2    Obrien, D.I.3
  • 20
    • 34249902025 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: Preclinical biology and mechanisms of action
    • DOI 10.2337/dc07-0228
    • Drucker DJ. Dipeptidyl peptidase-4 inhibition and the treatment of type 2 diabetes: preclinical biology and mechanisms of action. Diabetes Care 2007;30:1335-43 (Pubitemid 46871135)
    • (2007) Diabetes Care , vol.30 , Issue.6 , pp. 1335-1343
    • Drucker, D.J.1
  • 22
    • 77957157551 scopus 로고    scopus 로고
    • The multiple faces of CXCL12 (SDF-1alpha) in the regulation of immunity during health and disease
    • Karin N. The multiple faces of CXCL12 (SDF-1alpha) in the regulation of immunity during health and disease. J Leukoc Biol 2010;88:463-73
    • (2010) J Leukoc Biol , Issue.88 , pp. 463-73
    • Karin, N.1
  • 23
    • 76349097770 scopus 로고    scopus 로고
    • The dipeptidyl peptidase IV family in cancer and cell biology
    • Yu DM, Yao TW, Chowdhury S, et al. The dipeptidyl peptidase IV family in cancer and cell biology. FEBS J 2010;277:1126-44
    • (2010) FEBS J , vol.277 , pp. 1126-44
    • Yu, D.M.1    Yao, T.W.2    Chowdhury, S.3
  • 24
    • 0028790702 scopus 로고
    • Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule
    • Martin M, Huguet J, Centelles JJ, et al. Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule. J Immunol 1995;155:4630-43
    • (1995) J Immunol , vol.155 , pp. 4630-43
    • Martin, M.1    Huguet, J.2    Centelles, J.J.3
  • 25
    • 78651319979 scopus 로고    scopus 로고
    • Ongoing and future developments at the universal protein resource
    • UniProt Consortium
    • UniProt Consortium. Ongoing and future developments at the universal protein resource. Nucleic Acids Res 2011;39:D214-19
    • (2011) Nucleic Acids Res , vol.39
  • 27
    • 2342447229 scopus 로고    scopus 로고
    • 2-antiplasmin inhibition of fibrin digestion
    • DOI 10.1182/blood-2003-12-4240
    • Lee KN, Jackson KW, Christiansen VJ, et al. A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion. Blood 2004;103:3783-8 (Pubitemid 38596296)
    • (2004) Blood , vol.103 , Issue.10 , pp. 3783-3788
    • Lee, K.N.1    Jackson, K.W.2    Christiansen, V.J.3    Chung, K.H.4    McKee, P.A.5
  • 28
    • 0000038304 scopus 로고    scopus 로고
    • Binding to human dipeptidyl peptidase IV by adenosine deaminase and antibodies that inhibit ligand binding involves overlapping, discontinuous sites on a predicted β propeller domain
    • DOI 10.1046/j.1432-1327.1999.00902.x
    • Abbott CA, McCaughan GW, Levy MT, et al. Binding to human dipeptidyl peptidase IV by adenosine deaminase and antibodies that inhibit ligand binding involves overlapping, discontinuous sites on a predicted beta propeller domain. Eur J Biochem 1999;266:798-810 (Pubitemid 30010097)
    • (1999) European Journal of Biochemistry , vol.266 , Issue.3 , pp. 798-810
    • Abbott, C.A.1    McCaughan, G.W.2    Levy, M.T.3    Church, W.B.4    Gorrell, M.D.5
  • 32
    • 0043092068 scopus 로고    scopus 로고
    • A novel consensus motif in fibronectin mediates dipeptidyl peptidase IV adhesion and metastasis
    • DOI 10.1074/jbc.M303424200
    • Cheng HC, Abdel-Ghany M, Pauli BU. A novel consensus motif in fibronectin mediates dipeptidyl peptidase IV adhesion and metastasis. J Biol Chem 2003;278:24600-7 (Pubitemid 37548613)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.27 , pp. 24600-24607
    • Cheng, H.-C.1    Abdel-Ghany, M.2    Pauli, B.U.3
  • 33
    • 0035871225 scopus 로고    scopus 로고
    • Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells
    • DOI 10.1042/0264-6021:3550397
    • Gonzalez-Gronow M, Grenett HE, Weber MR, et al. Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells. Biochem J 2001;355:397-407 (Pubitemid 32397799)
    • (2001) Biochemical Journal , vol.355 , Issue.2 , pp. 397-407
    • Gonzalez-Gronow, M.1    Grenett, H.E.2    Weber, M.R.3    Gawdi, G.4    Pizzo, S.V.5
  • 34
    • 0035824614 scopus 로고    scopus 로고
    • Association of Na(+)-H(+) exchanger isoform NHE3 and dipeptidyl peptidase IV in the renal proximal tubule
    • Girardi AC, Degray BC, Nagy T, et al. Association of Na(+)-H(+) exchanger isoform NHE3 and dipeptidyl peptidase IV in the renal proximal tubule. J Biol Chem 2001;276:46671-7
    • (2001) J Biol Chem , vol.276 , pp. 46671-7
    • Girardi, A.C.1    Degray, B.C.2    Nagy, T.3
  • 35
    • 34447569148 scopus 로고    scopus 로고
    • The Simpson-Golabi-Behmel syndrome causative Glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26
    • DOI 10.1002/pmic.200600654
    • Davoodi J, Kelly J, Gendron NH, et al. The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26. Proteomics 2007;7:2300-10 (Pubitemid 47067213)
    • (2007) Proteomics , vol.7 , Issue.13 , pp. 2300-2310
    • Davoodi, J.1    Kelly, J.2    Gendron, N.H.3    MacKenzie, A.E.4
  • 36
    • 0025730216 scopus 로고
    • Lymphocyte interactions with extracellular matrix
    • Shimizu Y, Shaw S. Lymphocyte interactions with extracellular matrix. FASEB J 1991;5:2292-9 (Pubitemid 21892906)
    • (1991) FASEB Journal , vol.5 , Issue.9 , pp. 2292-2299
    • Shimizu, Y.1    Shaw, S.2
  • 37
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 1993;214:829-35 (Pubitemid 23188160)
    • (1993) European Journal of Biochemistry , vol.214 , Issue.3 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 40
    • 78650106131 scopus 로고    scopus 로고
    • Incorporating incretin-based therapies into clinical practice: Differences between glucagon-like Peptide 1 receptor agonists and dipeptidyl peptidase 4 inhibitors
    • Davidson JA. Incorporating incretin-based therapies into clinical practice: differences between glucagon-like Peptide 1 receptor agonists and dipeptidyl peptidase 4 inhibitors. Mayo Clin Proc 2010;85:S27-37
    • (2010) Mayo Clin Proc , vol.85
    • Davidson, J.A.1
  • 41
    • 79955816345 scopus 로고    scopus 로고
    • Small molecule dipeptidylpeptidase IV inhibitors under investigation for diabetes mellitus therapy
    • Gallwitz B. Small molecule dipeptidylpeptidase IV inhibitors under investigation for diabetes mellitus therapy. Expert Opin Investig Drugs 2011;20:723-32
    • (2011) Expert Opin Investig Drugs , Issue.20 , pp. 723-32
    • Gallwitz, B.1
  • 42
    • 6344253102 scopus 로고    scopus 로고
    • CD26/dipeptidyl peptidase IV and its role in cancer
    • Pro B, Dang NH. CD26/dipeptidyl peptidase IV and its role in cancer. Histol Histopathol 2004;19:1345-51 (Pubitemid 39386791)
    • (2004) Histology and Histopathology , vol.19 , Issue.4 , pp. 1345-1351
    • Pro, B.1    Dang, N.H.2
  • 43
    • 27844453866 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV activity and/or structure homologs: Contributing factors in the pathogenesis of rheumatoid arthritis?
    • DOI 10.1186/ar1852
    • Sedo A, Duke-Cohan JS, Balaziova E, et al. Dipeptidyl peptidase IV activity and/or structure homologs: contributing factors in the pathogenesis of rheumatoid arthritis? Arthritis Res Ther 2005;7:253-69 (Pubitemid 41646256)
    • (2005) Arthritis Research and Therapy , vol.7 , Issue.6 , pp. 253-269
    • Sedo, A.1    Duke-Cohan, J.S.2    Balaziova, E.3    Sedova, L.R.4
  • 44
    • 77951725805 scopus 로고    scopus 로고
    • Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts
    • Ospelt C, Mertens JC, Jungel A, et al. Inhibition of fibroblast activation protein and dipeptidylpeptidase 4 increases cartilage invasion by rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 2010;62:1224-35
    • (2010) Arthritis Rheum , Issue.62 , pp. 1224-35
    • Ospelt, C.1    Mertens, J.C.2    Jungel, A.3
  • 45
    • 77952814507 scopus 로고    scopus 로고
    • Inhibition of multifunctional dipeptidyl peptidase-IV: Is there a risk of oncological and immunological adverse effects?
    • Stulc T, Sedo A. Inhibition of multifunctional dipeptidyl peptidase-IV: is there a risk of oncological and immunological adverse effects? Diabetes Res Clin Pract 2010;88:125-31
    • (2010) Diabetes Res Clin Pract , Issue.88 , pp. 125-31
    • Stulc, T.1    Sedo, A.2
  • 46
    • 0021230368 scopus 로고
    • Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria
    • Umezawa H, Aoyagi T, Ogawa K, et al. Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria. J Antibiot (Tokyo) 1984;37:422-5 (Pubitemid 14129498)
    • (1984) Journal of Antibiotics , vol.37 , Issue.4 , pp. 422-425
    • Umezawa, H.1    Aoyagi, T.2    Ogawa, K.3
  • 47
    • 0024205414 scopus 로고
    • Dipeptidylpeptidase IV-inactivation with N-peptidyl-O-aroyl hydroxylamines
    • Demuth HU, Baumgrass R, Schaper C, et al. Dipeptidylpeptidase IV-inactivation with N-peptidyl-O-aroyl hydroxylamines. J Enzyme Inhib 1988;2:129-42
    • (1988) J Enzyme Inhib , vol.2 , pp. 129-42
    • Demuth, H.U.1    Baumgrass, R.2    Schaper, C.3
  • 49
    • 0028803516 scopus 로고
    • Aminoacylpyrrolidine-2-nitriles: Potent and stable inhibitors of dipeptidyl-peptidase IV (CD 26)
    • Li J, Wilk E, Wilk S. Aminoacylpyrrolidine-2-nitriles: potent and stable inhibitors of dipeptidyl-peptidase IV (CD 26). Arch Biochem Biophys 1995;323:148-54
    • (1995) Arch Biochem Biophys , vol.323 , pp. 148-54
    • Li, J.1    Wilk, E.2    Wilk, S.3
  • 50
    • 15944404686 scopus 로고    scopus 로고
    • The therapeutic potential of inhibitors of dipeptidyl peptidase IV (DPP IV) and related proline-specific dipeptidyl aminopeptidases
    • DOI 10.2174/0929867053507298
    • Augustyns K, Van der Veken P, Senten K, et al. The therapeutic potential of inhibitors of dipeptidyl peptidase IV (DPP IV) and related proline-specific dipeptidyl aminopeptidases. Curr Med Chem 2005;12:971-98 (Pubitemid 40443851)
    • (2005) Current Medicinal Chemistry , vol.12 , Issue.8 , pp. 971-998
    • Augustyns, K.1    Van Der Veken, P.2    Senten, K.3    Haemers, A.4
  • 52
    • 80054931112 scopus 로고    scopus 로고
    • Novo Nordisk A/S. WO0202560A2; 2002
    • Novo Nordisk A/S. WO0202560A2; 2002
  • 53
    • 80054883263 scopus 로고    scopus 로고
    • Boehringer Ingelheim Pharma KG. WO02068420A1; 2002
    • Boehringer Ingelheim Pharma KG. WO02068420A1; 2002
  • 54
    • 80054954481 scopus 로고    scopus 로고
    • Merck & Co. US6699871B2; 2004
    • Merck & Co. US6699871B2; 2004
  • 55
    • 80054895071 scopus 로고    scopus 로고
    • F. Hoffmann-La Roche AG. US6166063; 2000
    • F. Hoffmann-La Roche AG. US6166063; 2000
  • 56
    • 80054896601 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Co. US6395767B2;2002
    • Bristol-Myers Squibb Co. US6395767B2;2002
  • 57
    • 80054954903 scopus 로고    scopus 로고
    • Takeda. WO2005095381A1; 2005
    • Takeda. WO2005095381A1; 2005
  • 58
    • 69849115380 scopus 로고    scopus 로고
    • Mechanisms underlying the rapid degradation and elimination of the incretin hormones GLP-1 and GIP
    • Mentlein R. Mechanisms underlying the rapid degradation and elimination of the incretin hormones GLP-1 and GIP. Best Pract Res Clin Endocrinol Metab 2009;23:443-52
    • (2009) Best Pract Res Clin Endocrinol Metab , vol.23 , pp. 443-52
    • Mentlein, R.1
  • 60
    • 20444421293 scopus 로고    scopus 로고
    • Fibroblast activation protein-α and dipeptidyl peptidase IV (CD26): Cell-surface proteases that activate cell signaling and are potential targets for cancer therapy
    • DOI 10.1016/j.drup.2005.03.002, PII S1368764605000257
    • Kelly T. Fibroblast activation protein-alpha and dipeptidyl peptidase IV (CD26): cell-surface proteases that activate cell signaling and are potential targets for cancer therapy. Drug Resist Updat 2005;8:51-8 (Pubitemid 40797956)
    • (2005) Drug Resistance Updates , vol.8 , Issue.1-2 , pp. 51-58
    • Kelly, T.1
  • 61
    • 70549096922 scopus 로고    scopus 로고
    • Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition
    • Kirby M, Yu DM, O?Connor S, et al. Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition. Clin Sci (Lond) 2010;118:31-41
    • (2010) Clin Sci (Lond) , vol.118 , pp. 31-41
    • Kirby, M.1    Yu, D.M.2    Oconnor, S.3
  • 62
    • 79959422016 scopus 로고    scopus 로고
    • Low molecular weight inhibitors of Prolyl Oligopeptidase: A review of compounds patented from 2003 to 2010
    • Lopez A, Tarrago T, Giralt E. Low molecular weight inhibitors of Prolyl Oligopeptidase: a review of compounds patented from 2003 to 2010. Expert Opin Ther Patent 2011;21:1023-44
    • (2011) Expert Opin Ther Patent , vol.21 , pp. 1023-44
    • Lopez, A.1    Tarrago, T.2    Giralt, E.3
  • 63
    • 80054963112 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Co. WO2007053819A2; 2007
    • Bristol-Myers Squibb Co. WO2007053819A2; 2007
  • 64
    • 80054905057 scopus 로고    scopus 로고
    • National Health Research Institutes (Taiwan). US20070082932A1; 2007
    • National Health Research Institutes (Taiwan). US20070082932A1; 2007
  • 65
    • 80054951546 scopus 로고    scopus 로고
    • National Health Research Institutes (Taiwan). WO2009111239A2; 2009
    • National Health Research Institutes (Taiwan). WO2009111239A2; 2009
  • 66
    • 80054964196 scopus 로고    scopus 로고
    • Tufts University. WO2008119005A1; 2008
    • Tufts University. WO2008119005A1; 2008
  • 67
    • 80054909914 scopus 로고    scopus 로고
    • Kainos Medicine, ICC. WO2008087560A2; 2008
    • Kainos Medicine, ICC. WO2008087560A2; 2008
  • 68
    • 80054958407 scopus 로고    scopus 로고
    • Alantos Pharmaceuticals, I. WO2006116157A2; 2006
    • Alantos Pharmaceuticals, I. WO2006116157A2; 2006
  • 69
    • 80054884385 scopus 로고    scopus 로고
    • Merck & Co., I. WO2006009886A1; 2006
    • Merck & Co., I. WO2006009886A1; 2006
  • 70
    • 80054902985 scopus 로고    scopus 로고
    • Merck & Co., I. WO2006127530A2; 2006
    • Merck & Co., I. WO2006127530A2; 2006
  • 71
    • 80054931111 scopus 로고    scopus 로고
    • Novartis. WO2008077597A1; 2008
    • Novartis. WO2008077597A1; 2008
  • 72
    • 80054890334 scopus 로고    scopus 로고
    • F. Hoffmann-La Roche AG. WO2006066770; 2006
    • F. Hoffmann-La Roche AG. WO2006066770; 2006
  • 73
    • 80054901109 scopus 로고    scopus 로고
    • Merck & Co., I. WO2006039325A2; 2006
    • Merck & Co., I. WO2006039325A2; 2006
  • 74
    • 80054881022 scopus 로고    scopus 로고
    • F. Hoffmann-La Roche AG. WO2006066747A1; 2006
    • F. Hoffmann-La Roche AG. WO2006066747A1; 2006
  • 76
    • 80054887583 scopus 로고    scopus 로고
    • Astellas Pharma. WO2006098342A1; 2006
    • Astellas Pharma. WO2006098342A1; 2006
  • 77
    • 80054921613 scopus 로고    scopus 로고
    • Dong-A Pharm. D.-A. WO2008130151A1; 2008
    • Dong-A Pharm. D.-A. WO2008130151A1; 2008
  • 78
    • 80054911931 scopus 로고    scopus 로고
    • Dong-A Pharm. US20100120790A1; 2010
    • Dong-A Pharm. US20100120790A1; 2010
  • 79
    • 80054927207 scopus 로고    scopus 로고
    • Eli Lilly and Co. WO2007015767A1; 2007
    • Eli Lilly and Co. WO2007015767A1; 2007
  • 80
    • 80054907266 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Co. WO2006071762A2; 2006
    • Bristol-Myers Squibb Co. WO2006071762A2; 2006
  • 81
    • 80054937053 scopus 로고    scopus 로고
    • Phenomix Corp. WO2006017292A1; 2006
    • Phenomix Corp. WO2006017292A1; 2006
  • 82
    • 80054949726 scopus 로고    scopus 로고
    • Shanghai Hengrui Pharmaceutical Co. WO2008089636A1; 2008
    • Shanghai Hengrui Pharmaceutical Co. WO2008089636A1; 2008
  • 83
    • 80054891257 scopus 로고    scopus 로고
    • Shanghai Hengrui Pharmaceutical Co. EP2133077A1; 2007
    • Shanghai Hengrui Pharmaceutical Co. EP2133077A1; 2007
  • 84
    • 80054960271 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Co. WO2006127287A2; 2006
    • Bristol-Myers Squibb Co. WO2006127287A2; 2006
  • 85
    • 80054921120 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Co. WO2006071752A1; 2006
    • Bristol-Myers Squibb Co. WO2006071752A1; 2006
  • 86
    • 80054907493 scopus 로고    scopus 로고
    • Merck & Co., I. WO2006078676A2; 2006
    • Merck & Co., I. WO2006078676A2; 2006
  • 87
    • 80054906792 scopus 로고    scopus 로고
    • Boehringer Ingelheim Pharma KG. WO2008017670A1; 2008
    • Boehringer Ingelheim Pharma KG. WO2008017670A1; 2008
  • 88
    • 80054931110 scopus 로고    scopus 로고
    • Concert Pharmaceuticals. WO2008141021A1; 2008
    • Concert Pharmaceuticals. WO2008141021A1; 2008
  • 89
    • 80054906791 scopus 로고    scopus 로고
    • Aurigene Discovery Technologies. WO2006134613A2; 2006
    • Aurigene Discovery Technologies. WO2006134613A2; 2006
  • 90
    • 80054923492 scopus 로고    scopus 로고
    • Peakdale Molecular. WO2008040974A1; 2008
    • Peakdale Molecular. WO2008040974A1; 2008
  • 91
    • 80054955810 scopus 로고    scopus 로고
    • Peakdale Molecular. WO2008040995A1; 2008
    • Peakdale Molecular. WO2008040995A1; 2008
  • 92
    • 80054960740 scopus 로고    scopus 로고
    • Sanofi-Aventis. WO2006111261A1; 2006
    • Sanofi-Aventis. WO2006111261A1; 2006
  • 93
    • 80054928465 scopus 로고    scopus 로고
    • Dainippon Sumitomo Pharma. EP1690863A1; 2006
    • Dainippon Sumitomo Pharma. EP1690863A1; 2006
  • 94
    • 80054891256 scopus 로고    scopus 로고
    • Dainippon Sumitomo Pharma. US20070105890A1; 2007
    • Dainippon Sumitomo Pharma. US20070105890A1; 2007
  • 95
    • 80054946458 scopus 로고    scopus 로고
    • Sanofi-Aventis. WO2006015691A1; 2006
    • Sanofi-Aventis. WO2006015691A1; 2006
  • 96
    • 80054947856 scopus 로고    scopus 로고
    • Sanofi-Aventis. WO2006015699A1; 2006
    • Sanofi-Aventis. WO2006015699A1; 2006
  • 97
    • 80054904620 scopus 로고    scopus 로고
    • Sanofi-Aventis. WO2006015701A1; 2006
    • Sanofi-Aventis. WO2006015701A1; 2006
  • 98
    • 80054957017 scopus 로고    scopus 로고
    • Sanofi-Aventis. WO2006015700A1; 2006
    • Sanofi-Aventis. WO2006015700A1; 2006
  • 99
    • 80054918407 scopus 로고    scopus 로고
    • Boehringer Ingelheim Pharma KG. WO2006027204A1; 2006
    • Boehringer Ingelheim Pharma KG. WO2006027204A1; 2006
  • 100
    • 80054901237 scopus 로고    scopus 로고
    • Boehringer Ingelheim Pharma KG. WO2006029769; 2006
    • Boehringer Ingelheim Pharma KG. WO2006029769; 2006
  • 101
    • 80054932988 scopus 로고    scopus 로고
    • Boehringer Ingelheim Pharma KG. WO2009147125A1; 2009
    • Boehringer Ingelheim Pharma KG. WO2009147125A1; 2009
  • 102
    • 80054909434 scopus 로고    scopus 로고
    • Boehringer Ingelheim Pharma KG. WO2010086411A1 2010
    • Boehringer Ingelheim Pharma KG. WO2010086411A1 2010
  • 103
    • 80054962138 scopus 로고    scopus 로고
    • Boehringer Ingelheim Pharma KG. US20100173916A1 2010
    • Boehringer Ingelheim Pharma KG. US20100173916A1 2010
  • 104
    • 80054931672 scopus 로고    scopus 로고
    • Boehringer Ingelheim Pharma KG. US20100204250A1 2010
    • Boehringer Ingelheim Pharma KG. US20100204250A1 2010
  • 105
    • 80054895556 scopus 로고    scopus 로고
    • Novartis. WO2007071738A1; 2007
    • Novartis. WO2007071738A1; 2007
  • 106
    • 80054878545 scopus 로고    scopus 로고
    • Takeda. WO2006020017A2; 2006
    • Takeda. WO2006020017A2; 2006
  • 107
    • 80054965129 scopus 로고    scopus 로고
    • Takeda. WO2007112347; 2007
    • Takeda. WO2007112347; 2007
  • 108
    • 80054936012 scopus 로고    scopus 로고
    • Takeda. US7732446B1 2010
    • Takeda. US7732446B1 2010
  • 109
    • 80054956561 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Co. WO2008064107; 2008
    • Bristol-Myers Squibb Co. WO2008064107; 2008
  • 110
    • 80054896031 scopus 로고    scopus 로고
    • LG Life Sciences. WO2009082134A2; 2009
    • LG Life Sciences. WO2009082134A2; 2009
  • 111
    • 80054888498 scopus 로고    scopus 로고
    • F. Hoffmann-La Roche AG. WO2006058628A2; 2006
    • F. Hoffmann-La Roche AG. WO2006058628A2; 2006
  • 113
    • 74049094489 scopus 로고    scopus 로고
    • Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors
    • Boehringer M, Fischer H, Hennig M, et al. Aryl- and heteroaryl- substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett 2010;20:1106-8
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 1106-8
    • Boehringer, M.1    Fischer, H.2    Hennig, M.3
  • 114
    • 80054880014 scopus 로고    scopus 로고
    • Merck & Co., I. WO2006058064; 2006
    • Merck & Co., I. WO2006058064; 2006
  • 115
    • 80054889565 scopus 로고    scopus 로고
    • Merck & Co., I. WO2007024993; 2007
    • Merck & Co., I. WO2007024993; 2007
  • 116
    • 67650002790 scopus 로고    scopus 로고
    • Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors
    • Edmondson SD, Mastracchio A, Cos JM, et al. Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors. Bioorg Med Chem Lett 2009;19:4097-101
    • (2009) Bioorg Med Chem Lett , vol.19 , pp. 4097-101
    • Edmondson, S.D.1    Mastracchio, A.2    Cos, J.M.3
  • 117
    • 80054886577 scopus 로고    scopus 로고
    • Merck. WO2006023750A2; 2006
    • Merck. WO2006023750A2; 2006
  • 118
    • 80054964195 scopus 로고    scopus 로고
    • Santhera Pharmaceuticals. WO2006097175A1; 2006
    • Santhera Pharmaceuticals. WO2006097175A1; 2006
  • 119
    • 80054948787 scopus 로고    scopus 로고
    • Santhera Pharmaceuticals. WO2008028662A1; 2008
    • Santhera Pharmaceuticals. WO2008028662A1; 2008
  • 120
    • 80054918406 scopus 로고    scopus 로고
    • LG Life Sciences. WO2006104356A1; 2006
    • LG Life Sciences. WO2006104356A1; 2006
  • 121
    • 80054878094 scopus 로고    scopus 로고
    • LG Life Sciences. WO2008093960A1; 2008
    • LG Life Sciences. WO2008093960A1; 2008
  • 122
    • 80054890333 scopus 로고    scopus 로고
    • Eli Lilly and Co. WO2007015805; 2007
    • Eli Lilly and Co. WO2007015805; 2007
  • 123
    • 80054881021 scopus 로고    scopus 로고
    • Eli Lilly and Co. WO2007015807; 2007
    • Eli Lilly and Co. WO2007015807; 2007
  • 124
    • 80054952434 scopus 로고    scopus 로고
    • Panacea Biotec. WO2009093269; 2009
    • Panacea Biotec. WO2009093269; 2009
  • 125
    • 80054919347 scopus 로고    scopus 로고
    • Takeda. WO2006068978A2; 2006
    • Takeda. WO2006068978A2; 2006
  • 126
    • 80054933627 scopus 로고    scopus 로고
    • Glenmark Pharmaceuticals. WO20060400625A1; 2006
    • Glenmark Pharmaceuticals. WO20060400625A1; 2006
  • 127
    • 80054923491 scopus 로고    scopus 로고
    • Glenmark Pharmaceuticals. WO2006011035A1; 2006
    • Glenmark Pharmaceuticals. WO2006011035A1; 2006
  • 128
    • 80054886109 scopus 로고    scopus 로고
    • Glenmark Pharmaceuticals. WO2007099385A1; 2007
    • Glenmark Pharmaceuticals. WO2007099385A1; 2007
  • 129
    • 80054888048 scopus 로고    scopus 로고
    • Santhera Pharmaceuticals. WO2006013104; 2006
    • Santhera Pharmaceuticals. WO2006013104; 2006
  • 130
    • 80054921505 scopus 로고    scopus 로고
    • Santhera Pharmaceuticals. WO2009003681; 2009
    • Santhera Pharmaceuticals. WO2009003681; 2009
  • 131
    • 80054915304 scopus 로고    scopus 로고
    • Orchid Research Laboratories. WO2008029217; 2008
    • Orchid Research Laboratories. WO2008029217; 2008
  • 132
    • 80054911562 scopus 로고    scopus 로고
    • Orchid Research Laboratories. WO2010079413; 2010
    • Orchid Research Laboratories. WO2010079413; 2010
  • 133
    • 80054964696 scopus 로고    scopus 로고
    • Ranbaxy Laboratories. WO07029086; 2007
    • Ranbaxy Laboratories. WO07029086; 2007
  • 134
    • 47149101243 scopus 로고    scopus 로고
    • Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors
    • Sattigeri JA, Andappan MM, Kishore K, et al. Discovery of conformationally rigid 3-azabicyclo[3.1.0]hexane-derived dipeptidyl peptidase-IV inhibitors. Bioorg Med Chem Lett 2008;18:4087-91
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 4087-91
    • Sattigeri, J.A.1    Andappan, M.M.2    Kishore, K.3
  • 135
    • 78650915884 scopus 로고    scopus 로고
    • RBx- 0597, a potent, selective and slow-binding inhibitor of dipeptidyl peptidase-IV for the treatment of type 2 diabetes
    • Singh S, Sethi S, Khanna V, et al. RBx- 0597, a potent, selective and slow-binding inhibitor of dipeptidyl peptidase-IV for the treatment of type 2 diabetes. Eur J Pharmacol 2011;652:157-63
    • (2011) Eur J Pharmacol , vol.652 , pp. 157-63
    • Singh, S.1    Sethi, S.2    Khanna, V.3
  • 136
    • 80054942838 scopus 로고    scopus 로고
    • Concert Pharmaceuticals. WO2009045476; 2009
    • Concert Pharmaceuticals. WO2009045476; 2009
  • 137
    • 80054910742 scopus 로고    scopus 로고
    • Glenmark Pharmaceuticals. WO2006090244; 2006
    • Glenmark Pharmaceuticals. WO2006090244; 2006
  • 138
    • 80054897042 scopus 로고    scopus 로고
    • Matrix Laboratories. WO2007113634; 2007
    • Matrix Laboratories. WO2007113634; 2007
  • 139
    • 80054915784 scopus 로고    scopus 로고
    • Lupin. WO2010146597 2010
    • Novartis. WO2009068531; 2009
  • 140
    • 80054901906 scopus 로고    scopus 로고
    • Lupin. WO2010146597 2010
    • Lupin. WO2009037719; 2009
  • 141
    • 80054919346 scopus 로고    scopus 로고
    • Lupin. WO2010146597 2010
    • Lupin. WO2010146597 2010
  • 142
    • 80054893670 scopus 로고    scopus 로고
    • Susan Marie Royalty. WO2006012441; 2006
    • Susan Marie Royalty. WO2006012441; 2006
  • 143
    • 80054945355 scopus 로고    scopus 로고
    • Susan Marie Royalty. WO2006012395; 2006
    • Susan Marie Royalty. WO2006012395; 2006
  • 144
    • 80054956013 scopus 로고    scopus 로고
    • Susan Marie Royalty. US7842707; 2010
    • Susan Marie Royalty. US7842707; 2010
  • 145
    • 80054955342 scopus 로고    scopus 로고
    • Phenomix Corp. US20060264401; 2006
    • Phenomix Corp. US20060264401; 2006
  • 146
    • 80054903866 scopus 로고    scopus 로고
    • Phenomix Corp. US20070185061; 2007
    • Phenomix Corp. US20070185061; 2007
  • 147
    • 80054879573 scopus 로고    scopus 로고
    • Phenomix Corp. US7317109; 2008
    • Phenomix Corp. US7317109; 2008
  • 148
    • 80054889074 scopus 로고    scopus 로고
    • Phenomix Corp. US20070299036; 2007
    • Phenomix Corp. US20070299036; 2007
  • 149
    • 80054896030 scopus 로고    scopus 로고
    • Phenomix Corp. US20080182995; 2008
    • Phenomix Corp. US20080182995; 2008
  • 150
    • 80054924905 scopus 로고    scopus 로고
    • Phenomix Corp. WO2008027273; 2008
    • Phenomix Corp. WO2008027273; 2008
  • 151
    • 80054923490 scopus 로고    scopus 로고
    • Phenomix Corp. WO2008144730; 2008
    • Phenomix Corp. WO2008144730; 2008
  • 152
    • 80054958885 scopus 로고    scopus 로고
    • Phenomix Corp. WO2010107809; 2010
    • Phenomix Corp. WO2010107809; 2010
  • 153
    • 80054942362 scopus 로고    scopus 로고
    • Phenomix Corp. US7674913; 2010
    • Phenomix Corp. US7674913; 2010
  • 154
    • 80054948786 scopus 로고    scopus 로고
    • Phenomix Corp. US7576121; 2009
    • Phenomix Corp. US7576121; 2009
  • 155
    • 80054944015 scopus 로고    scopus 로고
    • Phenomix Corp. US20080300413; 2008
    • Phenomix Corp. US20080300413; 2008
  • 156
    • 80054902375 scopus 로고    scopus 로고
    • Tufts University. WO2007100374; 2007
    • Tufts University. WO2007100374; 2007
  • 157
    • 80054903451 scopus 로고    scopus 로고
    • Tufts University. WO2008118848; 2008
    • Tufts University. WO2008118848; 2008
  • 158
    • 80054921119 scopus 로고    scopus 로고
    • Tufts University. WO2010099537; 2010
    • Tufts University. WO2010099537; 2010
  • 159
    • 53549132011 scopus 로고    scopus 로고
    • Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: Determinants of potency and in vivo efficacy and safety
    • Connolly BA, Sanford DG, Chiluwal AK, et al. Dipeptide boronic acid inhibitors of dipeptidyl peptidase IV: determinants of potency and in vivo efficacy and safety. J Med Chem 2008;51:6005-13
    • (2008) J Med Chem , vol.51 , pp. 6005-13
    • Connolly, B.A.1    Sanford, D.G.2    Chiluwal, A.K.3
  • 160
    • 80054890766 scopus 로고    scopus 로고
    • F. Hoffmann-La Roche AG. WO2007054577; 2007
    • F. Hoffmann-La Roche AG. WO2007054577; 2007
  • 161
    • 80054887582 scopus 로고    scopus 로고
    • Cadila Pharmaceuticals. WO2010029422; 2010
    • Cadila Pharmaceuticals. WO2010029422; 2010
  • 162
    • 79953713734 scopus 로고    scopus 로고
    • Selective inhibition of dipeptidyl peptidase 4 by targeting a substrate-specific secondary binding site
    • Kuhn-Wache K, Bar JW, Hoffmann T, et al. Selective inhibition of dipeptidyl peptidase 4 by targeting a substrate-specific secondary binding site. Biol Chem 2011;392:223-31
    • (2011) Biol Chem , Issue.392 , pp. 223-31
    • Kuhn-Wache, K.1    Bar, J.W.2    Hoffmann, T.3
  • 163
    • 79953325779 scopus 로고    scopus 로고
    • Novel aspects of cellular action of dipeptidyl peptidase IV/CD26
    • Ansorge S, Nordhoff K, Bank U, et al. Novel aspects of cellular action of dipeptidyl peptidase IV/CD26. Biol Chem 2011;392:153-68
    • (2011) Biol Chem , Issue.392 , pp. 153-68
    • Ansorge, S.1    Nordhoff, K.2    Bank, U.3
  • 164
    • 79959773411 scopus 로고    scopus 로고
    • DPP-4 inhibitors: Impact on glycemic control and cardiovascular risk factors
    • Dicker D. DPP-4 inhibitors: impact on glycemic control and cardiovascular risk factors. Diabetes Care 2011;34(Suppl 2):S276-8
    • (2011) Diabetes Care , vol.34 , Issue.SUPPL. 2
    • Dicker, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.